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Text
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<a href="http://doi.org/10.1016/j.molbrainres.2005.02.030" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.molbrainres.2005.02.030</a>
Pages
143–151
Issue
1
Volume
137
Dublin Core
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Title
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APeg3, a novel paternally expressed gene 3 antisense RNA transcript specifically expressed in vasopressinergic magnocellular neurons in the rat supraoptic nucleus.
Publisher
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Brain research. Molecular brain research
Date
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2005
2005-06
Subject
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3' Untranslated Regions/genetics; Amino Acid; Animals; Antisense/*genetics/isolation & purification/*metabolism; Conserved Sequence/genetics; DNA-Binding Proteins/genetics/*metabolism; Gene Expression Regulation/*genetics; Genetic/genetics; Genomic Imprinting/genetics; Hypothalamo-Hypophyseal System/cytology/metabolism; Kruppel-Like Transcription Factors; Male; Messenger/genetics/metabolism; Molecular Sequence Data; Neurons/*metabolism; Nucleic Acid; Protein Kinases/genetics/*metabolism; Rats; RNA; Sequence Homology; Sprague-Dawley; Supraoptic Nucleus/cytology/*metabolism; Transcription; Transcription Factors/genetics/*metabolism; Vasopressins/*metabolism; Water-Electrolyte Balance/genetics
Creator
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Glasgow Eric; Ryu Seung-Lim; Yamashita Mitsuo; Zhang Bing-Jun; Mutsuga Noriko; Gainer Harold
Description
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Vasopressin (VP) and oxytocin (OT) play critical roles in the regulation of salt and water balance, lactation, and various behaviors and are expressed at very high levels in specific magnocellular neurons (MCNs) in the hypothalamo-neurohypophysial system (HNS). In addition to the cell-specific expression of the VP and OT genes in these cells, there are other transcripts that are preferentially expressed in the VP or OT MCNs. One such gene, paternally expressed gene 3 (Peg3), is an imprinted gene expressed exclusively from the paternal allele that encodes a Kruppel-type zinc finger-containing protein involved in maternal behavior and is abundantly expressed in the VP-MCNs. We report here the robust expression in the VP-MCNs of an RNA, which we designate APeg3 that is transcribed in the antisense direction to the 3' untranslated region of the Peg3 gene. The APeg3 mRNA is about 1 kb in size, and the full-length sequence of APeg3, as determined by 5' and 3' RACE, contains an open reading frame that predicts a protein of 93 amino acids and is predominantly expressed in VP-MCNs. Both Peg3 and APeg3 gene expression in the VP-MCNs increase during systemic hyperosmolality in vivo, demonstrating that both of these genes are osmoregulated.
Identifier
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<a href="http://doi.org/10.1016/j.molbrainres.2005.02.030" target="_blank" rel="noreferrer noopener">10.1016/j.molbrainres.2005.02.030</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2005
3' Untranslated Regions/genetics
Amino Acid
Animals
Antisense/*genetics/isolation & purification/*metabolism
Brain research. Molecular brain research
Conserved Sequence/genetics
DNA-Binding Proteins/genetics/*metabolism
Gainer Harold
Gene Expression Regulation/*genetics
Genetic/genetics
Genomic Imprinting/genetics
Glasgow Eric
Hypothalamo-Hypophyseal System/cytology/metabolism
Kruppel-Like Transcription Factors
Male
Messenger/genetics/metabolism
Molecular Sequence Data
Mutsuga Noriko
Neurons/*metabolism
Nucleic Acid
Protein Kinases/genetics/*metabolism
Rats
RNA
Ryu Seung-Lim
Sequence Homology
Sprague-Dawley
Supraoptic Nucleus/cytology/*metabolism
Transcription
Transcription Factors/genetics/*metabolism
Vasopressins/*metabolism
Water-Electrolyte Balance/genetics
Yamashita Mitsuo
Zhang Bing-Jun