1
40
6
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0014-2999(93)90664-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0014-2999(93)90664-4</a>
Pages
79–84
Issue
1
Volume
249
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Comparison of the behavioral effects of ibogaine from three sources: mediation of discriminative activity.
Publisher
An entity responsible for making the resource available
European journal of pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-11
Subject
The topic of the resource
*Discrimination (Psychology); Animal/*drug effects; Animals; Behavior; Dose-Response Relationship; Drug; Ibogaine/*pharmacology; Male; Rats; Serotonin Receptor Agonists/pharmacology; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Schechter M D; Gordon T L
Description
An account of the resource
Ibogaine is an alkaloid employed for its hallucinatory properties in West Central Africa which has been the subject of alleged efficacy as an aid in the interruption and treatment of chemical dependency. The major sources of the Schedule I agent are: Sigma Chemical Co., the National Institute on Drug Abuse and as NDA International Inc.'s Endabuse. The intent of the present study was to, for the first time, train rats to discriminate the interoceptive stimuli produced by (10 mg/kg, intraperitoneally administered) ibogaine. Once trained, these rats were used to investigate the dose-response effects to ibogaine from each of the three suppliers. In addition, stimulus generalization to the dopamine antagonist CGS 10476B, as well as to the serotonergically active compounds fenfluramine, TFMPP (1-(m-trifluoromethylphenyl)piperazine, DOI (1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane), MDMA (3,4-methylenedioxymethamphetamine), quipazine and LSD, was tested. The results indicate that ibogaine is readily discriminable from its vehicle and that ibogaine from each of the three supplies produced statistically similar discrimination with ED50 values ranging from 2.5 to 3.4 mg/kg. In addition, various doses of the novel drugs tested produced, at best, intermediate ibogaine-appropriate responding and, thus, no drug tested can be considered to generalize to ibogaine-like stimuli. Discussion concerns the multiple actions of ibogaine that have been cited in the scientific literature. The similarity in potency of ibogaine from three potential suppliers should allow for pre-clinical work using any of these research samples to be comparable.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0014-2999(93)90664-4" target="_blank" rel="noreferrer noopener">10.1016/0014-2999(93)90664-4</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Discrimination (Psychology)
1993
Animal/*drug effects
Animals
Behavior
Dose-Response Relationship
Drug
European journal of pharmacology
Gordon T L
Ibogaine/*pharmacology
Male
Rats
Schechter M D
Serotonin Receptor Agonists/pharmacology
Sprague-Dawley
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(94)00386-w" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(94)00386-w</a>
Pages
313–316
Issue
2
Volume
51
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Serotonergic mediation of cocaine seizures in mice.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-07
Subject
The topic of the resource
Animals; Brain Chemistry/drug effects; Cinanserin/pharmacology; Cocaine/*toxicity; Epilepsy; Female; Fenfluramine/pharmacology; Inbred Strains; Male; Mice; Seizures/chemically induced/*physiopathology; Serotonin Antagonists/pharmacology; Serotonin Receptor Agonists/pharmacology; Serotonin/*physiology; Status Epilepticus/chemically induced/physiopathology; Tonic-Clonic/chemically induced/physiopathology
Creator
An entity primarily responsible for making the resource
Schechter M D; Meehan S M
Description
An account of the resource
We used genetically heterogeneous HS mice to investigate the effects of drugs that alter brain concentrations of serotonin on cocaine-induced convulsions and lethality. The racemer of fenfluramine, which increases synaptic serotonin, was coadministered with a dose (60 mg/kg, intraperitoneally) of cocaine that does not produce status epilepticus or death. This drug combination significantly increased the occurrence and decreased the time of onset of status epilepticus, but did not affect lethality. Likewise, 2.5 mg/kg of the D-isomer, of fenfluramine increased the occurrence of status epilepticus. Neither isomer effected lethality. When 2.5 mg/kg cinanserin, a drug that antagonizes postsynaptic serotonergic receptors, was coadministered with a higher (95 mg/kg) dose of cocaine, the time of onset of status epilepticus was significantly increased, whereas lethality was reduced. The results are discussed in light of the action of cocaine upon serotonin neurons and the relationship between seizurogenic activity and cocaine-induced lethality.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(94)00386-w" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(94)00386-w</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
Animals
Brain Chemistry/drug effects
Cinanserin/pharmacology
Cocaine/*toxicity
Epilepsy
Female
Fenfluramine/pharmacology
Inbred Strains
Male
Meehan S M
Mice
Pharmacology, biochemistry, and behavior
Schechter M D
Seizures/chemically induced/*physiopathology
Serotonin Antagonists/pharmacology
Serotonin Receptor Agonists/pharmacology
Serotonin/*physiology
Status Epilepticus/chemically induced/physiopathology
Tonic-Clonic/chemically induced/physiopathology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0166-4328(95)00167-0" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0166-4328(95)00167-0</a>
Pages
199–205
Issue
1
Volume
74
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Discriminative stimulus properties of CGS 10746B: similarity to dopamine D1 receptor antagonists.
