Recombinant OA/gpnmb induces differentiation and Src/ERK/AKT activation in osteoblast
Cell Biology
Sondag G R; Ali O; Mbimba T; Fulp C; Abdelmagid S; Safadi F F
Molecular Biology of the Cell
2012
2012
Journal Article
n/a
A Novel Hybrid-Structured Titanium Surface Promotes Adhesion of Human Dermal Fibroblasts and Osteogenesis of Human Mesenchymal Stem Cells while Reducing S-epidermidis Biofilm Accumulation
differentiation; energy; hydrophilicity; implants; in-vitro; Materials Science; nanotopography; osseointegration; osteoactivin; osteoblast lineage cells; responses
We provide a comparative analysis of protein adsorption, primary human cell behavior, and biofilm formation on modified titanium substrates of either micro-, nano-, or hybrid micro/nano-scale feature sizes. While studies revealed that nano-scale structures initially decreased the attachment and spreading of both human fibroblasts (hDFs) and mesenchymal stem cells (hMSCs), hMSC differentiation studies revealed that hybrid structures promoted the highest levels of osteogenic gene expression and attenuated biofilm formation by Staphylococcus epidermidis. Taken together, this novel approach of generating a hybrid topographical feature results in a potential implant material capable of enhanced dermal cell adhesion and osteogenic differentiation while limiting biofilm accumulation.
Park B W; Krieger J; Sondag G R; Moussa F M; Rankenberg J; Safadi F F; Gatsonis N A; McGimpsey W G; Lambert C R; Malcuit C
Advanced Engineering Materials
2016
2016-04
Journal Article
<a href="http://doi.org/10.1002/adem.201500282" target="_blank" rel="noreferrer noopener">10.1002/adem.201500282</a>