Browse Items (38 total)
- Tags: Signal Transduction
Mutation in Osteoactivin Promotes Receptor Activator of NFkappaB Ligand (RANKL)-mediated Osteoclast Differentiation and Survival but Inhibits Osteoclast Function.
Tags: *Mutation, 2015, Abdelmagid Samir M, Akt, Animals, Belcher Joyce Y, Bone, bone marrow, Bone Remodeling, Cell Differentiation/*physiology, Cell Survival/*physiology, Department of Anatomy & Neurobiology, Eye Proteins/*genetics, Hankenson Kurt D, Inbred DBA, Khol Matthew, Malcuit Christopher, MAP kinases (MAPKs), Mbimba Thomas, Membrane Glycoproteins/*genetics, Mice, Moussa Fouad M, NEOMED College of Medicine, Novak Kimberly, OSTEOACTIVIN, osteoclast, Osteoclasts/*cytology, osteopetrosis, RANK Ligand/metabolism/*physiology, Safadi Fayez F, Signal Transduction, Sondag Gregory R, Stinnett Hilary, The Journal of biological chemistry, X-Ray Microtomography, Yu Bing
Osteoactivin regulates head and neck squamous cell carcinoma invasion by modulating matrix metalloproteases.
Tags: *Cell Movement, 2018, Arosarena Oneida A, Barr Eric W, Carcinoma, Cell Line, cell lines, Department of Anatomy & Neurobiology, Enzymologic, Extracellular Matrix, Gene Expression Regulation, Head and Neck Neoplasms/*enzymology/genetics/pathology, Human, Humans, Journal of cellular physiology, matrix metalloproteinases, Membrane Glycoproteins/genetics/*metabolism, Messenger/genetics/metabolism, NEOMED College of Medicine, neoplasm invasion, Neoplasm Invasiveness, Neoplastic, RNA, RNA Interference, Safadi Fayez F, Secreted/genetics/*metabolism, Signal Transduction, Squamous Cell Carcinoma of Head and Neck, Squamous Cell/*enzymology/genetics/pathology, Tarr Joseph T, Thorpe Ryan, Transfection, Tumor, Yankey Hilary
Tags: *Cell Movement, 2016, Arosarena Oneida A, Barr Eric W, Bryant Evan, Carcinoma, Cell Adhesion, Cell Line, Cell Proliferation, Cell Survival, Dela Cadena Raul A, Denny Michael F, Department of Anatomy & Neurobiology, Enzyme Activation, Gene Expression Regulation, Head and Neck Neoplasms/genetics/*metabolism/pathology, Humans, Integrin beta1/metabolism, Journal of cellular physiology, Membrane Glycoproteins/genetics/*metabolism, Messenger/metabolism, Mitogen-Activated Protein Kinases/metabolism, Mouth Neoplasms/genetics/*metabolism/pathology, NEOMED College of Medicine, Neoplasm Invasiveness, Neoplastic, Protein Binding, RNA, RNA Interference, Safadi Fayez F, Signal Transduction, Squamous Cell Carcinoma of Head and Neck, Squamous Cell/genetics/*metabolism/pathology, Thorpe Ryan, Time Factors, Transfection, Tumor
Tags: 2015, Arshanapalli Ashish, Autoantibodies/immunology, Biological, Cytokine, Cytokines, Dermatomyositis, Dermatomyositis/*immunology/physiopathology/therapy, Humans, Inflammatory myopathy, Interferon Type I/*metabolism, Models, Pathogenesis, Shah Mihir, Signal Transduction, Somani Ally-Khan, Type I interferons, Veerula Vindhya
Augmentation of Muscle Blood Flow by Ultrasound Cavitation Is Mediated by ATP and Purinergic Signaling.
