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Stability of myosin heavy chain isoforms in selectively denervated adult rat muscle spindles.

BACKGROUND: Rat intrafusal fibers consist of multiple isoforms of myosin heavy chains (MHCs) whose expression involves complex interactions among motor neurons, sensory neurons, and muscle cells during spindle development. Little is known about the…

Quantifying rat pulmonary intravascular mononuclear phagocytes.

Cells of the mononuclear phagocyte system (MPS) protect the host by clearing effete and foreign particulates from the circulation. The current study was designed to identify, quantify, harvest, and provide a partial functional characterization of the…

Inhibition of dopamine and choline acetyltransferase concentrations in rat CNS neurons by rat alpha 1- and alpha 2-macroglobulins.

Previous studies have implicated human alpha-2-macroglobulin (alpha2M) as a potential regulator of neuronal development and function. Rat alpha-1-macroglobulin (alpha1M) and acute-phase alpha-2-macroglobulin (alpha2M) are murine homologues of human…

Afferent-inherent regulation of myosin heavy chain isoforms in rat muscle spindles.

Whether afferents exert their morphogenetic influence on spindles through release of trophic factors at intrafusal fiber junctions or via participation in proprioceptive pathways which modulate the motor activity to muscles was investigated by…

Multiple binding sites for [125I]RTI-121 and other cocaine analogs in rat frontal cerebral cortex.

In an effort to identify novel binding sites for cocaine and its analogs, we carried out binding studies with the high-affinity and selective ligand [125I]RTI-121 in rat frontal cortical tissue. Very low densities of binding sites were found.…

Castration differentially alters [3H]nisoxetine binding to norepinephrine uptake sites in olfactory bulb and frontal cortex of male rats.

In the present study, [3H]nisoxetine binding to norepinephrine (NE) uptake sites and [3H]norepinephrine uptake were investigated within olfactory bulb (OB) and frontal cortex homogenates from intact and castrated male rats. Statistically significant…

Tags: *Orchiectomy, 1999, Adrenergic/drug effects/*metabolism, Animals, Boja J W, Dluzen D E, Fluoxetine/*analogs & derivatives/metabolism, Frontal Lobe/drug effects/*metabolism, Kinetics, Male, Norepinephrine/metabolism, Olfactory Bulb/drug effects/*metabolism, Rats, Receptors, Shang Y, Sprague-Dawley, Synapse (New York, N.Y.), Synaptosomes/drug effects/metabolism, Testosterone/pharmacology

Distribution and origin of corticotropin-releasing factor-immunoreactive axons in the female rat lumbosacral spinal cord.

Corticotropin-releasing factor (CRF) is a neuropeptide traditionally known for its hormonal role in the hypothalamic/pituitary/adrenal stress axis. However, CRF has been reported in axons in sites that may be considered outside of the direct stress…

Estrogen receptor-alpha and neural circuits to the spinal cord during pregnancy.

Estrogen receptor immunoreactivity and mRNAs are present in spinal cord neurons in locations that are associated with sensory and autonomic innervation of female reproductive organs. The present study was undertaken to examine the expression of…

Hypothalamic paraventricular axons projecting to the female rat lumbosacral spinal cord contain oxytocin immunoreactivity.

Oxytocin-containing axons project from the hypothalamic paraventricular nucleus to the neurohypophysis and thoracic spinal cord to ultimately influence uterine contractions and autonomic activity, respectively. Whether or not oxytocin-immunoreactive…

Tags: *Synaptic Transmission, 2001, Animals, Axons/*physiology, Female, Immunohistochemistry, Journal of neuroscience research, Lumbosacral Region, Nerve Fibers/metabolism/physiology, Oxytocin/*metabolism, Papka R E, Paraventricular Hypothalamic Nucleus/*physiology, Puder B A, Rats, Spinal Cord/*physiology, Sprague-Dawley

Activation and circuitry of uterine-cervix-related neurons in the lumbosacral dorsal root ganglia and spinal cord at parturition.

Stimulation of the uterine cervix at parturition activates neural circuits involving primary sensory nerves and supraspinally projecting neurons of the lumbosacral spinal cord, resulting in output of hypothalamic neurohormones. Dorsal root ganglia…

Glutamate and metabotropic glutamate receptors associated with innervation of the uterine cervix during pregnancy: receptor antagonism inhibits c-Fos expression in rat lumbosacral spinal cord at parturition.

