1
40
1
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0042-6822(92)90093-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0042-6822(92)90093-5</a>
Pages
339–341
Issue
1
Volume
186
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Differences in the integration pattern and episomal forms of human papillomavirus type 16 DNA found within an invasive cervical neoplasm and its metastasis.
Publisher
An entity responsible for making the resource available
Virology
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-01
Subject
The topic of the resource
Carcinoma; DNA; Electrophoresis; Female; Gel; Humans; Neoplasm Metastasis; Papillomaviridae/*genetics; Plasmids; Squamous Cell/*microbiology/pathology; Two-Dimensional; Uterine Cervical Neoplasms/*microbiology/pathology; Vaginal Neoplasms/microbiology/pathology/secondary; Viral/analysis; Virus Integration
Creator
An entity primarily responsible for making the resource
Galehouse D; Jenison E; DeLucia A
Description
An account of the resource
Human papillomavirus (HPV) type 16 DNA was found in three separate neoplastic lesions within a female patient. The physical state of the viral DNA in each lesion was determined by two-dimensional agarose gel electrophoresis. The primary cervical tumor contained large amounts of several distinct episomal forms as well as integrated HPV DNA. Metastatic tumor tissue found in the vagina had greatly reduced levels of episomal DNA and a viral DNA integration pattern that was different from that of the primary tumor. The vulvar carcinoma in situ had what appears to be free and integrated forms of viral DNA. The results show that although metastatic tissue retained HPV DNA, further rearrangements of the integrated viral DNA pattern found in the primary tumor may occur with a dramatic decrease of episomal forms during malignant progression.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0042-6822(92)90093-5" target="_blank" rel="noreferrer noopener">10.1016/0042-6822(92)90093-5</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1992
Carcinoma
DeLucia A
Department of Integrative Medical Sciences
DNA
Electrophoresis
Female
Galehouse D
Gel
Humans
Jenison E
NEOMED College of Medicine
Neoplasm Metastasis
Papillomaviridae/*genetics
Plasmids
Squamous Cell/*microbiology/pathology
Two-Dimensional
Uterine Cervical Neoplasms/*microbiology/pathology
Vaginal Neoplasms/microbiology/pathology/secondary
Viral/analysis
Virology
Virus Integration