1
40
10
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
1–6
Issue
1
Volume
28
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Tetrahydro-beta-carboline may produce its stimulus effects via 5HT1B receptors.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1987
1987-09
Subject
The topic of the resource
Male; Animals; Rats; Serotonin/*metabolism; Piperazines/pharmacology; Discrimination Learning/drug effects; Serotonin Antagonists/pharmacology; Carbolines/*pharmacology; Metergoline/pharmacology; Inbred Strains; Receptors
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
To further clarify the role of 5-hydroxytryptamine (5HT) in the behavioral effects of tetrahydro-beta-carboline, male rats were trained to discriminate either 20 mg/kg THBC from its vehicle (n = 10) or 2.0 mg/kg fenfluramine from saline (n = 5). THBC was observed to produce fenfluramine-like effects in the fenfluramine-trained rats while fenfluramine produced THBC-like effects in the
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1987
Animals
Carbolines/*pharmacology
Discrimination Learning/drug effects
Inbred Strains
Male
Metergoline/pharmacology
Pharmacology, biochemistry, and behavior
Piperazines/pharmacology
Rats
Receptors
Schechter M D
Serotonin Antagonists/pharmacology
Serotonin/*metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
211–217
Issue
2
Volume
160
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Spinal beta-endorphin analgesia involves an interaction with local monoaminergic systems.
Publisher
An entity responsible for making the resource available
European journal of pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
1989-01
Subject
The topic of the resource
Male; Animals; Rats; Adrenergic alpha-Antagonists/pharmacology; Injections; Serotonin Antagonists/pharmacology; Naltrexone/pharmacology; Spinal Cord/*drug effects; Biogenic Monoamines/*physiology; Analgesics/administration & dosage/antagonists & inhibitors/*pharmacology; beta-Endorphin/administration & dosage/antagonists & inhibitors/*pharmacology; Norepinephrine/physiology; Serotonin/physiology; Inbred Strains; Spinal
Creator
An entity primarily responsible for making the resource
Crisp T; Stafinsky J L; Hess J E; Uram M
Description
An account of the resource
beta-Endorphin administered intrathecally (i.t.) in rats produced a dose-dependent elevation in tail-flick latency. Naltrexone administered i.t. as a pretreatment reversed the spinal antinociceptive action of beta-endorphin, suggesting that the opioid interacts directly with spinal opiate receptors. Spinal administration of the alpha 1-adrenoceptor antagonist WB-4101 failed to alter the analgesic effects of the opioid, whereas the alpha 2-adrenoceptor antagonist yohimbine completely blocked beta-endorphin-induced elevations in tail-flick latency. Thus, there is an apparent specificity for the alpha
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1989
Adrenergic alpha-Antagonists/pharmacology
Analgesics/administration & dosage/antagonists & inhibitors/*pharmacology
Animals
beta-Endorphin/administration & dosage/antagonists & inhibitors/*pharmacology
Biogenic Monoamines/*physiology
Crisp T
European journal of pharmacology
Hess J E
Inbred Strains
Injections
Male
Naltrexone/pharmacology
Norepinephrine/physiology
Rats
Serotonin Antagonists/pharmacology
Serotonin/physiology
Spinal
Spinal Cord/*drug effects
Stafinsky J L
Uram M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0306-3623(91)90441-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0306-3623(91)90441-8</a>
Pages
247–251
Issue
2
Volume
22
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Analgesic effects of serotonin and receptor-selective serotonin agonists in the rat spinal cord.
