1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neulet.2004.01.061" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neulet.2004.01.061</a>
Pages
135–138
Issue
3
Volume
359
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The effect of gender and the neurotrophin, BDNF, upon methamphetamine-induced neurotoxicity of the nigrostriatal dopaminergic system in mice.
Publisher
An entity responsible for making the resource available
Neuroscience letters
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-04
Subject
The topic of the resource
Animals; Brain-Derived Neurotrophic Factor/deficiency/genetics/*metabolism; Central Nervous System Stimulants/poisoning; Corpus Striatum/*drug effects/*metabolism; Dopamine/*metabolism; Dose-Response Relationship; Drug; Female; Humans; Male; Methamphetamine/*poisoning; Mice; Mutation; Neurotoxicity Syndromes/*etiology/*metabolism; Sex Factors; Structure-Activity Relationship; Substantia Nigra/drug effects/metabolism; Transgenic
Creator
An entity primarily responsible for making the resource
Dluzen Dean E
Description
An account of the resource
The interactive effects between gender and a selective alteration in the neurotrophin, brain-derived neurotrophic factor (BDNF) upon methamphetamine (MA)-induced neurotoxicity of the nigrostriatal dopaminergic (NSDA) system were assessed. MA treatment produced a greater degree of NSDA neurotoxicity (indicated by greater reductions in corpus striatal dopamine levels) in wild type control BDNF male versus female mice. This sex difference was unaltered in heterozygous mutant BDNF (BDNF +/-) mice and in mice which overexpress BDNF (DBH:BDNF +). Both BDNF mutant conditions resulted in preservation of corpus striatal dopamine levels following MA treatment as compared with their respective MA-treated wild type controls. The relative amount of this preservation was greater in male BDNF mutants, with values being significantly greater than females in the BDNF +/- condition. These results suggest that alterations in BDNF do not alter basic gender differences in MA-induced NSDA neurotoxicity, but may produce a neuroprotection against MA which is relatively greater in males.
Identifier
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<a href="http://doi.org/10.1016/j.neulet.2004.01.061" target="_blank" rel="noreferrer noopener">10.1016/j.neulet.2004.01.061</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2004
Animals
Brain-Derived Neurotrophic Factor/deficiency/genetics/*metabolism
Central Nervous System Stimulants/poisoning
Corpus Striatum/*drug effects/*metabolism
Dluzen Dean E
Dopamine/*metabolism
Dose-Response Relationship
Drug
Female
Humans
Male
Methamphetamine/*poisoning
Mice
Mutation
Neuroscience letters
Neurotoxicity Syndromes/*etiology/*metabolism
Sex Factors
Structure-Activity Relationship
Substantia Nigra/drug effects/metabolism
Transgenic
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s00702-007-0017-0" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00702-007-0017-0</a>
Pages
809–817
Issue
6
Volume
115
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Sex differences in striatal dopaminergic function within heterozygous mutant dopamine transporter knock-out mice.
