1
40
158
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0306-3623(94)00154-f" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0306-3623(94)00154-f</a>
Pages
161–168
Issue
1
Volume
26
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A lack of supersensitivity to opioid receptor agonists following chronic spinal opioid receptor antagonist administration in the rat.
Publisher
An entity responsible for making the resource available
General pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-01
Subject
The topic of the resource
5)-; Ala(2)-MePhe(4)-Gly(5)-; Animals; D-Penicillamine (2; Dose-Response Relationship; Drug; Enkephalin; Enkephalins/*pharmacology; Male; Naltrexone/analogs & derivatives/pharmacology; Narcotic Antagonists/*pharmacology; Opioid/*drug effects; Rats; Receptors; Somatostatin/analogs & derivatives/pharmacology; Species Specificity; Spinal Cord/*drug effects; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Keck B J; Stafinsky J L; Uram M; Crisp T
Description
An account of the resource
1. Male Sprague-Dawley rats were chronically tested with intrathecal (i.t.) receptor selective opioid antagonists to determine if antinociceptive supersensitivity developed to selective i.t. opioid receptor agonists. 2. A subcutaneously implanted osmotic minipump was used to deliver the mu-opioid receptor antagonist CTOP (0.3 nmol) or the delta-opioid receptor antagonist naltrindole (5.5 nmol) for 7 days. 3. Following a 24 hr washout period, rats received a single i.t. dose (ED50) of either DAMPGO (for CTOP-treated animals) or DPDPE (for naltrindole-treated animals) and the antinociceptive effects of the agents were tested on the tail-flick test. 4. Our findings revealed that chronic spinal treatment with selective opioid receptor antagonists did not induce an antinociceptive supersensitivity to selective opioid receptor agonists. 5. Perhaps this lack of supersensitivity is reflective of difficulties inherent to opioid receptor antagonists that do not possess negative intrinsic activity.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0306-3623(94)00154-f" target="_blank" rel="noreferrer noopener">10.1016/0306-3623(94)00154-f</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
5)-
Ala(2)-MePhe(4)-Gly(5)-
Animals
Crisp T
D-Penicillamine (2
Dose-Response Relationship
Drug
Enkephalin
Enkephalins/*pharmacology
General pharmacology
Keck B J
Male
Naltrexone/analogs & derivatives/pharmacology
Narcotic Antagonists/*pharmacology
Opioid/*drug effects
Rats
Receptors
Somatostatin/analogs & derivatives/pharmacology
Species Specificity
Spinal Cord/*drug effects
Sprague-Dawley
Stafinsky J L
Uram M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(92)91689-c" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(92)91689-c</a>
Pages
305–309
Issue
1
Volume
592
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A single restraint stress exposure potentiates analgesia induced by intrathecally administered DAGO.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-10
Subject
The topic of the resource
Ala(2)-MePhe(4)-Gly(5)-; Analgesics/*pharmacology; Analysis of Variance; Animals; Drug Synergism; Enkephalin; Enkephalins/*pharmacology; Injections; Male; Pain Measurement; Physical; Physiological/*physiopathology; Rats; Reaction Time; Restraint; Spinal; Sprague-Dawley; Stress
Creator
An entity primarily responsible for making the resource
Calcagnetti D J; Stafinsky J L; Crisp T
Description
An account of the resource
In rats, restraint exposure potentiates the magnitude and duration of analgesia following both the peripheral and intracerebroventricular administration of several opioid agonists as compared to non-stressed controls. It has been suggested that the site of action whereby restraint leads to potentiated opioid analgesia is located supraspinally. However, the possible contribution of spinal analgesic mechanisms also warrants investigation. Thus, the purpose of the present study was two-fold: (1) to determine whether a single exposure to restraint stress would result in the dose-dependent potentiation of analgesia following the intrathecal (i.t.) administration of the mu (mu)-receptor selective opioid agonist [D-Ala2,N-Me-Phe4,Gly5-ol]enkephalin (DAGO) and (2) to quantify the degree of analgesia in restrained vs. non-restrained rats using the tail-flick and hot-plate analgesic assays. Using rats implanted with chronic i.t. cannula, dose- and time-course curves were observed following the i.t. administration of DAGO. The results demonstrate that both the duration and magnitude of analgesia was significantly potentiated in restrained rats compared to non-restrained controls. Restraint-treated rats receiving 0.15-0.6 micrograms of DAGO i.t. showed 1.3-1.5-fold potentiation of analgesia in the tail-flick assay and a 2.3-5.6-fold potentiation using the hot-plate assay. Restraint immobilization potentiated the magnitude and duration of DAGO-induced analgesia administered by the i.t. route as measured by the tail-flick and hot-plate assays. These data suggest that spinal analgesic mechanisms significantly contribute to the enhanced analgesic potency of opioids in subjects exposed to restraint stress.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(92)91689-c" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(92)91689-c</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1992
Ala(2)-MePhe(4)-Gly(5)-
Analgesics/*pharmacology
Analysis of Variance
Animals
Brain research
Calcagnetti D J
Crisp T
Drug Synergism
Enkephalin
Enkephalins/*pharmacology
Injections
Male
Pain Measurement
Physical
Physiological/*physiopathology
Rats
Reaction Time
Restraint
Spinal
Sprague-Dawley
Stafinsky J L
Stress
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0165-0270(93)90086-7" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0165-0270(93)90086-7</a>
Pages
235–246
Issue
3
Volume
47
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A system for measuring electrophysiological multiple unit activity and extracellular dopamine concentration at single electrodes.
Publisher
An entity responsible for making the resource available
Journal of neuroscience methods
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-05
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/analysis; Amphetamine/pharmacology; Animals; Ascorbic Acid/analysis; Cerebral Cortex/drug effects/metabolism/*physiology; Dopamine/*analysis/metabolism; Electric Stimulation/instrumentation/methods; Electrochemistry/instrumentation/methods; Electrophysiology/instrumentation/*methods; Extracellular Space/chemistry; Hydroxyindoleacetic Acid/analysis; Male; Rats; Serotonin/analysis; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Glynn G E; Yamamoto B K
Description
An account of the resource
A technique is described for measuring electrophysiological multiple-unit activity and extracellular dopamine concentration with in vivo voltammetry at an array of 8 electrodes. In addition, new procedures in the construction of the voltammetric electrode that reduce the effects of capacitance and improve sensitivity are outlined. A system of relays controlling the connections of the electrode and associated systems is also detailed. Both in vitro and in vivo voltammetric selectivity tests indicate an almost exclusive response to dopamine. A large increase in extracellular dopamine concentration was detected in response to 2.5 mg/kg D-amphetamine. Both prestimulus and cortical stimulation evoked increases in striatal multiple-unit activity were measured.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0165-0270(93)90086-7" target="_blank" rel="noreferrer noopener">10.1016/0165-0270(93)90086-7</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1993
3
4-Dihydroxyphenylacetic Acid/analysis
Amphetamine/pharmacology
Animals
Ascorbic Acid/analysis
Cerebral Cortex/drug effects/metabolism/*physiology
Dopamine/*analysis/metabolism
Electric Stimulation/instrumentation/methods
Electrochemistry/instrumentation/methods
Electrophysiology/instrumentation/*methods
Extracellular Space/chemistry
Glynn G E
Hydroxyindoleacetic Acid/analysis
Journal of neuroscience methods
Male
Rats
Serotonin/analysis
Sprague-Dawley
Yamamoto B K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(93)90910-f" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(93)90910-f</a>
Pages
281–284
Issue
2
Volume
613
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Ablation of the hypothalamic arcuate-median eminence region reduces the concentration of vasoactive intestinal peptide in the anterior pituitary gland of male rats.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-06
Subject
The topic of the resource
Adrenal Glands/anatomy & histology; Animals; Anterior/*physiology; Arcuate Nucleus of Hypothalamus/*physiology; Drinking Behavior; Hypothalamo-Hypophyseal System/*physiology; Male; Median Eminence/*physiology; Organ Size; Pituitary Gland; Pituitary Gland/anatomy & histology; Prolactin/blood/metabolism; Rats; Sprague-Dawley; Testis/anatomy & histology; Time Factors; Vasoactive Intestinal Peptide/*metabolism
Creator
An entity primarily responsible for making the resource
Carrillo A J; Dluzen D E
Description
An account of the resource
This study was designed to determine the influence of the hypothalamus on the content of vasoactive intestinal peptide (VIP) in the anterior pituitary. Disruption of the hypothalamic-pituitary connection was performed by ablating the arcuate-median eminence (ARC-ME) region in adult male rats. Fifteen days later, there was a significant reduction in pituitary mass, adrenal and testicular weight and an increase in water consumption and serum prolactin levels indicating the elimination of hypothalamic influence on the pituitary gland in the ARC-ME group when compared to controls. Anterior pituitary VIP content was also significantly reduced in the lesion group. These data suggest that the hypothalamus is involved in the regulation of pituitary VIP.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(93)90910-f" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(93)90910-f</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1993
Adrenal Glands/anatomy & histology
Animals
Anterior/*physiology
Arcuate Nucleus of Hypothalamus/*physiology
Brain research
Carrillo A J
Dluzen D E
Drinking Behavior
Hypothalamo-Hypophyseal System/*physiology
Male
Median Eminence/*physiology
Organ Size
Pituitary Gland
Pituitary Gland/anatomy & histology
Prolactin/blood/metabolism
Rats
Sprague-Dawley
Testis/anatomy & histology
Time Factors
Vasoactive Intestinal Peptide/*metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/jnr.20690" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/jnr.20690</a>
Pages
875–889
Issue
6
Volume
82
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Activation and circuitry of uterine-cervix-related neurons in the lumbosacral dorsal root ganglia and spinal cord at parturition.
Publisher
An entity responsible for making the resource available
Journal of neuroscience research
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-12
Subject
The topic of the resource
Analysis of Variance; Animals; Blotting; Cell Count/methods; Cervix Uteri/*cytology; Cyclic AMP Response Element-Binding Protein/metabolism; Estrogen Receptor alpha/metabolism; Female; Ganglia; Gene Expression Regulation/physiology; Immunohistochemistry/methods; Lumbosacral Region; Models; Nerve Net/cytology/*physiology; Neurological; Neurons/classification/*physiology; Oncogene Proteins v-fos/metabolism; Parturition/*physiology; Pregnancy; Rats; Spinal Cord/*cytology; Spinal/*cytology; Sprague-Dawley; Stilbamidines/metabolism; Time Factors; Western/methods
Creator
An entity primarily responsible for making the resource
Puder B A; Papka R E
Description
An account of the resource
Stimulation of the uterine cervix at parturition activates neural circuits involving primary sensory nerves and supraspinally projecting neurons of the lumbosacral spinal cord, resulting in output of hypothalamic neurohormones. Dorsal root ganglia (DRG) and spinal neurons of these circuits are not well-characterized. The objectives of this study were to detail the activation of DRG and spinal neurons of the L6/S1 levels that are stimulated at late pregnancy, verify hypothalamic projections of activated spinal neurons, and determine whether activated neurons express estrogen receptor-alpha (ERalpha). Expression of phosphorylated cyclic-AMP response element-binding protein (PCREB) and Fos immunohistochemistry were used to "mark" activated DRG and spinal neurons, respectively. Retrograde tracing identified uterine-cervix-related and spinohypothalamic neurons. Baseline PCREB expression in the DRG increased during pregnancy and peaked during the last trimester. Some PCREB-expressing neurons contained retrograde tracer identifying them as cervix-related neurons. Fos-expressing neurons were few in spinal cords of nonpregnant and day 22 pregnant rats but were numerous in parturient animals. Some Fos-expressing neurons located in the dorsal half of the spinal cord contained retrograde tracer identifying them as spinohypothalamic neurons. Some DRG neurons expressing PCREB also expressed ERalpha, and some spinal neurons activated at parturition projected axons to the hypothalamus and expressed ERalpha. These results indicate that DRG and spinal cord neurons are activated at parturition; that those in the spinal cord are present in areas involved in autonomic and sensory processing; that some spinal neurons project axons to the hypothalamus, ostensibly part of a neuroendocrine reflex; and that sensory and spinal neurons can respond to estrogens. Moreover, some activated sensory neurons may be involved in the animal's perception of labor pain.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/jnr.20690" target="_blank" rel="noreferrer noopener">10.1002/jnr.20690</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2005
Analysis of Variance
Animals
Blotting
Cell Count/methods
Cervix Uteri/*cytology
Cyclic AMP Response Element-Binding Protein/metabolism
Estrogen Receptor alpha/metabolism
Female
Ganglia
Gene Expression Regulation/physiology
Immunohistochemistry/methods
Journal of neuroscience research
Lumbosacral Region
Models
Nerve Net/cytology/*physiology
Neurological
Neurons/classification/*physiology
Oncogene Proteins v-fos/metabolism
Papka R E
Parturition/*physiology
Pregnancy
Puder B A
Rats
Spinal Cord/*cytology
Spinal/*cytology
Sprague-Dawley
Stilbamidines/metabolism
Time Factors
Western/methods
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajpheart.1993.265.4.H1184" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpheart.1993.265.4.H1184</a>
Pages
H1184–1188
Issue
4
Volume
265
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Acute exercise enhances nitric oxide modulation of vascular response to phenylephrine.
Publisher
An entity responsible for making the resource available
The American journal of physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-10
Subject
The topic of the resource
*Physical Exertion; Animals; Arginine/analogs & derivatives/pharmacology; Blood Flow Velocity; Blood Pressure/drug effects; Blood Vessels/*drug effects; Dose-Response Relationship; Drug; Female; Heart Rate/drug effects; Iliac Artery/drug effects/physiology; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide/antagonists & inhibitors/*physiology; Phenylephrine/*pharmacology; Rats; Sprague-Dawley; Time Factors; Vasoconstriction/drug effects/physiology
Creator
An entity primarily responsible for making the resource
Patil R D; DiCarlo S E; Collins H L
Description
An account of the resource
The influence of the release of endothelium-derived nitric oxide (NO) on the vasoconstrictor response to phenylephrine (PE) was evaluated before and after a single bout of dynamic exercise. Each rat ran on a motor-driven treadmill at
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajpheart.1993.265.4.H1184" target="_blank" rel="noreferrer noopener">10.1152/ajpheart.1993.265.4.H1184</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Physical Exertion
1993
Animals
Arginine/analogs & derivatives/pharmacology
Blood Flow Velocity
Blood Pressure/drug effects
Blood Vessels/*drug effects
Collins H L
DiCarlo S E
Dose-Response Relationship
Drug
Female
Heart Rate/drug effects
Iliac Artery/drug effects/physiology
Male
NG-Nitroarginine Methyl Ester
Nitric Oxide/antagonists & inhibitors/*physiology
Patil R D
Phenylephrine/*pharmacology
Rats
Sprague-Dawley
The American journal of physiology
Time Factors
Vasoconstriction/drug effects/physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/(sici)1097-4598(199712)20:12%3C1549::aid-mus10%3E3.0.co;2-w" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/(sici)1097-4598(199712)20:12%3C1549::aid-mus10%3E3.0.co;2-w</a>
Pages
1549–1560
Issue
12
Volume
20
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Afferent-inherent regulation of myosin heavy chain isoforms in rat muscle spindles.
