1
40
1
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0306-3623(92)90291-q" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0306-3623(92)90291-q</a>
Pages
1087–1091
Issue
6
Volume
23
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The noradrenergic component contributing to spinal fentanyl-induced antinociception is supraspinally mediated.
Publisher
An entity responsible for making the resource available
General pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-11
Subject
The topic of the resource
Adrenergic Antagonists; Analgesics/*pharmacology; Animals; Fentanyl/*pharmacology; Injections; Intraventricular; Male; Methysergide/pharmacology; Naltrexone/pharmacology; Norepinephrine/*physiology; Pain Measurement/drug effects; Phentolamine/pharmacology; Rats; Reaction Time/drug effects; Serotonin Antagonists; Spinal; Spinal Cord/*physiology; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Crisp T; Stafinsky J L; Perni V C; Uram M
Description
An account of the resource
1. Male Sprague-Dawley rats were fitted with intrathecal (i.t.) and intracerebroventricular (i.c.v.) catheters. Fentanyl was injected either i.t. or i.c.v., and the antinociceptive efficacy of fentanyl was evaluated using the tail-flick analgesiometric assay. 2. Fentanyl dose-dependently elevated tail-flick latency (TFL) following i.c.v. or i.t. administration. The antinociceptive effects of fentanyl were reversed by naltrexone. 3. Experiments were also designed to evaluate the effects of serotonin and alpha-adrenoceptor antagonists on i.t. or i.c.v. fentanyl-induced elevations in TFL. 4. Phentolamine administered i.t. reversed both the spinal and supraspinal antinociceptive effects of fentanyl, whereas i.t. methysergide did not significantly alter the i.t. or i.c.v. effects of the mu agonist. 5. These data suggest that fentanyl-induced antinociception does not rely on local serotonergic neuronal activation. Due to the highly lipophilic nature of fentanyl, it is possible that the noradrenergic component contributing to spinal fentanyl-induced analgesia is supraspinally-mediated.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0306-3623(92)90291-q" target="_blank" rel="noreferrer noopener">10.1016/0306-3623(92)90291-q</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1992
Adrenergic Antagonists
Analgesics/*pharmacology
Animals
Crisp T
Fentanyl/*pharmacology
General pharmacology
Injections
Intraventricular
Male
Methysergide/pharmacology
Naltrexone/pharmacology
Norepinephrine/*physiology
Pain Measurement/drug effects
Perni V C
Phentolamine/pharmacology
Rats
Reaction Time/drug effects
Serotonin Antagonists
Spinal
Spinal Cord/*physiology
Sprague-Dawley
Stafinsky J L
Uram M