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<a href="http://doi.org/" target="_blank" rel="noreferrer noopener">http://doi.org/</a>
Pages
78-79
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1
Volume
53
ISSN
1073-2322
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January 2021 List
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NEOMED College of Medicine
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Department of Integrative Medical Science
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Alcohol intoxication disrupts SHH-GLI1 signaling in mediating activation of primitive hematopoietic precursor cells during the granulopoietic response to bacteremia
Publisher
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Shock
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-06
Creator
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Shi X; Simms KJ; Zhang P
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<a href="http://doi.org/" target="_blank" rel="noreferrer noopener"></a>
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journalArticle
2020
Department of Integrative Medical Sciences
January 2021 List
journalArticle
NEOMED College of Medicine
Shi X
Shock
Simms KJ
Zhang P
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1111/acer.14429" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/acer.14429</a>
ISSN
1530-0277
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NEOMED College of Medicine
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Department of Integrative Medical Sciences
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Acute alcohol intoxication impairs sonic hedgehog-GLI1 signaling and activation of primitive hematopoietic precursor cells in the early stage of host response to bacteremia.
Publisher
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Alcoholism, Clinical And Experimental Research
Date
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2020
2020-08-09
Subject
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Alcohol; Bacteremia; Hematopoietic Stem Cells; Host Response; Sonic Hedgehog
Creator
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Shi X;Simms KJ;Zhang P
Description
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Background: Activation of hematopoietic stem cells [HSCs, lineage(lin) - stem cell growth factor receptor (c-kit) + stem cell antigen-1(Sca-1) + , or LKS cells in mice] is critical for initiating the granulopoietic response. This study determined the effect of alcohol exposure on sonic hedgehog (SHH) signaling in the regulation of HSC activation during bacteremia.; Methods: Acute alcohol intoxication was induced in mice by intraperitoneal (i.p.) injection of 20% alcohol (5 g alcohol/kg body weight). Control mice received i.p. saline. Thirty minutes later, mice were intravenously (i.v.) injected with Escherichia coli (E. coli, 1 to 5 × 10 7 CFUs/mouse) or saline.; Results: SHH expression by lineage-negative bone marrow cells (BMCs) was significantly increased 24 hours after E. coli infection. Extracellular signal-regulated kinase 1/2 (ERK1/2)-specificity protein 1 (Sp1) signaling promotes SHH expression. ERK1/2 was markedly activated in BMCs 8 hours following E. coli infection. Alcohol suppressed both the activation of ERK1/2 and up-regulation of SHH expression following E. coli infection. E. coli infection up-regulated GLI family zinc finger 1 (Gli1) gene expression by BMCs and increased Gli1 protein content in LKS cells. The extent of Gli1 expression was correlated with the activity of proliferation in LKS cells. Alcohol inhibited up-regulation of Gli1 expression and activation of LKS cells in response to E. coli infection. Alcohol also interrupted the granulopoietic response to bacteremia.; Conclusion: These data show that alcohol disrupts SHH-Gli1 signaling and HSC activation in the early stage of the granulopoietic response, which may serve as an important mechanism underlying the impairment of immune defense against bacterial infection in host excessively consuming alcohol. (© 2020 by the Research Society on Alcoholism.)
Identifier
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<a href="http://doi.org/10.1111/acer.14429" target="_blank" rel="noreferrer noopener">10.1111/acer.14429</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
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journalArticle
2020
Alcohol
alcoholism
Alcoholism, Clinical and Experimental Research
bacteremia
Clinical and Experimental Research
Department of Integrative Medical Sciences
hematopoietic stem cells
host response
journalArticle
NEOMED College of Medicine
September 2020 List
Shi X
Simms KJ
sonic hedgehog
Zhang P
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1111/acer.14429" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/acer.14429</a>
ISSN
1530-0277 0145-6008
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Locate full-text within NEOMED Library's e-journal collections
<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1111/acer.14429" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1111/acer.14429</a>
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Update Year & Number
August 2020 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Integrative Medical Sciences
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Acute alcohol intoxication impairs SHH-GLI1 signaling and activation of primitive hematopoietic precursor cells in the early stage of host response to bacteremia.
Publisher
An entity responsible for making the resource available
Alcoholism, Clinical and Experimental Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-08-09
Subject
The topic of the resource
bacteremia; alcohol; hematopoietic stem cells; host response; sonic hedgehog
Creator
An entity primarily responsible for making the resource
Shi X; Simms KJ; Zhang P
Description
An account of the resource
BACKGROUND: Activation of hematopoietic stem cells [HSCs, lineage(lin)(-) stem cell growth factor receptor(c-kit)(+) stem cell antigen-1(Sca-1)(+) or LKS cells in mice], is critical for initiating the granulopoietic response. This study determined the effect of alcohol exposure on sonic hedgehog (SHH) signaling in the regulation of HSC activation during bacteremia. METHODS: Acute alcohol intoxication was induced in mice by intraperitoneal (i.p.) injection of 20% alcohol (5 g alcohol/kg body weight). Control mice received i.p. saline. Thirty minutes later, mice were intravenously (i.v.) injected with Escherichia coli (E. coli, 1 - 5 x 10(7) CFUs/mouse) or saline. RESULTS: SHH expression by lineage negative bone marrow cells (BMCs) was significantly increased 24 h after E. coli infection. Extracellular signal-regulated kinase 1/2 (ERK1/2)-specificity protein 1 (Sp1) signaling promotes SHH expression. ERK1/2 was markedly activated in BMCs 8 h following E. coli infection. Alcohol suppressed both the activation of ERK1/2 and up-regulation of SHH expression following E. coli infection. E. coli infection up-regulated GLI family zinc finger 1 (Gli1) gene expression by BMCs and increased Gli1 protein content in LKS cells. The extent of Gli1 expression was correlated with the activity of proliferation in LKS cells. Alcohol inhibited up-regulation of Gli1 expression and activation of LKS cells in response to E. coli infection. Alcohol also interrupted the granulopoietic response to bacteremia. CONCLUSION: These data show that alcohol disrupts SHH-Gli1 signaling and HSC activation in the early stage of the granulopoietic response, which may serve as an important mechanism underlying the impairment of immune defense against bacterial infection in host excessively consuming alcohol.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1111/acer.14429" target="_blank" rel="noreferrer noopener">10.1111/acer.14429</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2020
Alcohol
alcoholism
Alcoholism, Clinical and Experimental Research
August 2020 List
bacteremia
Clinical and Experimental Research
Department of Integrative Medical Sciences
hematopoietic stem cells
host response
journalArticle
NEOMED College of Medicine
Shi X
Simms KJ
sonic hedgehog
Zhang P