Publisher
An entity responsible for making the resource available
Behavioural brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-01
Subject
The topic of the resource
Amphetamines/pharmacology; Animals; Antipsychotic Agents/*pharmacology; Cholinergic Agents/pharmacology; Clozapine/pharmacology; Cues; Discrimination (Psychology)/*drug effects; Discrimination Learning/drug effects; Dopamine D1/*antagonists & inhibitors; Dose-Response Relationship; Drug; Generalization; Male; Rats; Receptors; Response/drug effects; Serotonin Agents/pharmacology; Serotonin Receptor Agonists/pharmacology; Sprague-Dawley; Thiazepines/*pharmacology
Creator
An entity primarily responsible for making the resource
Meehan S M; Schechter M D
Description
An account of the resource
CGS 10746B is an imidazole-derivative related to the atypical antipsychotic clozapine which produces a decrease in dopamine release without altering dopamine metabolism or occupying D2 receptors. Rats were trained on an appetitively-motivated, two-choice, operant task to discriminate 20.0 mg/kg CGS 10746B from its vehicle. CGS 10746B was highly discriminable, producing rapid acquisition of the discrimination, and its effects were dose-responsive allowing generation of an ED50 value of 6.16 mg/kg. Substitution tests were conducted with other typical and atypical antipsychotic compounds: haloperidol, chlorpromazine, clozapine and SCH 23390. Additional tests examined generalization from the CGS 10746B stimulus properties to the calcium channel blocker isradipine, as well as to the anticholinergics atropine, scopolamine and methylscopolamine, as well as to the serotonergic agonist DOI. Clozapine and SCH 23390 were the only substances to substitute for the CGS 10746B stimulus cue. Results are discussed in terms of potential D1 receptor selectivity of CGS 10746B.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0166-4328(95)00167-0" target="_blank" rel="noreferrer noopener">10.1016/0166-4328(95)00167-0</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1996
Amphetamines/pharmacology
Animals
Antipsychotic Agents/*pharmacology
Behavioural brain research
Cholinergic Agents/pharmacology
Clozapine/pharmacology
Cues
Discrimination (Psychology)/*drug effects
Discrimination Learning/drug effects
Dopamine D1/*antagonists & inhibitors
Dose-Response Relationship
Drug
Generalization
Male
Meehan S M
Rats
Receptors
Response/drug effects
Schechter M D
Serotonin Agents/pharmacology
Serotonin Receptor Agonists/pharmacology
Sprague-Dawley
Thiazepines/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0741-8329(95)02004-7" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0741-8329(95)02004-7</a>
Pages
569–572
Issue
6
Volume
12
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
MDMA (Ecstasy) substitutes for the ethanol discriminative cue in HAD but not LAD rats.
Publisher
An entity responsible for making the resource available
Alcohol (Fayetteville, N.Y.)
