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Text
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URL Address
<a href="http://doi.org/10.1002/jnr.490350207" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/jnr.490350207</a>
Pages
170–182
Issue
2
Volume
35
Dublin Core
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Title
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Serotonin-activated alpha 2-macroglobulin inhibits neurite outgrowth and survival of embryonic sensory and cerebral cortical neurons.
Publisher
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Journal of neuroscience research
Date
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1993
1993-06
Subject
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Afferent/drug effects/ultrastructure; alpha-Macroglobulins/metabolism/*pharmacology; Animals; Bovine/pharmacology; Cell Survival/drug effects; Cells; Chick Embryo; Cultured; Frontal Lobe/*cytology/embryology; Ganglia; Humans; Nerve Growth Factors/*antagonists & inhibitors/pharmacology; Neurites/drug effects/ultrastructure; Neurons; Neurons/*drug effects/ultrastructure; Protein Binding; Rats; Serotonin/metabolism/*pharmacology; Serum Albumin; Spinal/*cytology/embryology
Creator
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Liebl D J; Koo P H
Description
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Methylamine-modified alpha-2-macroglobulin (MA-alpha 2M) has been recently shown to inhibit the biological activity of beta-nerve growth factor (NGF) in promoting neurite outgrowth by embryonic dorsal root ganglia in culture (Koo PH, Liebl DJ, J Neurosci Res 31:678-692, 1992). The objectives of this study are to determine whether alpha 2M can also be modified by larger aromatic biogenic amines such as
Identifier
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<a href="http://doi.org/10.1002/jnr.490350207" target="_blank" rel="noreferrer noopener">10.1002/jnr.490350207</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1993
Afferent/drug effects/ultrastructure
alpha-Macroglobulins/metabolism/*pharmacology
Animals
Bovine/pharmacology
Cell Survival/drug effects
Cells
Chick Embryo
Cultured
Frontal Lobe/*cytology/embryology
Ganglia
Humans
Journal of neuroscience research
Koo P H
Liebl D J
Nerve Growth Factors/*antagonists & inhibitors/pharmacology
Neurites/drug effects/ultrastructure
Neurons
Neurons/*drug effects/ultrastructure
Protein Binding
Rats
Serotonin/metabolism/*pharmacology
Serum Albumin
Spinal/*cytology/embryology