1 40 2 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1097/00054725-200604002-00040" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/00054725-200604002-00040</a> Rights Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Pages S20-S20 Volume 12 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Reduced paneth cell alpha-defensins and antimicrobial activity in ileal Crohn's disease Publisher An entity responsible for making the resource available Inflammatory Bowel Diseases Date A point or period of time associated with an event in the lifecycle of the resource 2006 2006-04 Subject The topic of the resource Gastroenterology & Hepatology Creator An entity primarily responsible for making the resource Wehkamp J; Salzman N H; Porter E; Nuding S; Weichenthal M; Petras R E; Schaeffeler E; Schwab M; Linzmeier R; Feathers R W; Chu H T; Lima H; Fellermann K; Ganz T; Stange E F; Bevins C L Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1097/00054725-200604002-00040" target="_blank" rel="noreferrer noopener">10.1097/00054725-200604002-00040</a> Format The file format, physical medium, or dimensions of the resource Journal Article 2006 Bevins C L Chu H T Feathers R W Fellermann K Ganz T Gastroenterology & Hepatology Inflammatory Bowel Diseases Journal Article Lima H Linzmeier R Nuding S Petras R E Porter E Salzman N H Schaeffeler E Schwab M Stange E F Wehkamp J Weichenthal M Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1073/pnas.0505256102" target="_blank" rel="noreferrer noopener">http://doi.org/10.1073/pnas.0505256102</a> Rights Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Pages 18129-18134 Issue 50 Volume 102 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Reduced Paneth cell alpha-defensins in ileal Crohn's disease Publisher An entity responsible for making the resource available Proceedings of the National Academy of Sciences of the United States of America Date A point or period of time associated with an event in the lifecycle of the resource 2005 2005-12 Subject The topic of the resource bacteria; expression; gene; human intestinal defensin; inflammatory bowel disease; inflammatory bowel disease; innate; innate immunity; intestine; mechanisms; microflora; mutations; peptides; Science & Technology - Other Topics Creator An entity primarily responsible for making the resource Wehkamp J; Salzman N H; Porter E; Nuding S; Weichenthal M; Petras R E; Shen B; Schaeffeler E; Schwab M; Linzmeier R; Feathers R W; Chu H T; Lima H; Fellermann K; Ganz T; Stange E F; Bevins C L Description An account of the resource The pathogenesis of Crohn's disease (CD), an idiopathic inflammatory bowel disease, is attributed, in part, to intestinal bacteria that may initiate and perpetuate mucosal inflammation in genetically susceptible individuals. Paneth cells (PC) are the major source of antimicrobial peptides in the small intestine, including human alpha-defensins HD5 and HD6. We tested the hypothesis that reduced expression of PC alpha-defensins compromises mucosal host defenses and predisposes patients to CD of the ileum. We report that patients with CID of the ileum have reduced antibacterial activity in their intestinal mucosal extracts. These specimens also showed decreased expression of PC alpha-defensins, whereas the expression of eight other PC products either remained unchanged or increased when compared with controls. The specific decrease of alpha-defensins was independent of the degree of inflammation in the specimens and was not observed in either CD of the colon, ulcerative colitis, or pouchitis. The functional consequence of alpha-defensin expression levels was examined by using a transgenic mouse model, where we found changes in HD5 expression levels, comparable to those observed in CD, had a pronounced impact on the luminal microbiota. Thus, the specific deficiency of PC defensins that characterizes ileal CD may compromise innate immune defenses of the ileal mucosa and initiate and/or perpetuate this disease. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1073/pnas.0505256102" target="_blank" rel="noreferrer noopener">10.1073/pnas.0505256102</a> Format The file format, physical medium, or dimensions of the resource Journal Article 2005 Bacteria Bevins C L Chu H T expression Feathers R W Fellermann K Ganz T gene human intestinal defensin inflammatory bowel disease Innate Innate immunity Intestine Journal Article Lima H Linzmeier R mechanisms microflora mutations Nuding S Peptides Petras R E Porter E Proceedings of the National Academy of Sciences of the United States of America Salzman N H Schaeffeler E Schwab M Science & Technology - Other Topics Shen B Stange E F Wehkamp J Weichenthal M