1
40
3
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Text
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URL Address
<a href="http://doi.org/10.1006/gyno.1993.1274" target="_blank" rel="noreferrer noopener">http://doi.org/10.1006/gyno.1993.1274</a>
Pages
210–213
Issue
2
Volume
51
Dublin Core
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Title
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The effect of immediate intraperitoneal carboplatinum on wound healing.
Publisher
An entity responsible for making the resource available
Gynecologic oncology
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-11
Subject
The topic of the resource
Animals; Carboplatin/*administration & dosage/pharmacology; Dose-Response Relationship; Drug; Injections; Intraperitoneal; Male; Postoperative Period; Rats; Sprague-Dawley; Tissue Adhesions/etiology; Wound Healing/*drug effects
Creator
An entity primarily responsible for making the resource
Hopkins M P; Shellhaas C; Clark T; Stakleff K S; Jenison E L
Description
An account of the resource
The effect of introducing intraperitoneal carboplatinum on wound healing immediately after wound closure was studied using a rat model. All animals were opened through a midline incision. A bowel anastomosis was then performed in a single-or two-layer fashion using 6-O suture. Immediately after closing the abdominal wall, each animal was percutaneously injected with either normal saline for controls (n = 11), or carboplatinum, 3 (n = 8), 9, (n = 19, or 12 mg/kg (n = 4). Abdominal and skin incisions were closed separately using 4-O silk suture. Animals were sacrificed 7 days postoperatively. Adhesions were blindly assessed on the following scale: 0 (no adhesions), 1 (filmy adhesions), 2 (firm adhesions), and 3 (dense adhesions). Anastomoses were assessed for leakage. Three centimeters of the incision were harvested to evaluate wound breaking strength. Analysis of abdominal wound breaking strengths showed control = 1320 g +/- 220, 3 mg = 1055 g +/- 155, 9 mg = 891 g +/- 127, and 12 mg = 594 g +/- 165 (P \textless 0.025). Evaluation for dense adhesions resulted in control = 27%, 3 mg/kg = 50%, 9 mg = 63%, and 12 mg = 100% (P \textless 0.0001). Immediate instillation of intraperitoneal carboplatinum had a significant effect on wound healing with a decrease in abdominal tensile strength directly related to the dose instilled. It also had a significant effect on adhesion formation with a higher dose leading to a higher incidence of adhesion formation. Based on animal model data, it appears that the immediate instillation of intraperitoneal carboplatinum at the time of laparotomy incision closure could lead to significant problems with wound strength and adhesion formation.
Identifier
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<a href="http://doi.org/10.1006/gyno.1993.1274" target="_blank" rel="noreferrer noopener">10.1006/gyno.1993.1274</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1993
Animals
Carboplatin/*administration & dosage/pharmacology
Clark T
Dose-Response Relationship
Drug
Gynecologic oncology
Hopkins M P
Injections
Intraperitoneal
Jenison E L
Male
Postoperative Period
Rats
Shellhaas C
Sprague-Dawley
Stakleff K S
Tissue Adhesions/etiology
Wound Healing/*drug effects
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
29-30
Volume
110
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Dublin Core
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Title
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CORRELATION OF DRAIN CREATININE VALUE WITH CYSTOGRAM FINDINGS AFTER ROBOTIC ASSISTED LAPAROSCOPIC PROSTATECTOMY
Publisher
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Bju International
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-10
Subject
The topic of the resource
Urology & Nephrology
Creator
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Nething J B; Patel K N; Dave C N; Stakleff K S; Ricchiuti D J
Identifier
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n/a
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Journal Article
2012
Bju International
Dave C N
Journal Article
Nething J B
Patel K N
Ricchiuti D J
Stakleff K S
Urology & Nephrology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.jvsv.2012.07.012" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jvsv.2012.07.012</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
68-74
Issue
1
Volume
1
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Title
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Evaluation Of Embolic Protection Devices For Fat Emboli Prevention
Publisher
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Journal of Vascular Surgery-Venous and Lymphatic Disorders
Date
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2013
2013-01
Subject
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Cardiovascular System & Cardiology; Surgery
Creator
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Lanzinger W; Caldwell J; Schoenfeld A; Horne W; Sloan P; Stakleff K S; Zink J; Netzley R; Wright D
Description
An account of the resource
Background: Patients with acutely treated femoral shaft fractures with reamed intramedullary nailing are at risk for acute respiratory distress syndrome due to liberation of bone marrow fat particles that travel to the lung and cause damage to the parenchyma. The purpose of this study was to demonstrate: (1) the ability of clinically applicable embolic protection devices to capture such particles; (2) how such a device affects cardiopulmonary function after reamed intramedullary nailing; and (3) evaluation of lung pathology to determine whether filtration affects pulmonary embolic load. Methods: A total of 12 canines were anesthetized, and hemodynamic monitoring was established. Carotid embolic protection devices were introduced into the iliac vein, and ipsilateral intramedullary reaming and nailing was performed. Cardiopulmonary parameters were recorded at timed intervals up to 60 minutes after the procedure. The control group (n = 4) was compared with groups treated with Accunet (n = 4) and Spider (n = 4) filters. A blinded histopathological review was performed on lung specimens to determine the average number of emboli per section and to measure the area (mm(2)) of embolic load by digital image analysis. Results: Gross inspection of the embolic protection devices showed the presence of bone marrow debris. A significant change was observed in pH levels (control = -0.052, filters = +0.005; P < .05) within the 60 minutes after intramedullary nailing. Serum bicarbonate (meq/dL) values were noted to have similar changes of -2.7 and -1.8 at 10 and 60 minutes, whereas the experimental group was +0.6 and +0.8 at the same time intervals (P = .01 and .0004, respectively). Pulmonary measurements for pO(2) and oxygen saturation were analogous to the serum parameters with decreases in the control group in comparison with the filter groups. The mean numbers of emboli and area measurements of embolic load were significantly reduced in the filter group (all P < .01). Conclusions: Embolic protection devices were effective in capturing embolic debris from reamed intramedullary nailing of lower extremity long bones and demonstrated a protective effect on pulmonary function and significantly decreased the number and size of emboli in the lung. Based on these findings, patients with long bone fractures at risk for pulmonary complications and acute respiratory distress syndrome could benefit from the placement of embolic protection devices prior to intramedullary fixation. While this study utilized filtration devices designed for carotid embolic protection, further study is warranted to determine optimal filter design in this setting.
Identifier
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<a href="http://doi.org/10.1016/j.jvsv.2012.07.012" target="_blank" rel="noreferrer noopener">10.1016/j.jvsv.2012.07.012</a>
Format
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Journal Article or Conference Abstract Publication
2013
Caldwell J
Cardiovascular System & Cardiology
Horne W
Journal Article or Conference Abstract Publication
Journal of Vascular Surgery-Venous and Lymphatic Disorders
Lanzinger W
Netzley R
Schoenfeld A
Sloan P
Stakleff K S
Surgery
Wright D
Zink J