1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1093/ajcp/100.1.47" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/ajcp/100.1.47</a> Rights Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Pages 47-51 Issue 1 Volume 100 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource EMERGENCE OF ANTIMICROBIAL RESISTANCE IN GRAM-NEGATIVE BACILLI CAUSING BACTEREMIA DURING THERAPY Publisher An entity responsible for making the resource available American Journal of Clinical Pathology Date A point or period of time associated with an event in the lifecycle of the resource 1993 1993-07 Subject The topic of the resource beta-lactam antibiotics; cephalosporins; enterobacter-cloacae; Pathology Creator An entity primarily responsible for making the resource Siebert J D; Thomson R B; Tan J S; Gerson L W Description An account of the resource Treatment of serious infections caused by gram-negative bacilli with beta-lactam antimicrobial agents can induce Class I beta-lactamase production. This phenomenon can result in resistant microorganisms, and has been postulated to be a cause of therapeutic failure. The charts of patients bacteremic with Pseudomonas aeruginosa, Serratia marcescens, Enterobacter cloacae, Citrobacter freundii, Proteus vulgaris, and Providencia species (n=120) during a 3-year period were reviewed to determine how common the emergence of resistance was, and to determine if in vitro susceptibility testing was a reliable therapeutic guide. Emergence of resistance was believed to occur when a subsequent bacteremic isolate showed at least a fourfold increase in minimum inhibitory concentration accompanied by a change of interpretive susceptibility category. In the group of patients who survived at least 48 hours that received beta-lactam therapy (n=76), one case of emergence of resistance was identified (1.3%). Emergence of resistance to beta-lactam antimicrobial agents did not commonly cause therapeutic failure at our institution, and susceptibility testing of gram-negative bacilli by usual methods was a reliable guide to antimicrobial therapy. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1093/ajcp/100.1.47" target="_blank" rel="noreferrer noopener">10.1093/ajcp/100.1.47</a> Format The file format, physical medium, or dimensions of the resource Journal Article 1993 American journal of clinical pathology beta-lactam antibiotics cephalosporins enterobacter-cloacae Gerson L W Journal Article Pathology Siebert J D Tan J S Thomson R B