1
40
2
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neuroscience.2012.10.069" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuroscience.2012.10.069</a>
Pages
55–70
Volume
229
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Failure of axonal transport induces a spatially coincident increase in astrocyte BDNF prior to synapse loss in a central target.
Publisher
An entity responsible for making the resource available
Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-01
Subject
The topic of the resource
Animal; Animals; Astrocytes/*metabolism; Axonal Transport/*physiology; Brain-Derived Neurotrophic Factor/*metabolism; Disease Models; Glaucoma/genetics/*metabolism; Messenger/genetics/metabolism; Mice; Optic Nerve Diseases/genetics/metabolism; Rats; Retinal Ganglion Cells/*metabolism; RNA; Superior Colliculi/metabolism; Synapses/*metabolism; Visual Pathways/metabolism
Creator
An entity primarily responsible for making the resource
Crish S D; Dapper J D; MacNamee S E; Balaram P; Sidorova T N; Lambert W S; Calkins D J
Description
An account of the resource
Failure of anterograde transport to distal targets in the brain is a common feature of neurodegenerative diseases. We have demonstrated in rodent models of glaucoma, the most common optic neuropathy, early loss of anterograde transport along the retinal ganglion cell (RGC) projection to the superior colliculus (SC) is retinotopic and followed by a period of persistence of RGC axon terminals and synapses through unknown molecular pathways. Here we use the DBA/2J mouse model of hereditary glaucoma and an acute rat model to demonstrate that retinotopically focal transport deficits in the SC are accompanied by a spatially coincident increase in brain-derived neurotrophic factor (BDNF), especially in hypertrophic astrocytes. These neurochemical changes occur prior to loss of RGC synapses in the DBA/2J SC. In contrast to BDNF protein, levels of Bdnf mRNA decreased with transport failure, even as mRNA encoding synaptic structures remained unchanged. In situ hybridization signal for Bdnf mRNA was the strongest in SC neurons, and labeling for the immature precursor pro-BDNF was very limited. Subcellular fractionation of SC indicated that membrane-bound BDNF decreased with age in the DBA/2J, while BDNF released from vesicles remained high. These results suggest that in response to diminished axonal function, activated astrocytes in the brain may sequester mature BDNF released from target neurons to counter stressors that otherwise would challenge survival of projection synapses.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neuroscience.2012.10.069" target="_blank" rel="noreferrer noopener">10.1016/j.neuroscience.2012.10.069</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2013
Animal
Animals
Astrocytes/*metabolism
Axonal Transport/*physiology
Balaram P
Brain-Derived Neurotrophic Factor/*metabolism
Calkins D J
Crish S D
Dapper J D
Department of Pharmaceutical Sciences
Disease Models
Glaucoma/genetics/*metabolism
Lambert W S
MacNamee S E
Messenger/genetics/metabolism
Mice
NEOMED College of Pharmacy
Neuroscience
Optic Nerve Diseases/genetics/metabolism
Rats
Retinal Ganglion Cells/*metabolism
RNA
Sidorova T N
Superior Colliculi/metabolism
Synapses/*metabolism
Visual Pathways/metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neures.2011.11.004" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neures.2011.11.004</a>
Pages
129–139
Issue
2
Volume
72
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Synaptic activity-induced Ca(2+) signaling in avian cochlear nucleus magnocellularis neurons.
Publisher
An entity responsible for making the resource available
Neuroscience research
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-02
Subject
The topic of the resource
Animals; Calcium Signaling/*physiology; Chick Embryo; Chickens; Cochlear Nucleus/*metabolism; GABA-A/metabolism; Inhibitory Postsynaptic Potentials/physiology; Neurons/*metabolism; Organ Culture Techniques; Patch-Clamp Techniques; Receptors; Synapses/*metabolism; Synaptic Transmission/*physiology
Creator
An entity primarily responsible for making the resource
Wang Lie-Cheng; Tang Zheng-Quan; Lu Yong
Description
An account of the resource
Neurons of the avian cochlear nucleus magnocellularis (NM) receive glutamatergic inputs from the spiral ganglion cells via the auditory nerve and feedback GABAergic inputs primarily from the superior olivary nucleus. We investigated regulation of Ca(2+) signaling in NM neurons with ratiometric Ca(2+) imaging in chicken brain slices. Application of exogenous glutamate or GABA increased the intracellular Ca(2+) concentration ([Ca(2+)](i)) in NM neurons. Interestingly,
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neures.2011.11.004" target="_blank" rel="noreferrer noopener">10.1016/j.neures.2011.11.004</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2012
Animals
Calcium Signaling/*physiology
Chick Embryo
Chickens
Cochlear Nucleus/*metabolism
Department of Anatomy & Neurobiology
GABA-A/metabolism
Inhibitory Postsynaptic Potentials/physiology
Lu Yong
NEOMED College of Medicine
Neurons/*metabolism
Neuroscience research
Organ Culture Techniques
Patch-Clamp Techniques
Receptors
Synapses/*metabolism
Synaptic Transmission/*physiology
Tang Zheng-Quan
Wang Lie-Cheng