1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(88)90390-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(88)90390-5</a>
Pages
817–824
Issue
4
Volume
31
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Serotonergic-dopaminergic mediation of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy").
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988-12
Subject
The topic of the resource
Male; Time Factors; Animals; Rats; Dopamine Agents/*pharmacology; Discrimination (Psychology)/*drug effects; Serotonin/*physiology; *Dopamine Antagonists; Serotonin Antagonists/*pharmacology; Amphetamines/*pharmacology; Dose-Response Relationship; Drug; Inbred Strains; 3; N-Methyl-3; Stimulus; 4-methylenedioxyamphetamine; 4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology; *Generalization
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
A series of three experiments were conducted to investigate the possible serotonergic and dopaminergic mediation of the discriminative stimulus properties of the "designer" drug MDMA. In Experiment 1, rats trained to discriminate 1.5 mg/kg (+/-)-MDMA from its vehicle at 20 min postadministration were shown to generalize to another drug of abuse, N-ethyl-3,4-methylenedioxyamphetamine (MDE) and to the serotonergically-active agents norfenfluramine and TFMPP. In contrast, testing of various dopaminergically-active agonists did not result in MDMA-like responding. In Experiment 2, dopaminergic and serotonergic antagonist were employed to observe their effect upon MDMA discrimination at 20 min postinjection. The serotonin antagonist pirenperone significantly decreased MDMA discrimination, whereas the dopamine decreasing drugs CGS 10746B and haloperidol had no effect. In Experiment 3, another group of rats were trained to discriminate MDMA at 105 min postadministration to investigate if, at this (later) time, the dopaminergic properties of MDMA may be more salient. Indeed, the dopaminergically-active drugs had a heightened effect upon MDMA at this later time, although the serotonergic component of the MDMA discriminative stimulus was predominant. The results suggest that the effects of MDMA at 20 min postadministration are solely serotonergic in nature. At 105 min postinjection there appears to be the presence of a weak dopaminergic component. This biphasic serotonergic-then-dopaminergic action of MDMA may explain the reported human experience with the drug, as well as the often controversial results in the literature.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(88)90390-5" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(88)90390-5</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Dopamine Antagonists
*Generalization
1988
3
4-methylenedioxyamphetamine
4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
Amphetamines/*pharmacology
Animals
Discrimination (Psychology)/*drug effects
Dopamine Agents/*pharmacology
Dose-Response Relationship
Drug
Inbred Strains
Male
N-Methyl-3
Pharmacology, biochemistry, and behavior
Rats
Schechter M D
Serotonin Antagonists/*pharmacology
Serotonin/*physiology
Stimulus
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0306-3623(91)90226-v" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0306-3623(91)90226-v</a>
Pages
889–893
Issue
5
Volume
22
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effect of serotonin depletion by p-chlorophenylalanine upon discriminative behaviours.
Publisher
An entity responsible for making the resource available
General pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1905-6
Subject
The topic of the resource
Male; Animals; Rats; Dopamine/physiology; Brain Chemistry/drug effects; Central Nervous System Stimulants/pharmacology; Discrimination (Psychology)/*drug effects; Serotonin/*physiology; Fenclonine/*pharmacology; Serotonin Antagonists/*pharmacology; Inbred Strains
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
1. Para-chlorophenylalanine (p-CPA), a competitive inhibitor of the serotonin (5-HT) synthesis enzyme tryptophan hydroxylase, was administered to rats at a dosage (100 mg/kg daily for 3 days) that depletes 5-HT. 2. Different groups of these rats were previously trained to discriminate the interoceptive stimuli produced by amphetamine, cathinone, 3,4-methylenedioxymethamphetamine (MDMA),
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0306-3623(91)90226-v" target="_blank" rel="noreferrer noopener">10.1016/0306-3623(91)90226-v</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
Animals
Brain Chemistry/drug effects
Central Nervous System Stimulants/pharmacology
Discrimination (Psychology)/*drug effects
Dopamine/physiology
Fenclonine/*pharmacology
General pharmacology
Inbred Strains
Male
Rats
Schechter M D
Serotonin Antagonists/*pharmacology
Serotonin/*physiology