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-12
Subject
The topic of the resource
4-methylenedioxyamphetamine/*pharmacology; Alcohol Drinking/*genetics/psychology; Animals; Central Nervous System Depressants/*pharmacology; Cues; Discrimination (Psychology)/*drug effects; Discrimination Learning/drug effects; Dose-Response Relationship; Drug; Ethanol/*pharmacology; Generalization; Male; N-Methyl-3; Piperazines/pharmacology; Rats; Serotonin Agents/*pharmacology; Serotonin Receptor Agonists/pharmacology; Stimulus
Creator
An entity primarily responsible for making the resource
Meehan S M; Gordon T L; Schechter M D
Description
An account of the resource
Selectively bred high- and low-alcohol-drinking (HAD/LAD) rats were trained to discriminate the interoceptive stimuli produced by IP-administered 600 mg/kg ethanol (10% w/v in a two-lever, food-motivated operant task. Once criterion discrimination was attained, animals were tested with 3.0, 1.5, 1.0, and 0.5 mg/kg MDMA. Although no differences in alcohol discrimination were observed between the HAD and LAD animals, the HAD line was significantly more sensitive than the LAD line to the effects of MDMA. These results provide additional information to the growing body of evidence suggesting serotonergic mediation of some of the behavioral effects of ethanol.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0741-8329(95)02004-7" target="_blank" rel="noreferrer noopener">10.1016/0741-8329(95)02004-7</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
4-methylenedioxyamphetamine/*pharmacology
Alcohol (Fayetteville, N.Y.)
Alcohol Drinking/*genetics/psychology
Animals
Central Nervous System Depressants/*pharmacology
Cues
Discrimination (Psychology)/*drug effects
Discrimination Learning/drug effects
Dose-Response Relationship
Drug
Ethanol/*pharmacology
Generalization
Gordon T L
Male
Meehan S M
N-Methyl-3
Piperazines/pharmacology
Rats
Schechter M D
Serotonin Agents/*pharmacology
Serotonin Receptor Agonists/pharmacology
Stimulus
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0024-3205(96)00668-6" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0024-3205(96)00668-6</a>
Pages
PL83–90
Issue
6
Volume
60
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Serotonergic mediation of fenfluramine discriminative stimuli in fawn-hooded rats.
Publisher
An entity responsible for making the resource available
Life sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1905-06
Subject
The topic of the resource
*Discrimination Learning; 4-methylenedioxyamphetamine/pharmacology; Animals; Dose-Response Relationship; Drug; Fenfluramine/administration & dosage/*pharmacology; Fluoxetine/pharmacology; Ibogaine/pharmacology; Male; Methoxydimethyltryptamines/pharmacology; N-Methyl-3; Piperazines/pharmacology; Quipazine/pharmacology; Rats; Serotonin Agents/administration & dosage/*pharmacology; Serotonin Receptor Agonists/pharmacology; Serotonin/*metabolism; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
Fenfluramine, a drug that induces increased synaptic serotonin, was used to train Fawn-Hooded rats in a drug discrimination paradigm. This strain of rats is thought to possess a genetic serotonin storage abnormality. The intent of the study was to see if the Fawn-Hooded rat was similar or dissimilar to the more frequently used strain of Sprague-Dawley rat in its ability to learn to discriminate 2.0 mg/kg fenfluramine administered intraperitoneally. In addition, drugs presumed to work upon central serotonergic neurons were given to the fenfluramine-trained Fawn-Hooded rats to investigate if the cueing properties of the training drug generalized to other agents. Results indicate that the Fawn-Hooded rats learn to discriminate fenfluramine from its vehicle at the same rate, and with a similar sensitivity to lower doses, as do the Sprague-Dawley rats. Furthermore, fenfluramine was shown to completely generalize to MDMA (over 90%); TFMPP, m-CPP, quipazine and fluoxetine produced intermediate results (over 70%) and 5-MeODMT and ibogaine were vehicle-like (less than 70%). As these results coincide with those previously found in Sprague-Dawley rats, the conclusion is that the functional capacity to discriminate fenfluramine appears to be like that of other rat lines, and serotonergically-mediated, in the Fawn-Hooded rat. Suggestions to explain these results are offered and discussed.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0024-3205(96)00668-6" target="_blank" rel="noreferrer noopener">10.1016/s0024-3205(96)00668-6</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Discrimination Learning
