1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
S40-S41
Issue
1
Volume
9
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Development of a physiologic model for breast cancer invasion and metastasis
Publisher
An entity responsible for making the resource available
Annals of Surgical Oncology
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-01
Subject
The topic of the resource
Oncology; Surgery
Creator
An entity primarily responsible for making the resource
Stakleff K D S; Cheek J T; Evans D M; Fenton A H
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2002
Annals of surgical oncology
Cheek J T
Evans D M
Fenton A H
Journal Article
oncology
Stakleff K D S
Surgery
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1136/ijgc-00009577-200503000-00010" target="_blank" rel="noreferrer noopener">http://doi.org/10.1136/ijgc-00009577-200503000-00010</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
246-254
Issue
2
Volume
15
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A novel early-stage orthotopic model for ovarian cancer in the Fischer 344 rat
Publisher
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International Journal of Gynecological Cancer
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-03
Subject
The topic of the resource
animal-model; epithelial neoplasms; Fischer 344 rats; gene-therapy; guinea-pigs; hormone; induction; mice; mouse model; Obstetrics & Gynecology; Oncology; orthotopic; ovarian-cancer; stimulation; tumors
Creator
An entity primarily responsible for making the resource
Stakleff K D S; Rouse A G; Ryan A P; Haller N A; Von Gruenigen V E
Description
An account of the resource
The purpose of our study was to ascertain the progression of metastases in a novel ovarian cancer model designed to mimic early-stage disease by utilizing an orthotopic injection technique. Female Fischer 344 rats were injected with either 10(4) or 10(5) NuTu-19 cells by intraperitoneal or orthotopic injection. Peritoneal washings and histologic specimens were examined to correlate the incidence and extent of tumor growth. In a second phase, orthotopic injections of 10(2) and 10(3) cells were compared to that of 10(4) cells. Progression of ovarian cancer was observed by gross and microscopic examinations in both intraperitoneal and orthotopic models. Pelvic extension and abdominal adhesions uniquely characterized the orthotopically injected animals. Numbers of identifiable metastases declined with lower cell inocula, confirming that early-stage disease was extended to at least 14 days with 10(2) NuTu-19 cells. The orthotopic ovarian cancer model emulates early disease with the initiation of a primary tumor that is localized within the inherent microenvironment. The orthotopic model offers a clinically relevant alternative for future cancer research that allows for the investigation of therapeutic strategies against early stages of the disease process.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1136/ijgc-00009577-200503000-00010" target="_blank" rel="noreferrer noopener">10.1136/ijgc-00009577-200503000-00010</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2005
animal-model
epithelial neoplasms
Fischer 344 rats
gene-therapy
guinea-pigs
Haller N A
hormone
induction
International Journal of Gynecological Cancer
Journal Article
Mice
Mouse model
Obstetrics & Gynecology
oncology
orthotopic
ovarian-cancer
Rouse A G
Ryan A P
Stakleff K D S
Stimulation
tumors
von Gruenigen V E
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1046/j.1525-1438.2003.13317.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1046/j.1525-1438.2003.13317.x</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
405-412
Issue
4
Volume
13
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Rodent models for ovarian cancer research
Publisher
An entity responsible for making the resource available
International Journal of Gynecological Cancer
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-07
Subject
The topic of the resource
animal models; carcinoma cell-line; epithelial; gene-therapy; immunodeficient mice; luteinizing-hormone; lysophosphatidic acid; metastasis in-vivo; mouse models; neoplasms; nude-mice; Obstetrics & Gynecology; Oncology; ovarian-cancer; p53; review; tumor-associated antigens
Creator
An entity primarily responsible for making the resource
Stakleff K D S; Von Gruenigen V E
Description
An account of the resource
Animal models that are biologically and clinically relevant are essential for conducting research to investigate the pathophysiologic progression of disease and to develop diagnostic or therapeutic strategies. Several rodent models that vary in methods of induction allow appropriate in vivo evaluation for ovarian cancer. The types of rodent models discussed include chemically (nonhormonal and hormonal) induced, genetic (knockout and transgenic), xenograft, and syngeneic. A summary of the available rodent models is provided with a discussion of the advantages and disadvantages of each. Optimization and application of these rodent models to future research may benefit the detection and treatment of ovarian cancer.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1046/j.1525-1438.2003.13317.x" target="_blank" rel="noreferrer noopener">10.1046/j.1525-1438.2003.13317.x</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2003
Animal models
carcinoma cell-line
epithelial
gene-therapy
immunodeficient mice
International Journal of Gynecological Cancer
Journal Article
luteinizing-hormone
lysophosphatidic acid
metastasis in-vivo
mouse models
Neoplasms
nude-mice
Obstetrics & Gynecology
oncology
ovarian-cancer
p53
review
Stakleff K D S
tumor-associated antigens
von Gruenigen V E