Dorsal root ganglia (DRG) neurons connect the spinal cord and uterine cervix, and are activated at parturition with subsequent stimulation of secondary neurons in the spinal dorsal horn and autonomic areas. Neuropeptide neurotransmitters and…

Tags: 2007, Animals, Cervix Uteri/*innervation, Department of Anatomy & Neurobiology, Excitatory Amino Acid Antagonists/pharmacology, Female, Ganglia, Gene Expression Regulation/drug effects/*physiology, Ghosh Chaitali, Glutamates/*metabolism, Hafemeister Jen, Journal of neuroscience research, Lumbosacral Region, Messenger/biosynthesis, Metabotropic Glutamate 5, Metabotropic Glutamate/*metabolism, Miller Kenneth E, NEOMED College of Medicine, Neurons/drug effects, Oncogene Proteins v-fos/metabolism, Papka Raymond E, Parturition/*metabolism, Pregnancy/*metabolism, Pyridines/pharmacology, Rats, Receptor, Receptors, Reverse Transcriptase Polymerase Chain Reaction/methods, RNA, Spinal Cord/drug effects/*physiology, Spinal/cytology, Sprague-Dawley, Storey-Workley Megan, Usip Sharon, Vesicular Glutamate Transport Protein 1/metabolism

Intracranial infusion of monoamine-activated alpha 2-macroglobulin decreases dopamine concentrations within the rat caudate putamen.

Monoamine-activated alpha 2-macroglobulin (alpha 2M) has been shown to inhibit choline acetyltransferase in basal forebrain neurons as well as neurotrophin-dependent neuronal functions. The objective of this study was to determine whether…

Tags: *Nerve Degeneration, 1994, alpha-Macroglobulins/*pharmacology/physiology/toxicity, Animals, Caudate Nucleus/*drug effects/metabolism, Dluzen D E, Dopamine/*metabolism, Hu Y Q, Infusion Pumps, Journal of neuroscience research, Koo P H, Male, Putamen/*drug effects/metabolism, Rats, Sprague-Dawley

Alteration of dopamine release by rat caudate putamen tissues superfused with alpha 2-macroglobulin.

Monoamine-activated alpha-2-macroglobulin (alpha 2M) has been shown to decrease the dopamine concentrations in rat caudate putamen (CP) in vivo as well as inhibit choline acetyltransferase activities in the culture of basal forebrain neurons. In this…

Biocompatibility and in vivo tolerability of a new class of photoresponsive alkoxylphenacyl-based polycarbonates.

Potential toxicities of chromophoric or polymeric units of most photoresponsive delivery systems have impacted clinical relevance. Herein, we evaluated the biocompatibility and tolerability of alkoxylphenacyl-based polycarbonates (APPs) as a new…

Suppression of inflammatory cascade is implicated in methyl amooranin-mediated inhibition of experimental mammary carcinogenesis.

Breast cancer represents the second leading cause of cancer-related deaths among women worldwide and preventive therapy could reverse or delay the devastating impact of this disease. Methyl-amooranin (methyl-25-hydroxy-3-oxoolean-12-en-28-oate,…

Binding of sequence-specific proteins to the 3'-untranslated region of vasoactive intestinal peptide mRNA.

Multimeric AUUUA elements in an AU-rich 3'-untranslated region (3'-UTR) have been shown to confer message instability to numerous ephemeral transcripts through the formation of RNA-protein complexes. We show here that the 3'-UTR of VIP mRNA, which…

The effect of GDNF on nigrostriatal dopaminergic function in response to a two-pulse K(+) stimulation.

We examined the effect of glial cell line-derived neurotrophic factor (GDNF) upon nigrostriatal dopaminergic function in response to two-pulse potassium (K(+)) stimulation in rats under in vivo microdialysis conditions. The two-pulse infusion…

The effect of immediate intraperitoneal carboplatinum on wound healing.

The effect of introducing intraperitoneal carboplatinum on wound healing immediately after wound closure was studied using a rat model. All animals were opened through a midline incision. A bowel anastomosis was then performed in a single-or…

Tags: 1993, Animals, Carboplatin/*administration & dosage/pharmacology, Clark T, Dose-Response Relationship, Drug, Gynecologic oncology, Hopkins M P, Injections, Intraperitoneal, Jenison E L, Male, Postoperative Period, Rats, Shellhaas C, Sprague-Dawley, Stakleff K S, Tissue Adhesions/etiology, Wound Healing/*drug effects

Induction of ethanol dependence increases signal peptidase mRNA levels in rat brain.