Publisher
An entity responsible for making the resource available
Muscle & nerve
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-12
Subject
The topic of the resource
Afferent Pathways/physiology; Afferent/*physiology; Animals; Denervation; Female; Ganglia; Ganglionectomy; Isomerism; Muscle Spindles/*metabolism; Myosin Heavy Chains/*metabolism; Neurons; Rats; Spinal Cord/physiology; Spinal/physiology; Sprague-Dawley; Toes/innervation
Creator
An entity primarily responsible for making the resource
Walro J M; Wang J; Story G M
Description
An account of the resource
Whether afferents exert their morphogenetic influence on spindles through release of trophic factors at intrafusal fiber junctions or via participation in proprioceptive pathways which modulate the motor activity to muscles was investigated by comparing myosin heavy chain (MHC) expression in intrafusal fibers after ablation of afferents (deafferentation, or DA) to the extensor digitorum longus (EDL) of adult rats or after ablation of the corresponding central processes of afferents to the spinal cord (central-process ablation, or CPA). DA and CPA elicited an exaggerated pedal plantarflexion, and hypertrophy of the EDL concomitant with atrophy of the soleus in the affected hindlimb. Frequencies and patterns of expression of seven MHCs expressed by intrafusal fibers in CPA muscles were indistinguishable from normal rats. However, frequencies and patterns of expression of several MHCs were abnormal following DA. Thus factors transported anterogradely from afferents to intrafusal fibers may regulate MHC expression in intrafusal fibers.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/(sici)1097-4598(199712)20:12%3C1549::aid-mus10%3E3.0.co;2-w" target="_blank" rel="noreferrer noopener">10.1002/(sici)1097-4598(199712)20:12%3C1549::aid-mus10%3E3.0.co;2-w</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1997
Afferent Pathways/physiology
Afferent/*physiology
Animals
Denervation
Female
Ganglia
Ganglionectomy
Isomerism
Muscle & nerve
Muscle Spindles/*metabolism
Myosin Heavy Chains/*metabolism
Neurons
Rats
Spinal Cord/physiology
Spinal/physiology
Sprague-Dawley
Story G M
Toes/innervation
Walro J M
Wang J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s00395-017-0631-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00395-017-0631-4</a>
Pages
41–41
Issue
4
Volume
112
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Alignment of inducible vascular progenitor cells on a micro-bundle scaffold improves cardiac repair following myocardial infarction.
Publisher
An entity responsible for making the resource available
Basic research in cardiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-07
Subject
The topic of the resource
*Cardiovascular regeneration; *Ischemic heart diseases; *Micro-bundle scaffold; *Myocardial infarction; *Neovascularization; *Stem cells; *Tissue Scaffolds; *Vascular progenitor cells; Animal; Animals; Cell Differentiation; Cell Proliferation; Cell Survival; Cells; Coculture Techniques; Cultured; Disease Models; Endothelial Progenitor Cells/metabolism/*transplantation; Fibroblast Growth Factor 2/metabolism; Lactic Acid/*chemistry; Muscle; Myocardial Infarction/metabolism/pathology/physiopathology/*surgery; Myocardium/metabolism/*pathology; Myocytes; Paracrine Communication; Phenotype; Physiologic; Polyglycolic Acid/*chemistry; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Signal Transduction; Smooth; Smooth Muscle/metabolism/*transplantation; Sprague-Dawley; Time Factors; Tissue Engineering/*methods; Vascular Endothelial Growth Factor A/metabolism; Vascular/metabolism/*transplantation; Ventricular Remodeling
Creator
An entity primarily responsible for making the resource
Jamaiyar Anurag; Wan Weiguo; Ohanyan Vahagn; Enrick Molly; Janota Danielle; Cumpston Devan; Song Hokyung; Stevanov Kelly; Kolz Christopher L; Hakobyan Tatev; Dong Feng; Newby Bi-Min Zhang; Chilian William M; Yin Liya
Description
An account of the resource
Ischemic heart disease is still the leading cause of death even with the advancement of pharmaceutical therapies and surgical procedures. Early vascularization in the ischemic heart is critical for a better outcome. Although stem cell therapy has great potential for cardiovascular regeneration, the ideal cell type and delivery method of cells have not been resolved. We tested a new approach of stem cell therapy by delivery of induced vascular progenitor cells (iVPCs) grown on polymer micro-bundle scaffolds in a rat model of myocardial infarction. iVPCs partially reprogrammed from vascular endothelial cells (ECs) had potent angiogenic potential and were able to simultaneously differentiate into vascular smooth muscle cells (SMCs) and ECs in 2D culture. Under hypoxic conditions, iVPCs also secreted angiogenic cytokines such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) as measured by enzyme-linked immunosorbent assay (ELISA). A longitudinal micro-scaffold made from poly(lactic-co-glycolic acid) was sufficient for the growth and delivery of iVPCs. Co-cultured ECs and SMCs aligned well on the micro-bundle scaffold similarly as in the vessels. 3D cell/polymer micro-bundles formed by iVPCs and micro-scaffolds were transplanted into the ischemic myocardium in a rat model of myocardial infarction (MI) with ligation of the left anterior descending artery. Our in vivo data showed that iVPCs on the micro-bundle scaffold had higher survival, and better retention and engraftment in the myocardium than free iVPCs. iVPCs on the micro-bundles promoted better cardiomyocyte survival than free iVPCs. Moreover, iVPCs and iVPC/polymer micro-bundles treatment improved cardiac function (ejection fraction and fractional shortening, endocardial systolic volume) measured by echocardiography, increased vessel density, and decreased infarction size [endocardial and epicardial infarct (scar) length] better than untreated controls at 8 weeks after MI. We conclude that iVPCs grown on a polymer micro-bundle scaffold are new promising approach for cell-based therapy designed for cardiovascular regeneration in ischemic heart disease.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s00395-017-0631-4" target="_blank" rel="noreferrer noopener">10.1007/s00395-017-0631-4</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Cardiovascular regeneration
*Ischemic heart diseases
*Micro-bundle scaffold
*Myocardial infarction
*Neovascularization
*Stem cells
*Tissue Scaffolds
*Vascular progenitor cells
2017
Animal
Animals
Basic research in cardiology
Cell Differentiation
Cell Proliferation
Cell Survival
Cells
Chilian William M
Coculture Techniques
Cultured
Cumpston Devan
Department of Integrative Medical Sciences
Disease Models
Dong Feng
Endothelial Progenitor Cells/metabolism/*transplantation
Enrick Molly
Fibroblast Growth Factor 2/metabolism
Hakobyan Tatev
Jamaiyar Anurag
Janota Danielle
Kolz Christopher L
Lactic Acid/*chemistry
Muscle
Myocardial Infarction/metabolism/pathology/physiopathology/*surgery
Myocardium/metabolism/*pathology
Myocytes
NEOMED College of Medicine
Newby Bi-Min Zhang
Ohanyan Vahagn
Paracrine Communication
Phenotype
Physiologic
Polyglycolic Acid/*chemistry
Polylactic Acid-Polyglycolic Acid Copolymer
Rats
Signal Transduction
Smooth
Smooth Muscle/metabolism/*transplantation
Song Hokyung
Sprague-Dawley
Stevanov Kelly
Time Factors
Tissue Engineering/*methods
Vascular Endothelial Growth Factor A/metabolism
Vascular/metabolism/*transplantation
Ventricular Remodeling
Wan Weiguo
Yin Liya
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s007020050114" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s007020050114</a>
Pages
1091–1101
Issue
10
Volume
105
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Alteration in L-DOPA evoked dopamine and DOPAC output under conditions of impaired vesicular dopamine storage.
Publisher
An entity responsible for making the resource available
Journal of neural transmission (Vienna, Austria : 1996)
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1905-06
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/*metabolism; Animals; Dopamine Agents/*pharmacology; Dopamine/*metabolism; Levodopa/*pharmacology; Male; Pharmaceutical Vehicles; Rats; Reserpine/pharmacology; Sprague-Dawley; Synaptic Vesicles/*drug effects/metabolism; Tetrabenazine/pharmacology
Creator
An entity primarily responsible for making the resource
Xu K; Dluzen D E
Description
An account of the resource
We examined the effect of L-dihydroxyphenylalanine (L-DOPA) infusion in vitro upon dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) output from superfused corpus striatum of vehicle and reserpine or tetrabenazine (TBZ) treated male rats. Specifically, we tested the effects of two 20-min infusions of L-DOPA (5 uM) upon DA and DOPAC output (pg/mg/min) in reserpine (5 mg/kg, i.p., 24 hours before sacrifice; n=11), TBZ (30 mg/kg, i.p. 1 hour before sacrifice; n=8) or vehicle (n=21) treated rats. There was an overall significantly higher L-DOPA evoked DA output from the vehicle (12.22+/-1.74) versus reserpine (4.39+/-2.40) (p \textless 0.05), but not TBZ (9.16+/-2.81) treated rats. In addition, the DA response to the second L-DOPA infusion was significantly increased over that of the first response in the vehicle (9.40+/-2.11 vs. 15.04+/-2.78) (p \textless 0.05), but not reserpine or TBZ treated rats. The overall DOPAC outputs did not achieve a statistically significant difference among all treatment groups. However, the DOPAC outputs following the second L-DOPA infusion were significantly reduced in reserpine (41.15+/-6.10 vs. 20.27+/-4.54) and TBZ (21.38+/-4.41 vs. 10.87+/-2.36) (both p \textless 0.05), but not vehicle (28.99+/-4.00 vs. 24.91+/-4.78) treated rats. We conclude that: 1) the storage capacity of DA neurons is one of the important elements involved in affecting L-DOPA's effects upon DA and DOPAC output, 2) the shunting of storage to metabolism may represent a common characteristic in impaired nigrostriatal dopaminergic system, and 3) TBZ may operate differently from reserpine in the nigrostriatal dopaminergic system.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s007020050114" target="_blank" rel="noreferrer noopener">10.1007/s007020050114</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1998
3
4-Dihydroxyphenylacetic Acid/*metabolism
Animals
Dluzen D E
Dopamine Agents/*pharmacology
Dopamine/*metabolism
Journal of neural transmission (Vienna, Austria : 1996)
Levodopa/*pharmacology
Male
Pharmaceutical Vehicles
Rats
Reserpine/pharmacology
Sprague-Dawley
Synaptic Vesicles/*drug effects/metabolism
Tetrabenazine/pharmacology
Xu K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/jnr.490430109" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/jnr.490430109</a>
Pages
71–77
Issue
1
Volume
43
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Alteration of dopamine release by rat caudate putamen tissues superfused with alpha 2-macroglobulin.
Publisher
An entity responsible for making the resource available
Journal of neuroscience research
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-01
Subject
The topic of the resource
alpha-Macroglobulins/drug effects/*pharmacology/physiology; Alzheimer Disease/metabolism; Animals; Caudate Nucleus/*drug effects/metabolism; Chemical; Dopamine/*metabolism; Male; Methylamines/pharmacology; Nerve Growth Factor/physiology; Nerve Growth Factors/physiology; Neurotoxins/*pharmacology; Parkinson Disease/metabolism; Perfusion; Putamen/*drug effects/metabolism; Rats; Receptors; Sprague-Dawley; Stimulation
Creator
An entity primarily responsible for making the resource
Hu Y Q; Liu B J; Dluzen D E; Koo P H
Description
An account of the resource
Monoamine-activated alpha-2-macroglobulin (alpha 2M) has been shown to decrease the dopamine concentrations in rat caudate putamen (CP) in vivo as well as inhibit choline acetyltransferase activities in the culture of basal forebrain neurons. In this study, we further investigated the effects of methylamine-activated alpha 2M (MA-alpha 2M) upon striatal dopaminergic function by determining whether a direct infusion of this glycoprotein will alter dopamine (DA) release in vitro from superfused CP tissue fragments. In experiment 1, an infusion of 2.8 microM MA-alpha 2M produced a statistically significant increase in DA release compared with control superfusions. In experiment 2, varying doses (0, 0.7, 1.4, 2.8, 4.1 microM) of MA-alpha 2M were tested for their capacity to alter DA release. Only the 2.8 microM dose of MA-alpha 2M was effective in producing a significant increase of DA release. In experiment 3, the normal form of alpha 2M (N-alpha 2M) at 2.8 microM was compared with the control superfusions. The infusion of N-alpha 2M produced an increase in DA release which was substantially lower than the DA increase induced by MA-alpha 2M, and not significantly different from that of the control superfusion. These results show that MA-alpha 2M, like some other neurotoxins, can markedly alter CP dopaminergic function as indicated by the acute increase in DA release following infusion of this glycoprotein, and these effects are exerted at a relatively narrow range of doses. Taken together, these data suggest that this glycoprotein, if allowed to accumulate in the central nervous system (CNS), may promote some neurodegenerative changes that can occur in disorders like Parkinson's disease.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/jnr.490430109" target="_blank" rel="noreferrer noopener">10.1002/jnr.490430109</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1996
alpha-Macroglobulins/drug effects/*pharmacology/physiology
Alzheimer Disease/metabolism
Animals
Caudate Nucleus/*drug effects/metabolism
Chemical
Dluzen D E
Dopamine/*metabolism
Hu Y Q
Journal of neuroscience research
Koo P H
Liu B J
Male
Methylamines/pharmacology
Nerve Growth Factor/physiology
Nerve Growth Factors/physiology
Neurotoxins/*pharmacology
Parkinson Disease/metabolism
Perfusion
Putamen/*drug effects/metabolism
Rats
Receptors
Sprague-Dawley
Stimulation
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.2174/138920112798868575" target="_blank" rel="noreferrer noopener">http://doi.org/10.2174/138920112798868575</a>
Pages
229–234
Issue
1
Volume
13
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Alteration of hepatic proinflammatory cytokines is involved in the resveratrol-mediated chemoprevention of chemically-induced hepatocarcinogenesis.
