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Text
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URL Address
<a href="http://doi.org/10.1016/s0166-2236(98)01339-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0166-2236(98)01339-3</a>
Pages
180–184
Issue
4
Volume
22
Dublin Core
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Title
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Why adult mammalian intrafusal and extrafusal fibers contain different myosin heavy-chain isoforms.
Publisher
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Trends in neurosciences
Date
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1999
1999-04
Subject
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*Muscle Development; Afferent Pathways/physiology; Aging/metabolism; Animals; Cell Lineage; Developmental; Fetal Proteins/metabolism; Gene Expression Regulation; Knockout; Mammals/anatomy & histology/*metabolism; Mice; Morphogenesis; Muscle; Muscle Contraction; Muscle Fibers; Muscle Proteins/deficiency/physiology; Muscle Spindles/physiology; Myosin Heavy Chains/*metabolism; Nerve Tissue Proteins/deficiency/physiology; Protein Isoforms/*metabolism; Rats; Skeletal/*chemistry/classification; Skeletal/chemistry/embryology/*growth & development/ultrastructure; Transgenic
Creator
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Walro J M; Kucera J
Description
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Multiple isoforms of the contractile protein myosin are present in mammalian skeletal muscles. The diversity of the heavy-chain subunits of myosin (MyHCs) in intrafusal fibers is thought to reflect a pathway of differentiation that is unique to muscle spindles. In fact, intrafusal MyHCs are developmental isoforms expressed by the prenatal precursors of both intrafusal and extrafusal fibers. In adult limbs, developmental MyHCs persist in intrafusal, but not extrafusal fibers principally due to the afferent neurons that arrest their maturational replacement by MyHCs associated with faster shortening velocities. The slow shortening velocities that are characteristic of developmental MyHCs might be adaptive for precise calibration of muscle spindles as sense organs.
Identifier
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<a href="http://doi.org/10.1016/s0166-2236(98)01339-3" target="_blank" rel="noreferrer noopener">10.1016/s0166-2236(98)01339-3</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Muscle Development
1999
Afferent Pathways/physiology
Aging/metabolism
Animals
Cell Lineage
Developmental
Fetal Proteins/metabolism
Gene Expression Regulation
Knockout
Kucera J
Mammals/anatomy & histology/*metabolism
Mice
Morphogenesis
Muscle
Muscle Contraction
Muscle Fibers
Muscle Proteins/deficiency/physiology
Muscle Spindles/physiology
Myosin Heavy Chains/*metabolism
Nerve Tissue Proteins/deficiency/physiology
Protein Isoforms/*metabolism
Rats
Skeletal/*chemistry/classification
Skeletal/chemistry/embryology/*growth & development/ultrastructure
Transgenic
Trends in neurosciences
Walro J M