1
40
4
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0378-1119(03)00631-0" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0378-1119(03)00631-0</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
71-82
Volume
313
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Regulation of human sterol 27-hydroxylase gene (CYP27A1) by bile acids and hepatocyte nuclear factor 4 alpha (HNF4 alpha)
Publisher
An entity responsible for making the resource available
Gene
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-08
Subject
The topic of the resource
rat; liver; bile acid synthesis; down-regulation; hepatocytes; nuclear receptor; transcriptional regulation; negative feedback-regulation; Genetics & Heredity; cholesterol 7-alpha-hydroxylase; cholic-acid; farnesoid X receptor; heterodimer partner; x-receptor; small; alpha-fetoprotein transcription factor; cerebrotendinous xanthomatosis; factor 4-alpha
Creator
An entity primarily responsible for making the resource
Chen W L; Chiang J Y L
Description
An account of the resource
Mitochondrial sterol 27-hydroxylase (CYP27Al) catalyses sterol side-chain oxidation of bile acid synthesis front cholesterol, and the first reaction of the acidic bile acid biosynthetic pathway. Hydrophobic bile acids suppress human CYP27Al gene reporter activity when assayed in human hepatocellular blastoma HepG2 cells. Bile acids also inhibit CYP27Al reporter activity in human embryonic kidney 293 cells. A putative bile acid response element (BARE) was mapped to a region downstream of nt - 147 of the human CYP27Al gene, within which a binding site for a liver-specific nuclear receptor, HNF4alpha, is identified. HNF4alpha strongly stimulates CYP27Al gene transcription and mutation of its binding site markedly reduced promoter activity. Results suggest that human CYP27Al gene transcription is suppressed by bile acids and HNF4alpha plays a pivotal role in transcriptional regulation of this gene. (C) 2003 Elsevier Science B.V. All rights reserved.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0378-1119(03)00631-0" target="_blank" rel="noreferrer noopener">10.1016/s0378-1119(03)00631-0</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2003
alpha-fetoprotein transcription factor
Bile acid synthesis
cerebrotendinous xanthomatosis
Chen W L
Chiang J Y L
cholesterol 7-alpha-hydroxylase
cholic-acid
Down-Regulation
factor 4-alpha
Farnesoid X receptor
gene
Genetics & Heredity
hepatocytes
heterodimer partner
Journal Article or Conference Abstract Publication
Liver
negative feedback-regulation
Nuclear Receptor
rat
Small
transcriptional regulation
x-receptor
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1358/dof.2010.35.8.1520865" target="_blank" rel="noreferrer noopener">http://doi.org/10.1358/dof.2010.35.8.1520865</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
635-641
Issue
8
Volume
35
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
FARNESOID X RECEPTOR: ACTING THROUGH BILE ACIDS TO TREAT METABOLIC DISORDERS
Publisher
An entity responsible for making the resource available
Drugs of the Future
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-08
Subject
The topic of the resource
fatty liver-disease; foam-cell formation; growth-factor receptor; heterodimer partner; insulin-resistance; nonalcoholic steatohepatitis; orphan nuclear receptor; Pharmacology & Pharmacy; primary rat hepatocytes; protein-kinase-c; regulatory cascade; small
Creator
An entity primarily responsible for making the resource
Zhang Y
Description
An account of the resource
The famesoid X receptor (FXR) is a member of the nuclear receptor superfamily and plays an important role in maintaining bile acid, lipid and glucose homeostasis. Bile acids are endogenous ligands for FXR. However, bile acids may also activate pathways independent of FXR. The development of specific FXR agonists has provided important insights into the role of FXR in metabolism. Recent data have demonstrated that FXR is a therapeutic target for the treatment of certain metabolic disorders. This review will focus on recent advances in the role of FXR in metabolic disease.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1358/dof.2010.35.8.1520865" target="_blank" rel="noreferrer noopener">10.1358/dof.2010.35.8.1520865</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2010
Drugs of the future
fatty liver-disease
foam-cell formation
growth-factor receptor
heterodimer partner
insulin-resistance
Journal Article
Nonalcoholic steatohepatitis
orphan nuclear receptor
Pharmacology & Pharmacy
primary rat hepatocytes
protein-kinase-c
regulatory cascade
Small
Zhang Y
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1124/dmd.112.048694" target="_blank" rel="noreferrer noopener">http://doi.org/10.1124/dmd.112.048694</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1-11
Issue
1
Volume
41
Search for Full-text
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Title
A name given to the resource
Role of Nuclear Receptors in Lipid Dysfunction and Obesity-Related Diseases
Publisher
An entity responsible for making the resource available
Drug Metabolism and Disposition