Publisher
An entity responsible for making the resource available
Current pharmaceutical biotechnology
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-01
Subject
The topic of the resource
Female; Animals; Rats; Gene Expression Regulation/drug effects; Liver/drug effects/metabolism; Resveratrol; Diethylnitrosamine; Anticarcinogenic Agents/pharmacology/*therapeutic use; Cytokines/genetics/*metabolism; Phenobarbital; Stilbenes/pharmacology/*therapeutic use; Sprague-Dawley; RNA; Messenger/metabolism; Liver Neoplasms; Experimental/chemically induced/metabolism/*prevention & control
Creator
An entity primarily responsible for making the resource
Mbimba Thomas; Awale Prabha; Bhatia Deepak; Geldenhuys Werner J; Darvesh Altaf S; Carroll Richard T; Bishayee Anupam
Description
An account of the resource
Hepatocellular carcinoma (HCC), one of the most common cancers in the world, is a leading cause of cancerrelated mortality. HCC develops most frequently in the background of oxidative stress and chronic hepatic inflammation due to viral infections, alcohol abuse as well as exposure to environmental and dietary carcinogens. As the prognosis of HCC is extremely poor and mostly unresponsive to current chemotherapeutic treatment regimens, novel preventive approaches like chemoprevention are urgently needed. We have recently found that resveratrol, a dietary polyphenol present in grapes, berries, peanuts as well as red wine, prevents diethylnitrosamine (DENA)-initiated hepatocarcinogenesis in rats through suppression of inflammation and oxidative stress. As cytokines are considered to be important mediators of inflammation, the objective of the present study was to investigate the effects of resveratrol on hepatic cytokines during DENA-initiated hepatocarcinogenesis in rats. Liver samples were harvested from our previous study in which resveratrol (50, 100 and 300 mg/kg) was found to exert a chemopreventive action against rat liver tumorigenesis induced by DENA. The levels of proinflammatory cytokines, namely tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin- 6 (IL-6), were measured using enzyme-linked immunosorbent assays. The mRNA expression of these cytokines was studied by reverse transcriptase-polymerase chain reaction for comparison. Resveratrol treatment reversed the DENAinduced alteration of the level and expression of hepatic TNF-alpha, IL-1beta and IL-6. From the current results in conjunction with our previous findings, it can be concluded that resveratrol-mediated chemoprevention of rat liver carcinogenesis is related to alteration of proinflammatory cytokines.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.2174/138920112798868575" target="_blank" rel="noreferrer noopener">10.2174/138920112798868575</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2012
Animals
Anticarcinogenic Agents/pharmacology/*therapeutic use
Awale Prabha
Bhatia Deepak
Bishayee Anupam
Carroll Richard T
Current pharmaceutical biotechnology
Cytokines/genetics/*metabolism
Darvesh Altaf S
Department of Pharmaceutical Sciences
Diethylnitrosamine
Experimental/chemically induced/metabolism/*prevention & control
Female
Geldenhuys Werner J
Gene Expression Regulation/drug effects
Liver Neoplasms
Liver/drug effects/metabolism
Mbimba Thomas
Messenger/metabolism
NEOMED College of Pharmacy
Phenobarbital
Rats
Resveratrol
RNA
Sprague-Dawley
Stilbenes/pharmacology/*therapeutic use
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1161/HYPERTENSIONAHA.107.098459" target="_blank" rel="noreferrer noopener">http://doi.org/10.1161/HYPERTENSIONAHA.107.098459</a>
Pages
704–711
Issue
3
Volume
51
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Angiotensin II-induced extracellular signal-regulated kinase 1/2 activation is mediated by protein kinase Cdelta and intracellular calcium in adult rat cardiac fibroblasts.
Publisher
An entity responsible for making the resource available
Hypertension (Dallas, Tex. : 1979)
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-03
Subject
The topic of the resource
Acetophenones/pharmacology; Angiotensin II/*physiology; Animals; Benzopyrans/pharmacology; Calcium/*metabolism; Cell Proliferation; Cells; Cultured; Enzyme Activation; ErbB Receptors/metabolism; Fibroblasts/*metabolism; Male; Mitogen-Activated Protein Kinase 1/*metabolism; Mitogen-Activated Protein Kinase 3/*metabolism; Myocardium/*cytology/metabolism; Phorbol Esters/pharmacology; Phosphorylation; Protein Kinase C-delta/genetics/*metabolism; Rats; Signal Transduction/physiology; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Olson Erik R; Shamhart Patricia E; Naugle Jennifer E; Meszaros J Gary
Description
An account of the resource
Angiotensin II (Ang II)-induced proliferation of cardiac fibroblasts is a major contributing factor to the pathogenesis of cardiac fibrosis. Ang II activates extracellular signal-regulated kinase (ERK) 1/2 to induce cardiac fibroblast proliferation, but the signaling pathways leading to ERK 1/2 activation have not been elucidated in these cells. The goal of the current study was to identify the intracellular mediators of Ang II-induced ERK 1/2 activation in adult rat cardiac fibroblasts. We determined that 100 nmol/L of Ang II-induced ERK 1/2 phosphorylation is inhibited by simultaneous chelation of cytosolic calcium and downregulation of protein kinase C (PKC) by phorbol ester or by the specific PKCdelta inhibitor rottlerin, as well as PKCdelta small interfering RNA, but not by inhibition of 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetate, phorbol ester, rottlerin, or PKCdelta small interfering RNA alone. We also found that Ang II does not transactivate the epidermal growth factor receptor in adult cardiac fibroblasts, because pretreatment with 1 mumol/L of AG 1478 did not significantly inhibit [(3)H]-thymidine incorporation or ERK 1/2 activation. In addition, immunoprecipitation of the epidermal growth factor receptor demonstrated no significant Ang II-induced phosphorylation of tyrosine residues. Inhibition of phosphatidylinositide 3-kinase, PKCzeta, and src tyrosine kinase had no effect on Ang II-induced ERK 1/2 activation. Collectively, these data demonstrate that Ang II does not transactivate the epidermal growth factor receptor in adult rat cardiac fibroblasts to activate ERK 1/2, a common pathway described in vascular smooth muscle and other cell types, but rather occurs via activation of distinct parallel signaling pathways mechanistically controlled by intracellular Ca(2+) and PKCdelta.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1161/HYPERTENSIONAHA.107.098459" target="_blank" rel="noreferrer noopener">10.1161/HYPERTENSIONAHA.107.098459</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2008
Acetophenones/pharmacology
Angiotensin II/*physiology
Animals
Benzopyrans/pharmacology
Calcium/*metabolism
Cell Proliferation
Cells
Cultured
Department of Integrative Medical Sciences
Enzyme Activation
ErbB Receptors/metabolism
Fibroblasts/*metabolism
Hypertension (Dallas, Tex. : 1979)
Male
Meszaros J Gary
Mitogen-Activated Protein Kinase 1/*metabolism
Mitogen-Activated Protein Kinase 3/*metabolism
Myocardium/*cytology/metabolism
Naugle Jennifer E
NEOMED College of Medicine
Olson Erik R
Phorbol Esters/pharmacology
Phosphorylation
Protein Kinase C-delta/genetics/*metabolism
Rats
Shamhart Patricia E
Signal Transduction/physiology
Sprague-Dawley
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.jnutbio.2010.09.001" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jnutbio.2010.09.001</a>
Pages
1035–1046
Issue
11
Volume
22
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Anthocyanin-rich black currant (Ribes nigrum L.) extract affords chemoprevention against diethylnitrosamine-induced hepatocellular carcinogenesis in rats.
Publisher
An entity responsible for making the resource available
The Journal of nutritional biochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-11
Subject
The topic of the resource
Animals; Anthocyanins/*therapeutic use; Anticarcinogenic Agents/therapeutic use; Apoptosis/drug effects; bcl-2-Associated X Protein/metabolism; Cell Proliferation/drug effects; Chemoprevention; Diethylnitrosamine; Down-Regulation; Experimental/metabolism/pathology; Liver Neoplasms; Liver Neoplasms/chemically induced/*prevention & control; Liver/pathology; Male; Phenobarbital; Plant Extracts/*therapeutic use; Proliferating Cell Nuclear Antigen/metabolism; Proto-Oncogene Proteins c-bcl-2/metabolism; Rats; Ribes/chemistry; Sprague-Dawley; Up-Regulation
Creator
An entity primarily responsible for making the resource
Bishayee Anupam; Mbimba Thomas; Thoppil Roslin J; Haznagy-Radnai Erzsebet; Sipos Peter; Darvesh Altaf S; Folkesson Hans G; Hohmann Judit
Description
An account of the resource
Anthocyanins are known to possess potent anticarcinogenic properties against several cancers thus demonstrating potential for cancer prevention. Black currant (Ribes nigrum L., Grossulariaceae) fruits have a high anthocyanin content. This "superfruit" is known to possess various pharmacological effects including alleviation of chronic oxidative stress and inflammation. In contrast to a large volume of literature on the health benefits of black currant, limited evidence on antitumor effects of black currant exists with virtually no data on the prevention of experimental carcinogenesis. In the current study, we have investigated the chemopreventive effects of an anthocyanin-rich black currant skin extract (BCSE) utilizing our well-characterized model of rat liver carcinogenesis. Initiation of hepatocarcinogenesis was done by intraperitoneal injection of diethylnitrosamine (DENA) followed by promotion with phenobarbital. The rats were exposed to dietary BCSE for 4 weeks prior to initiation, and the treatment was continued for 22 consecutive weeks. BCSE dose-dependently decreased the incidence, total number, multiplicity, size and volume of preneoplastic hepatic nodules. The antihepatocarcinogenic effect of BCSE was confirmed by histopathological examination of liver sections. Immunohistochemical analysis of proliferating cell nuclear antigen and DNA fragmentation revealed BCSE-mediated inhibition of abnormal cell proliferation and induction of apoptosis in
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.jnutbio.2010.09.001" target="_blank" rel="noreferrer noopener">10.1016/j.jnutbio.2010.09.001</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2011
Animals
Anthocyanins/*therapeutic use
Anticarcinogenic Agents/therapeutic use
Apoptosis/drug effects
bcl-2-Associated X Protein/metabolism
Bishayee Anupam
Cell Proliferation/drug effects
Chemoprevention
Darvesh Altaf S
Department of Pharmaceutical Sciences
Diethylnitrosamine
Down-Regulation
Experimental/metabolism/pathology
Folkesson Hans G
Haznagy-Radnai Erzsebet
Hohmann Judit
Liver Neoplasms
Liver Neoplasms/chemically induced/*prevention & control
Liver/pathology
Male
Mbimba Thomas
NEOMED College of Pharmacy
Phenobarbital
Plant Extracts/*therapeutic use
Proliferating Cell Nuclear Antigen/metabolism
Proto-Oncogene Proteins c-bcl-2/metabolism
Rats
Ribes/chemistry
Sipos Peter
Sprague-Dawley
The Journal of nutritional biochemistry
Thoppil Roslin J
Up-Regulation
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.molbrainres.2005.02.030" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.molbrainres.2005.02.030</a>
Pages
143–151
Issue
1
Volume
137
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
APeg3, a novel paternally expressed gene 3 antisense RNA transcript specifically expressed in vasopressinergic magnocellular neurons in the rat supraoptic nucleus.
Publisher
An entity responsible for making the resource available
Brain research. Molecular brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-06
Subject
The topic of the resource
3' Untranslated Regions/genetics; Amino Acid; Animals; Antisense/*genetics/isolation & purification/*metabolism; Conserved Sequence/genetics; DNA-Binding Proteins/genetics/*metabolism; Gene Expression Regulation/*genetics; Genetic/genetics; Genomic Imprinting/genetics; Hypothalamo-Hypophyseal System/cytology/metabolism; Kruppel-Like Transcription Factors; Male; Messenger/genetics/metabolism; Molecular Sequence Data; Neurons/*metabolism; Nucleic Acid; Protein Kinases/genetics/*metabolism; Rats; RNA; Sequence Homology; Sprague-Dawley; Supraoptic Nucleus/cytology/*metabolism; Transcription; Transcription Factors/genetics/*metabolism; Vasopressins/*metabolism; Water-Electrolyte Balance/genetics
Creator
An entity primarily responsible for making the resource
Glasgow Eric; Ryu Seung-Lim; Yamashita Mitsuo; Zhang Bing-Jun; Mutsuga Noriko; Gainer Harold
Description
An account of the resource
Vasopressin (VP) and oxytocin (OT) play critical roles in the regulation of salt and water balance, lactation, and various behaviors and are expressed at very high levels in specific magnocellular neurons (MCNs) in the hypothalamo-neurohypophysial system (HNS). In addition to the cell-specific expression of the VP and OT genes in these cells, there are other transcripts that are preferentially expressed in the VP or OT MCNs. One such gene, paternally expressed gene 3 (Peg3), is an imprinted gene expressed exclusively from the paternal allele that encodes a Kruppel-type zinc finger-containing protein involved in maternal behavior and is abundantly expressed in the VP-MCNs. We report here the robust expression in the VP-MCNs of an RNA, which we designate APeg3 that is transcribed in the antisense direction to the 3' untranslated region of the Peg3 gene. The APeg3 mRNA is about 1 kb in size, and the full-length sequence of APeg3, as determined by 5' and 3' RACE, contains an open reading frame that predicts a protein of 93 amino acids and is predominantly expressed in VP-MCNs. Both Peg3 and APeg3 gene expression in the VP-MCNs increase during systemic hyperosmolality in vivo, demonstrating that both of these genes are osmoregulated.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.molbrainres.2005.02.030" target="_blank" rel="noreferrer noopener">10.1016/j.molbrainres.2005.02.030</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2005
3' Untranslated Regions/genetics
Amino Acid
Animals
Antisense/*genetics/isolation & purification/*metabolism
Brain research. Molecular brain research
Conserved Sequence/genetics
DNA-Binding Proteins/genetics/*metabolism
Gainer Harold
Gene Expression Regulation/*genetics
Genetic/genetics
Genomic Imprinting/genetics
Glasgow Eric
Hypothalamo-Hypophyseal System/cytology/metabolism
Kruppel-Like Transcription Factors
Male
Messenger/genetics/metabolism
Molecular Sequence Data
Mutsuga Noriko
Neurons/*metabolism
Nucleic Acid
Protein Kinases/genetics/*metabolism
Rats
RNA
Ryu Seung-Lim
Sequence Homology
Sprague-Dawley
Supraoptic Nucleus/cytology/*metabolism
Transcription
Transcription Factors/genetics/*metabolism
Vasopressins/*metabolism
Water-Electrolyte Balance/genetics
Yamashita Mitsuo
Zhang Bing-Jun
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1074/jbc.M502751200" target="_blank" rel="noreferrer noopener">http://doi.org/10.1074/jbc.M502751200</a>
Pages
30517–30525
Issue
34
Volume
280
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bcl-2 positively regulates Sox9-dependent chondrocyte gene expression by suppressing the MEK-ERK1/2 signaling pathway.