Tags: 2017, Adenosine Triphosphate – Metabolism, Adenosine Triphosphate/*metabolism, Ammi Azzdine Y, Animal Studies, Animals, Belcik J Todd, Chilian William M, Chon Chae Ryung, Circulation, contrast echocardiography, Davidson Brian P, Department of Integrative Medical Sciences, Equipment and Supplies, Field Joshua, Harmann Leanne, Hemodynamics, Humans, Inbred C57BL, Liang Sherry, Linden Joel, Lindner Jonathan R, Male, Mice, Microbubbles, Microcirculation, Muscle, NEOMED College of Medicine, Neurotransmitter Agents – Metabolism, Perfusion, Purinergic Agents/*metabolism, Qi Yue, Signal Transduction, Skeletal – Blood Supply, Skeletal/*blood supply, Ultrasonography – Methods, Ultrasonography/*methods, Wu Melinda D, Xie Aris, Yadava Mrinal
Hepatic Cannabinoid Receptor Type 1 Mediates Alcohol-Induced Regulation of Bile Acid Enzyme Genes Expression Via CREBH
Tags: 2013, Acids, activation, Ahn S H, Alcohol, Alcohols, Bile, BILE acids, bound, cb1 receptors, Chanda D, Chiang J Y L, Choi H S, cholesterol 7-alpha-hydroxylase, Damage prevention, Deregulation, Diabetes Mellitus, element-binding protein, endocannabinoid system, endoplasmic-reticulum stress, er stress, exposure, Fatty Liver, gene-expression, Genes, hepatocytes, Homeostasis, human hepatocytes, insulin, insulin-resistance, Jeong W I, Journal Article or Conference Abstract Publication, Kim D K, Kim J R, Kim Y H, Koo S H, Kwon J, Lee C H, leptin resistance, Li T, Liver, Liver Diseases, Metabolism, Mice, Misra J, Muridae, Ohio, Park T S, PloS one, Regulatory mechanisms (biology), RNA extraction, Rodents, Science & Technology - Other Topics, Sciences: Comprehensive Works, Signal Transduction, Signaling, Synthesis, transcription factor
Low-density lipoprotein receptor-related protein mediates in PC12 cell cultures the inhibition of nerve growth factor-promoted neurite outgrowth by pregnancy zone protein and alpha(2)-macroglobulin
Tags: 2002, alpha-2-macroglobulin, alpha-macroglobulin, alpha-macroglobulins, amyloid precursor protein, Binding, Chiabrando G A, cytosolic adapter, gene-expression, Journal Article or Conference Abstract Publication, Journal of neuroscience research, Koo P H, low-density lipoprotein receptor-related protein, lrp, neurological diseases, Neurosciences & Neurology, Phosphorylation, rat alpha-1-macroglobulin, Receptors, Sanchez M C, Signal Transduction, Skornicka E L, trk, Trk regulation
The opposing effects of retinoic acid and phorbol esters converge to a common response element in the promoter of the rat cholesterol 7 alpha-hydroxylase gene (CYP7A).
Tags: *Promoter Regions, 1996, Animals, Base Sequence, Biochemical and biophysical research communications, Cell Line, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics/metabolism, Crestani M, Department of Integrative Medical Sciences, DNA Primers, Galli G, Genetic, Molecular Sequence Data, Mutagenesis, NEOMED College of Medicine, Rats, Sadeghpour A, Signal Transduction, Stroup D, Tetradecanoylphorbol Acetate/*pharmacology, Tretinoin/*pharmacology
G-protein-coupled bile acid receptor plays a key role in bile acid metabolism and fasting-induced hepatic steatosis in mice.
