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Text
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URL Address
<a href="http://doi.org/10.1016/j.ctrv.2009.10.002" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ctrv.2009.10.002</a>
Pages
43–53
Issue
1
Volume
36
Dublin Core
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Title
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Resveratrol in the chemoprevention and treatment of hepatocellular carcinoma.
Publisher
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Cancer treatment reviews
Date
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2010
2010-02
Subject
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Anticarcinogenic Agents/*therapeutic use; Antineoplastic Agents – Therapeutic Use; Carcinoma; Hepatocellular – Drug Therapy; Hepatocellular – Prevention and Control; Hepatocellular/*drug therapy/*prevention & control; Humans; Liver Neoplasms – Drug Therapy; Liver Neoplasms – Prevention and Control; Liver Neoplasms/*drug therapy/*prevention & control; Resveratrol; Stilbenes – Therapeutic Use; Stilbenes/*therapeutic use
Creator
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Bishayee Anupam; Politis Themos; Darvesh Altaf S
Description
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Hepatocellular carcinoma (HCC) is one of the most common cancers and lethal diseases in the world. Although the majority of HCC cases occur in developing countries of Asia and Africa, the prevalence of liver cancer has risen considerably in Japan, Western Europe as well as the United States. HCC most commonly develops in patients with chronic liver disease, the etiology of which includes viral hepatitis (B and C), alcohol, obesity, iron overload and dietary carcinogens, including aflatoxins and nitrosamines. The current treatment modalities, including surgical resection and liver transplantation, have been found to be mostly ineffective. Hence, there is an obvious critical need to develop alternative strategies for the chemoprevention and treatment of HCC. Oxidative stress as well as inflammation has been implicated in the development and progression of hepatic neoplasia. Using naturally occurring phytochemicals and dietary compounds endowed with potent antioxidant and antiinflammatory properties is a novel approach to prevent and control HCC. One such compound, resveratrol, present in grapes, berries, peanuts as well as red wine, has emerged as a promising molecule that inhibits carcinogenesis with a pleiotropic mode of action. This review examines the current knowledge on mechanism-based in vitro and in vivo studies on the chemopreventive and chemotherapeutic potential of resveratrol in liver cancer. Pre-clinical and clinical toxicity studies as well as pharmacokinetic data of resveratrol have also been highlighted in this review. Future directions and challenges involved in the use of resveratrol for the prevention and treatment of HCC are also discussed.
Identifier
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<a href="http://doi.org/10.1016/j.ctrv.2009.10.002" target="_blank" rel="noreferrer noopener">10.1016/j.ctrv.2009.10.002</a>
Rights
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2010
Anticarcinogenic Agents/*therapeutic use
Antineoplastic Agents – Therapeutic Use
Bishayee Anupam
Cancer treatment reviews
Carcinoma
Darvesh Altaf S
Department of Pharmaceutical Sciences
Hepatocellular – Drug Therapy
Hepatocellular – Prevention and Control
Hepatocellular/*drug therapy/*prevention & control
Humans
Liver Neoplasms – Drug Therapy
Liver Neoplasms – Prevention and Control
Liver Neoplasms/*drug therapy/*prevention & control
NEOMED College of Pharmacy
Politis Themos
Resveratrol
Stilbenes – Therapeutic Use
Stilbenes/*therapeutic use