1
40
6
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(88)90310-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(88)90310-3</a>
Pages
53–57
Issue
1
Volume
31
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Use of TFMPP stimulus properties as a model of 5-HT1B receptor activation.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988-09
Subject
The topic of the resource
Male; Animals; Rats; Serotonin/pharmacology; Pharmaceutical Vehicles; Discrimination Learning/*drug effects; Norfenfluramine/pharmacology; Piperazines/*pharmacology; Dose-Response Relationship; Drug; Receptors; Biological; Models; Serotonin/*drug effects/physiology
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
Recent evidence indicates that when 1-(3-trifluoromethylphenyl)piperazine (TFMPP) is used as a training drug in the drug discrimination paradigm it produces a stimulus effect that is site-selective at the 5-HT1B receptor. The present study sought to employ this procedure in order to assess the similarity of novel agents to TFMPP. First, rats were trained to reliably discriminate between the stimulus properties of intraperitoneally administered 1.0 mg/kg TFMPP and its vehicle. Following the acquisition of this discrimination, administration of various doses of TFMPP produced a typical dose-response relationship with an ED50 of 0.27 mg/kg. Rats were subsequently tested with another 5-HT1B specific agonist
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(88)90310-3" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(88)90310-3</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1988
Animals
Biological
Discrimination Learning/*drug effects
Dose-Response Relationship
Drug
Male
Models
Norfenfluramine/pharmacology
Pharmaceutical Vehicles
Pharmacology, biochemistry, and behavior
Piperazines/*pharmacology
Rats
Receptors
Schechter M D
Serotonin/*drug effects/physiology
Serotonin/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
81–91
Issue
1
Volume
74
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Rat alpha1-macroglobulin enhances nerve growth factor-promoted neurite outgrowth, TrkA phosphorylation, and gene expression of pheochromocytoma PC12 cells.
Publisher
An entity responsible for making the resource available
Journal of neurochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
2000-01
Subject
The topic of the resource
Animals; Phosphorylation/drug effects; Rats; Transcription Factors/genetics; Gene Expression/*drug effects; Nerve Growth Factor/*pharmacology; *Immediate-Early Proteins; alpha-Macroglobulins/drug effects/metabolism/*pharmacology; Carrier Proteins; DNA-Binding Proteins/genetics; Early Growth Response Protein 1; Matrix Metalloproteinase 3/metabolism; Membrane Proteins; Nerve Growth Factors/genetics; Neurites/drug effects/*physiology; PC12 Cells/drug effects/metabolism/*physiology; Proto-Oncogene Proteins c-jun/genetics; Serotonin/pharmacology; Sprague-Dawley; Receptor; trkA/*metabolism
Creator
An entity primarily responsible for making the resource
Lee P G; Koo P H
Description
An account of the resource
Monoamine-activated human alpha2-macroglobulin (alpha2M) has been previously demonstrated to inhibit TrkA-, TrkB-, and TrkC-mediated signal transduction. Rat alpha1-macroglobulin (alpha1M) and alpha2M are structural homologues of human alpha2M, but rat alpha1M is distinctly different from rat alpha2M in many ways and its role in the mammalian nervous system is unknown. In this report, monoamine-activated rat alpha1M was demonstrated to enhance in a dose-dependent manner nerve growth factor (NGF)-promoted neurite outgrowth in pheochromocytoma PC12 cells. Monoamine-activated alpha1M by itself, however, was neither neurotrophic nor mitogenic to PC12 cells. To investigate further its possible mode of action, the ability of monoamine-activated alpha1M and normal alpha1M to bind and to activate the NGF receptor (TrkA) was investigated. Monoamine-activated alpha1M formed a more stable complex with TrkA than normal alpha1 M, but the binding of monoamine-activated alpha1M to TrkA was adversely affected by prior stimulation of TrkA with NGF. In addition, monoamine-activated alpha1M enhanced the NGF-promoted TrkA phosphorylation and up-regulated the expression of NGF-inducible immediate-early genes (c-jun and NGFI-A) and delayed-response genes (SCG10 and transin) in PC12 cells; normal alpha1M, in contrast, produced little or no effect. This study demonstrates that alpha1M, the constitutive form of alpha-macroglobulin in the rat, possesses the ability to promote NGF-mediated differentiation in PC12 cells, possibly via its direct action on TrkA receptors and TrkA-mediated signal transduction and gene expression.
