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Text
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URL Address
<a href="http://doi.org/10.1016/0361-9230(92)90153-o" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0361-9230(92)90153-o</a>
Pages
843–846
Issue
6
Volume
29
Dublin Core
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Title
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Increases in the locomotor activity of rats after intracerebral administration of cathinone.
Publisher
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Brain research bulletin
Date
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1992
1992-12
Subject
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Alkaloids/administration & dosage/*pharmacology; Animals; Cerebral Ventricles/drug effects/*physiology; Dose-Response Relationship; Drug; Injections; Intraventricular; Male; Motor Activity/*drug effects; Nucleus Accumbens/drug effects/*physiology; Psychotropic Drugs/administration & dosage/*pharmacology; Rats; Sprague-Dawley; Stereotaxic Techniques; Substantia Nigra/drug effects/*physiology
Creator
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Calcagnetti D J; Schechter M D
Description
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There is a widespread practice among people living in Eastern Africa and Southern Arabia of chewing the leaves of the Khat shrub so as to produce pharmacological effects that are practically indistinguishable from those produced by amphetamine (AMPH). Cathinone (CATH) has been identified as the psychostimulant constituent of this plant and, although the locomotor elevating effects of centrally administered AMPH and cocaine (COC) in rats are well known, there is a paucity of data regarding CATH. Three experiments were, therefore, conducted to measure locomotor activity following central administration of CATH in rats. The first experiment determined the dose-dependent effects of CATH on activity following intracerebroventricular (ICV) administration. As psychostimulant effects are believed, at least in part, to be mediated by dopaminergic systems, in Experiment 2 CATH was injected into the dopamine nerve terminals of the nucleus accumbens. Experiment 3 examined the effects of CATH injection into the dopamine cell body region of the substantia nigra, and activity was measured. Results of the ICV injection of CATH revealed a dose-dependent increase of activity. The highest dose tested (64 micrograms) yielded a 117% increase in activity when compared to baseline, whereas a 20 micrograms bilateral nucleus accumbens (NA) injection of CATH increased activity fivefold. These findings evidence the hypothesis that the effects of CATH are dopaminergically mediated. Substantia nigra (SN) injections of CATH were without effect.
Identifier
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<a href="http://doi.org/10.1016/0361-9230(92)90153-o" target="_blank" rel="noreferrer noopener">10.1016/0361-9230(92)90153-o</a>
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1992
Alkaloids/administration & dosage/*pharmacology
Animals
Brain research bulletin
Calcagnetti D J
Cerebral Ventricles/drug effects/*physiology
Dose-Response Relationship
Drug
Injections
Intraventricular
Male
Motor Activity/*drug effects
Nucleus Accumbens/drug effects/*physiology
Psychotropic Drugs/administration & dosage/*pharmacology
Rats
Schechter M D
Sprague-Dawley
Stereotaxic Techniques
Substantia Nigra/drug effects/*physiology