1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(91)90389-j" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(91)90389-j</a>
Pages
5–13
Issue
1
Volume
39
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
HAS and LAS rats respond differentially to behavioral effects of ethanol, pentobarbital, chlorpromazine and chlordiazepoxide.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-05
Subject
The topic of the resource
Male; Animals; Rats; Ethanol/*pharmacology; Behavior; Discrimination (Psychology)/drug effects; Motor Activity/drug effects; Sleep/drug effects; *Hypnotics and Sedatives; Chlordiazepoxide/*pharmacology; Chlorpromazine/*pharmacology; Pentobarbital/*pharmacology; Animal/*drug effects
Creator
An entity primarily responsible for making the resource
Krimmer E C
Description
An account of the resource
The drug discrimination paradigm (DD) was used to evaluate differences in performance of rats selectively bred for differential sensitivity to the hypnotic effects of ethanol. Tenth generation high-alcohol sensitive (HAS) and low-alcohol sensitive (LAS) rats were trained to discriminate between ethanol (1.0 g/kg, IP) and saline vehicle on a VR-5 schedule of reinforcement. The HAS strain was more sensitive to the discriminative effects of ethanol than the LAS strain, but the magnitude of difference was much smaller than the differential sleep-time differences. The biphasic action of ethanol was differentially seen when the LAS animals exhibited increased activity during both DD and spontaneous motor activity measures and the HAS exhibited decreased activity during DD only. Pentobarbital and chlordiazepoxide but not chlorpromazine elicited the ethanol discriminative choice in both HAS and LAS strains. Response rates during DD indicated a dissociation of rate depressant effects and discriminative performance following ethanol. These findings are discussed in relationship to some current and future uses of selectively bred animal strains and DD for studying the effects of alcohol.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(91)90389-j" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(91)90389-j</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Hypnotics and Sedatives
1991
Animal/*drug effects
Animals
Behavior
Chlordiazepoxide/*pharmacology
Chlorpromazine/*pharmacology
Discrimination (Psychology)/drug effects
Ethanol/*pharmacology
Krimmer E C
Male
Motor Activity/drug effects
Pentobarbital/*pharmacology
Pharmacology, biochemistry, and behavior
Rats
Sleep/drug effects
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(92)90508-d" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(92)90508-d</a>
Pages
1233–1240
Issue
4
Volume
43
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Biphasic effects of ethanol tested with drug discrimination in HAD and LAD rats.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-12
Subject
The topic of the resource
Alcohol Drinking/genetics/*psychology; Animals; Discrimination (Psychology)/*drug effects; Discrimination Learning/drug effects; Dose-Response Relationship; Drug; Ethanol/*pharmacology; Inbred Strains; Male; Pentobarbital/pharmacology; Rats; Serotonin Antagonists/pharmacology; Sleep/drug effects; Time Factors; Tropanes/pharmacology
Creator
An entity primarily responsible for making the resource
Krimmer E C
Description
An account of the resource
Seventh-generation selectively bred high-alcohol-drinking (HAD) and low-alcohol-drinking (LAD) rats were trained to make differential responses for ethanol (0.75 g/kg, IP) and saline vehicle, following postadministration intervals (PI) of 2 min (HAD-2 and LAD-2 animals) and 30 min (HAD-30 and LAD-30 animals). ED50 values of 0.395 and 0.352 g/kg, respectively, for HAD-2 and LAD-2 animals and 0.269 and 0.314 g/kg, respectively, for HAD-30 and LAD-30 animals reflect the absence of any phenotypic difference for the discriminative stimulus effects of ethanol. HAD-2 animals were more responsive than LAD-2 animals to the stimulating effects of ethanol as measured by total response rates during training sessions. The differential ethanol response generalized to pentobarbital in all four groups but not to morphine, an alternative CNS depressant. The specific antagonist of 5-hydroxytryptamine3 receptors,
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(92)90508-d" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(92)90508-d</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1992
Alcohol Drinking/genetics/*psychology
Animals
Discrimination (Psychology)/*drug effects
Discrimination Learning/drug effects
Dose-Response Relationship
Drug
Ethanol/*pharmacology
Inbred Strains
Krimmer E C
Male
Pentobarbital/pharmacology
Pharmacology, biochemistry, and behavior
Rats
Serotonin Antagonists/pharmacology
Sleep/drug effects
Time Factors
Tropanes/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/bf02245271" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/bf02245271</a>
Pages
564–568
Issue
4
Volume
107
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Differences in response to the aversive properties and activity effects of low dose ethanol in LAS and HAS selectively bred rats.
Publisher
An entity responsible for making the resource available
Psychopharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1905-6
Subject
The topic of the resource
Animals; Avoidance Learning/*drug effects; Conditioning; Dose-Response Relationship; Drug; Ethanol/*pharmacology; Motor Activity/drug effects; Operant/drug effects; Rats; Sleep/drug effects; Species Specificity
Creator
An entity primarily responsible for making the resource
Schechter M D; Krimmer E C
Description
An account of the resource
Rats selectively bred for high alcohol sleep times (HAS) and those that are less affected (LAS) by hypnotic doses (3.0-3.6 g/kg) of ethanol were tested for differential responses to the aversive effects of 1.0 g/kg ethanol in a conditioned place preference task. Likewise, the effects of 0.3-1.0 g/kg ethanol on spontaneous locomotor activity over a 30-min period, as well as the loss of righting reflex with a higher ethanol dose (3.0 g/kg), were determined in these animals. The LAS rats reacted more aversively to 1.0 g/kg during conditioned place aversion testing than the HAS animals and also had a shorter mean sleeping time following 3.0 g/kg ethanol. Furthermore, dose-related depression of spontaneous motor activity was seen in the HAS animals and not in the LAS animals over a 30-min period using doses of 0.3, 0.6, or 1.0 g/kg (10% w/v) ethanol. Taken together, the results indicate that the intoxicating sequelae of high ethanol doses, such as ataxia and sedation, may not be correlated with the aversive effects of low ethanol doses.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/bf02245271" target="_blank" rel="noreferrer noopener">10.1007/bf02245271</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1992
Animals
Avoidance Learning/*drug effects
Conditioning
Dose-Response Relationship
Drug
Ethanol/*pharmacology
Krimmer E C
Motor Activity/drug effects
Operant/drug effects
Psychopharmacology
Rats
Schechter M D
Sleep/drug effects
Species Specificity