Publisher
An entity responsible for making the resource available
General pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1905-06
Subject
The topic of the resource
Male; Animals; Rats; Pain Measurement; Piperazines/pharmacology; Spinal Cord/*physiology; Tetrahydronaphthalenes/pharmacology; Injections; Amphetamines/pharmacology; Biguanides/pharmacology; Serotonin Antagonists/pharmacology; Reaction Time/drug effects; *Analgesics; 8-Hydroxy-2-(di-n-propylamino)tetralin; Serotonin/*pharmacology; Inbred Strains; Receptors; Spinal; Serotonin/*drug effects/physiology
Creator
An entity primarily responsible for making the resource
Crisp T; Stafinsky J L; Spanos L J; Uram M; Perni V C; Donepudi H B
Description
An account of the resource
1. Serotonin (5-HT) and selective 5-HT receptor agonists were administered intrathecally (i.t.) in rats, and the antinociceptive efficacy of these agents was assessed on the tail-flick and hot plate tests. 2. The 5-HT receptor agonists examined in this study included the 5-HT1A agonist
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0306-3623(91)90441-8" target="_blank" rel="noreferrer noopener">10.1016/0306-3623(91)90441-8</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Analgesics
1991
8-Hydroxy-2-(di-n-propylamino)tetralin
Amphetamines/pharmacology
Animals
Biguanides/pharmacology
Crisp T
Donepudi H B
General pharmacology
Inbred Strains
Injections
Male
Pain Measurement
Perni V C
Piperazines/pharmacology
Rats
Reaction Time/drug effects
Receptors
Serotonin Antagonists/pharmacology
Serotonin/*drug effects/physiology
Serotonin/*pharmacology
Spanos L J
Spinal
Spinal Cord/*physiology
Stafinsky J L
Tetrahydronaphthalenes/pharmacology
Uram M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
347–353
Issue
3
Volume
202
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Possible serotonergic and dopaminergic mediation of the
Publisher
An entity responsible for making the resource available
European journal of pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-09
Subject
The topic of the resource
Male; Animals; Rats; Serotonin/pharmacology; Discrimination Learning/drug effects; Serotonin Antagonists/pharmacology; Motor Activity/drug effects; Designer Drugs/pharmacology; Fenclonine/pharmacology; Inbred Strains; Receptors; 3; N-Methyl-3; 4-methylenedioxyamphetamine; 4-Methylenedioxyamphetamine/*analogs & derivatives/pharmacology; Dopamine/*drug effects; Serotonin/*drug effects
Creator
An entity primarily responsible for making the resource
Boja J W; Schechter M D
Description
An account of the resource
Eight male rats previously trained to discriminate 2.0 mg/kg
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
3
4-methylenedioxyamphetamine
4-Methylenedioxyamphetamine/*analogs & derivatives/pharmacology
Animals
Boja J W
Designer Drugs/pharmacology
Discrimination Learning/drug effects
Dopamine/*drug effects
European journal of pharmacology
Fenclonine/pharmacology
Inbred Strains
Male
Motor Activity/drug effects
N-Methyl-3
Rats
Receptors
Schechter M D
Serotonin Antagonists/pharmacology
Serotonin/*drug effects
Serotonin/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(94)00386-w" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(94)00386-w</a>
Pages
313–316
Issue
2
Volume
51
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Serotonergic mediation of cocaine seizures in mice.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-07
Subject
The topic of the resource
Animals; Brain Chemistry/drug effects; Cinanserin/pharmacology; Cocaine/*toxicity; Epilepsy; Female; Fenfluramine/pharmacology; Inbred Strains; Male; Mice; Seizures/chemically induced/*physiopathology; Serotonin Antagonists/pharmacology; Serotonin Receptor Agonists/pharmacology; Serotonin/*physiology; Status Epilepticus/chemically induced/physiopathology; Tonic-Clonic/chemically induced/physiopathology
Creator
An entity primarily responsible for making the resource
Schechter M D; Meehan S M
Description
An account of the resource
We used genetically heterogeneous HS mice to investigate the effects of drugs that alter brain concentrations of serotonin on cocaine-induced convulsions and lethality. The racemer of fenfluramine, which increases synaptic serotonin, was coadministered with a dose (60 mg/kg, intraperitoneally) of cocaine that does not produce status epilepticus or death. This drug combination significantly increased the occurrence and decreased the time of onset of status epilepticus, but did not affect lethality. Likewise, 2.5 mg/kg of the D-isomer, of fenfluramine increased the occurrence of status epilepticus. Neither isomer effected lethality. When 2.5 mg/kg cinanserin, a drug that antagonizes postsynaptic serotonergic receptors, was coadministered with a higher (95 mg/kg) dose of cocaine, the time of onset of status epilepticus was significantly increased, whereas lethality was reduced. The results are discussed in light of the action of cocaine upon serotonin neurons and the relationship between seizurogenic activity and cocaine-induced lethality.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(94)00386-w" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(94)00386-w</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
