Browse Items · NEOMED Bibliography Database

Testosterone modulation of striatal dopamine output in orchidectomized mice.

Three experiments are presented in which dopamine (DA) responses from superfused striatal tissue of orchidectomized (ORCH) mice treated or not with testosterone (T) are compared. In experiment 1, potassium-stimulated DA output was significantly…

Sex differences in nitric oxide-mediated attenuation of vascular reactivity to vasopressin are abolished by gonadectomy.

In the rat thoracic aorta, contractile responses to vasopressin are two-fold higher in females than in males, primarily because nitric oxide-mediated attenuation of contraction is greater in males than in females. To determine the role of the gonadal…

Role of dopamine D1 receptors in cocaine lethality.

One group of heterogeneously bred HS mice was assigned to test coadministration of the selective D1 antagonist SCH 23390 with a dose of cocaine (95 mg/kg) that was observed to produce 80% lethality, whereas a second group was tested by cotreatment…

Tags: 1995, Animals, Benzazepines/pharmacology, Cocaine/*toxicity, Dopamine Agonists/pharmacology, Dopamine D1/agonists/antagonists & inhibitors/*drug effects, Female, Inbred Strains, Lethal Dose 50, Male, Meehan S M, Mice, Pharmacology, biochemistry, and behavior, Phenanthridines/pharmacology, Receptors, Schechter M D, Sex Characteristics

The lethal effects of ethanol and cocaine and their combination in mice: implications for cocaethylene formation.

The HS line of mice was used to determine the LD50 values for cocaine and ethanol, as well as for cocaethylene, the enzymatic product of their coadministration. The LD50 of cocaethylene was found to be significantly lower than that of cocaine, and…

Tags: 1995, Animals, Central Nervous System Depressants/*toxicity, Cocaine/*analogs & derivatives/metabolism/toxicity, Dopamine Uptake Inhibitors/*toxicity, Dose-Response Relationship, Drug, Drug Interactions, Ethanol/*toxicity, Female, Lethal Dose 50, Male, Meehan S M, Mice, Pharmacology, biochemistry, and behavior, Schechter M D, Sex Characteristics

Estrogen as a neuroprotectant against MPTP-induced neurotoxicity in C57/B1 mice.

Castrated retired breeder male and female mice were treated or not with a 17 beta-estradiol pellet. At 10 days postcastration +/- estrogen treatment all animals were treated with MPTP. Five days later, concentrations of dopamine were determined from…

Linking Sex Differences in Non-Alcoholic Fatty Liver Disease to Bile Acid Signaling, Gut Microbiota, and High Fat Diet.

This commentary highlights the article by Jena et al that studied the complex interplay between diet, bile acids, sex, and dysbiosis in hepatic steatosis and inflammation.

Tags: *Diet, *Non-alcoholic Fatty Liver Disease, 2017, Bile Acids and Salts, Chiang John Y L, Department of Integrative Medical Sciences, Gastrointestinal Microbiome, High-Fat, Humans, NEOMED College of Medicine, Sex Characteristics, The American journal of pathology

Exacerbation of sensorimotor dysfunction in mice deficient in Atp13a2 and overexpressing human wildtype alpha-synuclein.

Loss of function mutations in the gene ATP13A2 are associated with Kufor-Rakeb Syndrome and Neuronal Ceroid Lipofuscinosis, the former designated as an inherited form of Parkinson's disease (PD). The function of ATP13A2 is unclear but in vitro…

Genetic alteration in the dopamine transporter differentially affects male and female nigrostriatal transporter systems.

Female mice with a heterozygous mutation of their dopamine transporter (+/- DAT) showed relatively robust reductions in striatal DAT specific binding (38-50%), while +/- DAT males showed modest reductions (24-32%). Significant decreases in substantia…

Zinc sulfate taste acuity reflects dietary zinc intake in males.

Gauging an individual's response after they taste a solution of zinc sulfate has been proposed as a method of determining nutritional zinc deficiency, a so-called "zinc taste test." Despite the lack of evidence regarding any relationship between…

Aging and sex differences in striatal dopaminergic function.

In this report the potassium- (30 mM) and amphetamine- (10 microM) stimulated responses of dopamine (DA) and 3,4-dihydroxy phenylacetic acid (DOPAC) from superfused striatal tissue of female and male mice as sampled at 2, 6, 18 and 24 months of age…

Diabetes reduces growth and body composition more in male than in female rats.

Food restriction and/or starvation has a consistently greater and more permanent effect on physical growth in males than in females. Because diabetes may be viewed as being analogous to starvation, we tested the hypothesis that diabetes would reduce…

Daily exercise reduces fat, protein and body mass in male but not female rats.

This study was designed to compare the estimated energy balance, linear growth (body and bone lengths) and body composition (all components including body mass, total body water, fat, protein and ash) response to daily spontaneous running (DSR) in…

Gender and the behavioral manifestations of neuropathic pain.

