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Text
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URL Address
<a href="http://doi.org/10.1080/10408398.2014.982243" target="_blank" rel="noreferrer noopener">http://doi.org/10.1080/10408398.2014.982243</a>
Pages
1753–1775
Issue
10
Volume
56
Dublin Core
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Title
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Potential Benefits of Edible Berries in the Management of Aerodigestive and Gastrointestinal Tract Cancers: Preclinical and Clinical Evidence.
Publisher
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Critical reviews in food science and nutrition
Date
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2016
2016-07
Subject
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aerodigestive and gastrointestinal tract; Animal; Animal Studies; Animals; Anthocyanins/analysis/pharmacology; Anticarcinogenic Agents/*analysis/pharmacology; Antineoplastic Agents – Analysis; Antineoplastic Agents – Pharmacodynamics; Benzopyrans – Analysis; Benzopyrans – Pharmacodynamics; Berry; Biological; cancer; chemoprevention; Clinical Trials; Clinical Trials as Topic; Digestion – Drug Effects; Digestion/drug effects; Disease Models; Ellagic Acid/analysis/pharmacology; Fruit; Fruit/*chemistry; Gastrointestinal Neoplasms – Prevention and Control; Gastrointestinal Neoplasms/*prevention & control; Human; Humans; Models; Phytochemicals – Analysis; Phytochemicals – Pharmacodynamics; Phytochemicals/analysis/pharmacology; Plant Extracts – Analysis; Plant Extracts – Pharmacodynamics; Plant Extracts/*analysis/pharmacology; Polyphenols – Analysis; Polyphenols – Pharmacodynamics; Polyphenols/analysis/pharmacology; treatment
Creator
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Bishayee Anupam; Haskell Yennie; Do Chau; Siveen Kodappully Sivaraman; Mohandas Nima; Sethi Gautam; Stoner Gary D
Description
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Epidemiological reports as well as experimental studies have demonstrated the significant health benefits provided by regular berry consumption. Berries possess both prophylactic and therapeutic potential against several chronic illnesses, such as cardiovascular, neurodegenerative, and neoplastic diseases. Berries owe their health benefits to phytoconstituents, such as polyphenolic anthocyanins, ellagic acid, and a diverse array of phytochemicals bestowed with potent antioxidant and anti-inflammatory effects as well as the ability to engage a multitude of signaling pathways. This review highlights the principal chemical constituents present in berries and their primary molecular targets. The article presents and critically analyzes the chemopreventive and therapeutic potential of berry extracts, fractions, and bioactive components on various cancers of the gastrointestinal tract (GIT), including esophageal, stomach, intestinal, and colorectal cancers as well as cancers of the upper aerodigestive tract, such as oral cancer. The current status of clinical studies evaluating berry products in several aforementioned cancers is presented. Various emerging issues including dose-ranging and dosage forms, the role of synergy and the usage of combination therapy as well as other relevant areas essential for the development of berry phytoconstituents as mainstream chemopreventive and therapeutic agents against aerodigestive and GIT cancers are critically discussed.
Identifier
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<a href="http://doi.org/10.1080/10408398.2014.982243" target="_blank" rel="noreferrer noopener">10.1080/10408398.2014.982243</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2016
aerodigestive and gastrointestinal tract
Animal
Animal Studies
Animals
Anthocyanins/analysis/pharmacology
Anticarcinogenic Agents/*analysis/pharmacology
Antineoplastic Agents – Analysis
Antineoplastic Agents – Pharmacodynamics
Benzopyrans – Analysis
Benzopyrans – Pharmacodynamics
Berry
Biological
Bishayee Anupam
Cancer
Chemoprevention
Clinical Trials
Clinical Trials as Topic
Critical reviews in food science and nutrition
Digestion – Drug Effects
Digestion/drug effects
Disease Models
Do Chau
Ellagic Acid/analysis/pharmacology
Fruit
Fruit/*chemistry
Gastrointestinal Neoplasms – Prevention and Control
Gastrointestinal Neoplasms/*prevention & control
Haskell Yennie
Human
Humans
Models
Mohandas Nima
Phytochemicals – Analysis
Phytochemicals – Pharmacodynamics
Phytochemicals/analysis/pharmacology
Plant Extracts – Analysis
Plant Extracts – Pharmacodynamics
Plant Extracts/*analysis/pharmacology
Polyphenols – Analysis
Polyphenols – Pharmacodynamics
Polyphenols/analysis/pharmacology
Sethi Gautam
Siveen Kodappully Sivaraman
Stoner Gary D
Treatment