Animals
Brain Chemistry/drug effects
Cinanserin/pharmacology
Cocaine/*toxicity
Epilepsy
Female
Fenfluramine/pharmacology
Inbred Strains
Male
Meehan S M
Mice
Pharmacology, biochemistry, and behavior
Schechter M D
Seizures/chemically induced/*physiopathology
Serotonin Antagonists/pharmacology
Serotonin Receptor Agonists/pharmacology
Serotonin/*physiology
Status Epilepticus/chemically induced/physiopathology
Tonic-Clonic/chemically induced/physiopathology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(93)90183-t" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(93)90183-t</a>
Pages
661–664
Issue
3
Volume
44
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Cocaine discrimination is attenuated by isradipine and CGS 10746B.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-03
Subject
The topic of the resource
Animals; Antipsychotic Agents/*pharmacology; Calcium Channel Blockers/*pharmacology; Cocaine/antagonists & inhibitors/*pharmacology; Conditioning; Discrimination (Psychology)/*drug effects; Dose-Response Relationship; Drug; Ibogaine/pharmacology; Isradipine/*pharmacology; Male; Operant/drug effects; Rats; Serotonin Antagonists/pharmacology; Sprague-Dawley; Thiazepines/*pharmacology; Tropanes/pharmacology
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
The discriminative stimulus properties of cocaine are thought to be mediated by dopaminergic mechanisms that may be modulated by calcium ion influx and/or interact with 5-hydroxytryptamine3 (5-HT3) receptors. To test these possibilities, rats were trained to discriminate between the stimulus properties of 10.0 mg/kg cocaine and its vehicle in a two-lever, food-motivated operant task. Once trained, rats showed a dose-related decrease in discriminative performance when tested with lower cocaine doses. An analysis of the dose-response curve indicated an ED50 value of 3.04 mg/kg. Pretreatment with the presynaptic dopamine release-inhibiting agent CGS 10746B (20-40 mg/kg) resulted in a dose-related decrease in cocaine discrimination with the highest dose significantly attenuating cocaine discrimination. Pretreatment with 10-30 mg/kg isradipine, a calcium channel blocker, also resulted in a dose-related decrease in cocaine discriminative performance. In contrast to these positive results, pretreatment with the 5-HT3 receptor antagonist MDL 72222 (3.5-7.0 mg/kg), or the same doses of ibogaine, did not significantly affect cocaine discrimination. The results suggest that cocaine controls differential responding in a discriminative stimulus task by mechanisms that involve presynaptic release of dopamine, which may be regulated by neuronal calcium influx through L-type calcium channels.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(93)90183-t" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(93)90183-t</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1993
Animals
Antipsychotic Agents/*pharmacology
Calcium Channel Blockers/*pharmacology
Cocaine/antagonists & inhibitors/*pharmacology
Conditioning
Discrimination (Psychology)/*drug effects
Dose-Response Relationship
Drug
Ibogaine/pharmacology
Isradipine/*pharmacology
Male
Operant/drug effects
Pharmacology, biochemistry, and behavior
Rats
Schechter M D
Serotonin Antagonists/pharmacology
Sprague-Dawley
Thiazepines/*pharmacology
Tropanes/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(92)90508-d" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(92)90508-d</a>
Pages
1233–1240
Issue
4
Volume
43
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Biphasic effects of ethanol tested with drug discrimination in HAD and LAD rats.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-12
Subject
The topic of the resource
Alcohol Drinking/genetics/*psychology; Animals; Discrimination (Psychology)/*drug effects; Discrimination Learning/drug effects; Dose-Response Relationship; Drug; Ethanol/*pharmacology; Inbred Strains; Male; Pentobarbital/pharmacology; Rats; Serotonin Antagonists/pharmacology; Sleep/drug effects; Time Factors; Tropanes/pharmacology
Creator
An entity primarily responsible for making the resource
Krimmer E C
Description
An account of the resource