A model of peripheral nerve injury was used to study gender differences in the development and progression of chronic constriction injury (CCI)-induced hyperalgesia and allodynia in male and female Fischer 344 FBNF1 hybrid rats. Rats were randomly…

Estrogen differentially modulates nicotine-evoked dopamine release from the striatum of male and female rats.

In the present experiment we examined the effects of an in vitro infusion of nicotine (10 microM) upon dopamine release from superfused striatum of castrated male and female rats treated or not treated with estrogen. Estrogen exerted bidirectional…

Tags: 1997, Anderson L I, Animals, Corpus Striatum/drug effects/*metabolism, Dluzen D E, Dopamine/*metabolism, Estradiol/*pharmacology, Female, In Vitro Techniques, Kinetics, Male, Neuroscience letters, Nicotine/*pharmacology, Orchiectomy, Ovariectomy, Rats, Sex Characteristics, Sprague-Dawley

Alterations in the mechanical properties and composition of skin in human growth hormone transgenic mice.

Growth hormone is known to stimulate connective tissue, but the degree to which it influences skin biomechanical properties is unclear. This study tested the hypothesis that human growth hormone transgene expression changes the material properties…

Tags: *Biomechanical Phenomena, *Skin Physiological Phenomena, 2007, Animals, Connective tissue research, Elasticity, Female, Human Growth Hormone/*genetics, Humans, King Donna, Male, Mechanical, Mice, Serrat Maria A, Sex Characteristics, Skin/anatomy & histology/*chemistry, Stress, Transgenic, Vinyard Christopher J

Using the Sauvegrain method to predict peak height velocity in boys and girls.

BACKGROUND: Correlating peak height velocity (PHV) with assessments of skeletal maturity has important implications in the treatment of scoliosis and other pediatric orthopaedic disorders. This study aims to compare the appearance of the elbow to the…

Gender difference in cardiopulmonary reflex inhibition of sympathetic nerve activity.

We tested the hypothesis that reflex responses to mechanical [increase in left atrial pressure (LAP) 0-25 mmHg] and chemical stimulation [left atrial injection of phenylbiguanide (PBG), 0.5-10 mg/kg] of cardiopulmonary receptors are greater in female…

Daily exercise and gender influence postexercise cardiac autonomic responses in hypertensive rats.

The influence of daily spontaneous running (DSR) and gender on postexercise cardiac autonomic responses was examined in spontaneously hypertensive rats. Rats were weaned at 4-5 wk of age and were randomly assigned to a sedentary (7 males and 6…

Mesenteric vascular responses to vasopressin during development of DOCA-salt hypertension in male and female rats.

Deoxycorticosterone acetate (DOCA)-salt hypertension develops to a greater extent in male (M) than in female (F) rats. To determine the role of the vasculature, reactivity to arginine vasopressin (AVP) and prostanoid output were examined in the…

Sex differences in methamphetamine-evoked striatal dopamine output are abolished following gonadectomy: comparisons with potassium-evoked output and responses in prepubertal mice.

Sex differences are reported for methamphetamine (MA)-induced neurotoxicity of the nigrostriatal dopaminergic system. In an attempt to understand some of the bases for these differences, we investigated MA-evoked dopamine (DA) responses from…

Tags: 2005, Animals, Dluzen Dean E, Dopamine Uptake Inhibitors/*pharmacology, Dopamine/*metabolism, Female, In Vitro Techniques, Male, Methamphetamine/*pharmacology, Mice, Neostriatum/drug effects/*metabolism, Neuroendocrinology, Orchiectomy, Ovariectomy, Potassium/*pharmacology, Salvaterra Ty J, Sex Characteristics, Sexual Maturation

Estrogen as neuroprotectant of nigrostriatal dopaminergic system: laboratory and clinical studies.

In this review, we relate both laboratory and clinical evidence associated with the capacity for estrogen to function as a modulator of nigrostriatal dopaminergic pathology. To accomplish this goal, we have divided this review into three parts. In…

Tags: *Neuroprotective Agents, 2003, Basal Ganglia Diseases/prevention & control, Dluzen Dean, Dopamine/*physiology, Endocrine, Estrogens/*pharmacology, Horstink Martin, Humans, Neostriatum/cytology/drug effects/*physiology, Parkinson Disease/pathology/prevention & control, Sex Characteristics, Substantia Nigra/cytology/drug effects/*physiology

Obesity- and sex-related alterations in growth hormone messenger RNA levels.

The secretion of growth hormone (GH) is abnormal in genetically obese Zucker rats. Measurements of pulsatile GH release and circulating GH levels in lean (Fa/?) and obese (fa/fa) rats have shown that both are reduced in the latter. We have studied…

Tags: 1989, Ahmad I, Animals, Carrillo A J, DNA Probes, Female, Finkelstein J A, Male, Messenger/metabolism, Molecular and cellular endocrinology, Nucleic Acid Hybridization, Obesity/*genetics/metabolism, Prolactin/genetics, Rats, RNA, Sex Characteristics, Somatomedins/*genetics, Steggles A W, Zucker

Browse Items (22 total)