1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neuroscience.2004.09.033" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuroscience.2004.09.033</a>
Pages
369–382
Issue
2
Volume
130
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effects of neonatal and prepubertal hormonal manipulations upon estrogen neuroprotection of the nigrostriatal dopaminergic system within female and male mice.
Publisher
An entity responsible for making the resource available
Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
1905-06
Subject
The topic of the resource
*Sex Characteristics; Aging/metabolism; Animal; Animals; Disease Models; Dopamine/metabolism; Estrogens/metabolism/*pharmacology; Female; Gonads/growth & development/metabolism; Male; Methamphetamine/antagonists & inhibitors/toxicity; Mice; Neostriatum/*drug effects/metabolism/physiopathology; Neural Pathways/drug effects/metabolism/physiopathology; Neuroprotective Agents/metabolism/*pharmacology; Newborn; Orchiectomy; Ovariectomy; Sexual Maturation/physiology; Substantia Nigra/*drug effects/metabolism/physiopathology; Testosterone/metabolism/*pharmacology
Creator
An entity primarily responsible for making the resource
Anderson L I; Leipheimer R E; Dluzen D E
Description
An account of the resource
Estrogen (E) can function as a neuroprotectant of the nigrostriatal dopaminergic (NSDA) system against methamphetamine (MA) neurotoxicity in female, but not male, mice. In the present report we examined whether the organizational effects of gonadal steroid hormones, as exerted in the early postnatal period, or developmental effects, as exerted during the pubertal period, would contribute to this sexually dimorphic neuroprotectant action of E. Neonatal gonadectomy and treatment with testosterone of female mice, retained the ability to show an E neuroprotectant response when tested as adults. However, females not treated with gonadal steroids failed to show an E-dependent neuroprotectant response. Neonatal gonadectomy of male mice, failed to result in the display of an E neuroprotectant response when tested as adults. Prepubertal gonadectomy of female mice, with or without testosterone treatment, abolished the capacity for E to produce neuroprotection against MA-induced NSDA neurotoxicity. Nor did prepubertal gonadectomy enable male mice to show an E neuroprotectant response. Taken together these results demonstrate that none of the manipulations performed within male mice enabled them to show an E-dependent neuroprotective response against MA-induced neurotoxicity of the NSDA system when tested as adults. For the female, it appears that the presences of gonadal steroids at these two developmental periods are needed for the display of an E-dependent neuroprotectant response within the adult.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neuroscience.2004.09.033" target="_blank" rel="noreferrer noopener">10.1016/j.neuroscience.2004.09.033</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sex Characteristics
2005
Aging/metabolism
Anderson L I
Animal
Animals
Disease Models
Dluzen D E
Dopamine/metabolism
Estrogens/metabolism/*pharmacology
Female
Gonads/growth & development/metabolism
Leipheimer R E
Male
Methamphetamine/antagonists & inhibitors/toxicity
Mice
Neostriatum/*drug effects/metabolism/physiopathology
Neural Pathways/drug effects/metabolism/physiopathology
Neuroprotective Agents/metabolism/*pharmacology
Neuroscience
Newborn
Orchiectomy
Ovariectomy
Sexual Maturation/physiology
Substantia Nigra/*drug effects/metabolism/physiopathology
Testosterone/metabolism/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s00702-003-0045-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00702-003-0045-3</a>
Pages
1215–1224
Issue
11
Volume
110
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Acute effects of estrogen upon methamphetamine induced neurotoxicity of the nigrostriatal dopaminergic system.
Publisher
An entity responsible for making the resource available
Journal of neural transmission (Vienna, Austria : 1996)
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-11
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/metabolism; Animals; Dopamine/metabolism; Drug Interactions; Estrogens/metabolism/*pharmacology; Female; Methamphetamine/antagonists & inhibitors/*toxicity; Mice; Neostriatum/*drug effects/metabolism/physiopathology; Neural Pathways/*drug effects/metabolism/physiopathology; Neuroprotective Agents/metabolism/pharmacology; Neurotoxins/antagonists & inhibitors/toxicity; Ovariectomy; Parkinson Disease/drug therapy/metabolism/physiopathology; Presynaptic Terminals/drug effects/metabolism; Reaction Time/drug effects/physiology; Sex Factors; Substantia Nigra/*drug effects/metabolism/physiopathology
Creator
An entity primarily responsible for making the resource
Gajjar T M; Anderson L I; Dluzen D E
Description
An account of the resource