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Immediate-Early Proteins
2000
alpha-Macroglobulins/drug effects/metabolism/*pharmacology
Animals
Carrier Proteins
DNA-Binding Proteins/genetics
Early Growth Response Protein 1
Gene Expression/*drug effects
Journal of neurochemistry
Koo P H
Lee P G
Matrix Metalloproteinase 3/metabolism
Membrane Proteins
Nerve Growth Factor/*pharmacology
Nerve Growth Factors/genetics
Neurites/drug effects/*physiology
PC12 Cells/drug effects/metabolism/*physiology
Phosphorylation/drug effects
Proto-Oncogene Proteins c-jun/genetics
Rats
Receptor
Serotonin/pharmacology
Sprague-Dawley
Transcription Factors/genetics
trkA/*metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
347–353
Issue
3
Volume
202
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Possible serotonergic and dopaminergic mediation of the
Publisher
An entity responsible for making the resource available
European journal of pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-09
Subject
The topic of the resource
Male; Animals; Rats; Serotonin/pharmacology; Discrimination Learning/drug effects; Serotonin Antagonists/pharmacology; Motor Activity/drug effects; Designer Drugs/pharmacology; Fenclonine/pharmacology; Inbred Strains; Receptors; 3; N-Methyl-3; 4-methylenedioxyamphetamine; 4-Methylenedioxyamphetamine/*analogs & derivatives/pharmacology; Dopamine/*drug effects; Serotonin/*drug effects
Creator
An entity primarily responsible for making the resource
Boja J W; Schechter M D
Description
An account of the resource
Eight male rats previously trained to discriminate 2.0 mg/kg
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
3
4-methylenedioxyamphetamine
4-Methylenedioxyamphetamine/*analogs & derivatives/pharmacology
Animals
Boja J W
Designer Drugs/pharmacology
Discrimination Learning/drug effects
Dopamine/*drug effects
European journal of pharmacology
Fenclonine/pharmacology
Inbred Strains
Male
Motor Activity/drug effects
N-Methyl-3
Rats
Receptors
Schechter M D
Serotonin Antagonists/pharmacology
Serotonin/*drug effects
Serotonin/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(88)90350-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(88)90350-4</a>
Pages
305–311
Issue
2
Volume
31
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Norfenfluramine, the fenfluramine metabolite, provides stimulus control: evidence for serotonergic mediation.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988-10
Subject
The topic of the resource
Male; Time Factors; Animals; Rats; Behavior; Serotonin/pharmacology; Discrimination (Psychology)/*drug effects; Fenfluramine/*analogs & derivatives/*pharmacology; Norfenfluramine/*pharmacology; Serotonin/physiology; Dose-Response Relationship; Drug; Inbred Strains; Receptors; Animal/*drug effects
Creator
An entity primarily responsible for making the resource
Boja J W; Schechter M D
Description
An account of the resource
Nine male rats were trained to discriminate 1.4 mg/kg norfenfluramine (NF) from its vehicle using a two-lever, food-motivated, operant discrimination task. Once trained, the rats showed a dose-dependent decrease in responding on the
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(88)90350-4" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(88)90350-4</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1988
Animal/*drug effects
Animals
Behavior
Boja J W
Discrimination (Psychology)/*drug effects
Dose-Response Relationship
Drug
Fenfluramine/*analogs & derivatives/*pharmacology
Inbred Strains
Male
Norfenfluramine/*pharmacology
Pharmacology, biochemistry, and behavior
Rats
Receptors
Schechter M D
Serotonin/pharmacology
Serotonin/physiology
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jappl.1988.65.3.1367" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jappl.1988.65.3.1367</a>
Pages
1367–1371
Issue
3
Volume
65
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effect of papaverine on pulmonary vascular permeability to proteins.
