Browse Items (10 total)
- Tags: Sondag Gregory R
Identification of Novel Agents for the Treatment of Brain Metastases of Breast Cancer.
Tags: 2017, ADME, Animals, Antineoplastic Agents/*therapeutic use, Apoptosis, Brain cancer, Brain Neoplasms/*drug therapy/pathology/*secondary, Breast Neoplasms/*pathology, Cell Line, Chemotherapy, CNS, Current cancer drug targets, Department of Anatomy & Neurobiology, distribution, Drug Discovery, Drug Resistance, Female, Geldenhuys Werner J, Griffith Jessica I G, Humans, Lockman Paul R, Mice, NEOMED College of Medicine, Safadi Fayez F, Sondag Gregory R, Terell-Hall Tori B, Tumor, Venishetty Vinay K
Osteoactivin (GPNMB) ectodomain protein promotes growth and invasive behavior of human lung cancer cells.
Tags: *Cell Movement, *Cell Proliferation, 2016, Animals, Apoptosis, Biomarkers, Carcinoma, Cell Adhesion, Cultured, Department of Anatomy & Neurobiology, Department of Pharmaceutical Sciences, Female, GPNMB, Humans, integrin, Lung cancer, Lung Neoplasms/metabolism/*pathology, Manickavasagam Dharani, Membrane Glycoproteins/*metabolism, Mice, Moussa Fouad M, NEOMED College of Medicine, NEOMED College of Pharmacy, Neoplasm Invasiveness, Non-Small-Cell Lung/metabolism/*pathology, Novak Kimberly, NSCLC, Nude, Oncotarget, Oyewumi Moses O, Paulic Nikola, Protein Domains, Safadi Fayez F, Sondag Gregory R, Tumor Cells, Tumor/*metabolism, Wehrung Daniel, Xenograft Model Antitumor Assays
Mutation in Osteoactivin Promotes Receptor Activator of NFkappaB Ligand (RANKL)-mediated Osteoclast Differentiation and Survival but Inhibits Osteoclast Function.
Tags: *Mutation, 2015, Abdelmagid Samir M, Akt, Animals, Belcher Joyce Y, Bone, bone marrow, Bone Remodeling, Cell Differentiation/*physiology, Cell Survival/*physiology, Department of Anatomy & Neurobiology, Eye Proteins/*genetics, Hankenson Kurt D, Inbred DBA, Khol Matthew, Malcuit Christopher, MAP kinases (MAPKs), Mbimba Thomas, Membrane Glycoproteins/*genetics, Mice, Moussa Fouad M, NEOMED College of Medicine, Novak Kimberly, OSTEOACTIVIN, osteoclast, Osteoclasts/*cytology, osteopetrosis, RANK Ligand/metabolism/*physiology, Safadi Fayez F, Signal Transduction, Sondag Gregory R, Stinnett Hilary, The Journal of biological chemistry, X-Ray Microtomography, Yu Bing
Osteoactivin inhibition of osteoclastogenesis is mediated through CD44-ERK signaling.
Tags: *MAP Kinase Signaling System, *Signal Transduction, 2016, Abdelmagid Samir M, Animals, Cell Differentiation, Cells, Cultured, Department of Anatomy & Neurobiology, Experimental & molecular medicine, Eye Proteins/*metabolism, Geldenhuys Werner J, Hyaluronan Receptors/*metabolism, Inbred C57BL, Jaber Fatima A, Male, Mbimba Thomas S, Membrane Glycoproteins/*metabolism, Mice, Moussa Fouad M, NEOMED College of Medicine, Novak Kimberly, Osteoclasts/*cytology/metabolism, RANK Ligand/metabolism, Recombinant Proteins/metabolism, Safadi Fayez F, Sondag Gregory R, Yu Bing
Mutation in osteoactivin decreases bone formation in vivo and osteoblast differentiation in vitro.
Tags: *Signal Transduction, 2014, Abdelmagid Samir M, Alkaline Phosphatase/metabolism, Animals, Apoptosis, Belcher Joyce Y, Bone and Bones/metabolism/pathology, Cell Differentiation/genetics, Del Carpio-Cano Fabiola E, Department of Anatomy & Neurobiology, Eye Proteins/*genetics, Frara Nagat A, Inbred DBA, Lababidi Suzanne L, Male, Membrane Glycoproteins/*genetics, Mice, Moussa Fouad M, Mutation, NEOMED College of Medicine, Newborn, Novak Kimberly M, Osteoblasts/cytology/*physiology, Osteocalcin/*genetics, Osteogenesis/*genetics, Phenotype, Razmpour Roshanak, Receptors, Safadi Fayez F, Sanyurah Afif S, Sondag Gregory R, The American journal of pathology, Transforming Growth Factor beta/metabolism
The Role of MicroRNAs and Their Targets in Osteoarthritis.