Tags: *Gene Expression Regulation, 2017, Analysis of Variance, Animal, Animals, Bile Acids and Salts/*metabolism, Boehme Shannon, Chiang John Y L, Department of Integrative Medical Sciences, Disease Models, Donepudi Ajay C, Energy Metabolism/physiology, Fasting, Fatty Liver/*metabolism/pathology, G-Protein-Coupled/*genetics, Hepatology (Baltimore, Md.), Homeostasis/genetics, Inbred C57BL, Li Feng, Lipid Metabolism/genetics, Male, Mice, NEOMED College of Medicine, Oxygen Consumption/physiology, Random Allocation, Receptors, RNA-Binding Proteins/*metabolism, Signal Transduction
Tags: *drug discovery, *Ligands, 2017, Adenosine/metabolism, Animals, Atherosclerosis, Cardiac death, Cardiovascular Diseases/drug therapy/metabolism, Cardiovascular System/metabolism, Department of Integrative Medical Sciences, Geldenhuys Werner J, Hanif Ahmad, Humans, Hydrogen Bonding, Models, Molecular, Molecular Structure, Molecules (Basel, Switzerland), myocardial infarction, Nayeem Mohammed A, NEOMED College of Medicine, Protein Binding, Purinergic P1/*chemistry/*metabolism, Receptors, Signal Transduction, Structure-Activity Relationship, Vascular tone, Yun June
Integrin mediated adhesion of osteoblasts to connective tissue growth factor (CTGF/CCN2) induces cytoskeleton reorganization and cell differentiation.
Tags: *Cell Differentiation, 2015, Animals, Barbe Mary F, Cell Adhesion, Cell Line, Connective Tissue Growth Factor/chemistry/*metabolism, Core Binding Factor Alpha 1 Subunit/metabolism, Cytoskeleton/*metabolism, Department of Anatomy & Neurobiology, Extracellular Signal-Regulated MAP Kinases/metabolism, Focal Adhesion Protein-Tyrosine Kinases/metabolism, Hendesi Honey, Integrins/*metabolism, Mice, Monroy M Alexandra, NEOMED College of Medicine, Osteoblasts/*cytology/*metabolism, PloS one, Popoff Steven N, rac GTP-Binding Proteins/metabolism, Receptors, Safadi Fayez F, Signal Transduction, Transcriptional Activation, Vitronectin/metabolism
Alignment of inducible vascular progenitor cells on a micro-bundle scaffold improves cardiac repair following myocardial infarction.
Tags: *Cardiovascular regeneration, *Ischemic heart diseases, *Micro-bundle scaffold, *Myocardial infarction, *Neovascularization, *Stem cells, *Tissue Scaffolds, *Vascular progenitor cells, 2017, Animal, Animals, Basic research in cardiology, Cell Differentiation, Cell Proliferation, Cell Survival, Cells, Chilian William M, Coculture Techniques, Cultured, Cumpston Devan, Department of Integrative Medical Sciences, Disease Models, Dong Feng, Endothelial Progenitor Cells/metabolism/*transplantation, Enrick Molly, Fibroblast Growth Factor 2/metabolism, Hakobyan Tatev, Jamaiyar Anurag, Janota Danielle, Kolz Christopher L, Lactic Acid/*chemistry, Muscle, Myocardial Infarction/metabolism/pathology/physiopathology/*surgery, Myocardium/metabolism/*pathology, Myocytes, NEOMED College of Medicine, Newby Bi-Min Zhang, Ohanyan Vahagn, Paracrine Communication, Phenotype, Physiologic, Polyglycolic Acid/*chemistry, Polylactic Acid-Polyglycolic Acid Copolymer, Rats, Signal Transduction, Smooth, Smooth Muscle/metabolism/*transplantation, Song Hokyung, Sprague-Dawley, Stevanov Kelly, Time Factors, Tissue Engineering/*methods, Vascular Endothelial Growth Factor A/metabolism, Vascular/metabolism/*transplantation, Ventricular Remodeling, Wan Weiguo, Yin Liya
Overexpressing superoxide dismutase 2 induces a supernormal cardiac function by enhancing redox-dependent mitochondrial function and metabolic dilation.
