Browse Items · NEOMED Bibliography Database

TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy.

BACKGROUND: Genetic variants of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) confer increased risk of developing late-onset Alzheimer's Disease (LOAD) and other neurodegenerative disorders. Recent studies provided insight into the…

Cardiac mitochondria and reactive oxygen species generation.

Mitochondrial reactive oxygen species (ROS) have emerged as an important mechanism of disease and redox signaling in the cardiovascular system. Under basal or pathological conditions, electron leakage for ROS production is primarily mediated by the…

Tags: 2014, Animals, Cardiac/*metabolism, Cardiovascular Diseases/*metabolism, Chen Yeong-Renn, Circulation research, Department of Integrative Medical Sciences, electron transport chain complex proteins, Heart/*metabolism, Humans, Membrane Potentials/physiology, Mitochondria, myocardial infarction, Myocytes, NEOMED College of Medicine, reactive oxygen species, Reactive Oxygen Species/*metabolism, Signal Transduction/physiology, Zweier Jay L

Bile acids: regulation of synthesis.

Bile acids are physiological detergents that generate bile flow and facilitate intestinal absorption and transport of lipids, nutrients, and vitamins. Bile acids also are signaling molecules and inflammatory agents that rapidly activate nuclear…

Tags: 2009, Animals, Bile Acids and Salts/*metabolism, Biological, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/metabolism, Cytoplasmic and Nuclear/metabolism, Department of Integrative Medical Sciences, Humans, Journal of lipid research, Models, NEOMED College of Medicine, Receptors, Signal Transduction/physiology

Hepatocyte nuclear factor 4alpha regulation of bile acid and drug metabolism.

The hepatocyte nuclear factor 4alpha (HNF4alpha) is a liver-enriched nuclear receptor that plays a critical role in early morphogenesis, fetal liver development, liver differentiation and metabolism. Human HNF4alpha gene mutations cause maturity…

Tags: 2009, Animals, Bile Acids and Salts/*metabolism, Chiang John Y L, Department of Integrative Medical Sciences, Expert opinion on drug metabolism & toxicology, Gene Expression Regulation, Genetic Predisposition to Disease, Hepatocyte Nuclear Factor 4/genetics/*metabolism, Humans, Lipid Metabolism, Liver/metabolism, Mutation, NEOMED College of Medicine, Pharmaceutical Preparations/*metabolism, Signal Transduction/physiology

Unconventional effects of estrogen uncovered.

The nigrostriatal dopamine system shows marked gender differences that, in many cases, can be attributable to estrogen. However, the virtual absence of conventional estrogen receptors within the nigrostriatal dopamine system has made it difficult to…

Tags: 2005, Animals, Corpus Striatum/*metabolism/physiology, Dluzen Dean E, Dopamine D2/metabolism, Dopamine/*metabolism, Estrogens/*physiology, GTP-Binding Proteins/metabolism, Humans, Receptors, Signal Transduction/physiology, Substantia Nigra/*metabolism/physiology, Trends in pharmacological sciences

The contribution of interleukin-2 to effective wound healing.

Ineffective skin wound healing is a significant source of morbidity and mortality. Roughly 6.5 million Americans experience chronically open wounds and the cost of treating these wounds numbers in the billions of dollars annually. In contrast, robust…

Primary cilia regulates the directional migration and barrier integrity of endothelial cells through the modulation of hsp27 dependent actin cytoskeletal organization.

Cilia are mechanosensing organelles that communicate extracellular signals into intracellular responses. Altered functions of primary cilia play a key role in the development of various diseases including polycystic kidney disease. Here, we show that…

A novel role of transforming growth factor beta1 in transcriptional repression of human cholesterol 7alpha-hydroxylase gene.

BACKGROUND & AIMS: Inhibition of cholesterol 7alpha-hydroxylase (CYP7A1) by bile acids and inflammatory cytokines provides an important mechanism to protect hepatocytes from bile acid toxicity during cholestasis. Transforming growth factor beta1…

Bile acid signaling in metabolic disease and drug therapy.

Bile acids are the end products of cholesterol catabolism. Hepatic bile acid synthesis accounts for a major fraction of daily cholesterol turnover in humans. Biliary secretion of bile acids generates bile flow and facilitates hepatobiliary secretion…

Angiotensin II-induced extracellular signal-regulated kinase 1/2 activation is mediated by protein kinase Cdelta and intracellular calcium in adult rat cardiac fibroblasts.

Angiotensin II (Ang II)-induced proliferation of cardiac fibroblasts is a major contributing factor to the pathogenesis of cardiac fibrosis. Ang II activates extracellular signal-regulated kinase (ERK) 1/2 to induce cardiac fibroblast proliferation,…

Impact of type 1 diabetes on cardiac fibroblast activation: enhanced cell cycle progression and reduced myofibroblast content in diabetic myocardium.

Diabetic patients are prone to developing myocardial fibrosis and suffer from decreased wound healing capabilities. The purpose of this study was to determine whether diabetes alters cardiac fibroblast activity in the myocardium in a 6-wk…

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