Differential Northern blot hybridization was used as a screening tool to identify mRNAs that respond quantitatively to the induction of ethanol dependence. Adult male rats were treated with repeated, high doses of ethanol for 4 consecutive days. This…

L-dopa infusion mode differentially affects corpus striatal dopamine efflux in the presence of reserpine.

In the present experiment we tested the effects of L-DOPA upon dopamine (DA) efflux in vitro from superfused corpus striatal tissue fragments in medium containing reserpine. The purposes of this experiment were first, to evaluate the effects of…

Tags: 1992, Amphetamine/pharmacology, Animals, Chromatography, Corpus Striatum/*drug effects/metabolism, Dluzen D E, Dopamine/*metabolism, High Pressure Liquid, Infusions, Intravenous, Journal of neural transmission. General section, Kratko F T Jr, Levodopa/*pharmacology, Male, Potassium/pharmacology, Rats, Reserpine/*pharmacology, Sprague-Dawley

L-DOPA modulation of corpus striatal dopamine and dihydroxyphenylacetic acid output from intact and 6-OHDA lesioned rats.

In the present report we examined the differences in in vitro dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) efflux from the corpus striatum (CS) of intact versus 6-hydroxydopamine (6-OHDA) lesioned (in substantia nigra) male rats in response…

Tags: *Sympathectomy, 1996, 3, 4-Dihydroxyphenylacetic Acid/*metabolism, Animals, Antiparkinson Agents/*pharmacology, Chemical, Corpus Striatum/drug effects/*metabolism, Dluzen D E, Dopamine/*metabolism, Journal of neural transmission (Vienna, Austria : 1996), Levodopa/*pharmacology, Male, Oxidopamine, Rats, Sprague-Dawley, Substantia Nigra/drug effects/metabolism, Xu K

The effect of reserpine treatment in vivo upon L-dopa and amphetamine evoked dopamine and DOPAC efflux in vitro from the corpus striatum of male rats.

In the present experiment we tested the effects of L-DOPA and amphetamine upon dopamine and DOPAC efflux in vitro from superfused corpus striatal tissue fragments of male rats who had been pretreated with reserpine. Male rats were treated with…

Tags: 1994, 3, 4-Dihydroxyphenylacetic Acid/*metabolism, Amphetamine/*pharmacology, Animals, Cell Compartmentation, Corpus Striatum/*drug effects/metabolism, Dluzen D E, Dopamine/*metabolism, Drug Interactions, Journal of neural transmission. General section, Levodopa/*pharmacology, Liu B, Male, Rats, Research Design, Reserpine/*pharmacology, Secretory Rate/drug effects, Sprague-Dawley

The discriminative properties of the D1 dopamine agonist dihydrexidine in the rat.

The objective of this study was to train rats to discriminate the interoceptive stimuli produced by a selective dopamine D1 agonist. Fourteen male Sprague-Dawley rats acquired the discrimination of the fully effective, high potency, D1 agonist…

Tags: 1995, Amphetamine/pharmacology, Animals, Apomorphine/pharmacology, Benzazepines/pharmacology, Cocaine/pharmacology, Discrimination (Psychology), Dopamine Agonists/pharmacology, Dopamine D1/*agonists, Dose-Response Relationship, Drug, Male, Phenanthridines/*pharmacology, Psychopharmacology, Rats, Receptors, Schechter M D, Sprague-Dawley

Impairment of pH gradient and membrane potential mediates redox dysfunction in the mitochondria of the post-ischemic heart.

The mitochondrial electrochemical gradient (Deltap), which comprises the pH gradient (DeltapH) and the membrane potential (DeltaPsi), is crucial in controlling energy transduction. During myocardial ischemia and reperfusion (IR), mitochondrial…

Alignment of inducible vascular progenitor cells on a micro-bundle scaffold improves cardiac repair following myocardial infarction.

