Practitioner assessment of mental health in dermatologic disease.
Patients with certain dermatologic skin diseases have been found to be at increased risk for depression and suicidal ideation. As there is not much information available on mental health interventions taken in dermatologic practices, we conducted a survey to assess the extent to which dermatologists monitor and follow up with the mental health of their patients. We discovered that dermatologists are aware of mental health issues associated with these dermatologic diseases but have no standard of care for their assessment. By obtaining this information, we can enable ourselves to fill in these deficiencies to help improve patient care.
Singh GK; Mostow EN
Dermatology Online Journal
2021
2021-05-15
Journal Article
<table width="91" style="border-collapse:collapse;width:68pt;"><colgroup><col width="91" style="width:68pt;" /></colgroup><tbody><tr style="height:15pt;"><td width="91" height="20" class="xl18" style="width:68pt;height:15pt;"><a href="http://doi.org/10.5070/D327553608">http://doi.org/10.5070/D327553608</a></td>
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An Integrated Safety Summary of Omadacycline, a Novel Aminomethylcycline Antibiotic
COMMUNICABLE diseases; community-acquired bacterial pneumonia; COMMUNITY-acquired pneumonia; DENTAL discoloration; omadacycline; PATIENT safety; safety; skin and skin structure infections; SKIN diseases; TEETH abnormalities; TETRACYCLINE; THERAPEUTIC use
Omadacycline is a semisynthetic tetracycline antibiotic. Phase III clinical trial results have shown that omadacycline has an acceptable safety profile in the treatment of acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia. Similar to most tetracyclines, transient nausea and vomiting and low-magnitude increases in liver aminotransferases were the most frequent treatment-emergent adverse events in phase III studies but were not treatment limiting. Package insert warnings and precautions for omadacycline include tooth discoloration; enamel hypoplasia; inhibition of bone growth following use in late pregnancy, infancy, or childhood up to 8 years of age; an imbalance in mortality (2%, compared with 1% in moxifloxacin-treated patients) was observed in the phase III study in patients with community-acquired bacterial pneumonia. Omadacycline has no effect on the QT interval, and its affinity for muscarinic M2 receptors resulted in transient heart rate increases following dosing.
Opal Steven; File Thomas M; van der Poll Tom; Tzanis Evan; Chitra Surya; McGovern Paul C
Clinical Infectious Diseases: An Official Publication Of The Infectious Diseases Society Of America
2019
2019-08
<a href="http://doi.org/10.1093/cid/ciz398" target="_blank" rel="noreferrer noopener">10.1093/cid/ciz398</a>
Best cases from the AFIP: atypical imaging features of bilateral Achilles tendon xanthomatosis.
Male; Middle Age; Skin Diseases; Achilles Tendon – Pathology; Achilles Tendon – Radiography; Connective Tissue Diseases – Pathology; Connective Tissue Diseases – Radiography; Metabolic – Pathology; Metabolic – Radiography
Rodriguez CP; Goyal M; Wasdahl D; Rodriguez Craig P; Goyal Manish; Wasdahl Daniel A
RadioGraphics
2008
2008-11
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1148/rg.287085001" target="_blank" rel="noreferrer noopener">10.1148/rg.287085001</a>
Cutaneous Vasculopathy Associated with Levamisole-Adulterated Cocaine.
