1
40
4
-
Text
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URL Address
<a href="http://doi.org/10.1152/jappl.1992.73.1.117" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jappl.1992.73.1.117</a>
Pages
117–122
Issue
1
Volume
73
Dublin Core
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Title
A name given to the resource
Circulating neuropeptide Y does not produce pulmonary hypertension during massive sympathetic activation.
Publisher
An entity responsible for making the resource available
Journal of applied physiology (Bethesda, Md. : 1985)
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-07
Subject
The topic of the resource
Adrenal Glands/drug effects/physiology; Adrenalectomy; Animals; Dogs; Hypertension; In Vitro Techniques; Neuropeptide Y/*physiology; Norepinephrine/pharmacology; Pulmonary Circulation/drug effects; Pulmonary/chemically induced/*physiopathology; Sympathetic Nervous System/*physiology; Veratrine/pharmacology
Creator
An entity primarily responsible for making the resource
Lang S A; Maron M B; Maender K C; Pilati C F
Description
An account of the resource
We tested the possibility that neuropeptide Y (NPY) may contribute to the pulmonary hypertension that occurs after massive sympathetic activation produced by intracisternal veratrine administration in the chloralose-anesthetized dog. In six dogs, veratrine caused arterial NPY-like immunoreactivity (NPY-LI) to rise from 873 +/- 150 (SE) pg/ml to peak values of 3,780 +/- 666 pg/ml by 60-120 min. (In 3 animals, adrenalectomy significantly reduced the increases in NPY-LI.) In five additional dogs, we infused porcine NPY for 30 min in doses that increased arterial NPY-LI to 8,354 +/- 1,514 pg/ml and observed only minor changes in pulmonary hemodynamics. In three isolated perfused canine left lower lung lobe (LLL) preparations, increasing doses of NPY were administered, producing levels of plasma NPY-LI, at the highest dose, that exceeded those observed after veratrine administration by three orders of magnitude. No changes in LLL arterial or double-occlusion capillary pressures were observed at any dose. Similarly, no changes in LLL hemodynamics were observed in three additional lobes when NPY was administered while norepinephrine was being infused. We conclude that it is unlikely that NPY plays a role as a circulating vasoactive agent in producing the pulmonary hypertension and edema that occur in this model.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jappl.1992.73.1.117" target="_blank" rel="noreferrer noopener">10.1152/jappl.1992.73.1.117</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1992
Adrenal Glands/drug effects/physiology
Adrenalectomy
Animals
Dogs
Hypertension
In Vitro Techniques
Journal of applied physiology (Bethesda, Md. : 1985)
Lang S A
Maender K C
Maron M B
Neuropeptide Y/*physiology
Norepinephrine/pharmacology
Pilati C F
Pulmonary Circulation/drug effects
Pulmonary/chemically induced/*physiopathology
Sympathetic Nervous System/*physiology
Veratrine/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajpheart.1996.271.5.H1840" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpheart.1996.271.5.H1840</a>
Pages
H1840–1848
Issue
5
Volume
271
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Daily exercise and gender influence arterial baroreflex regulation of heart rate and nerve activity.
Publisher
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The American journal of physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-11
Subject
The topic of the resource
*Physical Conditioning; *Sex Characteristics; Animal; Animals; Arteries/*physiology; Baroreflex/*physiology; Female; Heart Rate/*physiology; Lumbosacral Region; Male; Rats; Rest; Sprague-Dawley; Sympathetic Nervous System/*physiology
Creator
An entity primarily responsible for making the resource
Chen C Y; DiCarlo S E
Description
An account of the resource
The influence of daily spontaneous running (DSR) and gender on the arterial baroreflex regulation of heart rate (HR) and lumbar sympathetic nerve activity (LSNA) was examined in 13 male [7 sedentary (SED) and 6 DSR] and 12 female (6 SED and 6 DSR) Sprague-Dawley rats. After 8-9 wk of DSR or SED control, all animals were chronically instrumented with right femoral venous and left carotid arterial catheters and electrodes around the lumbar sympathetic trunk. DSR resulted in an increase in heart weight-to-body weight ratio (P = 0.001) in male and female rats and resting bradycardia in male rats (P = 0.001). Arterial baroreflex function was examined by ramp increases (1.25 +/- 0.07 mmHg/s) and decreases (1.47 mmHg/s) in arterial pressure. DSR attenuated the arterial baroreflex regulation of LSNA in a similar manner in female and male rats. DSR reduced the range (32 and 29% for female and male rats, respectively), maximum (26 and 21% for female and male rats, respectively), and maximum gain (Gmax; 46 and 17% for female and male rats, respectively). In contrast, there was a gender influence on the arterial baroreflex regulation of HR. For example, SED female rats had a higher Gmax (40%) than SED male rats. Furthermore, DSR altered the arterial baroreflex regulation of HR differently in male and female rats. DSR female rats had a reduced Gmax (38%), range (25%), and maximum (12%), whereas DSR male rats had a reduced maximum (17%) and minimum (23%). These results demonstrate that DSR attenuated the arterial baroreflex regulation of LSNA in a similar manner in female and male rats. In contrast, DSR altered the arterial baroreflex regulation of HR differently in female and male rats.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajpheart.1996.271.5.H1840" target="_blank" rel="noreferrer noopener">10.1152/ajpheart.1996.271.5.H1840</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Physical Conditioning
*Sex Characteristics
1996
Animal
Animals
Arteries/*physiology
Baroreflex/*physiology
Chen C Y
DiCarlo S E
Female
Heart Rate/*physiology
Lumbosacral Region
Male
Rats
Rest
Sprague-Dawley
Sympathetic Nervous System/*physiology
The American journal of physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajpheart.1997.273.3.H1606" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpheart.1997.273.3.H1606</a>
Pages
H1606–1610
Issue
3
Volume
273
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Daily exercise attenuates the sympathetic nerve response to exercise by enhancing cardiac afferents.