Publisher
An entity responsible for making the resource available
Journal of applied physiology (Bethesda, Md. : 1985)
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988-09
Subject
The topic of the resource
Animals; Blood Proteins/*metabolism; Capillary Permeability/*drug effects; Dogs; Female; In Vitro Techniques; Male; Osmosis; Papaverine/blood/*pharmacology; Pulmonary Circulation/*drug effects; Serotonin/pharmacology; Vasodilation/drug effects; Water-Electrolyte Balance/drug effects
Creator
An entity primarily responsible for making the resource
Maron M B; Pilati C F
Description
An account of the resource
Previous studies have suggested that papaverine, a drug commonly used in studies of transvascular fluid and solute exchange to eliminate confounding effects of changes in vascular tone, may itself increase vascular permeability. In this study, we determined the ability of papaverine to alter pulmonary vascular protein permeability by measuring the osmotic reflection coefficient (sigma) for total proteins in a canine isolated perfused left lower lung lobe (LLL) preparation. The reflection coefficient, determined by the hematocrit-protein double-indicator technique, for control LLL's was 0.83 +/- 0.04 (SE) (n = 7). In separate groups of LLL's, blood papaverine HCl concentrations of 10(-5), 10(-4), and 10(-3) M resulted in sigma's of 0.84 +/- 0.02 (n = 6), 0.73 +/- 0.04 (n = 7), and 0.53 +/- 0.04 (n = 6), respectively. When two LLL's from the 10(-4) M group with sigma's of 0.56 and 0.57 were excluded from the analysis, the average sigma for this group was 0.79 +/- 0.02. We conclude that papaverine increases protein permeability at a concentration of 10(-3) M but does so in only some lobes at 10(-4) M. These results suggest that caution be taken when using high concentrations of papaverine in fluid balance studies.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jappl.1988.65.3.1367" target="_blank" rel="noreferrer noopener">10.1152/jappl.1988.65.3.1367</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1988
Animals
Blood Proteins/*metabolism
Capillary Permeability/*drug effects
Dogs
Female
In Vitro Techniques
Journal of applied physiology (Bethesda, Md. : 1985)
Male
Maron M B
Osmosis
Papaverine/blood/*pharmacology
Pilati C F
Pulmonary Circulation/*drug effects
Serotonin/pharmacology
Vasodilation/drug effects
Water-Electrolyte Balance/drug effects
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/(SICI)1097-4547(19980215)51:4%3C541::AID-JNR14%3E3.0.CO;2-6" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/(SICI)1097-4547(19980215)51:4%3C541::AID-JNR14%3E3.0.CO;2-6</a>
Pages
541–550
Issue
4
Volume
51
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Inhibition of dopamine and choline acetyltransferase concentrations in rat CNS neurons by rat alpha 1- and alpha 2-macroglobulins.
Publisher
An entity responsible for making the resource available
Journal of neuroscience research
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-02
Subject
The topic of the resource
alpha-Macroglobulins/administration & dosage/*pharmacology; Animals; Cells; Choline O-Acetyltransferase/*antagonists & inhibitors; Corpus Striatum/drug effects/*enzymology/metabolism; Cultured; Dopamine Antagonists/*pharmacology; Dopamine/analysis/*metabolism; Enzyme Activation/drug effects; Injections; Intraventricular; Male; Neurons/drug effects/*enzymology/metabolism; Rats; Serotonin/pharmacology; Sprague-Dawley; Stereotaxic Techniques
Creator
An entity primarily responsible for making the resource
Hu Y Q; Liebl D J; Dluzen D E; Koo P H
Description
An account of the resource
Previous studies have implicated human alpha-2-macroglobulin (alpha2M) as a potential regulator of neuronal development and function. Rat alpha-1-macroglobulin (alpha1M) and acute-phase alpha-2-macroglobulin (alpha2M) are murine homologues of human alpha2M. In this report, we tested the effect of intracranially infused serotonin-activated rat alpha1M (5HT-alpha1M) on the concentration of dopamine (DA) in the corpus striatum in vivo and the effect of
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/(SICI)1097-4547(19980215)51:4%3C541::AID-JNR14%3E3.0.CO;2-6" target="_blank" rel="noreferrer noopener">10.1002/(SICI)1097-4547(19980215)51:4%3C541::AID-JNR14%3E3.0.CO;2-6</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1998
alpha-Macroglobulins/administration & dosage/*pharmacology
Animals
Cells
Choline O-Acetyltransferase/*antagonists & inhibitors
Corpus Striatum/drug effects/*enzymology/metabolism
Cultured
Dluzen D E
Dopamine Antagonists/*pharmacology
Dopamine/analysis/*metabolism
Enzyme Activation/drug effects
Hu Y Q
Injections
Intraventricular
Journal of neuroscience research
Koo P H
Liebl D J
Male
Neurons/drug effects/*enzymology/metabolism
Rats
Serotonin/pharmacology
Sprague-Dawley
Stereotaxic Techniques