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Text
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URL Address
<a href="http://doi.org/10.1016/s0165-0270(00)00161-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0165-0270(00)00161-8</a>
Pages
31–35
Issue
1
Volume
97
Dublin Core
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Title
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Secure cranial-mount intrathecal cannulation - a spinal administration technique in the rat.
Publisher
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Journal of neuroscience methods
Date
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2000
2000-04
Subject
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Analgesics; Anesthesia; Animals; Dose-Response Relationship; Drug; Injections; Microinjections; Morphine/administration & dosage/pharmacology; Opioid/administration & dosage/pharmacology; Rats; Spinal Cord/*physiology; Spinal/*instrumentation; Sprague-Dawley; Stereotaxic Techniques/*instrumentation
Creator
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Schechter J B; Crisp T
Description
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In order to identify an acute spinally mediated pharmacological effect of a bioactive substance, without incurring untoward supraspinal effects, it is necessary to administer the agent locally onto the spinal cord. The procedure delineated herein presents a modern technique to install a stable, permanent indwelling thecal cannulae with a cranially mounted aperture, and details a simple, repeatable administration system. These methods facilitate a quick, noninvasive spinal drug microadministration that is most useful for differentiation of the locus of pharmacological action without the behavioral disruption associated with other administration methodologies.
Identifier
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<a href="http://doi.org/10.1016/s0165-0270(00)00161-8" target="_blank" rel="noreferrer noopener">10.1016/s0165-0270(00)00161-8</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2000
Analgesics
Anesthesia
Animals
Crisp T
Dose-Response Relationship
Drug
Injections
Journal of neuroscience methods
Microinjections
Morphine/administration & dosage/pharmacology
Opioid/administration & dosage/pharmacology
Rats
Schechter J B
Spinal Cord/*physiology
Spinal/*instrumentation
Sprague-Dawley
Stereotaxic Techniques/*instrumentation