1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
850A
Issue
1
Volume
70
ISSN
0270-9139
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
ABLATION OF CISD2 IN HEPATOCYTES PROTECTS MICE FROM ETHANOL-INDUCED LIVER DAMAGE
Publisher
An entity responsible for making the resource available
Hepatology
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-10
Creator
An entity primarily responsible for making the resource
Stahl Zachary; Li Yun; Buehler Brian; You Min
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2019
Buehler Brian
Department of Pharmaceutical Sciences
Hepatology
Journal Article
Li Yun
NEOMED College of Pharmacy
November 2019 Update
Stahl Zachary
You Min
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.ajpath.2019.09.012" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ajpath.2019.09.012</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
ISSN
1525-2191
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<a href="http://ezproxy.neomed.idm.oclc.org/login?url=http://doi.org/10.1016/j.ajpath.2019.09.012" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1016/j.ajpath.2019.09.012</a>
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Intestinal SIRT1 Deficiency Protects Mice from Ethanol-Induced Liver Injury by Mitigating Ferroptosis
Publisher
An entity responsible for making the resource available
The American Journal Of Pathology
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-10-11
Creator
An entity primarily responsible for making the resource
Zhou Zhou; Ye Ting Jie; DeCaro Elizabeth; Buehler Brian; Stahl Zachary; Bonavita Gregory; Daniels Michael; You Min
Description
An account of the resource
Aberrant liver sirtuin 1 (SIRT1), a mammalian NAD+-dependent protein deacetylase, is implicated in the pathogenesis of alcoholic liver disease. However, the role of intestinal SIRT1 in alcoholic liver disease is presently unknown. This study investigated the involvement of intestine-specific SIRT1 in ethanol-induced liver dysfunction in mice. Ethanol feeding studies were performed on knockout mice with intestinal-specific SIRT1 deletion [SIRT1i knockout (KO)] and flox control [wild-type (WT)] mice with a chronic-plus-binge ethanol feeding protocol. After ethanol administration, hepatic inflammation and liver injury were substantially attenuated in the SIRT1iKO mice compared with the WT mice, suggesting that intestinal SIRT1 played a detrimental role in the ethanol-induced liver injury. Mechanistically, the hepatic protective effect of intestinal SIRT1 deficiency was attributable to ameliorated dysfunctional iron metabolism, increased hepatic glutathione contents, and attenuated lipid peroxidation, along with normalization of a panel of genes implicated in the ferroptosis process in the livers of ethanol-fed mice. This study demonstrates that ablation of intestinal SIRT1 protected mice from the ethanol-induced inflammation and liver damage. The protective effects of intestinal SIRT1 deficiency are mediated, at least partially, by mitigating hepatic ferroptosis. Targeting intestinal SIRT1 or dampening hepatic ferroptosis signaling may have therapeutic potential for alcoholic liver disease in humans.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.ajpath.2019.09.012" target="_blank" rel="noreferrer noopener">10.1016/j.ajpath.2019.09.012</a>
PMID: 31610175
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2019
Bonavita Gregory
Buehler Brian
Daniels Michael
DeCaro Elizabeth
Department of Pharmaceutical Sciences
Journal Article
NEOMED College of Graduate Studies
NEOMED College of Pharmacy
November 2019 Update
Stahl Zachary
The American journal of pathology
Ye Ting Jie
You Min
Zhou Zhou