Publisher
An entity responsible for making the resource available
The Journal of biological chemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-08
Subject
The topic of the resource
*Gene Expression Regulation; Adenoviridae/genetics; Animals; Apoptosis; beta-Galactosidase/metabolism; Blotting; Butadienes/pharmacology; Caspase Inhibitors; Cell Differentiation; Cell Line; Chondrocytes/*metabolism; Collagen Type II/metabolism; Down-Regulation; Enzyme Inhibitors/pharmacology; Fibroblasts/metabolism; Fluorescence; Genetic; High Mobility Group Proteins/*metabolism; Lac Operon; Luciferases/metabolism; MAP Kinase Kinase Kinases/*metabolism; Messenger/metabolism; Microscopy; Mitogen-Activated Protein Kinase 1/*metabolism; Mitogen-Activated Protein Kinase 3/*metabolism; NF-kappa B/metabolism; Nitriles/pharmacology; Phenotype; Phosphorylation; Promoter Regions; Protein Kinase C-alpha; Protein Kinase C/antagonists & inhibitors; Proteoglycans/metabolism; Proto-Oncogene Proteins c-bcl-2/*metabolism; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA; Signal Transduction; Small Interfering/metabolism; SOX9 Transcription Factor; Sprague-Dawley; Time Factors; Transcription; Transcription Factors/*metabolism; Transfection; Western
Creator
An entity primarily responsible for making the resource
Yagi Rieko; McBurney Denise; Horton Walter E Jr
Description
An account of the resource
Bcl-2 is an anti-apoptotic protein that has recently been shown to regulate other cellular functions. We previously reported that Bcl-2 regulates chondrocyte matrix gene expression, independent of its anti-apoptotic function. Here, we further investigate this novel function of Bcl-2 and examine three intracellular signaling pathways likely to be associated with this function. The present study demonstrates that the activity of Sox9, a master transcription factor that regulates the gene expression of chondrocyte matrix proteins, is suppressed by Bcl-2 small interference RNA in the presence of caspase inhibitors. This effect was attenuated by prior exposure of chondrocytes to an adenoviral vector expressing sense Bcl-2. In addition, the down-regulation of Bcl-2, Sox9, and chondrocyte-specific gene expression by serum withdrawal in primary chondrocytes was reversed by expressing Bcl-2. Inhibition of the protein kinase C alpha and NFkappaB pathways had no effect on the maintenance of Sox9-dependent gene expression by Bcl-2. In contrast, whereas the MEK-ERK1/2 pathway negatively regulated the differentiated phenotype in wild type chondrocytes, inhibition of this pathway reversed the loss of differentiation markers and fibroblastic phenotype in Bcl-2-deficient chondrocytes. In conclusion, the present study identifies a specific signaling pathway, namely, MEK-ERK1/2, that is downstream of Bcl-2 in the regulation of Sox9-dependent chondrocyte gene expression and phenotype.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1074/jbc.M502751200" target="_blank" rel="noreferrer noopener">10.1074/jbc.M502751200</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Gene Expression Regulation
2005
Adenoviridae/genetics
Animals
Apoptosis
beta-Galactosidase/metabolism
Blotting
Butadienes/pharmacology
Caspase Inhibitors
Cell Differentiation
Cell Line
Chondrocytes/*metabolism
Collagen Type II/metabolism
Department of Anatomy & Neurobiology
Down-Regulation
Enzyme Inhibitors/pharmacology
Fibroblasts/metabolism
Fluorescence
Genetic
High Mobility Group Proteins/*metabolism
Horton Walter E Jr
Lac Operon
Luciferases/metabolism
MAP Kinase Kinase Kinases/*metabolism
McBurney Denise
Messenger/metabolism
Microscopy
Mitogen-Activated Protein Kinase 1/*metabolism
Mitogen-Activated Protein Kinase 3/*metabolism
NEOMED College of Medicine
NF-kappa B/metabolism
Nitriles/pharmacology
Phenotype
Phosphorylation
Promoter Regions
Protein Kinase C-alpha
Protein Kinase C/antagonists & inhibitors
Proteoglycans/metabolism
Proto-Oncogene Proteins c-bcl-2/*metabolism
Rats
Reverse Transcriptase Polymerase Chain Reaction
RNA
Signal Transduction
Small Interfering/metabolism
SOX9 Transcription Factor
Sprague-Dawley
The Journal of biological chemistry
Time Factors
Transcription
Transcription Factors/*metabolism
Transfection
Western
Yagi Rieko
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.bcp.2014.03.012" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.bcp.2014.03.012</a>
Pages
490–502
Issue
4
Volume
89
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
BCNU-induced gR2 defect mediates S-glutathionylation of Complex I and respiratory uncoupling in myocardium.
Publisher
An entity responsible for making the resource available
Biochemical pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-06
Subject
The topic of the resource
Alkylating/*adverse effects/pharmacology; Animals; Antineoplastic Agents; Cardiotoxins/adverse effects/pharmacology; Carmustine/*adverse effects/pharmacology; Cattle; Cell Line; Complex I; Electron Transport Complex I/chemistry/*metabolism; Fatty Acids; Glutathione reductase; Glutathione Reductase/*antagonists & inhibitors/metabolism; Glutathione/*metabolism; Heart Ventricles/drug effects/metabolism/physiopathology; Heart/*drug effects/metabolism; Ion Channels/metabolism; Left/*chemically induced/metabolism/physiopathology; Male; Mice; Mitochondria; Mitochondrial Proteins/metabolism; Nonesterified/metabolism; Oxidative stress; Oxidative Stress/drug effects; Post-Translational/drug effects; Protein Processing; Rats; S-Glutathionylation; Sprague-Dawley; Superoxide Dismutase/genetics/metabolism; Systolic dysfunction; Transgenic; Uncoupling Protein 3; Ventricular Dysfunction
Creator
An entity primarily responsible for making the resource
Kang Patrick T; Chen Chwen-Lih; Ren Pei; Guarini Giacinta; Chen Yeong-Renn
Description
An account of the resource
A deficiency of mitochondrial glutathione reductase (or GR2) is capable of adversely affecting the reduction of GSSG and increasing mitochondrial oxidative stress. BCNU [1,3-bis (2-chloroethyl)-1-nitrosourea] is an anticancer agent and known inhibitor of cytosolic GR ex vivo and in vivo. Here we tested the hypothesis that a BCNU-induced GR2 defect contributes to mitochondrial dysfunction and subsequent impairment of heart function. Intraperitoneal administration of BCNU (40 mg/kg) specifically inhibited GR2 activity by 79.8 +/- 2.7% in the mitochondria of rat heart. However, BCNU treatment modestly enhanced the activities of mitochondrial Complex I and other ETC components. The cardiac function of BCNU-treated rats was analyzed by echocardiography, revealing a systolic dysfunction associated with decreased ejection fraction, decreased cardiac output, and an increase in left ventricular internal dimension and left ventricular volume in systole. The respiratory control index of isolated mitochondria from the myocardium was moderately decreased after BCNU treatment, whereas NADH-linked uncoupling of oxygen consumption was significantly enhanced. Extracellular flux analysis to measure the fatty acid oxidation of myocytes indicated a 20% enhancement after BCNU treatment. When the mitochondria were immunoblotted with antibodies against GSH and UCP3, both protein
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.bcp.2014.03.012" target="_blank" rel="noreferrer noopener">10.1016/j.bcp.2014.03.012</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2014
Alkylating/*adverse effects/pharmacology
Animals
Antineoplastic Agents
Biochemical pharmacology
Cardiotoxins/adverse effects/pharmacology
Carmustine/*adverse effects/pharmacology
Cattle
Cell Line
Chen Chwen-Lih
Chen Yeong-Renn
Complex I
Department of Integrative Medical Sciences
Electron Transport Complex I/chemistry/*metabolism
Fatty Acids
Glutathione reductase
Glutathione Reductase/*antagonists & inhibitors/metabolism
Glutathione/*metabolism
Guarini Giacinta
Heart Ventricles/drug effects/metabolism/physiopathology
Heart/*drug effects/metabolism
Ion Channels/metabolism
Kang Patrick T
Left/*chemically induced/metabolism/physiopathology
Male
Mice
Mitochondria
Mitochondrial Proteins/metabolism
NEOMED College of Medicine
Nonesterified/metabolism
Oxidative Stress
Oxidative Stress/drug effects
Post-Translational/drug effects
Protein Processing
Rats
Ren Pei
S-Glutathionylation
Sprague-Dawley
Superoxide Dismutase/genetics/metabolism
Systolic dysfunction
Transgenic
Uncoupling Protein 3
Ventricular Dysfunction
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajplung.90629.2008" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajplung.90629.2008</a>
Pages
L487–495
Issue
3
Volume
297
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Beta-adrenoceptor stimulation of alveolar fluid clearance is increased in rats with heart failure.
Publisher
An entity responsible for making the resource available
American journal of physiology. Lung cellular and molecular physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009-09
Subject
The topic of the resource
Adrenergic; Animals; beta/*metabolism; Body Fluids/*metabolism; Epithelial Cells/drug effects/metabolism/pathology; Gene Expression Regulation/drug effects; Heart Failure/blood/diagnostic imaging/*metabolism/*pathology; Hormones/blood; Hyperplasia; Ion Channels/genetics/metabolism; Male; Messenger/genetics/metabolism; Myocardial Infarction/blood/diagnostic imaging/pathology; Pulmonary Alveoli/drug effects/*pathology; Rats; Receptors; RNA; Sprague-Dawley; Terbutaline/pharmacology; Ultrasonography
Creator
An entity primarily responsible for making the resource
Maron Michael B; Luther Daniel J; Pilati Charles F; Ohanyan Vahagn; Li Tianbo; Koshy Shyny; Horne Walter I; Meszaros J Gary; Walro Jon M; Folkesson Hans G
Description
An account of the resource
The alveolar epithelium plays a critical role in resolving pulmonary edema. We thus hypothesized that its function might be upregulated in rats with heart failure, a condition that severely challenges the lung's ability to maintain fluid balance. Heart failure was induced by left coronary artery ligation. Echocardiographic and cardiovascular hemodynamics confirmed its development at 16 wk postligation. At that time, alveolar fluid clearance was measured by an increase in protein concentration over 1 h of a 5% albumin solution instilled into the lungs. Baseline alveolar fluid clearance was similar in heart failure and age-matched control rats. Terbutaline was added to the instillate to determine whether heart failure rats responded to beta-adrenoceptor stimulation. Alveolar fluid clearance in heart failure rats was increased by 194% after terbutaline stimulation compared with a 153% increase by terbutaline in control rats. To determine the mechanisms responsible for this accelerated alveolar fluid clearance, we measured ion transporter expression (ENaC, Na-K- ATPase, CFTR). No significant upregulation was observed for these ion transporters in the heart failure rats. Lung morphology showed significant alveolar epithelial type II cell hyperplasia in heart failure rats. Thus, alveolar epithelial type II cell hyperplasia is the likely explanation for the increased terbutaline-stimulated alveolar fluid clearance in heart failure rats. These data provide evidence for previously unrecognized mechanisms that can protect against or hasten resolution of alveolar edema in heart failure.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajplung.90629.2008" target="_blank" rel="noreferrer noopener">10.1152/ajplung.90629.2008</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2009
Adrenergic
American journal of physiology. Lung cellular and molecular physiology
Animals
beta/*metabolism
Body Fluids/*metabolism
Department of Integrative Medical Sciences
Epithelial Cells/drug effects/metabolism/pathology
Folkesson Hans G
Gene Expression Regulation/drug effects
Heart Failure/blood/diagnostic imaging/*metabolism/*pathology
Hormones/blood
Horne Walter I
Hyperplasia
Ion Channels/genetics/metabolism
Koshy Shyny
Li Tianbo
Luther Daniel J
Male
Maron Michael B
Messenger/genetics/metabolism
Meszaros J Gary
Myocardial Infarction/blood/diagnostic imaging/pathology
NEOMED College of Medicine
Ohanyan Vahagn
Pilati Charles F
Pulmonary Alveoli/drug effects/*pathology
Rats
Receptors
RNA
Sprague-Dawley
Terbutaline/pharmacology
Ultrasonography
Walro Jon M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1006/bbrc.1995.1885" target="_blank" rel="noreferrer noopener">http://doi.org/10.1006/bbrc.1995.1885</a>
Pages
819–825
Issue
3
Volume
211
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Binding of sequence-specific proteins to the 3'-untranslated region of vasoactive intestinal peptide mRNA.
Publisher
An entity responsible for making the resource available
Biochemical and biophysical research communications
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-06
Subject
The topic of the resource
Animals; Anterior/*metabolism; Base Sequence; Binding; Competitive; Cytoplasm/chemistry; Gene Expression Regulation; Genomic Library; Male; Messenger/*metabolism; Molecular Sequence Data; Pituitary Gland; Post-Transcriptional; Protein Binding; Proto-Oncogene Proteins c-fos/genetics; Rats; RNA; RNA Processing; RNA-Binding Proteins/*metabolism; RNA/metabolism; Sprague-Dawley; Subcellular Fractions; Tissue Distribution; Vasoactive Intestinal Peptide/*genetics
Creator
An entity primarily responsible for making the resource
Wolford J K; Signs S A
Description
An account of the resource
Multimeric AUUUA elements in an AU-rich 3'-untranslated region (3'-UTR) have been shown to confer message instability to numerous ephemeral transcripts through the formation of RNA-protein complexes. We show here that the 3'-UTR of VIP mRNA, which contains 3 AUUUA motifs in an AU-rich context, forms specific complexes with cytoplasmic proteins in a concentration-dependent, tissue-specific manner. We also demonstrate that an AU-rich segment of c-fos mRNA can successfully compete with VIP mRNA for binding with cytoplasmic proteins. These studies provide the first evidence for a mechanism by which VIP is post-transcriptionally regulated through specific sequences in its 3'-UTR.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1006/bbrc.1995.1885" target="_blank" rel="noreferrer noopener">10.1006/bbrc.1995.1885</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
Animals
Anterior/*metabolism
Base Sequence
Binding
Biochemical and biophysical research communications
Competitive
Cytoplasm/chemistry
Gene Expression Regulation
Genomic Library
Male
Messenger/*metabolism
Molecular Sequence Data
Pituitary Gland
Post-Transcriptional
Protein Binding
Proto-Oncogene Proteins c-fos/genetics
Rats
RNA
RNA Processing
RNA-Binding Proteins/*metabolism
RNA/metabolism
Signs S A
Sprague-Dawley
Subcellular Fractions
Tissue Distribution
Vasoactive Intestinal Peptide/*genetics
Wolford J K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/jps.23510" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/jps.23510</a>
Pages
1650–1660
Issue
5
Volume
102
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Biocompatibility and in vivo tolerability of a new class of photoresponsive alkoxylphenacyl-based polycarbonates.