1997
4-methylenedioxyamphetamine/pharmacology
Animals
Dose-Response Relationship
Drug
Fenfluramine/administration & dosage/*pharmacology
Fluoxetine/pharmacology
Ibogaine/pharmacology
Life sciences
Male
Methoxydimethyltryptamines/pharmacology
N-Methyl-3
Piperazines/pharmacology
Quipazine/pharmacology
Rats
Schechter M D
Serotonin Agents/administration & dosage/*pharmacology
Serotonin Receptor Agonists/pharmacology
Serotonin/*metabolism
Sprague-Dawley
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/S0091-3057(96)00161-X" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/S0091-3057(96)00161-X</a>
Pages
89–96
Issue
1
Volume
56
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Drug-drug discrimination: stimulus properties of drugs of abuse upon a serotonergic-dopaminergic continuum.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-01
Subject
The topic of the resource
4-methylenedioxyamphetamine/pharmacology; Amphetamine/pharmacology; Animals; Discrimination (Psychology)/*drug effects; Dopamine Agonists/pharmacology; Dopamine Uptake Inhibitors/pharmacology; Dopamine/*physiology; Dose-Response Relationship; Drug; Generalization; Lysergic Acid Diethylamide/pharmacology; Male; N-Methyl-3; Norfenfluramine/pharmacology; Propiophenones/pharmacology; Rats; Serotonin Agents/pharmacology; Serotonin Receptor Agonists/pharmacology; Serotonin Uptake Inhibitors/pharmacology; Serotonin/*physiology; Stimulus; Substance-Related Disorders/*psychology; Tetrahydronaphthalenes/pharmacology; Time Factors
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
Ten male N/Nih rats were trained to discriminate between the interoceptive cues produced by the purportedly dopaminergically-mediated drug d-amphetamine at 0.4 mg/kg intraperitoneally administered 20 min prior to training and those produced by the purportedly serotonergically-active agent norfenfluramine at 0.7 mg/kg. Once this discrimination was successfully acquired, the rats were tested with saline and with both drugs administered simultaneously and these manipulations were seen to produce random responding; indicating roughly equivalent cueing strength. Subsequently, various drugs thought to act upon serotonergic neurons, i.e., LSD and MDMA, were tested and shown to generalize in a dose-responsive manner to the norfenfluramine-appropriate lever. In contrast, the dopaminergically-active agent methcathinone and the D3 agonist 7-OH-DPAT produced generalization on the amphetamine-appropriate lever. Results are discussed in light of the increased specificity of behavioral testing available in a drug vs. drug discriminative paradigm using two drugs with different mechanisms of action.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/S0091-3057(96)00161-X" target="_blank" rel="noreferrer noopener">10.1016/S0091-3057(96)00161-X</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1997
4-methylenedioxyamphetamine/pharmacology
Amphetamine/pharmacology
Animals
Discrimination (Psychology)/*drug effects
Dopamine Agonists/pharmacology
Dopamine Uptake Inhibitors/pharmacology
Dopamine/*physiology
Dose-Response Relationship
Drug
Generalization
Lysergic Acid Diethylamide/pharmacology
Male
N-Methyl-3
Norfenfluramine/pharmacology
Pharmacology, biochemistry, and behavior
Propiophenones/pharmacology
Rats
Schechter M D
Serotonin Agents/pharmacology
Serotonin Receptor Agonists/pharmacology
Serotonin Uptake Inhibitors/pharmacology
Serotonin/*physiology
Stimulus
Substance-Related Disorders/*psychology
Tetrahydronaphthalenes/pharmacology
Time Factors