Seventh-generation selectively bred high-alcohol-drinking (HAD) and low-alcohol-drinking (LAD) rats were trained to make differential responses for ethanol (0.75 g/kg, IP) and saline vehicle, following postadministration intervals (PI) of 2 min (HAD-2 and LAD-2 animals) and 30 min (HAD-30 and LAD-30 animals). ED50 values of 0.395 and 0.352 g/kg, respectively, for HAD-2 and LAD-2 animals and 0.269 and 0.314 g/kg, respectively, for HAD-30 and LAD-30 animals reflect the absence of any phenotypic difference for the discriminative stimulus effects of ethanol. HAD-2 animals were more responsive than LAD-2 animals to the stimulating effects of ethanol as measured by total response rates during training sessions. The differential ethanol response generalized to pentobarbital in all four groups but not to morphine, an alternative CNS depressant. The specific antagonist of 5-hydroxytryptamine3 receptors,
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(92)90508-d" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(92)90508-d</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1992
Alcohol Drinking/genetics/*psychology
Animals
Discrimination (Psychology)/*drug effects
Discrimination Learning/drug effects
Dose-Response Relationship
Drug
Ethanol/*pharmacology
Inbred Strains
Krimmer E C
Male
Pentobarbital/pharmacology
Pharmacology, biochemistry, and behavior
Rats
Serotonin Antagonists/pharmacology
Sleep/drug effects
Time Factors
Tropanes/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(92)90055-k" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(92)90055-k</a>
Pages
37–41
Issue
1
Volume
41
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effect of altering dopamine or serotonin neurotransmitters upon cathinone discrimination.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-01
Subject
The topic of the resource
Alkaloids/*pharmacology; Animals; Antipsychotic Agents/pharmacology; Calcium Channel Blockers/pharmacology; Dihydropyridines/pharmacology; Discrimination (Psychology)/*drug effects; Discrimination Learning/drug effects; Dopamine/*physiology; Dose-Response Relationship; Drug; Inbred Strains; Isradipine; Male; Neurotransmitter Agents/*physiology; Psychotropic Drugs/*pharmacology; Rats; Serotonin Antagonists/pharmacology; Serotonin/*physiology; Thiazepines/pharmacology; Tropanes/pharmacology
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
Rats were trained to discriminate between the stimulus properties of 0.8 mg/kg l-cathinone and its vehicle in a two-lever, food-motivated operant task. Once trained, rats showed a dose-related decrease in discriminative performance when tested with lower cathinone doses. An analysis of the dose-response curve indicated an ED50 value of 0.23 mg/kg. Pretreatment with CGS 10746B (5-20 mg/kg) resulted in a dose-related decrease in cathinone discrimination with the highest dose blocking cathinone discrimination. In contrast to the ability of this dopamine release inhibitor to decrease cathinone discrimination, pretreatment with three doses of the calcium channel blocker isradipine (2.5-10 mg/kg) or with the 5-HT3 antagonist MDL 72222 (0.1-0.4 mg/kg) had no effect upon cathinone discrimination. The results suggest that cathinone controls differential responding in a discriminative stimulus task by a mechanism involving presynaptic release of dopamine, which may not be regulated by either neuronal calcium influx through L-type calcium channels or by serotonergic neurons.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(92)90055-k" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(92)90055-k</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1992
Alkaloids/*pharmacology
Animals
Antipsychotic Agents/pharmacology
Calcium Channel Blockers/pharmacology
Dihydropyridines/pharmacology
Discrimination (Psychology)/*drug effects
Discrimination Learning/drug effects
Dopamine/*physiology
Dose-Response Relationship
Drug
Inbred Strains
Isradipine
Male
Neurotransmitter Agents/*physiology
Pharmacology, biochemistry, and behavior
Psychotropic Drugs/*pharmacology
Rats
Schechter M D
Serotonin Antagonists/pharmacology
Serotonin/*physiology
Thiazepines/pharmacology
Tropanes/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(91)90133-m" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(91)90133-m</a>
Pages
591–595
Issue
3
Volume
39
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Serotonin contributes to the spinal antinociceptive effects of morphine.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-07
Subject
The topic of the resource