Publisher
An entity responsible for making the resource available
Journal of pharmaceutical sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-05
Subject
The topic of the resource
Alanine Transaminase/blood; Animals; Biocompatible Materials/chemistry/*metabolism/*toxicity; Cell Line; Creatine/blood; Cytokines/analysis; Erythrocytes/drug effects; Hemolysis/drug effects; Inbred BALB C; Kidney/drug effects/pathology; Light; Liver/drug effects/pathology; Macrophages/cytology/drug effects; Mice; Polycarboxylate Cement/chemistry/*metabolism/*toxicity; Rats; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Wehrung Daniel; Sun Shuangyi; Chamsaz Elaheh A; Joy Abraham; Oyewumi Moses O
Description
An account of the resource
Potential toxicities of chromophoric or polymeric units of most photoresponsive delivery systems have impacted clinical relevance. Herein, we evaluated the biocompatibility and tolerability of alkoxylphenacyl-based polycarbonates (APPs) as a new class of photoresponsive polymers. The polymers were applied as homopolymer or copolymers of polyethylene glycol (10%, w/w) or polycaprolactone (10%, w/w). APP polymers were comparable to poly(lactic-co-glycolic acid) (PLGA) based on cytotoxicity, macrophage activation, and blood compatibility. Data from biodistribution studies in BALB/c mice showed preferential accumulation in kidney and liver. Meanwhile, potential application of APP polymers as immediate or sustained (implants) drug delivery systems indicated that liver and kidney functions were not distorted. Also, plasma levels of tumor necrosis factor-alpha and interleukin-6 were comparable to PLGA-treated mice (p \textgreater 0.05). A histological analysis of liver and kidney sections showed no detectable damage for APP polymers. The overall data strongly supported potential consideration of APP polymers as photoresponsive delivery systems especially as implantable or tissue-mimicking photopatterned biomaterials.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/jps.23510" target="_blank" rel="noreferrer noopener">10.1002/jps.23510</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2013
Alanine Transaminase/blood
Animals
Biocompatible Materials/chemistry/*metabolism/*toxicity
Cell Line
Chamsaz Elaheh A
Creatine/blood
Cytokines/analysis
Department of Pharmaceutical Sciences
Erythrocytes/drug effects
Hemolysis/drug effects
Inbred BALB C
Journal of pharmaceutical sciences
Joy Abraham
Kidney/drug effects/pathology
Light
Liver/drug effects/pathology
Macrophages/cytology/drug effects
Mice
NEOMED College of Pharmacy
Oyewumi Moses O
Polycarboxylate Cement/chemistry/*metabolism/*toxicity
Rats
Sprague-Dawley
Sun Shuangyi
Wehrung Daniel
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.2174/156800912803987968" target="_blank" rel="noreferrer noopener">http://doi.org/10.2174/156800912803987968</a>
Pages
1244–1257
Issue
9
Volume
12
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Black currant anthocyanins abrogate oxidative stress through Nrf2- mediated antioxidant mechanisms in a rat model of hepatocellular carcinoma.
Publisher
An entity responsible for making the resource available
Current cancer drug targets
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-11
Subject
The topic of the resource
Male; Animals; Rats; Diet; Signal Transduction; NF-E2-Related Factor 2/genetics/*metabolism; *Phytotherapy; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Alkylating Agents/toxicity; Anthocyanins/*therapeutic use; Antioxidants/therapeutic use; Diethylnitrosamine/toxicity; Glutathione Transferase; Immunoenzyme Techniques; Lipid Peroxidation/drug effects; Nitric Oxide Synthase Type II/genetics/metabolism; Oxidative Stress/*drug effects; Ribes/*chemistry; Tyrosine/analogs & derivatives/metabolism; Carcinoma; Sprague-Dawley; Blotting; Western; RNA; Liver Neoplasms; Messenger/genetics; Experimental/chemically induced/metabolism/*prevention & control; Hepatocellular/chemically induced/metabolism/*prevention & control
Creator
An entity primarily responsible for making the resource
Thoppil Roslin J; Bhatia Deepak; Barnes Kendra F; Haznagy-Radnai Erzsebet; Hohmann Judit; Darvesh Altaf S; Bishayee Anupam
Description
An account of the resource
Hepatocellular carcinoma (HCC), considered to be one of the most lethal cancers with almost \textgreater 1 million deaths reported annually worldwide, remains a devastating disease with no known effective cure. Hence, chemopreventive strategies come into play, offering an effective and safe mode of treatment, ideal to ward off potential cancer risks and mortality. A major predisposing condition, pertinent to the development and progression of HCC is oxidative stress. We previously reported a striking chemopreventive effect of anthocyanin-rich black currant skin extract (BCSE) against diethylnitrosamine (DENA)-initiated hepatocarcinogenesis in rats. The current study aims to elucidate the underlying antioxidant mechanisms of black currant anthocyanins implicated in the previously observed chemopreventive effects against experimental hepatocarcinogenesis. Dietary BCSE (100 and 500 mg/kg) administered four weeks before and 18 weeks after DENA challenge decreased abnormal lipid peroxidation, protein oxidation, and expression of inducible nitric oxide synthase (iNOS) and 3-nitrotyrosine (3-NT) in a dose-responsive fashion. Mechanistic studies revealed that BCSE upregulated the gene expression of a number of hepatic antioxidant and carcinogen detoxifying enzymes, such as NAD(P)H:quinone oxidoreductase, glutathione S-transferase, and uridine diphosphate-glucuronosyltransferase isoenzymes, in DENA-initiated animals. Protein and mRNA expressions of nuclear factor E2-related factor 2 (Nrf2) were substantially elevated with BCSE treatment, providing a direct evidence of a coordinated activation of the Nrf2-regulated antioxidant pathway, which led to the upregulation of a variety of housekeeping genes. The results of our study provide substantial evidence that black currant bioactive anthocyanins exert chemopreventive actions against DENA-inflicted hepatocarcinogenesis by attenuating oxidative stress through activation of Nrf2 signaling pathway.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.2174/156800912803987968" target="_blank" rel="noreferrer noopener">10.2174/156800912803987968</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Phytotherapy
2012
Alkylating Agents/toxicity
Animals
Anthocyanins/*therapeutic use
Antioxidants/therapeutic use
Barnes Kendra F
Bhatia Deepak
Bishayee Anupam
Blotting
Carcinoma
Current cancer drug targets
Darvesh Altaf S
Department of Pharmaceutical Sciences
Diet
Diethylnitrosamine/toxicity
Experimental/chemically induced/metabolism/*prevention & control
Glutathione Transferase
Haznagy-Radnai Erzsebet
Hepatocellular/chemically induced/metabolism/*prevention & control
Hohmann Judit
Immunoenzyme Techniques
Lipid Peroxidation/drug effects
Liver Neoplasms
Male
Messenger/genetics
NEOMED College of Pharmacy
NF-E2-Related Factor 2/genetics/*metabolism
Nitric Oxide Synthase Type II/genetics/metabolism
Oxidative Stress/*drug effects
Rats
Real-Time Polymerase Chain Reaction
Reverse Transcriptase Polymerase Chain Reaction
Ribes/*chemistry
RNA
Signal Transduction
Sprague-Dawley
Thoppil Roslin J
Tyrosine/analogs & derivatives/metabolism
Western
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0196-9781(01)00638-6" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0196-9781(01)00638-6</a>
Pages
507–514
Issue
3
Volume
23
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Calcitonin gene-related peptide-receptor component protein expression in the uterine cervix, lumbosacral spinal cord, and dorsal root ganglia.
Publisher
An entity responsible for making the resource available
Peptides
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-03
Subject
The topic of the resource
Animals; Calcitonin Gene-Related Peptide/*biosynthesis/immunology/metabolism; Cervix Uteri/*metabolism; Female; Ganglia; Lumbosacral Region; Rats; Receptors; Spinal Cord/*metabolism; Spinal/*metabolism; Sprague-Dawley; Uterus/metabolism
Creator
An entity primarily responsible for making the resource
Pokabla M J; Dickerson I M; Papka R E
Description
An account of the resource
The neuropeptide calcitonin gene-related peptide (CGRP) may play a role in neurogenic inflammation, tissue remodeling of the uterine cervix, promoting vasodilation, parturition, and processing of sensory information in the spinal cord. CGRP-immunoreactive nerves of the cervix and spinal cord have been studied but cellular identification of the CGRP receptor has received little attention.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0196-9781(01)00638-6" target="_blank" rel="noreferrer noopener">10.1016/s0196-9781(01)00638-6</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2002
Animals
Calcitonin Gene-Related Peptide/*biosynthesis/immunology/metabolism
Cervix Uteri/*metabolism
Dickerson I M
Female
Ganglia
Lumbosacral Region
Papka R E
Peptides
Pokabla M J
Rats
Receptors
Spinal Cord/*metabolism
Spinal/*metabolism
Sprague-Dawley
Uterus/metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0361-9230(93)90087-r" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0361-9230(93)90087-r</a>
Pages
593–596
Issue
5
Volume
30
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Calcium channel blockade attenuates angiotensin II-induced drinking in rats.
Publisher
An entity responsible for making the resource available
Brain research bulletin
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1905-6
Subject
The topic of the resource
Amino Acid Sequence; Angiotensin II/*antagonists & inhibitors/pharmacology; Animals; Calcium Channel Blockers/administration & dosage/*pharmacology; Dimethyl Sulfoxide/pharmacology; Dose-Response Relationship; Drinking Behavior/*drug effects; Drug; Injections; Intraventricular; Isradipine/pharmacology; Male; Molecular Sequence Data; Rats; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Calcagnetti D J; Schechter M D
Description
An account of the resource
Lateral ventricular administration of angiotensin II (ANG II) produces potent dipsogenic effects in water-sated rats. ANG II seems to require functional voltage-gated calcium channels on neurons throughout circumventricular brain sites to exert its effects. Although there are at least three types of calcium channels, only L-type calcium channel-blocking drugs have been reported to decrease drinking. (4-(4-Benzofurazanyl)-1-4-dihydro-2,6-dimethyl-3,5-pyridine-dic arb oxylic acid methyl 1-methyl-ethyl ester) [PN 200-110; isradipine (ISR)], a selective L-type calcium channel blocker, has been shown to attenuate significantly the intake of sweetened water in water-sated rats following either peripheral or ICV administration, but ISR does not affect plain-water intake in water-deprived rats. The present experiment was designed to determine whether ISR would attenuate ANG II-induced drinking that is not either motivated by palatability or dependent on deprivation. Rats, each fitted with chronic indwelling ventricular cannulae, were pretreated with ISR (0.3, 3.0, and 30 micrograms/rat; ICV). ANG II (40 ng/rat; ICV) was administered 10 min later and rats were allowed free access to water for 15 min. Injections of ANG II plus saline and ANG II plus the ISR vehicle (dimethyl sulfoxide) did not attenuate ANG II-induced polydipsia, whereas ANG II+ISR (0.3 and 3.0 micrograms) attenuated ANG II-induced drinking to 62 and 22% of control, respectively. Results with the 30-micrograms dose were not different from the 3.0 dose.(ABSTRACT TRUNCATED AT 250 WORDS)
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0361-9230(93)90087-r" target="_blank" rel="noreferrer noopener">10.1016/0361-9230(93)90087-r</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1993
Amino Acid Sequence
Angiotensin II/*antagonists & inhibitors/pharmacology
Animals
Brain research bulletin
Calcagnetti D J
Calcium Channel Blockers/administration & dosage/*pharmacology
Dimethyl Sulfoxide/pharmacology
Dose-Response Relationship
Drinking Behavior/*drug effects
Drug
Injections
Intraventricular
Isradipine/pharmacology
Male
Molecular Sequence Data
Rats
Schechter M D
Sprague-Dawley
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s004419900071" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s004419900071</a>
Pages
63–74
Issue
1
Volume
298
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Calretinin-immunoreactive nerves in the uterus, pelvic autonomic ganglia, lumbosacral dorsal root ganglia and lumbosacral spinal cord.
Publisher
An entity responsible for making the resource available
Cell and tissue research
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
1999-10
Subject
The topic of the resource
Animals; Autonomic/*metabolism; Calbindin 2; Capsaicin/pharmacology; Female; Ganglia; Immunohistochemistry; Lumbosacral Region; Nerve Fibers/drug effects/metabolism; Pelvis; Rats; S100 Calcium Binding Protein G/*metabolism; Spinal Cord/*metabolism; Spinal/*metabolism; Sprague-Dawley; Uterus/*innervation
Creator
An entity primarily responsible for making the resource
Papka R E; Collins J; Copelin T; Wilson K
Description
An account of the resource
Nerves containing the calcium-binding protein calretinin have been reported in several organs but not in female reproductive organs and associated ganglia. This study was undertaken to determine if nerves associated with the uterus contain calretinin and the source(s) of calretinin-synthesizing nerves in the rat (are they sensory, efferent, or both?). Calretinin-immunoreactive nerves were present in the uterine horns and cervix where they were associated with arteries, uterine smooth muscle, glands, and the epithelium. Calretinin-immunoreactive terminals were apposed to neurons in the paracervical ganglia; in addition, some postganglionic neurons in this ganglion were calretinin positive. Calretinin perikarya were present in the lumbosacral dorsal root ganglia, no-dose ganglia, and lumbosacral spinal cord. Retrograde axonal tracing, utilizing Fluorogold injected into the uterus or paracervical parasympathetic ganglia, revealed calretinin-positive/Fluorogold-labeled neurons in the dorsal root and nodose ganglia. Also, capsaicin treatment substantially reduced the calretinin-positive fibers in the uterus and pelvic ganglia, thus indicating the sensory nature of these fibers. The presence of calretinin immunoreactivity identifies a subset of nerves that are involved in innervation of the pelvic viscera and have origins from lumbosacral dorsal root ganglia and vagal nodose ganglia. Though the exact function of calretinin in these nerves is not currently known, calretinin is likely to play a role in calcium regulation and their function.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s004419900071" target="_blank" rel="noreferrer noopener">10.1007/s004419900071</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1999
Animals
Autonomic/*metabolism
Calbindin 2
Capsaicin/pharmacology
Cell and tissue research
Collins J
Copelin T
Female
Ganglia
Immunohistochemistry
Lumbosacral Region
Nerve Fibers/drug effects/metabolism
Papka R E
Pelvis
Rats
S100 Calcium Binding Protein G/*metabolism
Spinal Cord/*metabolism
Spinal/*metabolism
Sprague-Dawley
Uterus/*innervation
Wilson K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/(SICI)1098-2396(19990315)31:4%3C250::AID-SYN2%3E3.0.CO;2-Z" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/(SICI)1098-2396(19990315)31:4%3C250::AID-SYN2%3E3.0.CO;2-Z</a>
Pages
250–255
Issue
4
Volume
31
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Castration differentially alters [3H]nisoxetine binding to norepinephrine uptake sites in olfactory bulb and frontal cortex of male rats.
