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40
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Text
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<a href="http://doi.org/10.1152/jn.1998.79.1.334" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.1998.79.1.334</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
334-341
Issue
1
Volume
79
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Title
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Aging differentially alters forms of long-term potentiation in rat hippocampal area CA1
Publisher
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Journal of Neurophysiology
Date
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1998
1998-01
Subject
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aged fischer-344 rats; alzheimers-disease; calcium channels; concentration-dependent manner; cortex; ltp induction; Neurosciences & Neurology; nmda receptors; Physiology; prefrontal; pyramidal neurons; synaptic transmission; visual cortex
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Shankar S; Teyler T J; Robbins N
Description
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Aging differentially alters forms of long-term potentiation in rat hippocampal area CAl. J. Neurophysiol. 79: 334-341, 1998. Long-term potentiation (LTP) of the Schaffer collateral/commissural inputs to CAI in the hippocampus was shown to consist of N-methyl-D-aspartate receptor (NMDAR) and voltage-dependent calcium channel (VDCC) dependent forms. In this study, the relative contributions of these two forms of LTP in in vitro hippocampal slices from young (2 mo) and old (24 mo) Fischer 344 rats were examined. Excitatory postsynaptic potentials (EPSP) were recorded extracellularly from stratum radiat-um before and after II tetanic stimulus consisting of four 200-Hz, 0.5-s trains given 5 s apart. Under control conditions, a compound LTP consisting of both forms was induced and was similar, in both time course and magnitude, in young and old animals. NMDAR-dependent LTP (nmdaLTP), isolated by the application of 10 mu M nifedipine (a voltage-dependent calcium channel blocker), was significantly reduced in magnitude in aged animals. The VDCC dependent form (vdccLTP), isolated by the application of 50 mu M D,L-2-amino-5-phosphonvalerate (APV), was significantly larger in aged animals. Although both LTP forms reached stable values 40-60 min posttetanus in young animals, in aged animals vdccLTP increased and nmdaLTP decreased during this time. In both young and old animals, the sum of the two isolated LTP forms approximated the magnitude of the compound LTP, and application of APV and nifedipine or genestein (a tyrosine kinase inhibitor) together blocked potentiation. These results suggest that aging causes a shift in synaptic plasticity from NMDAR-dependent mechanisms to VDCC-dependent mechanisms. The data are consistent with previous findings of increased L-type calcium current and decreased NMDAR number In aged CAI cells and may help explain age-related deficits in learning and memory.
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<a href="http://doi.org/10.1152/jn.1998.79.1.334" target="_blank" rel="noreferrer noopener">10.1152/jn.1998.79.1.334</a>
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Journal Article
1998
aged fischer-344 rats
alzheimers-disease
Calcium Channels
concentration-dependent manner
cortex
Journal Article
Journal of neurophysiology
ltp induction
Neurosciences & Neurology
nmda receptors
Physiology
prefrontal
pyramidal neurons
Robbins N
Shankar S
Synaptic Transmission
Teyler T J
visual cortex
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
S341-S342
Volume
37
Search for Full-text
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<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
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Title
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Feasibility Of Sheep Animal Model For Midurethral Sling Surgeries
Publisher
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Neurourology and Urodynamics
Date
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2018
2018-07
Subject
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Urology & Nephrology
Creator
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Isali I; Khalifa A O; Shankar S; Dannemiller S; Horne W; Evancho-Chapman M M; Akkus O; Hijaz A K
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n/a
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Journal Article or Conference Abstract Publication
2018
Akkus O
Dannemiller S
Evancho-Chapman M M
Hijaz A K
Horne W
Isali I
Journal Article or Conference Abstract Publication
Khalifa A O
Neurourology and Urodynamics
Shankar S
Urology & Nephrology