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Text
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URL Address
<a href="http://doi.org/10.2147/CPAA.S221736" target="_blank" rel="noreferrer noopener">http://doi.org/10.2147/CPAA.S221736</a>
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Pages
155-160
Volume
11
ISSN
1179-1438
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Update Year & Number
January 2020 Update
NEOMED College
NEOMED College of Medicine
NEOMED Department
NEOMED Student Publications; NEOMED College of Medicine Student Publications
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Title
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Perioperative Administration of Emend® (Aprepitant) at a Tertiary Care Children's Hospital: A 12-Month Survey
Publisher
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Clinical Pharmacology: Advances and Applications
Date
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2019
1905-07
Subject
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aprepitant; pediatric; postoperative nausea and vomiting
Creator
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Kanaparthi Anuradha; Kukura Sarah; Slenkovich Natalie; AlGhamdi Faris; Shafy Shabana Z; Hakim Mohammed; Tobias Joseph D
Description
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Introduction: Aprepitant (Emend®) is a novel antiemetic agent that works through antagonism of neurokinin-1 (NK-1) receptors. To date, there are limited data regarding its use to prevent postoperative nausea and vomiting (PONV) in children. We retrospectively reviewed our initial 12-months experience with aprepitant after it was made available for perioperative use. Methods: The anesthetic records of patients who received aprepitant were retrospectively reviewed and demographic, surgical, and medication data retrieved. Results: The study cohort included 31 patients (15 male and 16 female) ranging in age from 4 to 27 years (15.7 ± 7.4 years) and in weight from 14.4 to 175.7 kilograms (59.3 ± 30.2 kgs). Most of the patients (30 of 31) received the capsule form and 1 received the liquid. The average dose of aprepitant administered was 0.9 ± 0.6 mg/kg; however, only one patient received dosing expressed as mg/kg, and the majority received a 40 mg capsule. All of the patients in the cohort had either a previous history of PONV or risk factors for PONV. PONV occurred in the PACU in 1 patient and during the first 24 postoperative hours in 3 additional patients. No adverse effects related to aprepitant use were noted. Conclusion: Aprepitant was easily added to the preoperative regimen for pediatric patients who may require it. Our approach limited overuse and subsequent cost concerns. Future studies with a comparator group and a greater sample size are needed to demonstrate its efficacy, especially in comparison to time-honored agents such as ondansetron. No adverse effects were noted in our limited study cohort.
Identifier
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<a href="http://doi.org/10.2147/CPAA.S221736" target="_blank" rel="noreferrer noopener">10.2147/CPAA.S221736</a>
PMID: 31819673 PMCID: PMC6885572
Format
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Journal Article
2019
AlGhamdi Faris
aprepitant
Clinical Pharmacology: Advances and Applications
Hakim Mohammed
January 2020 Update
Journal Article
Kanaparthi Anuradha
Kukura Sarah
NEOMED College of Medicine Student
NEOMED Student Publications
Pediatric
postoperative nausea and vomiting
Shafy Shabana Z
Slenkovich Natalie
Tobias Joseph D