Tags: 2015, Adenosine Triphosphate/biosynthesis, Animals, Arterial Pressure/drug effects, Bioenergetics, Blood Flow Velocity/drug effects, Cardiac function, Cardiac/drug effects/*enzymology, Catalase/pharmacology, Chen Chwen-Lih, Chen Yeong-Renn, Chilian William M, Department of Integrative Medical Sciences, Echocardiography, Female, Gene Expression, Heart/drug effects/*enzymology, Hydrogen Peroxide/*metabolism/pharmacology, Injections, Intravenous, Journal of molecular and cellular cardiology, Kang Patrick T, Luther Daniel J, Male, Meszaros J Gary, Metabolic dilation, Mice, Mitochondria, Myocardium/*enzymology, Myocytes, NEOMED College of Medicine, NG-Nitroarginine Methyl Ester/pharmacology, Ohanyan Vahagn, Oxidation-Reduction, Oxygen Consumption/drug effects, Redox regulation, Signal Transduction, Stroke Volume/drug effects, Superoxide dismutase 2 (SOD2), Superoxide Dismutase/*genetics/metabolism, Transgenic, Transgenic mice, Vasodilation/*drug effects
Coordinate down-regulation of cartilage matrix gene expression in Bcl-2 deficient chondrocytes is associated with decreased SOX9 expression and decreased mRNA stability.
Tags: 2003, Aggrecans, Animals, C-Type, Cell Line, Chondrocytes/*physiology, Collagen Type II/genetics/metabolism, Dactinomycin, Down-Regulation, Extracellular Matrix Proteins/analysis/genetics/*metabolism, Gene Expression Regulation, Glycoproteins/analysis/genetics/*metabolism, High Mobility Group Proteins/genetics/*metabolism, Horton Walter E Jr, Journal of cellular biochemistry, Kinkel Mary D, Lectins, Matrilin Proteins, Messenger/analysis/biosynthesis, Polymerase Chain Reaction/methods, Proteoglycans/genetics/metabolism, Proto-Oncogene Proteins c-bcl-2/deficiency/genetics/*physiology, Rats, RNA, RNA Stability, Signal Transduction, SOX9 Transcription Factor, Transcription Factors/genetics/*metabolism, Transfection
Tags: 2015, Adenosine Triphosphate/*analogs & derivatives/*chemistry, Amino Acid, Amino Acid Sequence, Animals, ATP, Catalysis, Cercopithecus aethiops, Chemical Biology, Chou Wen-Hai, COS Cells, Geldenhuys Werner J, Glutamine/chemistry, Han Xiqian, Humans, Inbred C57BL, Kumar Varun, Leucine/chemistry, Lysine/chemistry, Messing Robert O, Mice, Molecular Sequence Data, Neutrophils/metabolism, Phenylalanine/chemistry, Phosphorylation, Protein Binding, Protein Kinase C (PKC), Protein Kinase C-delta/*metabolism, Protein Phosphorylation, Purines/chemistry, Sequence Homology, Signal Transduction, stroke, Substrate Specificity, Superoxides/chemistry, The Journal of biological chemistry, Transgenic, Wang Dan, Weng Yi-Chinn
Role of the adjacent stroma cells in prostate cancer development and progression: synergy between TGF-beta and IGF signaling.
Tags: 2014, Androgens/metabolism, Animals, BioMed research international, Disease Progression, Epithelial Cells/cytology, Estrogen/metabolism, Estrogens/metabolism, Humans, Jia Zhenyu, Lee Chung, Male, McClelland Michael, Mercola Dan, Mice, Prostate/metabolism, Prostatic Neoplasms/*metabolism, Rahmatpanah Farah, Receptors, Signal Transduction, Somatomedins/*metabolism, Stromal Cells/*cytology, Transforming Growth Factor beta/*metabolism, Zhang Qiang, Zi Xiaolin
Tags: 2015, Bile Acids and Salts/*metabolism, Biological Transport, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/metabolism, Current opinion in gastroenterology, Cytoplasmic and Nuclear/metabolism, Department of Integrative Medical Sciences, Diabetes Mellitus, Energy Metabolism, Homeostasis, Humans, Inflammation/*metabolism, Intestine, Li Tiangang, Liver/*metabolism/pathology, NEOMED College of Medicine, Obesity/*metabolism, Receptors, Signal Transduction, Small/*metabolism/pathology, Type 2/*metabolism
TGFbeta1, TNFalpha, and insulin signaling crosstalk in regulation of the rat cholesterol 7alpha-hydroxylase gene expression.
