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Text
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URL Address
<a href="http://doi.org/10.1124/dmd.112.048694" target="_blank" rel="noreferrer noopener">http://doi.org/10.1124/dmd.112.048694</a>
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Pages
1-11
Issue
1
Volume
41
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Title
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Role of Nuclear Receptors in Lipid Dysfunction and Obesity-Related Diseases
Publisher
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Drug Metabolism and Disposition
Date
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2013
2013-01
Subject
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bile-acid-homeostasis; carbohydrate-metabolism; constitutive androstane receptor; estrogen sulfotransferase; farnesoid X receptor; fatty liver-disease; glucose-homeostasis; heterodimer partner; insulin sensitivity; Pharmacology & Pharmacy; small; type-2 diabetes-mellitus
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Swanson H I; Wada T; Xie W; Renga B; Zampella A; Distrutti E; Fiorucci S; Kong B; Thomas A M; Guo G L; Narayanan R; Yepuru M; Dalton J T; Chiang J Y L
Description
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This article is a report on a symposium sponsored by the American Society for Pharmacology and Experimental Therapeutics and held at the Experimental Biology 12 meeting in San Diego, CA. The presentations discussed the roles of a number of nuclear receptors in regulating glucose and lipid homeostasis, the pathophysiology of obesity-related disease states, and the promise associated with targeting their activities to treat these diseases. While many of these receptors (in particular, constitutive androstane receptor and pregnane X receptor) and their target enzymes have been thought of as regulators of drug and xenobiotic metabolism, this symposium highlighted the advances made in our understanding of the endogenous functions of these receptors. Similarly, as we gain a better understanding of the mechanisms underlying bile acid signaling pathways in the regulation of body weight and glucose homeostasis, we see the importance of using complementary approaches to elucidate this fascinating network of pathways. The observation that some receptors, like the farnesoid X receptor, can function in a tissue-specific manner via well defined mechanisms has important clinical implications, particularly in the treatment of liver diseases. Finally, the novel findings that agents that selectively activate estrogen receptor beta can effectively inhibit weight gain in a high-fat diet model of obesity identifies a new role for this member of the steroid superfamily. Taken together, the significant findings reported during this symposium illustrate the promise associated with targeting a number of nuclear receptors for the development of new therapies to treat obesity and other metabolic disorders.
Identifier
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<a href="http://doi.org/10.1124/dmd.112.048694" target="_blank" rel="noreferrer noopener">10.1124/dmd.112.048694</a>
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Journal Article
2013
bile-acid-homeostasis
carbohydrate-metabolism
Chiang J Y L
constitutive androstane receptor
Dalton J T
Distrutti E
Drug Metabolism and Disposition
estrogen sulfotransferase
Farnesoid X receptor
fatty liver-disease
Fiorucci S
glucose-homeostasis
Guo G L
heterodimer partner
insulin sensitivity
Journal Article
Kong B
Narayanan R
Pharmacology & Pharmacy
Renga B
Small
Swanson H I
Thomas A M
type-2 diabetes-mellitus
Wada T
Xie W
Yepuru M
Zampella A