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Text
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URL Address
<a href="http://doi.org/10.1097/01.SMJ.0000155499.21189.75" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/01.SMJ.0000155499.21189.75</a>
Pages
564–566
Issue
5
Volume
98
Dublin Core
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Title
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Infliximab-induced headache and infliximab-induced meningitis: two ends of the same spectrum?
Publisher
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Southern medical journal
Date
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2005
2005-05
Subject
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Antibodies; Aseptic/*chemically induced/diagnosis; Crohn Disease/drug therapy; Female; Headache/*chemically induced; Humans; Infliximab; Meningitis; Middle Aged; Monoclonal/*adverse effects; Serum Sickness/*etiology
Creator
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Hegde Nikita; Gayomali Charina; Rich Michael W
Description
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This report describes a case of aseptic meningitis induced by the tumor necrosis factor-alpha inhibitor infliximab. The patient, a 51-year-old female, was being treated for Crohn's disease. After an infliximab infusion, she had headache, fever, arthralgia, myalgia, and meningismus. Cerebrospinal fluid analysis was remarkable for a neutrophilic pleocytosis and elevated protein. Other potential causes of meningitis were excluded. Her symptoms completely resolved within 24 hours of presentation. Because infliximab commonly causes headache and is very immunogenic, we infer that infliximab-induced meningitis is immune-mediated and underrecognized. Potential risk factors and means for minimizing its occurrence are offered.
Identifier
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<a href="http://doi.org/10.1097/01.SMJ.0000155499.21189.75" target="_blank" rel="noreferrer noopener">10.1097/01.SMJ.0000155499.21189.75</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2005
Antibodies
Aseptic/*chemically induced/diagnosis
Crohn Disease/drug therapy
Department of Internal Medicine
Female
Gayomali Charina
Headache/*chemically induced
Hegde Nikita
Humans
Infliximab
Meningitis
Middle Aged
Monoclonal/*adverse effects
NEOMED College of Medicine
Rich Michael W
Serum Sickness/*etiology
Southern medical journal