Adrenergic alpha-Antagonists/pharmacology; Adrenergic Antagonists; Analgesics/*pharmacology; Animals; Biogenic Monoamines/physiology; Dose-Response Relationship; Drug; Inbred Strains; Injections; Male; Morphine/*pharmacology; Naltrexone/pharmacology; Nerve Endings/drug effects; Opioid/drug effects; Rats; Reaction Time; Receptors; Serotonin Antagonists/pharmacology; Serotonin/*physiology; Spinal; Spinal Cord/*drug effects
Creator
An entity primarily responsible for making the resource
Crisp T; Stafinsky J L; Uram M; Perni V C; Weaver M F; Spanos L J
Description
An account of the resource
This study was designed to determine if morphine administered intrathecally (IT) interacts with serotonergic or noradrenergic nerve terminals in the spinal cord to produce analgesia on the spinally mediated tail-flick test. Male Sprague-Dawley rats were fitted with IT catheters. One week later, animals were spinally pretreated with receptor antagonists selective for opioid, serotonin or alpha-adrenoceptors, and the ability of these agents to alter spinal morphine-induced antinociception was assessed. Morphine dose-dependently elevated tail-flick latency in a naltrexone-reversible manner. The serotonin receptor antagonists spiroxatrine (5-HT1A), pindolol (5-HT1B), ritanserin (5-HT2) and ICS
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(91)90133-m" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(91)90133-m</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
Adrenergic alpha-Antagonists/pharmacology
Adrenergic Antagonists
Analgesics/*pharmacology
Animals
Biogenic Monoamines/physiology
Crisp T
Dose-Response Relationship
Drug
Inbred Strains
Injections
Male
Morphine/*pharmacology
Naltrexone/pharmacology
Nerve Endings/drug effects
Opioid/drug effects
Perni V C
Pharmacology, biochemistry, and behavior
Rats
Reaction Time
Receptors
Serotonin Antagonists/pharmacology
Serotonin/*physiology
Spanos L J
Spinal
Spinal Cord/*drug effects
Stafinsky J L
Uram M
Weaver M F
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0024-3205(94)00414-n" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0024-3205(94)00414-n</a>
Pages
475–483
Issue
7
Volume
56
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Blockade of cocaine-induced conditioned place preference: relevance to cocaine abuse therapeutics.
Publisher
An entity responsible for making the resource available
Life sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1905-06
Subject
The topic of the resource
Animals; Calcium Channel Blockers/pharmacology/therapeutic use; Cocaine/*antagonists & inhibitors; Conditioning (Psychology)/*drug effects; Humans; Narcotic Antagonists/pharmacology; Serotonin Antagonists/pharmacology; Substance-Related Disorders/*drug therapy
Creator
An entity primarily responsible for making the resource
Calcagnetti D J; Keck B J; Quatrella L A; Schechter M D
Description
An account of the resource
Conditioned place preference/aversion testing is a behavioral method believed capable of measuring the affective (positive, neutral or negative) properties of psychoactive drugs. Cocaine injections in rats reliably produces a positive place preference. Drugs that attenuate or block this effect of cocaine have obvious potential for developing treatments to address cocaine addiction as well as to add to the scientific understanding of the mechanism of cocaine's action at the cellular level. To date, six drugs have been reported to block the expression of a cocaine-induced conditioned place preference (CPP) and this review evidences the cocaine-induced CPP blockage by the two potent L-type calcium channel blockers, isradipine and nifedipine, the two serotonin-3 receptor antagonists, MDL72222 and ICS205-930, the delta opioid receptor selective antagonist naltrindole, and lastly, a mixed opioid agonist-antagonist buprenorphine. Additional evidence relating to the blockade of other cocaine behavioral effects by these putative blockers is addressed, where appropriate, from studies employing other procedures such as drug stimulus discrimination, self-administration, electrical brain stimulation and increases in locomotor activity. The significance of these findings is discussed in the context of their relevance to the development of treatment regimens to allow for cessation of cocaine abuse.
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<a href="http://doi.org/10.1016/0024-3205(94)00414-n" target="_blank" rel="noreferrer noopener">10.1016/0024-3205(94)00414-n</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
Animals
Calcagnetti D J
Calcium Channel Blockers/pharmacology/therapeutic use
Cocaine/*antagonists & inhibitors
Conditioning (Psychology)/*drug effects
Humans
Keck B J
Life sciences
Narcotic Antagonists/pharmacology
Quatrella L A
Schechter M D
Serotonin Antagonists/pharmacology
Substance-Related Disorders/*drug therapy