Publisher
An entity responsible for making the resource available
The American journal of physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-09
Subject
The topic of the resource
Afferent Pathways; Animal/*physiology; Animals; Baroreflex; Blood Pressure; Femoral Artery/physiology; Femoral Vein/physiology; Heart Rate; Heart/innervation/*physiology; Kidney/innervation; Physical Conditioning; Rabbits; Sympathetic Nervous System/*physiology
Creator
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DiCarlo S E; Stahl L K; Bishop V S
Description
An account of the resource
"Central command" may initiate the sympathoexcitatory responses at the onset of exercise by shifting the operating point of the arterial baroreflex toward higher pressures. Daily exercise (DE) attenuates the sympathoexcitatory responses to submaximal exercise. This DE-induced adaptation may be due, in part, to an enhanced inhibitory influence of cardiac afferents. This is suggested because cardiac afferents exert a tonic inhibitory influence on the arterial baroreflex which is enhanced by DE. Therefore, the influence of cardiac afferents on the regulation of renal sympathetic nerve activity (RSNA) during exercise was examined in a group of sedentary and age-matched DE rabbits. The rabbits were instrumented with a Silastic catheter inserted into the pericardial sac, electrodes around the renal sympathetic nerves, and catheters in the femoral artery and vein. In the sedentary rabbits, treadmill exercise (12 m/min, 20% grade) significantly increased mean arterial pressure (delta 18 +/- 3 mmHg), heart rate (delta 36 +/- 3 beats/min), and RSNA (delta 295 +/- 23%). More importantly, cardiac afferent blockade (2% intrapericardial procainamide) did not significantly alter the RSNA response to exercise in the sedentary rabbits. DE did not alter the mean arterial pressure (delta 15 +/- 1 mmHg) or heart rate (delta 55 +/- 8 beats/min) response to exercise; however, RSNA (delta 252 +/- 9%) was significantly reduced. In contrast to the sedentary rabbits, cardiac afferent blockade in the DE rabbits significantly increased the RSNA response to exercise (delta 417 +/- 30%). These results suggest that DE attenuates the RSNA response to dynamic exercise due, in part, to an enhanced inhibitory influence of cardiac afferents.
Identifier
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<a href="http://doi.org/10.1152/ajpheart.1997.273.3.H1606" target="_blank" rel="noreferrer noopener">10.1152/ajpheart.1997.273.3.H1606</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1997
Afferent Pathways
Animal/*physiology
Animals
Baroreflex
Bishop V S
Blood Pressure
DiCarlo S E
Femoral Artery/physiology
Femoral Vein/physiology
Heart Rate
Heart/innervation/*physiology
Kidney/innervation
Physical Conditioning
Rabbits
Stahl L K
Sympathetic Nervous System/*physiology
The American journal of physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/00005768-199606000-00006" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/00005768-199606000-00006</a>
Pages
677–684
Issue
6
Volume
28
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Onset of exercise increases lumbar sympathetic nerve activity in rats.
Publisher
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Medicine and science in sports and exercise
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-06
Subject
The topic of the resource
Animal/*physiology; Animals; Blood Pressure; Heart Rate; Lumbar Vertebrae/*innervation; Physical Conditioning; Rats; Sympathetic Nervous System/*physiology
Creator
An entity primarily responsible for making the resource
DiCarlo S E; Chen C Y; Collins H L
Description
An account of the resource
We hypothesized that lumbar sympathetic nerve activity (LSNA) increases at the onset of whole-body dynamic exercise in the rat. To test this hypothesis, we recorded LSNA, heart rate (HR), and arterial pressure (AP) at rest and during a graded exercise test in six adult rats. Rats were instrumented with arterial and venous catheters and recording electrodes around the lumbar sympathetic trunk. Following recovery, each rat ran continuously on a hand-driven or motorized treadmill at 6 m.min-1, 12 m.min-1, and 18 m.min-1 on a 10% grade for approximately 3 min at each workload. Before exercise, mean arterial pressure (MAP), HR, and LSNA averaged 108 +/- 4 mm Hg, 385 +/- 20 bpm, and 100%, respectively. As hypothesized, all variables increased abruptly and dramatically at the onset of treadmill exercise. For example, MAP (117 +/- 5 mm Hg), HR (450 +/- 15 bpm), and LSNA (225 +/- 19%) all increased significantly within the first 25 s of treadmill running at 6 m.min-1. As the exercise continued, there was a progressive increase in HR; however, MAP plateaued at 6 m.min-1 and LSNA plateaued at 12 m.min-1. Since LSNA increased at the onset of whole-body dynamic exercise in the rat, we suggest that the increase in LSNA at the onset of exercise is mediated by a central (feed forward) mechanism.
Identifier
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<a href="http://doi.org/10.1097/00005768-199606000-00006" target="_blank" rel="noreferrer noopener">10.1097/00005768-199606000-00006</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1996
Animal/*physiology
Animals
Blood Pressure
Chen C Y
Collins H L
DiCarlo S E
Heart Rate
Lumbar Vertebrae/*innervation
Medicine and science in sports and exercise
Physical Conditioning
Rats
Sympathetic Nervous System/*physiology