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-01
Subject
The topic of the resource
bile-acid-homeostasis; carbohydrate-metabolism; constitutive androstane receptor; estrogen sulfotransferase; farnesoid X receptor; fatty liver-disease; glucose-homeostasis; heterodimer partner; insulin sensitivity; Pharmacology & Pharmacy; small; type-2 diabetes-mellitus
Creator
An entity primarily responsible for making the resource
Swanson H I; Wada T; Xie W; Renga B; Zampella A; Distrutti E; Fiorucci S; Kong B; Thomas A M; Guo G L; Narayanan R; Yepuru M; Dalton J T; Chiang J Y L
Description
An account of the resource
This article is a report on a symposium sponsored by the American Society for Pharmacology and Experimental Therapeutics and held at the Experimental Biology 12 meeting in San Diego, CA. The presentations discussed the roles of a number of nuclear receptors in regulating glucose and lipid homeostasis, the pathophysiology of obesity-related disease states, and the promise associated with targeting their activities to treat these diseases. While many of these receptors (in particular, constitutive androstane receptor and pregnane X receptor) and their target enzymes have been thought of as regulators of drug and xenobiotic metabolism, this symposium highlighted the advances made in our understanding of the endogenous functions of these receptors. Similarly, as we gain a better understanding of the mechanisms underlying bile acid signaling pathways in the regulation of body weight and glucose homeostasis, we see the importance of using complementary approaches to elucidate this fascinating network of pathways. The observation that some receptors, like the farnesoid X receptor, can function in a tissue-specific manner via well defined mechanisms has important clinical implications, particularly in the treatment of liver diseases. Finally, the novel findings that agents that selectively activate estrogen receptor beta can effectively inhibit weight gain in a high-fat diet model of obesity identifies a new role for this member of the steroid superfamily. Taken together, the significant findings reported during this symposium illustrate the promise associated with targeting a number of nuclear receptors for the development of new therapies to treat obesity and other metabolic disorders.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1124/dmd.112.048694" target="_blank" rel="noreferrer noopener">10.1124/dmd.112.048694</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2013
bile-acid-homeostasis
carbohydrate-metabolism
Chiang J Y L
constitutive androstane receptor
Dalton J T
Distrutti E
Drug Metabolism and Disposition
estrogen sulfotransferase
Farnesoid X receptor
fatty liver-disease
Fiorucci S
glucose-homeostasis
Guo G L
heterodimer partner
insulin sensitivity
Journal Article
Kong B
Narayanan R
Pharmacology & Pharmacy
Renga B
Small
Swanson H I
Thomas A M
type-2 diabetes-mellitus
Wada T
Xie W
Yepuru M
Zampella A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/01.AOG.0000127940.45774.b4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/01.AOG.0000127940.45774.b4</a>
Pages
1035–1036
Issue
5
Volume
103
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Entero mesh vaginal fistula secondary to abdominal sacral colpopexy.
Publisher
An entity responsible for making the resource available
Obstetrics and gynecology
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-05
Subject
The topic of the resource
*Surgical Mesh; Abdomen; Female; Gynecologic Surgical Procedures; Humans; Intestinal Fistula/*etiology; Intestine; Middle Aged; Postoperative Complications/*etiology; Sacrum; Small; Uterine Prolapse/surgery; Vaginal Fistula/*etiology
Creator
An entity primarily responsible for making the resource
Hopkins Michael P; Rooney Christopher
Description
An account of the resource
BACKGROUND: Abdominal sacral colpopexy is a popular method for resupporting the vaginal apex. Bleeding and infection are the most common complications. We report a complication resulting in a small bowel fistula. CASE: A 48-year-old woman developed a chronic vaginal discharge 4-6 months after routine abdominal sacral colpopexy in which a velour mesh remained exposed in the pelvis. Conservative measures failed to control the intermittent copious discharge from the upper vaginal vault where the mesh was visualized. At laparotomy, an entero mesh vaginal fistula was discovered. Excellent long-term results were obtained by removal of the mesh along with resection of the involved small intestine. CONCLUSION: At the time of abdominal sacral colpopexy, we recommend that mesh not remain exposed in the pelvis.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/01.AOG.0000127940.45774.b4" target="_blank" rel="noreferrer noopener">10.1097/01.AOG.0000127940.45774.b4</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Surgical Mesh
2004
Abdomen
Female
Gynecologic Surgical Procedures
Hopkins Michael P
Humans
Intestinal Fistula/*etiology
Intestine
Middle Aged
Obstetrics and gynecology
Postoperative Complications/*etiology
Rooney Christopher
Sacrum
Small
Uterine Prolapse/surgery
Vaginal Fistula/*etiology