Olfactory bulbectomy disrupts the expression of cocaine-induced conditioned place preference.
Animals; Body Weight/drug effects/physiology; Cocaine/*pharmacology; Conditioning; Male; Narcotics/*pharmacology; Olfaction Disorders/psychology; Olfactory Bulb/anatomy & histology/*physiology; Operant/*drug effects; Rats; Reward; Smell/drug effects/*physiology; Sulfates/pharmacology; Zinc Compounds/pharmacology; Zinc Sulfate
The role of the olfactory sense in the expression of cocaine-induced conditioned place preference (CPP) was examined in adult male rats (n = 35) of the N/Nih strain. Consistent with the scientific literature, rats were observed to significantly (p \textless 0.05) increase (double) the seconds spent in their least-preferred chamber following cocaine-chamber pairings. Subsequently, groups of rats underwent one of three treatments: 1) olfactory bulbectomy (BULBX), 2) sham surgery (SHAM), or 3) sham surgery plus intranasal zinc sulfate perfusion (ZnSO4). Zinc sulfate was used to produce a temporary loss of olfaction. In a separate behavioral measure of olfactory acuity, both BULBX and ZnSO4-treated rats performed at an equally deficient level, in contrast to SHAM-treated rats that were not rendered anosmic. A second conditioned place preference test revealed that the ZnSO4-perfused and SHAM groups did not differ from their original postcocaine preference measurements. In contrast, the BULBX group spent significantly fewer seconds in the cocaine-paired chamber. After a 14-day interval, a third preference test revealed that SHAM and ZnSO4-treated rats displayed an equivalent preference for the cocaine-paired chamber (at 2.7 times above baseline). Interestingly, the seconds spent in the cocaine-paired chamber by BULBX rats did not differ from their baseline (e.g., precocaine exposure). These results suggest that bulbectomy disrupts the expression of cocaine-induced place preference. Interpretations of data from BULBX rats involving the production of an anhedonic condition and the relevance of olfactory bulbectomy as an animal model of anhedonic depression are discussed.
Calcagnetti D J; Quatrella L A; Schechter M D
Physiology & behavior
1996
1996-05
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1016/0031-9384(95)02119-1" target="_blank" rel="noreferrer noopener">10.1016/0031-9384(95)02119-1</a>
Role of olfactory bulb norepinephrine in the identification and recognition of chemical cues.
Adrenergic Agents/pharmacology; Animal/drug effects/physiology; Animals; Benzylamines/pharmacology; Chemoreceptor Cells/drug effects/*physiology; Dopamine/physiology; Hypothalamus/physiology; Male; Mental Recall/drug effects/*physiology; Norepinephrine/*physiology; Olfactory Bulb/drug effects/*physiology; Rats; Sex Attractants/physiology; Sexual Behavior; Smell/drug effects/*physiology; Sprague-Dawley; Testosterone/physiology
In this report the role of olfactory bulb (OB) norepinephrine (NE) in the identification and recognition of urinary chemical cues was examined. In Experiment 1, sexually naive adult male Sprague-Dawley rats were treated with either the noradrenergic neurotoxin, DSP-4, or the water vehicle, and tested for their ability to identify and recognize urinary chemical cues using a habituation-dishabituation paradigm. Treatment with DSP-4 produced an overall decrease in the amount of investigation directed to urine stimuli, with greatest reductions to urine from Zucker females. Overall, DSP-4 treatment did not alter habituation-dishabituation responses. Animals treated with DSP-4 showed a significant reduction in OB-NE, but not dopamine, concentrations. In Experiment 2, hypothalamic catecholamine concentrations and serum samples assayed for testosterone were determined from identically treated animals. Although the NE and dopamine content in MBH was significantly lower in the DSP-4 group, no significant differences in testosterone concentrations were obtained between
Guan X; Blank J L; Dluzen D E
Physiology & behavior
1993
1993-03
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1016/0031-9384(93)90136-4" target="_blank" rel="noreferrer noopener">10.1016/0031-9384(93)90136-4</a>