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Text
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URL Address
<a href="http://doi.org/10.1016/0306-3623(94)00154-f" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0306-3623(94)00154-f</a>
Pages
161–168
Issue
1
Volume
26
Dublin Core
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Title
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A lack of supersensitivity to opioid receptor agonists following chronic spinal opioid receptor antagonist administration in the rat.
Publisher
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General pharmacology
Date
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1995
1995-01
Subject
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5)-; Ala(2)-MePhe(4)-Gly(5)-; Animals; D-Penicillamine (2; Dose-Response Relationship; Drug; Enkephalin; Enkephalins/*pharmacology; Male; Naltrexone/analogs & derivatives/pharmacology; Narcotic Antagonists/*pharmacology; Opioid/*drug effects; Rats; Receptors; Somatostatin/analogs & derivatives/pharmacology; Species Specificity; Spinal Cord/*drug effects; Sprague-Dawley
Creator
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Keck B J; Stafinsky J L; Uram M; Crisp T
Description
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1. Male Sprague-Dawley rats were chronically tested with intrathecal (i.t.) receptor selective opioid antagonists to determine if antinociceptive supersensitivity developed to selective i.t. opioid receptor agonists. 2. A subcutaneously implanted osmotic minipump was used to deliver the mu-opioid receptor antagonist CTOP (0.3 nmol) or the delta-opioid receptor antagonist naltrindole (5.5 nmol) for 7 days. 3. Following a 24 hr washout period, rats received a single i.t. dose (ED50) of either DAMPGO (for CTOP-treated animals) or DPDPE (for naltrindole-treated animals) and the antinociceptive effects of the agents were tested on the tail-flick test. 4. Our findings revealed that chronic spinal treatment with selective opioid receptor antagonists did not induce an antinociceptive supersensitivity to selective opioid receptor agonists. 5. Perhaps this lack of supersensitivity is reflective of difficulties inherent to opioid receptor antagonists that do not possess negative intrinsic activity.
Identifier
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<a href="http://doi.org/10.1016/0306-3623(94)00154-f" target="_blank" rel="noreferrer noopener">10.1016/0306-3623(94)00154-f</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
5)-
Ala(2)-MePhe(4)-Gly(5)-
Animals
Crisp T
D-Penicillamine (2
Dose-Response Relationship
Drug
Enkephalin
Enkephalins/*pharmacology
General pharmacology
Keck B J
Male
Naltrexone/analogs & derivatives/pharmacology
Narcotic Antagonists/*pharmacology
Opioid/*drug effects
Rats
Receptors
Somatostatin/analogs & derivatives/pharmacology
Species Specificity
Spinal Cord/*drug effects
Sprague-Dawley
Stafinsky J L
Uram M