1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s11695-020-04987-2" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s11695-020-04987-2</a>
ISSN
1708-0428 0960-8923
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<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1007/s11695-020-04987-2" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1007/s11695-020-04987-2</a>
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Update Year & Number
Hospital List
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Pharmacotherapy for Obesity-Trends Using a Population Level National Database.
Publisher
An entity responsible for making the resource available
Obesity Surgery
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-09-28
Subject
The topic of the resource
Obesity; Weight loss; Morbid obesity; Anti-obesity drugs; Bariatric surgery
Creator
An entity primarily responsible for making the resource
Elangovan A; Shah R; Smith ZL
Description
An account of the resource
BACKGROUND: Despite the growing trend of obesity, the utilization of anti-obesity therapeutic interventions is not robust in the USA. We aimed to analyze the trends of anti-obesity pharmacotherapy using a population level database. METHODS: We used an electronic health record-derived database (Explorys, IBM Watson Health) to identify adults with obesity (body mass index ≥ 30 kg/m(2)), 2010-2019. Annual rates of anti-obesity pharmacotherapy were analyzed. To assess post-bariatric utilization of these medications, the trend of adults with morbid obesity (BMI ≥ 40 kg/m (2)) who were newly started on anti-obesity medications after sleeve gastrectomy was also analyzed. RESULTS: Among 11,195,020 adults with obesity, 274,160 (2.4%) were prescribed anti-obesity medications during the study period with an increase from 1.1% in 2010 to 2.9% in 2019 (p < 0.0001). A total of 900 (3.5%) of those with morbid obesity were started on weight loss medications within 5 years of sleeve gastrectomy. Women [odds ratio (OR) 3.57, 95% confidence interval (CI) 3.51-3.58], individuals under 50 years (OR 1.59, CI 1.57-1.60), non-Hispanics (OR 1.12, 1.10-1.14, p < 0.0001), African Americans (OR 1.18, CI 1.16-1.19), Medicaid (OR 1.70, CI 1.67-1.73), and commercial insurance holders (OR 2.46, 2.43-2.49) were more likely to receive anti-obesity pharmacotherapy, p < 0.001 for all comparisons. CONCLUSION: There has been a modest increase in the prevalence of anti-obesity medications in the last 10 years, but they remain significantly underutilized. Further studies addressing the barriers to anti-obesity pharmacotherapy might help in increasing the utilization of these medications among adults with obesity.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s11695-020-04987-2" target="_blank" rel="noreferrer noopener">10.1007/s11695-020-04987-2</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
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journalArticle
2020
Anti-obesity drugs
Bariatric Surgery
Elangovan A
Hospital List
journalArticle
Morbid obesity
Obesity
Obesity Surgery
Shah R
Smith ZL
Weight Loss
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
500A-501A
Volume
68
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Hyperammonemia Induced Redox Changes In Skeletal Muscle Perturbs Glucose-pyruvate Metabolism And Tissue Bioenergetics
Publisher
An entity responsible for making the resource available
Hepatology
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-10
Subject
The topic of the resource
Gastroenterology & Hepatology
Creator
An entity primarily responsible for making the resource
Gangadhariah M; Allawy A; Davuluri G; Kumar A; Kant S; Alchirazi K A; Shah R; Sandlers Y; Kasumov T; Mao X; O'Connell T; Harris R; Dasarathy S
Identifier
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n/a
Format
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Journal Article or Conference Abstract Publication
2018
Alchirazi K A
Allawy A
Dasarathy S
Davuluri G
Department of Pharmaceutical Sciences
Gangadhariah M
Gastroenterology & Hepatology
Harris R
Hepatology
Kant S
Kasumov T
Kumar A
Mao X
NEOMED College of Pharmacy
O'Connell T
Sandlers Y
Shah R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0040-8166(96)80072-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0040-8166(96)80072-3</a>
Pages
687–701
Issue
6
Volume
28
Dublin Core
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Title
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Flow cytometric and ultrastructural aspects of the synergistic antitumor activity of vitamin C-vitamin K3 combinations against human prostatic carcinoma cells.
Publisher
An entity responsible for making the resource available
Tissue & cell
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-12
Subject
The topic of the resource
*Prostatic Neoplasms; Antineoplastic Combined Chemotherapy Protocols/*pharmacology; Ascorbic Acid/administration & dosage; Cultured/drug effects/metabolism/ultrastructure; DNA/biosynthesis; Drug Synergism; Electron; Flow Cytometry; Hemostatics/administration & dosage; Humans; Male; Microscopy; Scanning; Thymidine/metabolism; Tritium; Tumor Cells; Vitamin K/administration & dosage
Creator
An entity primarily responsible for making the resource
Jamison J M; Gilloteaux J; Venugopal M; Koch J A; Sowick C; Shah R; Summers J L
Description
An account of the resource
Transmission and scanning electron microscopy and flow cytometry were employed to characterize the cytotoxic effects of vitamin C (VC), vitamin K3 (VK3), or VC-VK3 combinations on a human prostate carcinoma cell line (DU145) following a 1-h vitamin treatment and a 24-h incubation in culture medium. Cells exposed to VC exhibited membranous blebs, aberrant microvillar morphology, mitochondria with swollen cristae and intramitochondrial deposits, as well as nucleoli with segregated components. VK3-treated cells displayed a damaged cytoskeleton and membranes, a cytoplasm which contained large lumen, condensed polysomes, and severely damaged mitochondria with residual bodies, and nuclei which exhibited chromatic condensation, pyknosis, and karyolysis. VC-VK3-treated cells exhibited characteristics consistent with necrosis, i.e. swollen mitochondria and swollen, achromatic nuclei with marginated chromatin and intact envelopes, while other cells displayed characteristics consistent with apoptosis, i.e. expulsion of organelle-containing blebs, margination of nuclear chromatin, and segregation of nucleolar components. Vitamin treatment also decreased DNA synthesis, induced a S/G2 block in the cell cycle, and resulted in the accumulation of fragmented DNA. These results suggested that increased oxidative stress, subsequent membrane damage, and DNA fragmentation were responsible for enhanced cytotoxicity of the vitamin combination.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0040-8166(96)80072-3" target="_blank" rel="noreferrer noopener">10.1016/s0040-8166(96)80072-3</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Prostatic Neoplasms
1996
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Ascorbic Acid/administration & dosage
Cultured/drug effects/metabolism/ultrastructure
Department of Anatomy & Neurobiology
DNA/biosynthesis
Drug Synergism
Electron
Flow Cytometry
Gilloteaux J
Hemostatics/administration & dosage
Humans
Jamison J M
Koch J A
Male
Microscopy
NEOMED College of Medicine
Scanning
Shah R
Sowick C
Summers J L
Thymidine/metabolism
Tissue & cell
Tritium
Tumor Cells
Venugopal M
Vitamin K/administration & dosage