Tags: *Cartilage, *Inflammation, *MicroRNA, *OSTEOARTHRITIS, *Targets, 2016, Articular/*metabolism, Cartilage, Current rheumatology reports, Department of Anatomy & Neurobiology, Haqqi Tariq M, Inflammation/genetics/*metabolism, Intracellular Signaling Peptides and Proteins, MicroRNAs/genetics/*metabolism, NEOMED College of Medicine, Osteoarthritis/genetics/*metabolism, Sondag Gregory R
Transgenic Expression of Osteoactivin/gpnmb Enhances Bone Formation In Vivo and Osteoprogenitor Differentiation Ex Vivo.
Tags: 2016, Abdelmagid Samir M, Animals, Barbe Mary F, Bone and Bones/*metabolism, Bone Density/physiology, Bone Remodeling/genetics/*physiology, Bone Resorption/metabolism, Cell Differentiation/genetics/*physiology, Department of Anatomy & Neurobiology, Eye Proteins/genetics/*metabolism, Frara Nagat, Journal of cellular physiology, Membrane Glycoproteins/genetics/*metabolism, Mice, Moussa Fouad M, NEOMED College of Medicine, Osteoblasts/*cytology, Osteoclasts/*cytology, Osteogenesis/genetics, Owen Thomas A, Popoff Steven N, Protein-Serine-Threonine Kinases/metabolism, Receptor, Receptors, Safadi Fayez F, Sondag Gregory R, Transforming Growth Factor beta/metabolism, Transforming Growth Factor-beta Type I, Transgenic, Yingling Vanessa R
Osteoactivin induces transdifferentiation of C2C12 myoblasts into osteoblasts.
Tags: 2014, Abdelmagid Samir M, Alkaline Phosphatase/biosynthesis, Animals, Cell Line, Cell Transdifferentiation/*genetics, Core Binding Factor Alpha 1 Subunit/biosynthesis, Crowder Douglas C, Department of Anatomy & Neurobiology, Developmental/genetics, Eye Proteins/*genetics/metabolism, Focal Adhesion Protein-Tyrosine Kinases/biosynthesis, Gene Expression Regulation, Humans, Journal of cellular physiology, Lababidi Suzanne L, Membrane Glycoproteins/*genetics/metabolism, Mice, Moussa Fouad M, Myoblasts/cytology/*metabolism, NEOMED College of Medicine, Osteoblasts/cytology/*metabolism, Safadi Fayez F, Salihoglu Sibel, Sondag Gregory R
Macrophage-Associated Osteoactivin/GPNMB Mediates Mesenchymal Stem Cell Survival, Proliferation, and Migration Via a CD44-Dependent Mechanism.
Tags: *CD44, *M2 MACROPHAGES, *MSC, *OA/GPNMB, 2016, Animals, Cell Movement/*physiology, Cell Proliferation/*physiology, Cell Survival/physiology, Department of Anatomy & Neurobiology, Eye Proteins/genetics/*metabolism, Hyaluronan Receptors/genetics/*metabolism, Journal of cellular biochemistry, Kim Min-Ho, Knockout, Macrophages/cytology/*metabolism, Malcuit Christopher, MAP Kinase Signaling System/physiology, Membrane Glycoproteins/genetics/*metabolism, Mesenchymal Stem Cells/cytology/*metabolism, Mice, NEOMED College of Medicine, Safadi Fayez F, Sondag Gregory R, Yu Bing
Osteoactivin promotes osteoblast adhesion through HSPG and alphavbeta1 integrin.
Tags: 2014, 3T3 Cells, Abdelmagid Samir M, Actin Cytoskeleton/physiology, ADHESION, Alkaline Phosphatase/biosynthesis, Animals, Antibodies/immunology, Cell Adhesion, Cell Differentiation, Cell Line, Cell Proliferation, Chlorates/pharmacology, Department of Anatomy & Neurobiology, Extracellular Signal-Regulated MAP Kinases/biosynthesis, Eye Proteins/genetics/immunology/*metabolism, Focal Adhesion Kinase 1/biosynthesis, Focal Adhesions, Frara Nagat, Heparan Sulfate Proteoglycans/*metabolism, Heparin/pharmacology, Hisijara Israel Arango, Inbred C57BL, integrin, Journal of cellular biochemistry, Membrane Glycoproteins/genetics/immunology/*metabolism, Mice, Moussa Fouad M, NEOMED College of Medicine, OSTEOACTIVIN, OSTEOBLAST, OSTEOBLAST DIFFERENTIATION, Osteoblasts/*physiology, Osteogenesis/physiology, Protein Binding, Rats, Receptors, Recombinant Proteins, Safadi Fayez F, Scott Ethan M, Sondag Gregory R, Vitronectin/immunology/*metabolism