Intravenous infusion of iPSC-derived neural progenitors expressing GCase ameliorates alpha-synuclein aggregates in a mouse model of Gaucher disease
Endocrinology & Metabolism; Genetics & Heredity; medicine; Research & Experimental
Peng Y Y; Liou B; Inskeep V; Blackwood R; Fleming S; Mayhew C N; Sun Y
Molecular Genetics and Metabolism
2019
2019-02
Journal Article
<a href="http://doi.org/10.1016/j.ymgme.2018.12.295" target="_blank" rel="noreferrer noopener">10.1016/j.ymgme.2018.12.295</a>
Physicochemical characterization of liquid crystalline phases in model bile and lipid digestive mixtures: A H-2 NMR study
Crystallography
Phase properties of aqueous dispersions of model bile mixtures containing cholesterol, lecithin and bile salts and model mixed lipid digestive mixtures containing cholesterol, fatty acid, monoglyceride, lecithin and bile salts have been characterized by H-2 NMR. We have chemically incorporated a deuteriomethyl (CD3) group into one or two lipid components and utilized differences in motionally-averaged quadrupole splittings (Delta nu) and CD3 chemical shifts, to determine directly by peak-area integration, for a number of compositions on the phase diagram, the distribution of a H-2-labeled component between micellar, lamellar and solid phases, as well as the chemical compositions of these phases. Our data show that increasing cholesterol stabilizes lamellar phases whereas bile salts disrupt them and favor micelle formation.
Westerman P W; Jacquet R; Quinn B; Rinaldi P L; Daunch W A; Sun Y
Molecular Crystals and Liquid Crystals Science and Technology Section a-Molecular Crystals and Liquid Crystals
1997
1997
Journal Article
<a href="http://doi.org/10.1080/10587259708042006" target="_blank" rel="noreferrer noopener">10.1080/10587259708042006</a>
Physicochemical characterization by H-2 and H-1 NMR of aqueous lipid dispersions resembling bile
Biophysics
Westerman P W; Jacquet R; Quinn B; Rinaldi P; Sun Y
Biophysical Journal
1996
1996-02
Journal Article
n/a
Stabilization of discoidal nematic phase of aqueous lecithin bile salt dispersions by cholesterol: A H-2 and P-31 NMR study
Biophysics
Westerman P W; Jacquet R; Rinaldi P L; Daunch W A; Sun Y
Biophysical Journal
1997
1997-02
Journal Article
n/a