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Text
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URL Address
<a href="http://doi.org/10.1016/s0196-9781(01)00593-9" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0196-9781(01)00593-9</a>
Pages
167–183
Issue
1
Volume
23
Dublin Core
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Title
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Sensory nerves and neuropeptides in uterine cervical ripening.
Publisher
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Peptides
Date
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2002
2002-01
Subject
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Animal; Animals; Calcitonin Gene-Related Peptide/biosynthesis; Capsaicin/pharmacology; Cervical Ripening/*metabolism; Cervix Uteri/*innervation/*metabolism; Complementary/metabolism; Female; Genetic; Immunohistochemistry; Labor; Messenger/metabolism; Neurokinin-1/biosynthesis; Neurons/metabolism; Neuropeptides/*biosynthesis; Nitric Oxide Synthase/biosynthesis; Obstetric; Plasmids/metabolism; Postpartum Period; Pregnancy; Rats; Receptors; RNA; Secretogranin II; Sprague-Dawley; Substance P/biosynthesis; Transcription
Creator
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Collins J J; Usip S; McCarson K E; Papka R E
Description
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At the time of parturition (fetal delivery) the uterine cervix must "ripen," becoming soft, pliable, and dilated to accommodate the fetus' delivery. The fundamental processes underlying cervical ripening remain poorly understood. Knowledge that abundant autonomic and sensory nerves supply the uterine cervix, that transection of afferent nerves supplying the cervix blocks parturition, and that some of the changes in the cervix resemble those seen in inflammatory reactions suggests nerves may have a role in the cervical ripening changes. The present study utilized immunohistochemistry, plasma extravasation, and solution hybridization-nuclease protection assay to elucidate the complement of primary afferent nerves and some receptors in the rat cervix during pregnancy, and to determine if they may have roles in the ripening process at term. This study revealed an abundance of nerves associated with the cervical vasculature and myometrial smooth muscle containing immunoreactivity for substance P, calcitonin gene-related peptide, secretoneurin, and nitric oxide synthase throughout pregnancy. Many of these are small unmyelinated capsaicin-sensitive C-fibers. Substance P- (NK1-) and calcitonin gene-related peptide receptors were apparent on uterine cervix vasculature from pregnant, parturient, and postpartum rats. NK1 receptor mRNA was maximal at 20 days of pregnancy. Plasma extravasation of i.v. administered Evans Blue or Monastral Blue was most pronounced at parturition (shortly after NK1 mRNA is maximal); this was similar to plasma extravasation evoked by i.v. administration of substance P or capsaicin-treatment. This study revealed new data about the nervous system of the rat uterine cervix and that these nerves and their transmitters could very well be part of a neurogenic inflammatory process involved in cervical ripening.
Identifier
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<a href="http://doi.org/10.1016/s0196-9781(01)00593-9" target="_blank" rel="noreferrer noopener">10.1016/s0196-9781(01)00593-9</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2002
Animal
Animals
Calcitonin Gene-Related Peptide/biosynthesis
Capsaicin/pharmacology
Cervical Ripening/*metabolism
Cervix Uteri/*innervation/*metabolism
Collins J J
Complementary/metabolism
Department of Anatomy & Neurobiology
Female
Genetic
Immunohistochemistry
Labor
McCarson K E
Messenger/metabolism
NEOMED College of Medicine
Neurokinin-1/biosynthesis
Neurons/metabolism
Neuropeptides/*biosynthesis
Nitric Oxide Synthase/biosynthesis
Obstetric
Papka R E
Peptides
Plasmids/metabolism
Postpartum Period
Pregnancy
Rats
Receptors
RNA
Secretogranin II
Sprague-Dawley
Substance P/biosynthesis
Transcription
Usip S