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40
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<table width="91" style="border-collapse:collapse;width:68pt;"><colgroup><col width="91" style="width:68pt;" /></colgroup><tbody><tr style="height:15pt;"><td width="91" height="20" class="xl18" style="width:68pt;height:15pt;"><a href="http://doi.org/10.3389/fnsyn.2021.684141">http://doi.org/10.3389/fnsyn.2021.684141</a></td>
</tr></tbody></table>
NEOMED College
NEOMED College of Medicine
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Department of Anatomy & Neurobiology
Update Year & Number
Jan to Aug list 2021
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Title
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Effect of Unilateral Acoustic Trauma on Neuronal Firing Activity in the Inferior Colliculus of Mice.
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Hsiao C; Galazyuk AV
Publisher
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Frontiers In Synaptic Neuroscience
Date
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2021
2021-06-22
Description
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Neural hyperactivity induced by sound exposure often correlates with the development of hyperacusis and/or tinnitus. In laboratory animals, hyperactivity is typically induced by unilateral sound exposure to preserve one ear for further testing of hearing performance. Most ascending fibers in the auditory system cross into the superior olivary complex and then ascend contralaterally. Therefore, unilateral exposure should be expected to mostly affect the contralateral side above the auditory brain stem. On the other hand, it is well known that a significant number of neurons have crossing fibers at every level of the auditory pathway, which may spread the effect of unilateral exposure onto the ipsilateral side. Here we demonstrate that unilateral sound exposure causes development of hyperactivity in both the contra and ipsilateral inferior colliculus in mice. We found that both the spontaneous firing rate and bursting activity were increased significantly compared to unexposed mice. The neurons with characteristic frequencies at or above the center frequency of exposure showed the greatest increase. Surprisingly, this increase was more pronounced in the ipsilateral inferior colliculus. This study highlights the importance of considering both ipsi- and contralateral effects in future studies utilizing unilateral sound exposure.
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<table width="91" style="border-collapse:collapse;width:68pt;"><colgroup><col width="91" style="width:68pt;" /></colgroup><tbody><tr style="height:15pt;"><td width="91" height="20" class="xl18" style="width:68pt;height:15pt;"><a href="http://doi.org/10.3389/fnsyn.2021.684141">http://doi.org/10.3389/fnsyn.2021.684141</a></td>
</tr></tbody></table>
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Copyright © 2021 Hsiao and Galazyuk.
Format
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Journal Article
2021
binaural effect
hyperactivity
Sound exposure
unanesthetized mice
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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<a href="http://doi.org/10.3389/fnsyn.2021.684141" target="_blank" rel="noreferrer noopener">http://doi.org/10.3389/fnsyn.2021.684141</a>
Pages
684141
Volume
13
ISSN
1663-3563
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<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.3389/fnsyn.2021.684141" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.3389/fnsyn.2021.684141</a>
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Update Year & Number
July 2021 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Anatomy & Neurobiology
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Effect of Unilateral Acoustic Trauma on Neuronal Firing Activity in the Inferior Colliculus of Mice.
Publisher
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Frontiers In Synaptic Neuroscience
Date
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2021
1905-7
Subject
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binaural effect; bursting; hyperactivity; sound exposure; unanesthetized mice
Creator
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Hsiao C; Galazyuk AV
Description
An account of the resource
Neural hyperactivity induced by sound exposure often correlates with the development of hyperacusis and/or tinnitus. In laboratory animals, hyperactivity is typically induced by unilateral sound exposure to preserve one ear for further testing of hearing performance. Most ascending fibers in the auditory system cross into the superior olivary complex and then ascend contralaterally. Therefore, unilateral exposure should be expected to mostly affect the contralateral side above the auditory brain stem. On the other hand, it is well known that a significant number of neurons have crossing fibers at every level of the auditory pathway, which may spread the effect of unilateral exposure onto the ipsilateral side. Here we demonstrate that unilateral sound exposure causes development of hyperactivity in both the contra and ipsilateral inferior colliculus in mice. We found that both the spontaneous firing rate and bursting activity were increased significantly compared to unexposed mice. The neurons with characteristic frequencies at or above the center frequency of exposure showed the greatest increase. Surprisingly, this increase was more pronounced in the ipsilateral inferior colliculus. This study highlights the importance of considering both ipsi- and contralateral effects in future studies utilizing unilateral sound exposure.
Identifier
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<a href="http://doi.org/10.3389/fnsyn.2021.684141" target="_blank" rel="noreferrer noopener">10.3389/fnsyn.2021.684141</a>
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journalArticle
2021
binaural effect
bursting
Department of Anatomy & Neurobiology
Frontiers In Synaptic Neuroscience
Galazyuk AV
Hsiao C
hyperactivity
journalArticle
July 2021 List
NEOMED College of Medicine
Sound exposure
unanesthetized mice