Male; Biopsy; Middle Age; Diagnosis; Differential; Skin Diseases; Drug Contamination; Powders; Toxicology; Anthelmintics – Adverse Effects; Anthelmintics – Blood; Anthelmintics – Urine; Cocaine – Adverse Effects; Ear – Pathology; Exanthema – Etiology; Knee – Pathology; Purpura – Etiology; Vascular – Chemically Induced; Vascular – Diagnosis; Vascular – Symptoms
We report a case of cutaneous vasculopathy associated with the use of levamisole-adulterated cocaine. This recently described clinical entity is characterized by a purpuric rash with a predilection for the ears, leukopenia, and anti-neutrophilic cytoplasmic antibody (ANCA) positivity. It is estimated that more than 70% of the current United States cocaine supply is contaminated with levamisole. Levamisole is a widely available, inexpensive, white powder used as a 'cutting agent' in cocaine to expand volume and increase profits. It may also increase the euphoric and stimulatory effects of cocaine by increasing brain dopamine levels and producing amphetamine-like metabolites. Our patient exhibited a characteristic rash with involvement of the ears, leukopenia, and cocaine metabolites were detected in serum and urine. The presence of levamisole was confirmed in the urine utilizing gas chromatography-mass spectrometry. ANCA positivity was also present. Punch biopsy of the skin demonstrated vascular thrombosis and necrosis without true vasculitis. We review the literature for reported cases of cocaine- levamisole cutaneous vasculopathy syndrome, highlight the salient immunologic abnormalities, and contrast the features of this entity with idiopathic systemic vasculitis.
Huy Tran; Tan Debbie; Marnejon Thomas P
Clinical Medicine & Research
2013
2013-02
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.3121/cmr.2012.1085" target="_blank" rel="noreferrer noopener">10.3121/cmr.2012.1085</a>
Trimethoprim-sulfamethoxazole vs. Placebo for Skin Abscesses After Incision and Drainage.
Skin Diseases; Drainage; Postoperative Complications – Prevention and Control; Abscess – Surgery; Placebos – Administration and Dosage; Trimethoprim-Sulfamethoxazole Combination – Administration and Dosage
A multicenter, double-blind, randomized, clinical trial found that a seven-day course of trimethoprim-sulfamethoxazole following incision and drainage (I&D) resulted in a higher rate of cure for skin abscesses compared to I&D and placebo.
Watkins Richard R
Internal Medicine Alert
2016
2016-05-15
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Trimethoprim-sulfamethoxazole versus Placebo for Skin Abscesses After Incision and Drainage.
Placebo Effect; Human; Experimental Studies; Skin Diseases; Methicillin-Resistant Staphylococcus Aureus; Body Fluids; Drainage; Staphylococcal Infections; Surgical Wound; Trimethoprim-Sulfamethoxazole Combination; Abscess – Drug Therapy
The article discusses research published in the 2016 issue of the "New England Journal of Medicine" on a seven-day outpatient course of trimethoprim-sulfamethoxazole (TMP-SMX) as compared to placebo for skin abscesses after incision and drainage. The study examined the efficacy of TMP-SMX versus placebo in treating skin abscesses and determined the number of patients infected with methicillin-resistant Staphylococcus aureus (MRSA), as well as their susceptibility to TMP-SMX.
Watkins Richard R
Infectious Disease Alert
2016
2016-04
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Optimizing Antimicrobial Utilization: Job of a Steward, or Time for a Pilot?...Bush LM, Kaye D. Optimizing antimicrobial utilization: job of a steward, or time for a pilot? Clin Infect Dis 2017; 65:1195
Pharmacists; Physicians; Drug Utilization; Leadership; Drug Resistance; Microbial; Skin Diseases; Centers for Disease Control and Prevention (U.S.); Hospital Programs; Pilots; Antiinfective Agents – Therapeutic Use; Communicable Diseases – Drug Therapy; Infection – Drug Therapy; Infectious – Drug Therapy
Bush Larry M; Kaye Donald; Kullar Ravina; Goff Debra A; Bauer Karri A; File Thomas M Jr
Clinical Infectious Diseases
2017
2017-11
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1093/cid/cix530" target="_blank" rel="noreferrer noopener">10.1093/cid/cix530</a>
Young girl with lower leg rash.