Publisher
An entity responsible for making the resource available
Synapse (New York, N.Y.)
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
1999-03
Subject
The topic of the resource
*Orchiectomy; Adrenergic/drug effects/*metabolism; Animals; Fluoxetine/*analogs & derivatives/metabolism; Frontal Lobe/drug effects/*metabolism; Kinetics; Male; Norepinephrine/metabolism; Olfactory Bulb/drug effects/*metabolism; Rats; Receptors; Sprague-Dawley; Synaptosomes/drug effects/metabolism; Testosterone/pharmacology
Creator
An entity primarily responsible for making the resource
Shang Y; Boja J W; Dluzen D E
Description
An account of the resource
In the present study, [3H]nisoxetine binding to norepinephrine (NE) uptake sites and [3H]norepinephrine uptake were investigated within olfactory bulb (OB) and frontal cortex homogenates from intact and castrated male rats. Statistically significant reductions in the number of [3H]nisoxetine binding sites (Bmax) were found in OB from the castrates, while significantly increased Bmax values were obtained in the frontal cortex. Castration also significantly altered the affinity (Kd) of [3H]nisoxetine binding in the frontal cortex, but not in the OB. Assessment of [3H]norepinephrine uptake showed that in neither brain regions were there any statistically significant differences in Km nor Vmax between the castrated and intact male rats, indicating that the basal uptake process is not changed following castration in either of these brain areas. These results demonstrate the differential effects of castration upon [3H]nisoxetine binding sites between the OB and frontal cortex. Such findings provide new evidence for one of the mechanisms by which androgens may modulate central noradrenergic activity.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/(SICI)1098-2396(19990315)31:4%3C250::AID-SYN2%3E3.0.CO;2-Z" target="_blank" rel="noreferrer noopener">10.1002/(SICI)1098-2396(19990315)31:4%3C250::AID-SYN2%3E3.0.CO;2-Z</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Orchiectomy
1999
Adrenergic/drug effects/*metabolism
Animals
Boja J W
Dluzen D E
Fluoxetine/*analogs & derivatives/metabolism
Frontal Lobe/drug effects/*metabolism
Kinetics
Male
Norepinephrine/metabolism
Olfactory Bulb/drug effects/*metabolism
Rats
Receptors
Shang Y
Sprague-Dawley
Synapse (New York, N.Y.)
Synaptosomes/drug effects/metabolism
Testosterone/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0304-3940(02)00412-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0304-3940(02)00412-3</a>
Pages
81–84
Issue
2
Volume
328
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Castration increases nisoxetine-evoked norepinephrine levels in vivo within the olfactory bulb of male rats.
Publisher
An entity responsible for making the resource available
Neuroscience letters
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-08
Subject
The topic of the resource
Animal/drug effects/physiology; Animals; Atomoxetine Hydrochloride; Extracellular Space/metabolism; Fluoxetine/*analogs & derivatives/*pharmacology; Male; Microdialysis; Norepinephrine Plasma Membrane Transport Proteins; Norepinephrine/*metabolism; Olfactory Bulb/drug effects/*metabolism; Orchiectomy/*adverse effects; Presynaptic Terminals/drug effects/metabolism; Propylamines/pharmacology; Rats; Reproduction/*physiology; Sexual Behavior; Smell/drug effects/physiology; Sprague-Dawley; Symporters/antagonists & inhibitors/*metabolism; Testosterone/*deficiency/metabolism; Up-Regulation/drug effects/physiology
Creator
An entity primarily responsible for making the resource
Shang Yili; Dluzen Dean E
Description
An account of the resource
In the present experiment we compared differences in extracellular norepinephrine levels in vivo within the olfactory bulb of intact and castrated male rats following infusion of the norepinephrine transport inhibitors, nisoxetine and tomoxetine. With this approach it was possible to assess whether dynamic changes in in vivo norepinephrine transporter function occur as a function of the gonadal state of the animal. Norepinephrine levels following infusion of nisoxetine were significantly increased in castrated compared with intact male rats. While a similar trend was present in response to tomoxetine infusion, these differences failed to achieve a statistically significant difference. These results demonstrate that castration of male rats alters norepinephrine transporter function within the olfactory bulbs. The increased extracellular levels of norepinephrine in response to agents which inhibit transporter function suggest that castration reduces transporter activity. Such effects have important implications not only with regard to processes involving the norepinephrine system in the olfactory bulb but also to the generalized sites and mechanisms by which gonadal steroid hormones modulate central nervous system functions.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0304-3940(02)00412-3" target="_blank" rel="noreferrer noopener">10.1016/s0304-3940(02)00412-3</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2002
Animal/drug effects/physiology
Animals
Atomoxetine Hydrochloride
Dluzen Dean E
Extracellular Space/metabolism
Fluoxetine/*analogs & derivatives/*pharmacology
Male
Microdialysis
Neuroscience letters
Norepinephrine Plasma Membrane Transport Proteins
Norepinephrine/*metabolism
Olfactory Bulb/drug effects/*metabolism
Orchiectomy/*adverse effects
Presynaptic Terminals/drug effects/metabolism
Propylamines/pharmacology
Rats
Reproduction/*physiology
Sexual Behavior
Shang Yili
Smell/drug effects/physiology
Sprague-Dawley
Symporters/antagonists & inhibitors/*metabolism
Testosterone/*deficiency/metabolism
Up-Regulation/drug effects/physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0006-8993(97)01101-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0006-8993(97)01101-3</a>
Pages
119–124
Issue
1
Volume
779
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Castration reduces olfactory bulb norepinephrine transporter function as indicated by responses to noradrenergic uptake blockers.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-01
Subject
The topic of the resource
*Symporters; Adrenergic Uptake Inhibitors/*pharmacology; Animals; Atomoxetine Hydrochloride; Carrier Proteins/*metabolism; Infusions; Isotonic Solutions; Male; Norepinephrine Plasma Membrane Transport Proteins; Norepinephrine/*metabolism; Olfactory Bulb/*metabolism; Orchiectomy; Parenteral; Propylamines/pharmacology; Rats; Sprague-Dawley; Testis/*physiology; Thiophenes/pharmacology
Creator
An entity primarily responsible for making the resource
Shang Y; Dluzen D E
Description
An account of the resource
It has been demonstrated that castration alters the functioning of the olfactory bulb (OB)-norepinephrine (NE) system. In the present experiment, we examined one of the mechanisms by which castration modulates the OB-NE system by comparing NE uptake activity between intact and castrated male rats as studied using an in vitro superfusion technique. To accomplish this goal, NE output from the OB of intact and castrated male rats in response to infusion with two different drugs which alter NE uptake functions, tomoxetine and talsupram, were tested. Overall, NE outputs in response to tomoxetine were significantly higher in the castrated than in intact rats and both groups were significantly greater than non-infused controls. For the talsupram infusion group, NE outputs from the castrated, but not intact rats, were significantly greater than controls. No statistically significant differences were detected between the castrated and intact rats. These results demonstrate that castration alters the NE uptake activities in response to these noradrenergic uptake blockers and suggest that one mechanism by which castration alters OB-NE functioning is through reducing the uptake activity of NE within the OB. Such findings have important implications for olfactory-based learning and memory/recognition processes which are believed to involve the OB-NE system and are altered following castration.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0006-8993(97)01101-3" target="_blank" rel="noreferrer noopener">10.1016/s0006-8993(97)01101-3</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Symporters
1998
Adrenergic Uptake Inhibitors/*pharmacology
Animals
Atomoxetine Hydrochloride
Brain research
Carrier Proteins/*metabolism
Dluzen D E
Infusions
Isotonic Solutions
Male
Norepinephrine Plasma Membrane Transport Proteins
Norepinephrine/*metabolism
Olfactory Bulb/*metabolism
Orchiectomy
Parenteral
Propylamines/pharmacology
Rats
Shang Y
Sprague-Dawley
Testis/*physiology
Thiophenes/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s10637-009-9332-7" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s10637-009-9332-7</a>
Pages
380–391
Issue
2
Volume
29
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Chemopreventive doses of resveratrol do not produce cardiotoxicity in a rodent model of hepatocellular carcinoma.
Publisher
An entity responsible for making the resource available
Investigational new drugs
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-04
Subject
The topic of the resource
*Chemoprevention; Analysis of Variance; Animal; Animal Studies; Animal/drug effects; Animals; Antioxidants; Behavior; Blotting; Carcinoma; Cardiotoxicity; Cardiotoxins/*toxicity; Chemoprevention; Data Analysis Software; Descriptive Statistics; Disease Models; Doppler; Dose-Response Relationship; Drug; Echocardiography; Feeding Behavior/drug effects; Female; Fisher's Exact Test; Funding Source; Heart – Drug Effects; Heart/drug effects/physiopathology; Hepatocellular – Prevention and Control; Hepatocellular/*drug therapy/pathology/physiopathology; Hepatocytes/drug effects/pathology; Humans; Liver Neoplasms/*drug therapy/pathology/physiopathology; Liver/drug effects/pathology/physiopathology; Polyphenols – Therapeutic Use; Rats; Resveratrol; Sprague-Dawley; Stilbenes/*therapeutic use; Systole/drug effects; Western
Creator
An entity primarily responsible for making the resource
Luther Daniel J; Ohanyan Vahagn; Shamhart Patricia E; Hodnichak Cheryl M; Sisakian Hamayak; Booth Tristan D; Meszaros J Gary; Bishayee Anupam
Description
An account of the resource
Hepatocellular carcinoma (HCC), one of the most lethal cancers, results in more than one million fatalities worldwide every year. In view of the limited therapeutic alternatives and poor prognosis of liver cancer, preventive control approaches, notably chemoprevention, have been considered to be the best strategy in lowering the present prevalence of the disease. Resveratrol, a naturally occurring antioxidant and antiinflammatory agent found in grapes and red wine, inhibits carcinogenesis with a pleiotropic mode of action. Recently, we have reported that dietary resveratrol significantly prevents chemically-induced liver tumorigenesis in rats. One of the mechanisms of resveratrol-mediated chemoprevention of hepatocarcinogenesis could be related to its antiinflammatory action through hepatic cyclooxygenase (COX-2) inhibition. Although several COX-2 inhibitors are known to exert chemopreventive efficacy, not all are considered ideal candidates for chemoprevention due to the risk of adverse cardiovascular events. Accordingly, the objective of the present study was to evaluate the role of resveratrol on cardiac performance during experimental hepatocarcinogenesis initiated with diethylnitrosamine and promoted by phenobarbital. Rats had free access to diet supplemented with resveratrol four weeks before the carcinogen injection and 14 weeks thereafter. The cardiotoxicity of resveratrol was assessed by monitoring the cardiac function using transthoracic echocardiography as well as Western blot analysis of cardiac tissue. Long-term dietary administration of resveratrol dose-dependently suppressed hepatic tumor multiplicity, the principal endpoint for evaluating the chemopreventive potential of a candidate agent. The chemopreventive effects of resveratrol were also reflected in histopathological assessment of hepatic tissues. Resveratrol did not exhibit any cardiotoxicity but rather improved the cardiac function in a dose-responsive fashion. Our results indicate that resveratrol-mediated chemoprevention of rat liver carcinogenesis is devoid of any adverse cardiovascular events. Resveratrol may be developed as a chemopreventive as well as therapeutic drug for human HCC.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s10637-009-9332-7" target="_blank" rel="noreferrer noopener">10.1007/s10637-009-9332-7</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Chemoprevention
2011
Analysis of Variance
Animal
Animal Studies
Animal/drug effects
Animals
Antioxidants
Behavior
Bishayee Anupam
Blotting
Booth Tristan D
Carcinoma
Cardiotoxicity
Cardiotoxins/*toxicity
Chemoprevention
Data Analysis Software
Department of Integrative Medical Sciences
Descriptive Statistics
Disease Models
Doppler
Dose-Response Relationship
Drug
Echocardiography
Feeding Behavior/drug effects
Female
Fisher's Exact Test
Funding Source
Heart – Drug Effects
Heart/drug effects/physiopathology
Hepatocellular – Prevention and Control
Hepatocellular/*drug therapy/pathology/physiopathology
Hepatocytes/drug effects/pathology
Hodnichak Cheryl M
Humans
Investigational new drugs
Liver Neoplasms/*drug therapy/pathology/physiopathology
Liver/drug effects/pathology/physiopathology
Luther Daniel J
Meszaros J Gary
NEOMED College of Medicine
Ohanyan Vahagn
Polyphenols – Therapeutic Use
Rats
Resveratrol
Shamhart Patricia E
Sisakian Hamayak
Sprague-Dawley
Stilbenes/*therapeutic use
Systole/drug effects
Western
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s004410051290" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s004410051290</a>
Pages
293–305
Issue
2
Volume
296
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Cholinergic neurons of the pelvic autonomic ganglia and uterus of the female rat: distribution of axons and presence of muscarinic receptors.
