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Text
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Pages
277–279
Issue
2
Volume
90
Dublin Core
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Title
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Randomized comparison of gastric pH control with intermittent and continuous intravenous infusion of famotidine in ICU patients.
Publisher
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The American journal of gastroenterology
Date
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1995
1995-02
Subject
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Female; Humans; Male; Middle Aged; Aged; Treatment Outcome; Prospective Studies; Analysis of Variance; Double-Blind Method; Hydrogen-Ion Concentration; Intensive Care Units; Drug Administration Schedule; Famotidine/administration & dosage/*therapeutic use; Stomach Ulcer/blood/etiology/*prevention & control; Stomach/*drug effects/physiopathology; Infusions; Intravenous
Creator
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Heiselman D E; Hulisz D T; Fricker R; Bredle D L; Black L D
Description
An account of the resource
OBJECTIVE: To compare gastric pH control using intravenous famotidine as a primed, continuous infusion versus intermittent infusion. METHODS: In a prospective, double-blind study, 40 ICU patients at risk for stress ulceration were randomly assigned to receive either famotidine 20 mg intravenous bolus followed by 1.67 mg/h infusion or famotidine 20 mg intravenously every 12 h. Intraluminal gastric pH was recorded at baseline and every 4 h using a glass electrode. Clinical outcome indicators were also monitored. Subjects were studied for a minimum of 24 h and a maximum of 6 days. Continuous variables were analyzed by ANOVA and nominal variables by Fisher's exact test (alpha = 0.05). RESULTS: Nineteen patients were randomized to the continuous infusion group, and 21 were randomized to the intermittent group. Using gastric pH greater than 4.0 as an endpoint, the continuous group exhibited better pH control, both in terms of percentage of total measurements (83% versus 63%, p \textless 0.001) and time spent above pH 4.0 (91% versus 76%, p \textless 0.01). Similar results were found at pH greater than 5.0 (78% versus 56% for all measurements for the continuous and bolus groups, respectively (p \textless 0.001), and 88% versus 72% for the time spent above pH 5.0 (p \textless 0.01). Clinical outcomes, including evidence for gastrointestinal bleeding and hospital mortality, did not differ significantly between groups. CONCLUSION: Famotidine infusion at 1.67 mg/h, when preceded by a bolus dose of 20 mg, provides a greater and more sustained increase in gastric pH than intermittent administration of famotidine 20 mg every 12 h.
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
Aged
Analysis of Variance
Black L D
Bredle D L
Department of Internal Medicine
Double-Blind Method
Drug Administration Schedule
Famotidine/administration & dosage/*therapeutic use
Female
Fricker R
Heiselman D E
Hulisz D T
Humans
Hydrogen-Ion Concentration
Infusions
Intensive Care Units
Intravenous
Male
Middle Aged
NEOMED College of Medicine
Prospective Studies
Stomach Ulcer/blood/etiology/*prevention & control
Stomach/*drug effects/physiopathology
The American journal of gastroenterology
Treatment Outcome