1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
614A-614A
Volume
64
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Proteome Dynamics Reveals That High Density Lipoprotein Dysfunction In Nonalcoholic Steatohepatitis Is Related To Increased Degradation Of Hdl Proteins Involved In Reverse Cholesterol Transport
Publisher
An entity responsible for making the resource available
Hepatology
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-10
Subject
The topic of the resource
Gastroenterology & Hepatology
Creator
An entity primarily responsible for making the resource
Kasumov T; Lee K; Osme A; Dasarathy J; Li L; Willard B; Kalinina I; Dasarathy S; Smith J D; McCullough A J
Identifier
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n/a
Format
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Journal Article or Conference Abstract Publication
2016
Dasarathy J
Dasarathy S
Department of Pharmaceutical Sciences
Gastroenterology & Hepatology
Hepatology
Journal Article or Conference Abstract Publication
Kalinina I
Kasumov T
Lee K
Li L
McCullough A J
NEOMED College of Pharmacy
Osme A
Smith J D
Willard B
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1021/acs.jproteome.6b00601" target="_blank" rel="noreferrer noopener">http://doi.org/10.1021/acs.jproteome.6b00601</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
3388-3404
Issue
9
Volume
15
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Proteome Dynamics Reveals Pro-inflammatory Remodeling Of Plasma Proteome In A Mouse Model Of Nafld
Publisher
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Journal of Proteome Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-09
Subject
The topic of the resource
antiinflammatory properties; Atherosclerosis; Biochemistry & Molecular Biology; fatty liver-disease; gene-expression; HDL; heavy water; high-density-lipoprotein; mass-spectrometry; NAFLD; oxidized phospholipids; ppar-alpha; proteome dynamics; proteomics; rapid method; shotgun; statistical-model
Creator
An entity primarily responsible for making the resource
Li L; Bebek G; Previs S F; Smith J D; Sadygov R G; McCullough A J; Willard B; Kasumov T
Description
An account of the resource
Nonalcoholic fatty liver disease (NAFLD) is associated with an increased risk of cardiovascular disease. Because the liver is the major source of circulatory proteins, it is not surprising that hepatic disease could lead to alterations in the plasma proteome, which are therein implicated in atherosclerosis. The current study used low-density lipoprotein receptor-deficient (LDLR-/-) mice to examine the impact of Western diet (WD)-induced NAFLD on plasma proteome homeostasis. Using a (H2O)-H-2-metabolic labeling method, we found that a WD led to a proinflammatory distribution of circulatory proteins analyzed in apoB-depleted plasma, which was attributed to an increased production. The fractional turnover rates of short-lived proteins that are implicated in stress-response, lipid metabolism, and transport functions were significantly increased with WD (P < 0.05). Pathway analyses revealed that alterations in plasma proteome dynamics were related to the suppression of hepatic PPAR alpha, which was confirmed based on reduced gene and protein expression of PPAR alpha in mice fed a WD. These changes were associated with similar to 4-fold increase (P < 0.0001) in the proinflammatory property of apoB-depleted plasma. In conclusion, the proteome dynamics method reveals proinflammatory remodeling of the plasma proteome relevant to liver disease. The approach used herein may provide a useful metric of in vivo liver function and better enable studies of novel therapies surrounding NAFLD and other diseases.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1021/acs.jproteome.6b00601" target="_blank" rel="noreferrer noopener">10.1021/acs.jproteome.6b00601</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2016
antiinflammatory properties
Atherosclerosis
Bebek G
Biochemistry & Molecular Biology
Department of Pharmaceutical Sciences
fatty liver-disease
gene-expression
HDL
Heavy water
high-density-lipoprotein
Journal Article or Conference Abstract Publication
Journal of proteome research
Kasumov T
Li L
Mass-spectrometry
McCullough A J
NAFLD
NEOMED College of Pharmacy
oxidized phospholipids
PPAR-alpha
Previs S F
Proteome dynamics
proteomics
rapid method
Sadygov R G
shotgun
Smith J D
statistical-model
Willard B
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1213/00000539-198612000-00021" target="_blank" rel="noreferrer noopener">http://doi.org/10.1213/00000539-198612000-00021</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1364-1364
Issue
12
Volume
65
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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A VISUAL WARNING DEVICE FOR IMPROVED SAFETY
Publisher
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Anesthesia and Analgesia
Date
A point or period of time associated with an event in the lifecycle of the resource
1986
1986-12
Subject
The topic of the resource
Anesthesiology
Creator
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Williams L; Barton C; McVey J R; Smith J D
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1213/00000539-198612000-00021" target="_blank" rel="noreferrer noopener">10.1213/00000539-198612000-00021</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1986
Anesthesia and Analgesia
Anesthesiology
Barton C
Journal Article
McVey J R
Smith J D
Williams L