Tags: *Gene Expression Regulation, 2008, Animals, Cell Line, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics, Department of Integrative Medical Sciences, Enzymologic, Forkhead Transcription Factors/physiology, Humans, Insulin/*physiology, Journal of lipid research, Li Tiangang, Ma Huiyan, Male, NEOMED College of Medicine, Nerve Tissue Proteins/physiology, Rats, Signal Transduction, Smad3 Protein/antagonists & inhibitors/pharmacology, Sprague-Dawley, Transforming Growth Factor beta1/*physiology, Tumor, Tumor Necrosis Factor-alpha/*physiology
Anti-Inflammatory Mechanism Involved in Pomegranate-Mediated Prevention of Breast Cancer: the Role of NF-kappaB and Nrf2 Signaling Pathways.
Tags: 10-Dimethyl-1, 2-benzanthracene/toxicity, 2017, 9, Animal Studies, Animals, Anti-Inflammatory Agents/*pharmacology, anti-inflammatory effects, Anticarcinogenic Agents/pharmacology, Apoptosis/drug effects, Bhatia Deepak, Bishayee Anupam, Breast Neoplasms, breast tumor, Cell Transformation, Chemoprevention, COX-2, Cyclooxygenase 2/genetics/metabolism, DMBA, Dose-Response Relationship, Drug, Experimental/*prevention & control, Female, Gene Expression Regulation, HSP90, HSP90 Heat-Shock Proteins/genetics/metabolism, I-kappa B Kinase/genetics/metabolism, Inflammation Mediators, Mammary Neoplasms, Mandal Animesh, Neoplasms – Prevention and Control, Neoplastic, Neoplastic/drug effects, NF-E2-Related Factor 2/genetics/*metabolism, NF-kappa B/genetics/*metabolism, NF-kappaB, Nrf2, Nutrients, Physical Education and Training, Plant Preparations/*pharmacology, Pomegranate, Punica granatum, Punicaceae/*chemistry, Rats, Signal Transduction
Tags: 2016, Affo Silvia, Alcoholic/*immunology, Altamirano Jose, Animals, Arroyo Vicente, Bataller Ramon, Caballeria Juan, Cell Proliferation, Cells, Chen Jiegen, Collagen/genetics/metabolism, Common/*pathology, Crews Fulton, Cultured, Department of Pharmaceutical Sciences, Dumitru Raluca, Female, Gene Expression Profiling, Gene Expression Regulation, Gines Pere, Hepatic Duct, Hepatitis, Hepatocytes/*metabolism/pathology, Humans, Inbred BALB C, Keratins, Knockout, Lipopolysaccharides/metabolism, Lozano Juan Jose, Male, Matsushita Hiroshi, Mice, Middle Aged, Morales-Ibanez Oriol, NEOMED College of Pharmacy, Odena Gemma, Rautou Pierre-Emmanuel, Rodrigo-Torres Daniel, Sancho-Bru Pau, Scientific reports, Seki Ekihiro, Signal Transduction, Toll-Like Receptor 4/genetics/*metabolism, Type I/genetics/*metabolism, Valla Dominique, You Min, Zou Jian
Tags: *Collateral Circulation, *Coronary Circulation, *Energy Metabolism, *Neovascularization, 2013, American journal of physiology. Heart and circulatory physiology, angiogenesis, Animals, Arteriogenesis, Chilian William M, Coronary Vessels/metabolism, Department of Integrative Medical Sciences, Di Vincenzo Lola, Hardwick James P, Humans, Logan Suzanna, Mitochondria, Mitochondrial Proteins/metabolism, Muscle, Muscle/*metabolism, Myocytes, NEOMED College of Medicine, Ohanyan Vahagn, Oxidative Stress, Phenotype, Physiologic, Pung Yuh Fen, Reactive Oxygen Species/*metabolism, Redox-dependent signaling, Sam Wai Johnn, Signal Transduction, Smooth, Smooth Muscle/*metabolism, Vascular/*metabolism, Yin Liya
Apocynum Tablet Protects against Cardiac Hypertrophy via Inhibiting AKT and ERK1/2 Phosphorylation after Pressure Overload.