Publisher
An entity responsible for making the resource available
Cell and tissue research
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
1999-05
Subject
The topic of the resource
Acetylcholinesterase/*analysis; Animals; Autonomic/*cytology/physiology/ultrastructure; Autoradiography; Axonal Transport; Axons/physiology/*ultrastructure; Cervix Uteri/*innervation; Choline O-Acetyltransferase/*analysis; Female; Ganglia; Muscarinic/analysis/*metabolism; Quinuclidinyl Benzilate/pharmacokinetics; Rats; Receptors; Spinal Cord/cytology/metabolism; Sprague-Dawley; Tritium; Uterus/*innervation
Creator
An entity primarily responsible for making the resource
Papka R E; Traurig H H; Schemann M; Collins J; Copelin T; Wilson K
Description
An account of the resource
Acetylcholine (ACh) stimulates contraction of the uterus and dilates the uterine arterial supply. Uterine cholinergic nerves arise from the paracervical ganglia and were, in the past, characterized based on acetylcholinesterase (AChE) histochemistry. However, the histochemical reaction for acetylcholinesterase provides only indirect evidence of acetylcholine location and is a nonspecific marker for cholinergic nerves. The present study: (1) reevaluated cholinergic neurons of the paracervical ganglia, (2) examined the cholinergic innervation of the uterus by using retrograde axonal tracing and antibodies against molecules specific to cholinergic neurons, choline acetyltransferase and the vesicular acetylcholine transporter, and (3) examined muscarinic receptors in the paracervical ganglia using autoradiography and a radiolabeled agonist. Most ganglionic neurons were choline acetyltransferase- and vesicular acetylcholine transporter-immunoreactive and were apposed by choline acetyltransferase/vesicular acetylcholine transporter-immunoreactive terminals. Retrograde tracing showed that some cholinergic neurons projected axons to the uterus. These nerves formed moderately dense plexuses in the myometrium, cervical smooth muscle and microarterial system of the uterine horns and cervix. Finally, the paracervical ganglia contain muscarinic receptors. These results clearly reveal the cholinergic innervation of the uterus and cervix, a source of these nerves, and demonstrate the muscarinic receptor content of the paracervical ganglia. Cholinergic nerves could play significant roles in the control of uterine myometrium and vasculature.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s004410051290" target="_blank" rel="noreferrer noopener">10.1007/s004410051290</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1999
Acetylcholinesterase/*analysis
Animals
Autonomic/*cytology/physiology/ultrastructure
Autoradiography
Axonal Transport
Axons/physiology/*ultrastructure
Cell and tissue research
Cervix Uteri/*innervation
Choline O-Acetyltransferase/*analysis
Collins J
Copelin T
Female
Ganglia
Muscarinic/analysis/*metabolism
Papka R E
Quinuclidinyl Benzilate/pharmacokinetics
Rats
Receptors
Schemann M
Spinal Cord/cytology/metabolism
Sprague-Dawley
Traurig H H
Tritium
Uterus/*innervation
Wilson K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(95)00053-y" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(95)00053-y</a>
Pages
549–552
Issue
2
Volume
51
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Cocaethylene produces conditioned place preference in rats.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-07
Subject
The topic of the resource
Animals; Avoidance Learning/drug effects; Cocaine/*analogs & derivatives/pharmacology; Conditioning; Discrimination (Psychology)/drug effects; Male; Motor Activity/*drug effects; Operant/*drug effects; Rats; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
The ability of cocaethylene to produce either a conditioned place preference or a conditioned place aversion was tested in rats. Twelve male rats were administered 10 mg/kg cocaethylene and confined to their nonpreferred side of the conditioned place preference apparatus as determined on a baseline test day. Subsequently, these rats spent a greater amount of time in that cocaethylene-paired nonpreferred side when later tested in a drug-free state. In contrast, rats conditioned with the same dose of cocaethylene and confined in their preferred side, as well as other rats treated with saline on both sides, did not show a significant shift in their preference or aversion. Results are discussed in light of the rewarding activity of cocaethylene, a compound formed in humans who concurrently use cocaine and ethanol.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(95)00053-y" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(95)00053-y</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
Animals
Avoidance Learning/drug effects
Cocaine/*analogs & derivatives/pharmacology
Conditioning
Discrimination (Psychology)/drug effects
Male
Motor Activity/*drug effects
Operant/*drug effects
Pharmacology, biochemistry, and behavior
Rats
Schechter M D
Sprague-Dawley
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(94)00378-v" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(94)00378-v</a>
Pages
285–289
Issue
2
Volume
51
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Cocaethylene produces discriminative stimulus properties in the rat: effect of cocaine and ethanol coadministration.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-07
Subject
The topic of the resource
Animals; Cocaine/*analogs & derivatives/pharmacokinetics/*pharmacology; Discrimination (Psychology)/*drug effects; Dose-Response Relationship; Drug; Ethanol/pharmacokinetics/*pharmacology; Male; Rats; Reinforcement Schedule; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
Experimentally naive Sprague-Dawley male rats were trained to discriminate the interoceptive stimulus cues produced by either 10.0 mg/kg cocaine or 10.0 mg/kg cocaethylene from their saline vehicles. Although it required more sessions to train the cocaethylene rats, once they were trained to criterion performance the ED50 value for cocaethylene (2.89 mg/kg) was very similar to that of cocaine (3.04 mg/kg). Coadministration of a 300-mg/kg dose of ethanol that produced saline-like responding in cocaethylene-trained rats with 2.5 mg/kg cocaine allowed for 88.9% of first lever selections being made on the cocaethylene-appropriate lever. Time-course evidence using coadministered (1.25-mg/kg) cocaine and (300-mg/kg) ethanol indicated that the formation of cocaethylene was highest, as indicated by discriminative performance, at 15 min and progressively decreased as the postinjection interval was increased to 30, 60, and 120 min. The results are discussed in light of rapid formation of cocaethylene from cotreatment with ethanol and cocaine in the mouse, rat, and human subject. The suggestion is made as to the prevalent, and growing, use of this drug combination in the human population of cocaine abusers.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(94)00378-v" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(94)00378-v</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
Animals
Cocaine/*analogs & derivatives/pharmacokinetics/*pharmacology
Discrimination (Psychology)/*drug effects
Dose-Response Relationship
Drug
Ethanol/pharmacokinetics/*pharmacology
Male
Pharmacology, biochemistry, and behavior
Rats
Reinforcement Schedule
Schechter M D
Sprague-Dawley
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(93)90183-t" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(93)90183-t</a>
Pages
661–664
Issue
3
Volume
44
Dublin Core
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Title
A name given to the resource
Cocaine discrimination is attenuated by isradipine and CGS 10746B.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-03
Subject
The topic of the resource
Animals; Antipsychotic Agents/*pharmacology; Calcium Channel Blockers/*pharmacology; Cocaine/antagonists & inhibitors/*pharmacology; Conditioning; Discrimination (Psychology)/*drug effects; Dose-Response Relationship; Drug; Ibogaine/pharmacology; Isradipine/*pharmacology; Male; Operant/drug effects; Rats; Serotonin Antagonists/pharmacology; Sprague-Dawley; Thiazepines/*pharmacology; Tropanes/pharmacology
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
The discriminative stimulus properties of cocaine are thought to be mediated by dopaminergic mechanisms that may be modulated by calcium ion influx and/or interact with 5-hydroxytryptamine3 (5-HT3) receptors. To test these possibilities, rats were trained to discriminate between the stimulus properties of 10.0 mg/kg cocaine and its vehicle in a two-lever, food-motivated operant task. Once trained, rats showed a dose-related decrease in discriminative performance when tested with lower cocaine doses. An analysis of the dose-response curve indicated an ED50 value of 3.04 mg/kg. Pretreatment with the presynaptic dopamine release-inhibiting agent CGS 10746B (20-40 mg/kg) resulted in a dose-related decrease in cocaine discrimination with the highest dose significantly attenuating cocaine discrimination. Pretreatment with 10-30 mg/kg isradipine, a calcium channel blocker, also resulted in a dose-related decrease in cocaine discriminative performance. In contrast to these positive results, pretreatment with the 5-HT3 receptor antagonist MDL 72222 (3.5-7.0 mg/kg), or the same doses of ibogaine, did not significantly affect cocaine discrimination. The results suggest that cocaine controls differential responding in a discriminative stimulus task by mechanisms that involve presynaptic release of dopamine, which may be regulated by neuronal calcium influx through L-type calcium channels.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(93)90183-t" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(93)90183-t</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1993
Animals
Antipsychotic Agents/*pharmacology
Calcium Channel Blockers/*pharmacology
Cocaine/antagonists & inhibitors/*pharmacology
Conditioning
Discrimination (Psychology)/*drug effects
Dose-Response Relationship
Drug
Ibogaine/pharmacology
Isradipine/*pharmacology
Male
Operant/drug effects
Pharmacology, biochemistry, and behavior
Rats
Schechter M D
Serotonin Antagonists/pharmacology
Sprague-Dawley
Thiazepines/*pharmacology
Tropanes/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0014-2999(93)90664-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0014-2999(93)90664-4</a>
Pages
79–84
Issue
1
Volume
249
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Comparison of the behavioral effects of ibogaine from three sources: mediation of discriminative activity.
Publisher
An entity responsible for making the resource available
European journal of pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-11
Subject
The topic of the resource
*Discrimination (Psychology); Animal/*drug effects; Animals; Behavior; Dose-Response Relationship; Drug; Ibogaine/*pharmacology; Male; Rats; Serotonin Receptor Agonists/pharmacology; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Schechter M D; Gordon T L
Description
An account of the resource
Ibogaine is an alkaloid employed for its hallucinatory properties in West Central Africa which has been the subject of alleged efficacy as an aid in the interruption and treatment of chemical dependency. The major sources of the Schedule I agent are: Sigma Chemical Co., the National Institute on Drug Abuse and as NDA International Inc.'s Endabuse. The intent of the present study was to, for the first time, train rats to discriminate the interoceptive stimuli produced by (10 mg/kg, intraperitoneally administered) ibogaine. Once trained, these rats were used to investigate the dose-response effects to ibogaine from each of the three suppliers. In addition, stimulus generalization to the dopamine antagonist CGS 10476B, as well as to the serotonergically active compounds fenfluramine, TFMPP (1-(m-trifluoromethylphenyl)piperazine, DOI (1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane), MDMA (3,4-methylenedioxymethamphetamine), quipazine and LSD, was tested. The results indicate that ibogaine is readily discriminable from its vehicle and that ibogaine from each of the three supplies produced statistically similar discrimination with ED50 values ranging from 2.5 to 3.4 mg/kg. In addition, various doses of the novel drugs tested produced, at best, intermediate ibogaine-appropriate responding and, thus, no drug tested can be considered to generalize to ibogaine-like stimuli. Discussion concerns the multiple actions of ibogaine that have been cited in the scientific literature. The similarity in potency of ibogaine from three potential suppliers should allow for pre-clinical work using any of these research samples to be comparable.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0014-2999(93)90664-4" target="_blank" rel="noreferrer noopener">10.1016/0014-2999(93)90664-4</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Discrimination (Psychology)
1993
Animal/*drug effects
Animals
Behavior
Dose-Response Relationship
Drug
European journal of pharmacology
Gordon T L
Ibogaine/*pharmacology
Male
Rats
Schechter M D
Serotonin Receptor Agonists/pharmacology
Sprague-Dawley
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0014-2999(94)90329-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0014-2999(94)90329-8</a>
Pages
133–137
Issue
2
Volume
260
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Conditioned place aversion produced by dopamine release inhibition.
Publisher
An entity responsible for making the resource available
European journal of pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-08
Subject
The topic of the resource
Analysis of Variance; Animal; Animals; Antipsychotic Agents/administration & dosage/*pharmacology; Aversive Therapy; Conditioning (Psychology); Disease Models; Dopamine Antagonists/administration & dosage/*pharmacology; Dose-Response Relationship; Drug; Injections; Intraperitoneal; Male; Motor Activity/*drug effects; Random Allocation; Rats; Sprague-Dawley; Thiazepines/administration & dosage/*pharmacology
Creator
An entity primarily responsible for making the resource
Schechter M D; Meechan S M
Description
An account of the resource
CGS 10746B, a dopamine release inhibitor with properties similar to the atypical antipsychotic clozapine, was assessed as to its behavioral properties using spontaneous locomotor activity and the conditioned place preference test. Rats conditioned with interperitoneally administered doses of 1.25, 2.5, 5.0, 10.0, 20.0 or 30.0 mg/kg CGS 10746B showed a conditioned place aversion, whereas only doses of 5.0 mg/kg or greater suppressed locomotor activity. Results are discussed in terms of dopaminergic mediation of conditioned place preference and spontaneous locomotor activity and methodological concerns involved in employing the conditioned place preference test with drugs that produce opposing affective cues.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0014-2999(94)90329-8" target="_blank" rel="noreferrer noopener">10.1016/0014-2999(94)90329-8</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1994
Analysis of Variance
Animal
Animals
Antipsychotic Agents/administration & dosage/*pharmacology
Aversive Therapy
Conditioning (Psychology)
Disease Models
Dopamine Antagonists/administration & dosage/*pharmacology
Dose-Response Relationship
Drug
European journal of pharmacology
Injections
Intraperitoneal
Male
Meechan S M
Motor Activity/*drug effects
Random Allocation
Rats
Schechter M D
Sprague-Dawley
Thiazepines/administration & dosage/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0014-2999(93)90739-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0014-2999(93)90739-5</a>
Pages
135–138
Issue
1
Volume
232
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Conditioned place preference produced by the psychostimulant cathinone.
Publisher
An entity responsible for making the resource available
European journal of pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-02
Subject
The topic of the resource
Alkaloids/administration & dosage/*pharmacology; Animals; Central Nervous System Stimulants/administration & dosage/*pharmacology; Choice Behavior/drug effects; Conditioning (Psychology)/drug effects; Dose-Response Relationship; Drug; Habituation; Male; Motor Activity/*drug effects; Psychophysiologic; Rats; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Schechter M D; Meehan S M
Description
An account of the resource
Previous work has indicated that the psychostimulant cathinone produces a location preference in the conditioned place preference task. The present study expanded upon this earlier work by examining the dose-response nature of cathinone-induced conditioned place preference, as well as testing its effect upon spontaneous locomotor activity. At doses ranging from 0.2 to 1.6 mg/kg, cathinone produced a conditioned place preference at all but the lowest dose, and the highest dose but not the lowest dose increased locomotor activity. Results are discussed in terms of dopaminergic mediation of conditioned place preference and the relationship between conditioned place preference and locomotion being subserved by the same neuronal system.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0014-2999(93)90739-5" target="_blank" rel="noreferrer noopener">10.1016/0014-2999(93)90739-5</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1993
Alkaloids/administration & dosage/*pharmacology
Animals
Central Nervous System Stimulants/administration & dosage/*pharmacology
Choice Behavior/drug effects
Conditioning (Psychology)/drug effects
Dose-Response Relationship
Drug
European journal of pharmacology
Habituation
Male
Meehan S M
Motor Activity/*drug effects
Psychophysiologic
Rats
Schechter M D
Sprague-Dawley
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0278-5846(94)90014-0" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0278-5846(94)90014-0</a>
Pages
575–584
Issue
3
Volume
18
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Conditioned place preference/aversion to fenfluramine in fawn hooded and sprague-Dawley rats.