Estrogen acts as a neuroprotectant of the nigrostriatal dopaminergic system when given chronically to female mice prior to Methamphetamine (MA) insult. In this report, we tested the acute effects of Estradiol Benzoate (EB-10 microg in Oil) in ovariectomized CD-1 mice to function as a neuroprotectant when administered prior to (Experiment 1) or after (Experiment 2) MA treatment. Striatal dopamine (DA) concentrations and DOPAC/DA ratios were measured to assess the neuroprotective effects of EB. In Experiment 1, we observed that EB exerted a neuroprotective effect upon striatal dopamine concentrations when administered at 24 and 12, but not at 0.5, hours prior to MA injection and upon DOPAC/DA ratios when administered at 24, 12 and 0.5 hours prior to MA. In Experiment 2, no evidence for estrogen to protect the striatum from MA insult was obtained when EB was administered at 15, 30, 60 or 120 minutes after MA. These results show that EB can act as a modulator of MA-induced nigrostriatal dopaminergic neurotoxicity suggestive of a neuroprotectant, when administered within 0.5 hour of MA insult as assessed by measures of DOPAC/DA, but fails to prevent depletion of DA when given after MA insult. The data suggest that estrogen may exert this rapid neuroprotective effect through a non-genomic mechanism.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s00702-003-0045-3" target="_blank" rel="noreferrer noopener">10.1007/s00702-003-0045-3</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2003
3
4-Dihydroxyphenylacetic Acid/metabolism
Anderson L I
Animals
Dluzen D E
Dopamine/metabolism
Drug Interactions
Estrogens/metabolism/*pharmacology
Female
Gajjar T M
Journal of neural transmission (Vienna, Austria : 1996)
Methamphetamine/antagonists & inhibitors/*toxicity
Mice
Neostriatum/*drug effects/metabolism/physiopathology
Neural Pathways/*drug effects/metabolism/physiopathology
Neuroprotective Agents/metabolism/pharmacology
Neurotoxins/antagonists & inhibitors/toxicity
Ovariectomy
Parkinson Disease/drug therapy/metabolism/physiopathology
Presynaptic Terminals/drug effects/metabolism
Reaction Time/drug effects/physiology
Sex Factors
Substantia Nigra/*drug effects/metabolism/physiopathology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/syn.20307" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/syn.20307</a>
Pages
354–361
Issue
5
Volume
60
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effect of estrogen upon methamphetamine-induced neurotoxicity within the impaired nigrostriatal dopaminergic system.
Publisher
An entity responsible for making the resource available
Synapse (New York, N.Y.)
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-10
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/metabolism; Adrenergic Uptake Inhibitors/antagonists & inhibitors/toxicity; Animal; Animals; Corpus Striatum/*drug effects/metabolism/physiopathology; Disease Models; Dopamine/metabolism; Estrogens/metabolism/*pharmacology/therapeutic use; Female; Male; Methamphetamine/*antagonists & inhibitors/toxicity; Mice; Nerve Degeneration/chemically induced/*drug therapy/prevention & control; Neural Pathways/drug effects/metabolism/physiopathology; Neuroprotective Agents/metabolism/*pharmacology/therapeutic use; Neurotoxins/antagonists & inhibitors/toxicity; Orchiectomy; Ovariectomy; Parkinsonian Disorders/*drug therapy/physiopathology/prevention & control; Substantia Nigra/*drug effects/metabolism/physiopathology
Creator
An entity primarily responsible for making the resource
Liu Bin; Dluzen Dean E
Description
An account of the resource
In the present study, we investigated whether estrogen remains effective as a neuroprotectant within an impaired nigrostriatal dopaminergic (NSDA) system of gonadectomized female and male mice. In Experiment 1, mice were treated with four different regimens of methamphetamine (MA) to establish a protocol for an impaired NSDA system to be used in subsequent experiments. Based upon the results of Experiment 1, in Experiment 2 gonadectomized female mice received a treatment with either control (saline), low- or high-dose of MA to produce an initial NSDA impairment. At one week post-MA, mice received either estradiol benzoate (10 microg) or vehicle followed 24 h later with low-MA or saline. Estrogen altered the toxic effects of the second invasion of MA as indicated by a significant decrease in striatal dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations. In addition, DA and DOPAC depletion was greater in high- vs. low-dose MA. In gonadectomized male mice (Experiment 3), striatal DA and DOPAC concentrations showed greater decreases following high-, vs. low-doses of MA; however, estrogen did not alter these responses. These results demonstrate that the capacity for estrogen to protect or worsen MA-induced neurotoxicity of dopaminergic neurons is limited to female mice and depends on the condition of the NSDA system.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/syn.20307" target="_blank" rel="noreferrer noopener">10.1002/syn.20307</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2006
3
4-Dihydroxyphenylacetic Acid/metabolism
Adrenergic Uptake Inhibitors/antagonists & inhibitors/toxicity
Animal
Animals
Corpus Striatum/*drug effects/metabolism/physiopathology
Disease Models
Dluzen Dean E
Dopamine/metabolism
Estrogens/metabolism/*pharmacology/therapeutic use
Female
Liu Bin
Male
Methamphetamine/*antagonists & inhibitors/toxicity
Mice
Nerve Degeneration/chemically induced/*drug therapy/prevention & control
Neural Pathways/drug effects/metabolism/physiopathology
Neuroprotective Agents/metabolism/*pharmacology/therapeutic use
Neurotoxins/antagonists & inhibitors/toxicity
Orchiectomy
Ovariectomy
Parkinsonian Disorders/*drug therapy/physiopathology/prevention & control
Substantia Nigra/*drug effects/metabolism/physiopathology
Synapse (New York, N.Y.)