Tags: 2014, Animal Studies, Aorta – Physiopathology, Blotting, Descriptive Statistics, Echocardiography, Evidence-based Complementary & Alternative Medicine (eCAM), Funding Source, Gene Expression Profiling, Gong Kaizheng, Guo Liheng, Heart Diseases – Prevention and Control, Hypertrophy – Prevention and Control, In Vivo Studies, Liu Qin, Mice, One-Way Analysis of Variance, Phosphorylation – Drug Effects, Plant Extracts – Therapeutic Use, Post Hoc Analysis, Protein Kinases – Antagonists and Inhibitors, Qi Jianyong, Signal Transduction, Staining and Labeling, T-Tests, Vasoconstriction, Wang Lei, Western, Wu Jiashin, Yu Juan, Zhang Minzhou, Zhou Miao
Salvianolate reduces murine myocardial ischemia and reperfusion injury via ERK1/2 signaling pathways in vivo.
Tags: *MAP Kinase Signaling System/drug effects, 2017, Animal Studies, Animals, Blotting, Cardiotonic Agents/pharmacology/therapeutic use, Chinese journal of integrative medicine, Chinese medicine, Descriptive Statistics, extracellular signal-regulated kinase 1/2, Flavonoids/pharmacology, Guo Liheng, Heart Ventricle, Heart Ventricles/drug effects/pathology, Huang Dong-Hui, Huang Hai-Ding, Huang Xin, In Vivo Studies, Inbred C57BL, ischemia and reperfusion injury, Left, Male, Mice, Mitogen-Activated Protein Kinase 1/*metabolism, Mitogen-Activated Protein Kinase 3/*metabolism, Molecular Structure, Myocardial Ischemia – Drug Therapy, Myocardial Reperfusion Injury – Drug Therapy, Myocardial Reperfusion Injury/*drug therapy/enzymology/pathology, Organ Size/drug effects, P-Value, Phosphorylation, Phosphorylation/drug effects, Plant Extracts – Administration and Dosage, Plant Extracts/chemistry/pharmacology/*therapeutic use, protein kinase B, Protein Kinase Inhibitors – Administration and Dosage, Protein Kinase Inhibitors/pharmacology, Protein Kinases – Analysis, Protein Kinases – Drug Effects, Qi Jianyong, salvianolate, Signal Transduction, Staining and Labeling, Wang Lei, Western, Wu Jiashin, Yu Juan, Zhang Minzhou, Zhou Miao
Bile acid signaling in lipid metabolism: metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice.
Tags: 2015, Animals, Bile acid metabolism, Bile Acids and Salts/genetics/*metabolism, Biochimica et biophysica acta, Cheng Jie, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/genetics/metabolism, CYP7A1, Department of Integrative Medical Sciences, Diabetes Mellitus/genetics/*metabolism, Diet, farnesoid X receptor (FXR), Female, Ferrell Jessica M, Glucose/genetics/metabolism, Gonzalez Frank J, High-Fat/methods, Homeostasis, Inbred C57BL, Insulin Resistance, Intestinal Mucosa/metabolism, Jiang Changtao, Krausz Kristopher W, Li Tiangang, Lipid Metabolism/*physiology, lipidomics, Liver/metabolism, Male, Metabolome/*genetics, Metabolomics/methods, Mice, NEOMED College of Medicine, Obesity/genetics/*metabolism, Qi Yunpeng, Rats, Signal Transduction, tauro-beta-muricholic acid, Taurocholic Acid/analogs & derivatives/genetics/metabolism, Transgenic
Role of Neuropilin-1/Semaphorin-3A signaling in the functional and morphological integrity of the cochlea.