Publisher
An entity responsible for making the resource available
Progress in neuro-psychopharmacology & biological psychiatry
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-05
Subject
The topic of the resource
Animals; Avoidance Learning/*drug effects; Blood Platelets/metabolism; Brain Chemistry/genetics; Fenfluramine/*pharmacology; Habituation; Inbred Strains; Platelet Storage Pool Deficiency/physiopathology; Psychophysiologic/drug effects; Rats; Serotonin/metabolism/physiology; Species Specificity; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Meehan S M; Schechter M D
Description
An account of the resource
The Fawn Hooded (FH) rat strain possesses a genetic platelet storage pool deficiency which leads to an impaired capacity for platelets to store and release serotonin. While the relationship between this deficit and possible alterations in brain serotonergic levels or function remains unclear, numerous behavioral studies have indicated that FH rats exhibit differential responses to serotonergic agonists and antagonist relative to other strains. The current study used the conditioned place preference paradigm to examine the ability of fenfluramine to produce a conditioned place preference (CPP) or aversion (CPA) in FH and Sprague-Dawley (SD) rats. Results indicated that fenfluramine failed to produce CPP or CPA in SD rats, but did produce a CPA in FH rats. Results are discussed in terms of the use of conditioned place preference to assess putative differences in serotonergic functioning in FH rats.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0278-5846(94)90014-0" target="_blank" rel="noreferrer noopener">10.1016/0278-5846(94)90014-0</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1994
Animals
Avoidance Learning/*drug effects
Blood Platelets/metabolism
Brain Chemistry/genetics
Fenfluramine/*pharmacology
Habituation
Inbred Strains
Meehan S M
Platelet Storage Pool Deficiency/physiopathology
Progress in neuro-psychopharmacology & biological psychiatry
Psychophysiologic/drug effects
Rats
Schechter M D
Serotonin/metabolism/physiology
Species Specificity
Sprague-Dawley
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajplung.00124.2005" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajplung.00124.2005</a>
Pages
L478–484
Issue
3
Volume
290
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Congenital diaphragmatic hernia prevents absorption of distal air space fluid in late-gestation rat fetuses.
Publisher
An entity responsible for making the resource available
American journal of physiology. Lung cellular and molecular physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-03
Subject
The topic of the resource
*Gestational Age; *Hernias; Absorption; Amiloride/pharmacology; Animals; Body Fluids/*metabolism; Congenital; Diaphragmatic; Diaphragmatic/*metabolism; Epinephrine/metabolism; Epithelial Sodium Channels; Female; Fetal Organ Maturity; Fetus/*metabolism; Hernia; Male; Newborn; Phenyl Ethers/administration & dosage; Pregnancy; Propranolol/pharmacology; Rats; Respiratory System Abnormalities; Sodium Channels/metabolism; Sodium-Potassium-Exchanging ATPase/metabolism; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Folkesson Hans G; Chapin Cheryl J; Beard LaMonta L; Ertsey Robert; Matthay Michael A; Kitterman Joseph A
Description
An account of the resource
We hypothesized that congenital diaphragmatic hernia (CDH) may decrease distal air space fluid absorption due to immaturity of alveolar epithelial cells from a loss of the normal epithelial Na+ transport, as assessed by amiloride and epithelial Na+ channel (ENaC) and Na-K-ATPase expression, as well as failure to respond to endogenous epinephrine as assessed by propranolol. Timed-pregnant dams were gavage fed 100 mg of nitrofen at 9.5-day gestation to induce CDH in the fetuses, and distal air space fluid absorption experiments were carried out on
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajplung.00124.2005" target="_blank" rel="noreferrer noopener">10.1152/ajplung.00124.2005</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Gestational Age
*Hernias
2006
Absorption
American journal of physiology. Lung cellular and molecular physiology
Amiloride/pharmacology
Animals
Beard LaMonta L
Body Fluids/*metabolism
Chapin Cheryl J
Congenital
Diaphragmatic
Diaphragmatic/*metabolism
Epinephrine/metabolism
Epithelial Sodium Channels
Ertsey Robert
Female
Fetal Organ Maturity
Fetus/*metabolism
Folkesson Hans G
Hernia
Kitterman Joseph A
Male
Matthay Michael A
Newborn
Phenyl Ethers/administration & dosage
Pregnancy
Propranolol/pharmacology
Rats
Respiratory System Abnormalities
Sodium Channels/metabolism
Sodium-Potassium-Exchanging ATPase/metabolism
Sprague-Dawley
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajpheart.1996.271.5.H1840" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpheart.1996.271.5.H1840</a>
Pages
H1840–1848
Issue
5
Volume
271
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Daily exercise and gender influence arterial baroreflex regulation of heart rate and nerve activity.
Publisher
An entity responsible for making the resource available
The American journal of physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-11
Subject
The topic of the resource
*Physical Conditioning; *Sex Characteristics; Animal; Animals; Arteries/*physiology; Baroreflex/*physiology; Female; Heart Rate/*physiology; Lumbosacral Region; Male; Rats; Rest; Sprague-Dawley; Sympathetic Nervous System/*physiology
Creator
An entity primarily responsible for making the resource
Chen C Y; DiCarlo S E
Description
An account of the resource
The influence of daily spontaneous running (DSR) and gender on the arterial baroreflex regulation of heart rate (HR) and lumbar sympathetic nerve activity (LSNA) was examined in 13 male [7 sedentary (SED) and 6 DSR] and 12 female (6 SED and 6 DSR) Sprague-Dawley rats. After 8-9 wk of DSR or SED control, all animals were chronically instrumented with right femoral venous and left carotid arterial catheters and electrodes around the lumbar sympathetic trunk. DSR resulted in an increase in heart weight-to-body weight ratio (P = 0.001) in male and female rats and resting bradycardia in male rats (P = 0.001). Arterial baroreflex function was examined by ramp increases (1.25 +/- 0.07 mmHg/s) and decreases (1.47 mmHg/s) in arterial pressure. DSR attenuated the arterial baroreflex regulation of LSNA in a similar manner in female and male rats. DSR reduced the range (32 and 29% for female and male rats, respectively), maximum (26 and 21% for female and male rats, respectively), and maximum gain (Gmax; 46 and 17% for female and male rats, respectively). In contrast, there was a gender influence on the arterial baroreflex regulation of HR. For example, SED female rats had a higher Gmax (40%) than SED male rats. Furthermore, DSR altered the arterial baroreflex regulation of HR differently in male and female rats. DSR female rats had a reduced Gmax (38%), range (25%), and maximum (12%), whereas DSR male rats had a reduced maximum (17%) and minimum (23%). These results demonstrate that DSR attenuated the arterial baroreflex regulation of LSNA in a similar manner in female and male rats. In contrast, DSR altered the arterial baroreflex regulation of HR differently in female and male rats.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajpheart.1996.271.5.H1840" target="_blank" rel="noreferrer noopener">10.1152/ajpheart.1996.271.5.H1840</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Physical Conditioning
*Sex Characteristics
1996
Animal
Animals
Arteries/*physiology
Baroreflex/*physiology
Chen C Y
DiCarlo S E
Female
Heart Rate/*physiology
Lumbosacral Region
Male
Rats
Rest
Sprague-Dawley
Sympathetic Nervous System/*physiology
The American journal of physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jappl.1994.76.2.783" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jappl.1994.76.2.783</a>
Pages
783–786
Issue
2
Volume
76
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Daily exercise improved blood pressure homeostasis of rats subjected to surgical stress.
Publisher
An entity responsible for making the resource available
Journal of applied physiology (Bethesda, Md. : 1985)
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-02
Subject
The topic of the resource
*Blood Pressure; *Homeostasis; *Physical Conditioning; Animal; Animals; Female; Male; Operative/*adverse effects; Physiological/*etiology/*physiopathology; Rats; Running; Sprague-Dawley; Stress; Surgical Procedures
Creator
An entity primarily responsible for making the resource
Scislo T J; DiCarlo S E; Jarjoura D G
Description
An account of the resource
The effect of daily spontaneous running on blood pressure homeostasis (BPH) was evaluated in 19 male and 13 female control rats and 7 male and 13 female daily spontaneous running rats subjected to surgery and subsequent repetitive hemodynamic disturbances. BPH was operationally defined as the ability to maintain mean arterial pressure above 60 mmHg during the experimental protocol. The length of time the rats maintained BPH was compared across males and females and trained and control groups. Significant sex (P = 0.01) and training (P = 0.05) effects were found. Females maintained homeostasis longer than males and trained longer than controls. Sex effects were not due to differences in the body mass. The mechanisms responsible for the higher resistance to deterioration of homeostasis merit further investigation.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jappl.1994.76.2.783" target="_blank" rel="noreferrer noopener">10.1152/jappl.1994.76.2.783</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Blood Pressure
*Homeostasis
*Physical Conditioning
1994
Animal
Animals
DiCarlo S E
Female
Jarjoura D G
Journal of applied physiology (Bethesda, Md. : 1985)
Male
Operative/*adverse effects
Physiological/*etiology/*physiopathology
Rats
Running
Scislo T J
Sprague-Dawley
Stress
Surgical Procedures
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0031-9384(97)00148-0" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0031-9384(97)00148-0</a>
Pages
105–111
Issue
1
Volume
62
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Daily exercise reduces fat, protein and body mass in male but not female rats.
Publisher
An entity responsible for making the resource available
Physiology & behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-07
Subject
The topic of the resource
*Body Mass Index; Adipose Tissue/*metabolism; Animals; Body Composition/*physiology; Body Weight/physiology; Energy Metabolism/*physiology; Female; Gonadal Steroid Hormones/physiology; Male; Physical Exertion/*physiology; Proteins/*metabolism; Rats; Sex Characteristics; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Cortright R N; Chandler M P; Lemon P W; DiCarlo S E
Description
An account of the resource
This study was designed to compare the estimated energy balance, linear growth (body and bone lengths) and body composition (all components including body mass, total body water, fat, protein and ash) response to daily spontaneous running (DSR) in young male and female rats. We tested the hypothesis that due to gender differences in energy efficiency, DSR would reduce linear growth and body composition more in male rats. Fourteen male and sixteen female weanling Sprague-Dawley rats were randomly assigned to either a sedentary (SED) control (male 7, female 8) or DSR (male 7, female 8) group. The DSR rats were allowed to run spontaneously in running wheels while SED rats remained in standard rat cages for 9 weeks. Body mass, running distance and food intake were measured over the nine week period. Subsequently, chemical analysis was performed to measure carcass content of water, protein, fat and ash. Linear growth was assessed by measures of body and bone lengths. The estimated energy balance of the DSR rats was computed and compared between genders. Estimated energy balance was significantly more negative in females than males due to significantly greater DSR distance. Body and bone lengths were similar among the SED and DSR female and SED and DSR male rats. However, whole body mass, fat mass and protein mass were significantly lower only in DSR males. These results demonstrate that DSR reduced body mass, body fat and protein mass in male rats but not in female rats despite a more negative estimated energy balance in female rats. These findings suggest that females are better protected from an energy deficit due to DSR. Possible mechanisms include gender-specific hormonal responses.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0031-9384(97)00148-0" target="_blank" rel="noreferrer noopener">10.1016/s0031-9384(97)00148-0</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Body Mass Index
1997
Adipose Tissue/*metabolism
Animals
Body Composition/*physiology
Body Weight/physiology
Chandler M P
Cortright R N
DiCarlo S E
Energy Metabolism/*physiology
Female
Gonadal Steroid Hormones/physiology
Lemon P W
Male
Physical Exertion/*physiology
Physiology & behavior
Proteins/*metabolism
Rats
Sex Characteristics
Sprague-Dawley
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jappl.1995.78.4.1219" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jappl.1995.78.4.1219</a>
Pages
1219–1224
Issue
4
Volume
78
Dublin Core
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Title
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Daily spontaneous running alters behavioral and neurochemical indexes of nigrostriatal function.
Publisher
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Journal of applied physiology (Bethesda, Md. : 1985)
Date
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1995
1995-04
Subject
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Animal/*physiology; Animals; Behavior; Chromatography; Circadian Rhythm; Corpus Striatum/cytology/*physiology; Dopamine/*metabolism; High Pressure Liquid; In Vitro Techniques; Male; Neuropsychological Tests; Organ Size; Perfusion; Physical Conditioning; Potassium/*metabolism; Psychomotor Performance/*physiology; Random Allocation; Rats; Sprague-Dawley
Creator
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Dluzen D E; Liu B; Chen C Y; DiCarlo S E
Description
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Behavioral and neurochemical indexes of nigrostriatal dopaminergic function were compared between sedentary control rats (n = 12) and daily spontaneous running (DSR) male rats (n = 10). Nine weeks of DSR did not significantly alter body, heart, pituitary, or testes weights. DSR and control animals did differ in performance on a sensorimotor beam walking task, with DSR rats showing significantly shorter times required to cross the beam (60 +/- 17 vs. 119 +/- 14s; P \textless 0.02) as well as fewer slips off the beam (3.0 +/- 0.8 vs 6.2 +/- 1.1; P \textless 0.05). DSR animals also engaged in significantly greater durations of social investigation than control rats (43 +/- 5 vs 25 +/- 3 s; P \textless 0.01) when tested in a social investigation memory-recognition test. Basal dopamine release rates from superfused corpus striatal tissue fragments of DSR rats were about one-half those obtained from control animals (18 +/- 5 vs. 34 +/- 6 pg.mg-1.min-1; P \textless 0.05), whereas responses of these striatal tissue fragments to a depolarizing concentration of potassium were virtually identical (45 +/- 10 vs. 47 +/- 8 pg.mg-1.min-1). These data indicate that a relatively limited intensity of DSR insufficient to alter cardiovascular function can exert substantial effects on behavioral and neurochemical indicators of nigrostriatal dopaminergic activity.
Identifier
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<a href="http://doi.org/10.1152/jappl.1995.78.4.1219" target="_blank" rel="noreferrer noopener">10.1152/jappl.1995.78.4.1219</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
Animal/*physiology
Animals
Behavior
Chen C Y
Chromatography
Circadian Rhythm
Corpus Striatum/cytology/*physiology
DiCarlo S E
Dluzen D E
Dopamine/*metabolism
High Pressure Liquid
In Vitro Techniques
Journal of applied physiology (Bethesda, Md. : 1985)
Liu B
Male
Neuropsychological Tests
Organ Size
Perfusion
Physical Conditioning
Potassium/*metabolism
Psychomotor Performance/*physiology
Random Allocation
Rats
Sprague-Dawley