Publisher
An entity responsible for making the resource available
Journal of neural transmission (Vienna, Austria : 1996)
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-06
Subject
The topic of the resource
*Sex Characteristics; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Animals; Brain/drug effects/*metabolism; Corpus Striatum/drug effects/*metabolism; Dopamine Plasma Membrane Transport Proteins/*genetics; Dopamine Uptake Inhibitors/pharmacology; Dopamine/*metabolism; Down-Regulation/drug effects/genetics; Female; Gene Expression Regulation/drug effects/genetics; Heterozygote; Knockout; Male; Methamphetamine/pharmacology; Mice; Mutation/*genetics; Neural Pathways/drug effects/metabolism; Potassium Chloride/metabolism/pharmacology; Substantia Nigra/drug effects/metabolism; Synaptic Transmission/drug effects/genetics; Up-Regulation/drug effects/genetics
Creator
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Ji Jing; Dluzen Dean E
Description
An account of the resource
The issue of whether a deletion of the dopamine transporter (DAT) allele (+/- DAT) would differentially alter striatal dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) concentrations and DA release upon potassium and methamphetamine (MA) stimulation between male and female mice was examined. Striatal DA and DOPAC concentrations of female +/- DAT mice were significantly decreased as compared with wild type (+/+) controls and male +/- DAT mice. No such changes were obtained from the olfactory tubercle suggesting that these effects might be specific for the striatum. Potassium-stimulated DA was increased in male and female +/- DAT mice and maximally stimulated DA was obtained from +/- DAT females, although these mice showed the lowest DA concentrations. MA-evoked DA was increased in male and female +/- mice. While MA-evoked DA was significantly increased in +/+ males versus +/+ females, the +/- females showed the highest DA responses, thereby showing a reversal in the results seen in wild-type conditions. These findings indicate: (1) that a deficiency in the DAT interacts with the sex of the subject, (2)+/- DAT females show more extreme changes in dopaminergic responses, and (3) the importance for considering such variables such as sex when examining differences among knock-out conditions.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s00702-007-0017-0" target="_blank" rel="noreferrer noopener">10.1007/s00702-007-0017-0</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sex Characteristics
2008
3
4-Dihydroxyphenylacetic Acid/metabolism
Animals
Brain/drug effects/*metabolism
Corpus Striatum/drug effects/*metabolism
Dluzen Dean E
Dopamine Plasma Membrane Transport Proteins/*genetics
Dopamine Uptake Inhibitors/pharmacology
Dopamine/*metabolism
Down-Regulation/drug effects/genetics
Female
Gene Expression Regulation/drug effects/genetics
Heterozygote
Ji Jing
Journal of neural transmission (Vienna, Austria : 1996)
Knockout
Male
Methamphetamine/pharmacology
Mice
Mutation/*genetics
Neural Pathways/drug effects/metabolism
Potassium Chloride/metabolism/pharmacology
Substantia Nigra/drug effects/metabolism
Synaptic Transmission/drug effects/genetics
Up-Regulation/drug effects/genetics
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/BF01271190" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/BF01271190</a>
Pages
1295–1305
Issue
11
Volume
103
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
L-DOPA modulation of corpus striatal dopamine and dihydroxyphenylacetic acid output from intact and 6-OHDA lesioned rats.
Publisher
An entity responsible for making the resource available
Journal of neural transmission (Vienna, Austria : 1996)
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1905-06
Subject
The topic of the resource
*Sympathectomy; 3; 4-Dihydroxyphenylacetic Acid/*metabolism; Animals; Antiparkinson Agents/*pharmacology; Chemical; Corpus Striatum/drug effects/*metabolism; Dopamine/*metabolism; Levodopa/*pharmacology; Male; Oxidopamine; Rats; Sprague-Dawley; Substantia Nigra/drug effects/metabolism
Creator
An entity primarily responsible for making the resource
Xu K; Dluzen D E
Description
An account of the resource
In the present report we examined the differences in in vitro dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) efflux from the corpus striatum (CS) of intact versus 6-hydroxydopamine (6-OHDA) lesioned (in substantia nigra) male rats in response to different doses of two pulse infusions of L-dihydroxyphenylalanine (L-DOPA). In the first experiment, we tested the effects of two 20-min infusions of 5 uM L-DOPA. In the second experiment we repeated this protocol using 50 uM
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/BF01271190" target="_blank" rel="noreferrer noopener">10.1007/BF01271190</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sympathectomy
1996
3
4-Dihydroxyphenylacetic Acid/*metabolism
Animals
Antiparkinson Agents/*pharmacology
Chemical
Corpus Striatum/drug effects/*metabolism
Dluzen D E
Dopamine/*metabolism
Journal of neural transmission (Vienna, Austria : 1996)
Levodopa/*pharmacology
Male
Oxidopamine
Rats
Sprague-Dawley
Substantia Nigra/drug effects/metabolism
Xu K