Tags: 2017, Abdala Carolina, Animals, Coate Thomas Matthew, Cruz Charlene, Female, Friedman Rick A, Ge Marshall X, Gundimeda Usha, Inbred C57BL, Kelley Matthew William, Knockout, Lael Cantu Homero, Lavinsky Joel, Male, Mice, Michelle Baum Leah, Myint Anthony, Neurogenesis, Neurons/cytology, Neuropilin-1/genetics/*metabolism, Nikolakopoulou Angeliki Maria, Ohyama Takahiro, PLoS genetics, Salehi Pezhman, Semaphorin-3A/genetics/*metabolism, Signal Transduction, Spiral Ganglion/cytology/*embryology, Tao Litao, Wang Juemei
Tags: *Cell Differentiation, 2014, Adapala Ravi K, Animals, Blood Glucose/metabolism, Bryant Jennifer E, Canadian journal of physiology and pharmacology, cardiac fibroblast, Cell Movement, Cell Proliferation, Cells, Collagen, Collagen/metabolism, collagene, concentration elevee de glucose, Cultured, Department of Integrative Medical Sciences, diabete, Diabetes, fibroblaste cardiaque, Fibroblasts/*metabolism/pathology, Fibrosis, high glucose, Hyperglycemia/*metabolism/pathology, Luther Daniel J, Male, Meszaros J Gary, migration, Myocardium/*metabolism/pathology, myofibroblast, myofibroblastes, NEOMED College of Medicine, Petersen Kyle A, proliferation, Rats, Shamhart Patricia E, Signal Transduction, Sprague-Dawley, Thodeti Charles K
Functional selectivity, ligand-directed trafficking, conformation-specific agonism: what's in a name?
Propofol causes vasodilation in vivo via TRPA1 ion channels: role of nitric oxide and BKCa channels.
Tags: 2015, Animals, Arterial Pressure/drug effects, Bratz Ian N, Damron Derek S, Drug Evaluation, Female, Inbred C57BL, Knockout, Large-Conductance Calcium-Activated Potassium Channel alpha Subunits/*physiology, Male, Mice, Nitric Oxide/*physiology, PloS one, Preclinical, Propofol/*pharmacology, Signal Transduction, Sinha Sayantani, Sinharoy Pritam, Transient Receptor Potential Channels/genetics/*metabolism, TRPA1 Cation Channel, TRPV Cation Channels/genetics/metabolism, Vasodilator Agents/*pharmacology
Hepatocyte growth factor signaling pathway inhibits cholesterol 7alpha-hydroxylase and bile acid synthesis in human hepatocytes.
Tags: 2007, Bile Acids and Salts/*biosynthesis, Cells, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*biosynthesis, Cultured, Department of Integrative Medical Sciences, Ellis Ewa, Hepatocyte Growth Factor/*metabolism, Hepatocytes/*metabolism, Hepatology (Baltimore, Md.), Humans, NEOMED College of Medicine, Signal Transduction, Song Kwang-Hoon, Strom Stephen
Black currant anthocyanins abrogate oxidative stress through Nrf2- mediated antioxidant mechanisms in a rat model of hepatocellular carcinoma.