Ischemic heart disease is still the leading cause of death even with the advancement of pharmaceutical therapies and surgical procedures. Early vascularization in the ischemic heart is critical for a better outcome. Although stem cell therapy has…

Tags: *Cardiovascular regeneration, *Ischemic heart diseases, *Micro-bundle scaffold, *Myocardial infarction, *Neovascularization, *Stem cells, *Tissue Scaffolds, *Vascular progenitor cells, 2017, Animal, Animals, Basic research in cardiology, Cell Differentiation, Cell Proliferation, Cell Survival, Cells, Chilian William M, Coculture Techniques, Cultured, Cumpston Devan, Department of Integrative Medical Sciences, Disease Models, Dong Feng, Endothelial Progenitor Cells/metabolism/*transplantation, Enrick Molly, Fibroblast Growth Factor 2/metabolism, Hakobyan Tatev, Jamaiyar Anurag, Janota Danielle, Kolz Christopher L, Lactic Acid/*chemistry, Muscle, Myocardial Infarction/metabolism/pathology/physiopathology/*surgery, Myocardium/metabolism/*pathology, Myocytes, NEOMED College of Medicine, Newby Bi-Min Zhang, Ohanyan Vahagn, Paracrine Communication, Phenotype, Physiologic, Polyglycolic Acid/*chemistry, Polylactic Acid-Polyglycolic Acid Copolymer, Rats, Signal Transduction, Smooth, Smooth Muscle/metabolism/*transplantation, Song Hokyung, Sprague-Dawley, Stevanov Kelly, Time Factors, Tissue Engineering/*methods, Vascular Endothelial Growth Factor A/metabolism, Vascular/metabolism/*transplantation, Ventricular Remodeling, Wan Weiguo, Yin Liya

P2X receptors in the rat uterine cervix, lumbosacral dorsal root ganglia, and spinal cord during pregnancy.

ATP, an intracellular energy source, is released from cells during tissue stress, damage, or inflammation. The P2X subtype of the ATP receptor is expressed in rat dorsal root ganglion (DRG) cells, spinal cord dorsal horn, and axons in peripheral…

Vagal afferents from the uterus and cervix provide direct connections to the brainstem.

Previous anatomical studies demonstrated vagal innervation to the ovary and distal colon and suggested the vagus nerve has uterine inputs. Recent behavioral and physiological evidence indicated that the vagus nerves conduct sensory information from…

Tags: 1999, Animals, Berthoud H R, Brain Stem/*anatomy & histology, Cell and tissue research, Cervix Uteri/*innervation, Collins J J, Estrogen/metabolism, Female, Immunohistochemistry, Lin C E, Neurons/cytology/metabolism, Papka R E, Rats, Receptors, Sprague-Dawley, Uterus/*innervation, Vagus Nerve/*anatomy & histology/metabolism

Cholinergic neurons of the pelvic autonomic ganglia and uterus of the female rat: distribution of axons and presence of muscarinic receptors.

Acetylcholine (ACh) stimulates contraction of the uterus and dilates the uterine arterial supply. Uterine cholinergic nerves arise from the paracervical ganglia and were, in the past, characterized based on acetylcholinesterase (AChE) histochemistry.…

Calretinin-immunoreactive nerves in the uterus, pelvic autonomic ganglia, lumbosacral dorsal root ganglia and lumbosacral spinal cord.

Nerves containing the calcium-binding protein calretinin have been reported in several organs but not in female reproductive organs and associated ganglia. This study was undertaken to determine if nerves associated with the uterus contain calretinin…

Increased transperitoneal bacterial translocation in laparoscopic surgery.

BACKGROUND: The indications for laparoscopic surgery have expanded to include diseases possibly associated with peritonitis such as appendicitis, perforated peptic ulcers, and diverticulitis. The safety of carbon dioxide (CO2) pneumoperitoneum in the…

Alteration in L-DOPA evoked dopamine and DOPAC output under conditions of impaired vesicular dopamine storage.

We examined the effect of L-dihydroxyphenylalanine (L-DOPA) infusion in vitro upon dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) output from superfused corpus striatum of vehicle and reserpine or tetrabenazine (TBZ) treated male rats.…

Tags: 1998, 3, 4-Dihydroxyphenylacetic Acid/*metabolism, Animals, Dluzen D E, Dopamine Agents/*pharmacology, Dopamine/*metabolism, Journal of neural transmission (Vienna, Austria : 1996), Levodopa/*pharmacology, Male, Pharmaceutical Vehicles, Rats, Reserpine/pharmacology, Sprague-Dawley, Synaptic Vesicles/*drug effects/metabolism, Tetrabenazine/pharmacology, Xu K

Chemopreventive doses of resveratrol do not produce cardiotoxicity in a rodent model of hepatocellular carcinoma.