Female; Humans; Child; Antifungal Agents/therapeutic use; Leg Dermatoses/*diagnosis/drug therapy; Tinea/*diagnosis/drug therapy; Diagnosis; Differential; ANTIFUNGAL agents; KETOCONAZOLE; PERIODIC acid-Schiff reaction; RINGWORM; SKIN diseases; Skin Diseases – Diagnosis; Tinea – Diagnosis; Tinea – Drug Therapy; Antifungal Agents – Therapeutic Use; Skin Diseases – Drug Therapy
Saraiya Ami; Reddy Raveena; Brodell Robert
The Journal of Family Practice
2014
2014-07
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Infectious complications in diabetic patients.
Humans; *Diabetes Complications; Candidiasis/complications/therapy; Cholecystitis/complications/therapy; Infection/*complications/*therapy; Respiratory Tract Infections/complications/therapy; Urinary Tract Infections/complications/therapy; Skin Diseases; Infectious/complications/therapy
File T M Jr; Tan J S
Current therapy in endocrinology and metabolism
1997
1997
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Infectious complications in diabetic patients.
Female; Humans; Male; Incidence; Antifungal Agents/therapeutic use; Anti-Bacterial Agents/therapeutic use; Morbidity; *Diabetes Complications; Bacterial Infections/complications/*drug therapy/epidemiology; Candidiasis/complications/*drug therapy/epidemiology; Cholecystitis/complications/epidemiology/therapy; Respiratory Tract Infections/complications/*drug therapy/epidemiology; Urinary Tract Infections/complications/*drug therapy/epidemiology; Infectious/complications/*drug therapy/epidemiology; Skin Diseases
File T M Jr; Tan J S
Current therapy in endocrinology and metabolism
1994
1905-06
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Cutaneous abscesses in children: epidemiology in the era of methicillin-resistant Staphylococcus aureus in a pediatric emergency department.
*Methicillin-Resistant Staphylococcus aureus; Abscess – Epidemiology; Abscess – Microbiology; Abscess/*epidemiology/microbiology; Anti-Bacterial Agents/*therapeutic use; Antibiotics – Therapeutic Use; Child; Emergency Service; Female; Hospital; Human; Humans; Infant; Infectious – Epidemiology; Infectious – Microbiology; Male; Methicillin-Resistant Staphylococcus Aureus; Pediatrics; Preschool; Recurrence; Retrospective Design; Retrospective Studies; Skin Diseases; Soft Tissue Infections – Epidemiology; Soft Tissue Infections – Microbiology; Soft Tissue Infections/*epidemiology/microbiology; Staphylococcal Skin Infections/*epidemiology/microbiology
OBJECTIVE: Skin and soft tissue infections are a major public health issue. Previous literature suggests a recurrence rate of 4% in children. The purpose of this study was to examine the epidemiology, body location, and history of previous infections among children in the emergency department setting. METHODS: A retrospective study was performed using electronic medical records from all subjects treated in a large pediatric emergency department with attending physician diagnosis and billing codes indicative of a cutaneous abscess from July 1, 2007, to December 31, 2007. Descriptive statistics were used to evaluate abscess location, prior history of infection, bacterial etiology, and patient disposition. RESULTS: Three hundred eighteen abscess visits occurred in 308 individual subjects; 79% were due to methicillin-resistant Staphylococcus aureus. Approximately 14% of subjects presented with more than 1 abscess. Those 2 years or younger were more likely to have buttock abscesses (P \textless 0.001). Of the 192 subjects for whom responses were documented, 82 (43%) had a history of a prior abscess. Children 2 years or younger were significantly more likely to be hospitalized or go to the operating room: 49% versus 15% (P \textless 0.001). CONCLUSIONS: Many children with a cutaneous abscess have a prior history of infection. Multiple abscesses are common. Young children are more likely to have abscesses in the diaper area or be hospitalized. Studies of effective hygiene practices and interventions to reduce recurrence are urgently needed.
Holsenback Heather; Smith Lisa; Stevenson Michelle D
Pediatric emergency care
2012
2012-07
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1097/PEC.0b013e31825d20e1" target="_blank" rel="noreferrer noopener">10.1097/PEC.0b013e31825d20e1</a>