Tags: *Phytotherapy, 2012, Alkylating Agents/toxicity, Animals, Anthocyanins/*therapeutic use, Antioxidants/therapeutic use, Barnes Kendra F, Bhatia Deepak, Bishayee Anupam, Blotting, Carcinoma, Current cancer drug targets, Darvesh Altaf S, Department of Pharmaceutical Sciences, Diet, Diethylnitrosamine/toxicity, Experimental/chemically induced/metabolism/*prevention & control, Glutathione Transferase, Haznagy-Radnai Erzsebet, Hepatocellular/chemically induced/metabolism/*prevention & control, Hohmann Judit, Immunoenzyme Techniques, Lipid Peroxidation/drug effects, Liver Neoplasms, Male, Messenger/genetics, NEOMED College of Pharmacy, NF-E2-Related Factor 2/genetics/*metabolism, Nitric Oxide Synthase Type II/genetics/metabolism, Oxidative Stress/*drug effects, Rats, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, Ribes/*chemistry, RNA, Signal Transduction, Sprague-Dawley, Thoppil Roslin J, Tyrosine/analogs & derivatives/metabolism, Western
Myeloid Cell-Specific Lipin-1 Deficiency Stimulates Endocrine Adiponectin-FGF15 Axis and Ameliorates Ethanol-Induced Liver Injury in Mice.
Tags: 2016, Adiponectin/*blood, Alcoholic/blood/*genetics/metabolism, Animal, Animals, Chrast Roman, Department of Pharmaceutical Sciences, Disease Models, Fatty Liver, Fibroblast Growth Factors/*blood, Finck Brian N, Gene Knockout Techniques, Han Yoonhee, Hu Xudong, Jogasuria Alvin, Kim Chunki, Lipid Metabolism, Male, Mice, Myeloid Cells/*metabolism, NEOMED College of Pharmacy, NF-kappa B/metabolism, Nuclear Proteins/*deficiency, Organ Specificity, Phosphatidate Phosphatase/*deficiency, Scientific reports, Shen Hong, Signal Transduction, Wang Jiayou, Wu Jiashin, You Min
Bcl-2 positively regulates Sox9-dependent chondrocyte gene expression by suppressing the MEK-ERK1/2 signaling pathway.
Tags: *Gene Expression Regulation, 2005, Adenoviridae/genetics, Animals, Apoptosis, beta-Galactosidase/metabolism, Blotting, Butadienes/pharmacology, Caspase Inhibitors, Cell Differentiation, Cell Line, Chondrocytes/*metabolism, Collagen Type II/metabolism, Department of Anatomy & Neurobiology, Down-Regulation, Enzyme Inhibitors/pharmacology, Fibroblasts/metabolism, Fluorescence, Genetic, High Mobility Group Proteins/*metabolism, Horton Walter E Jr, Lac Operon, Luciferases/metabolism, MAP Kinase Kinase Kinases/*metabolism, McBurney Denise, Messenger/metabolism, Microscopy, Mitogen-Activated Protein Kinase 1/*metabolism, Mitogen-Activated Protein Kinase 3/*metabolism, NEOMED College of Medicine, NF-kappa B/metabolism, Nitriles/pharmacology, Phenotype, Phosphorylation, Promoter Regions, Protein Kinase C-alpha, Protein Kinase C/antagonists & inhibitors, Proteoglycans/metabolism, Proto-Oncogene Proteins c-bcl-2/*metabolism, Rats, Reverse Transcriptase Polymerase Chain Reaction, RNA, Signal Transduction, Small Interfering/metabolism, SOX9 Transcription Factor, Sprague-Dawley, The Journal of biological chemistry, Time Factors, Transcription, Transcription Factors/*metabolism, Transfection, Western, Yagi Rieko
Tags: 2017, alcoholic fatty liver disease, Alcoholic/*metabolism/pathology, AMP-Activated Protein Kinases/metabolism, Animals, Current molecular pharmacology, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Ethanol/chemistry/*metabolism, Fatty Liver, Humans, Inflammation, Inflammation/metabolism, Jogasuria Alvin, Lee Kwangwon, Lee Yoon-Kwang, Lipid Metabolism, Lipin-1, Liver/metabolism, NEOMED College of Graduate Studies, NEOMED College of Medicine, NEOMED College of Pharmacy, Phosphatidate Phosphatase/*metabolism, Sadana Prabodh, Signal Transduction, Sirtuin 1/metabolism, transcriptional regulators, Wu Jiashin, You Min, Zhang Yanqiao