Hepatocellular carcinoma (HCC), one of the most lethal cancers, results in more than one million fatalities worldwide every year. In view of the limited therapeutic alternatives and poor prognosis of liver cancer, preventive control approaches,…

Tags: *Chemoprevention, 2011, Analysis of Variance, Animal, Animal Studies, Animal/drug effects, Animals, Antioxidants, Behavior, Bishayee Anupam, Blotting, Booth Tristan D, Carcinoma, Cardiotoxicity, Cardiotoxins/*toxicity, Chemoprevention, Data Analysis Software, Department of Integrative Medical Sciences, Descriptive Statistics, Disease Models, Doppler, Dose-Response Relationship, Drug, Echocardiography, Feeding Behavior/drug effects, Female, Fisher's Exact Test, Funding Source, Heart – Drug Effects, Heart/drug effects/physiopathology, Hepatocellular – Prevention and Control, Hepatocellular/*drug therapy/pathology/physiopathology, Hepatocytes/drug effects/pathology, Hodnichak Cheryl M, Humans, Investigational new drugs, Liver Neoplasms/*drug therapy/pathology/physiopathology, Liver/drug effects/pathology/physiopathology, Luther Daniel J, Meszaros J Gary, NEOMED College of Medicine, Ohanyan Vahagn, Polyphenols – Therapeutic Use, Rats, Resveratrol, Shamhart Patricia E, Sisakian Hamayak, Sprague-Dawley, Stilbenes/*therapeutic use, Systole/drug effects, Western

Suppression of the inflammatory cascade is implicated in resveratrol chemoprevention of experimental hepatocarcinogenesis.

PURPOSE: Resveratrol, present in grapes and red wine, has been found to prevent diethylnitrosamine (DENA)-initiated rat liver tumorigenesis, though the chemopreventive mechanisms are not completely elucidated. The current study was designed to…

Morphological heterogeneity within the cingulate cortex in rat: a horseradish peroxidase transport study.

We compared the connections of two areas within rat cingulate cortex, the Cg1/Cg2 area vs the Cg3 area, by iontophoresing small quantities of wheatgerm agglutinin-horseradish peroxidase (WGA-HRP) into either of these two divisions and identifying…

A single restraint stress exposure potentiates analgesia induced by intrathecally administered DAGO.

In rats, restraint exposure potentiates the magnitude and duration of analgesia following both the peripheral and intracerebroventricular administration of several opioid agonists as compared to non-stressed controls. It has been suggested that the…

Depletion of olfactory bulb norepinephrine by 6-OHDA disrupts chemical cue but not social recognition responses in male rats.

In the present experiment, 6-OHDA was infused directly into the olfactory bulb (OB) to produce a localized neurotoxic lesion. Habituation/dishabituation behavioral tests were then conducted to measure recognition responses to chemical cues (urine as…

Ablation of the hypothalamic arcuate-median eminence region reduces the concentration of vasoactive intestinal peptide in the anterior pituitary gland of male rats.

This study was designed to determine the influence of the hypothalamus on the content of vasoactive intestinal peptide (VIP) in the anterior pituitary. Disruption of the hypothalamic-pituitary connection was performed by ablating the arcuate-median…

Comparison of the behavioral effects of ibogaine from three sources: mediation of discriminative activity.

Ibogaine is an alkaloid employed for its hallucinatory properties in West Central Africa which has been the subject of alleged efficacy as an aid in the interruption and treatment of chemical dependency. The major sources of the Schedule I agent are:…

Tags: *Discrimination (Psychology), 1993, Animal/*drug effects, Animals, Behavior, Dose-Response Relationship, Drug, European journal of pharmacology, Gordon T L, Ibogaine/*pharmacology, Male, Rats, Schechter M D, Serotonin Receptor Agonists/pharmacology, Sprague-Dawley

Conditioned place preference produced by the psychostimulant cathinone.

Previous work has indicated that the psychostimulant cathinone produces a location preference in the conditioned place preference task. The present study expanded upon this earlier work by examining the dose-response nature of cathinone-induced…

Tags: 1993, Alkaloids/administration & dosage/*pharmacology, Animals, Central Nervous System Stimulants/administration & dosage/*pharmacology, Choice Behavior/drug effects, Conditioning (Psychology)/drug effects, Dose-Response Relationship, Drug, European journal of pharmacology, Habituation, Male, Meehan S M, Motor Activity/*drug effects, Psychophysiologic, Rats, Schechter M D, Sprague-Dawley

Conditioned place aversion produced by dopamine release inhibition.

CGS 10746B, a dopamine release inhibitor with properties similar to the atypical antipsychotic clozapine, was assessed as to its behavioral properties using spontaneous locomotor activity and the conditioned place preference test. Rats conditioned…

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