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Text
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URL Address
<a href="http://doi.org/10.1128/aac.36.7.1400" target="_blank" rel="noreferrer noopener">http://doi.org/10.1128/aac.36.7.1400</a>
Pages
1400–1403
Issue
7
Volume
36
Dublin Core
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Title
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Pharmacokinetics of imipenem in serum and skin window fluid in healthy adults after intramuscular or intravenous administration.
Publisher
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Antimicrobial agents and chemotherapy
Date
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1992
1992-07
Subject
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Adult; Biological Availability; Cilastatin/administration & dosage/pharmacokinetics; Humans; Imipenem/administration & dosage/blood/*pharmacokinetics; Infusions; Injections; Intramuscular; Intravenous; Male; Middle Aged; Skin/*metabolism
Creator
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Signs S A; Tan J S; Salstrom S J; File T M
Description
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The pharmacokinetic profiles of imipenem after intramuscular (i.m.) and intravenous injections were examined in adult volunteers. Levels of imipenem in serum after i.m. injection of a microcrystalline suspension of imipenem-cilastatin (500 mg each) reached a peak (8.0 micrograms/ml) at 1.5 h after administration, and concentrations were maintained in excess of 1.5 micrograms/ml for 6 h. Serum elimination half-life (1.3 h), volume of distribution (14.5 liters), and area under the curve (AUC; 27.8 micrograms.h/ml) after i.m. injection did not significantly differ from those of a comparable dose given by intravenous infusion. Bioavailability after i.m. injection was 89%. Imipenem levels in skin window fluid after i.m. administration were maximal (4.3 micrograms/ml) at 4 h after injection, at which time imipenem concentrations exceeded those produced by intravenous infusion. The AUCskin window/AUCserum ratio for skin window fluid after i.m. injection was 68%, indicating good penetration of the drug into skin fluid. This study shows that i.m. injection of 500 mg of imipenem-cilastatin results in concentrations of imipenem in serum and skin fluid that are, for at least 6 h, consistent with antimicrobial activity against susceptible organisms.
Identifier
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<a href="http://doi.org/10.1128/aac.36.7.1400" target="_blank" rel="noreferrer noopener">10.1128/aac.36.7.1400</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1992
Adult
Antimicrobial agents and chemotherapy
Biological Availability
Cilastatin/administration & dosage/pharmacokinetics
Department of Internal Medicine
File T M
Humans
Imipenem/administration & dosage/blood/*pharmacokinetics
Infusions
Injections
Intramuscular
Intravenous
Male
Middle Aged
NEOMED College of Medicine
Salstrom S J
Signs S A
Skin/*metabolism
Tan J S