1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0165-3806(98)00100-x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0165-3806(98)00100-x</a>
Pages
115–119
Issue
1
Volume
110
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
GABAa receptor-mediated field potentials are enhanced in area CA1 following prenatal cocaine exposure.
Publisher
An entity responsible for making the resource available
Brain research. Developmental brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-09
Subject
The topic of the resource
*Prenatal Exposure Delayed Effects; AMPA/physiology; Animals; Bicuculline/analogs & derivatives/pharmacology; Cocaine/*pharmacology; Female; GABA-A/*physiology; GABA-B/physiology; Hippocampus/drug effects/*physiology; In Vitro Techniques; Membrane Potentials/drug effects/physiology; N-Methyl-D-Aspartate/physiology; Pregnancy; Quinoxalines/pharmacology; Rabbits; Receptors; Synapses/drug effects/physiology
Creator
An entity primarily responsible for making the resource
Little J Z; Teyler T J
Description
An account of the resource
Prenatal cocaine exposure results in several documented changes in neurotransmitter receptor number and structure. Increases have been reported for cortical catecholamine and indoleamine receptor number and binding affinity, in the subunit expression of glutamatergic NMDA and AMPA receptors in the striatum, and in GABA immunoreactivity in the anterior cingulate cortex. We sought information on the functional consequences of cocaine-induced alterations in receptor structure/number. Since hippocampal amino acid neurotransmitters are of critical importance and have been shown to be affected by cocaine, we studied field potentials produced by synaptic activation of isolated glutamatergic NMDA and AMPA receptors and GABAa and GABAb responsive receptors in area CA1 of rabbit hippocampal slices. We found the GABAa receptor population produced significantly larger field potentials in cocaine-exposed offspring compared to controls, while other receptors produced responses similar to controls.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0165-3806(98)00100-x" target="_blank" rel="noreferrer noopener">10.1016/s0165-3806(98)00100-x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Prenatal Exposure Delayed Effects
1998
AMPA/physiology
Animals
Bicuculline/analogs & derivatives/pharmacology
Brain research. Developmental brain research
Cocaine/*pharmacology
Female
GABA-A/*physiology
GABA-B/physiology
Hippocampus/drug effects/*physiology
In Vitro Techniques
Little J Z
Membrane Potentials/drug effects/physiology
N-Methyl-D-Aspartate/physiology
Pregnancy
Quinoxalines/pharmacology
Rabbits
Receptors
Synapses/drug effects/physiology
Teyler T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.1991.66.5.1538" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.1991.66.5.1538</a>
Pages
1538–1548
Issue
5
Volume
66
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Hyperpolarizing and depolarizing GABAA receptor-mediated dendritic inhibition in area CA1 of the rat hippocampus.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-11
Subject
The topic of the resource
2-Amino-5-phosphonovalerate/pharmacology; Animals; Bicuculline/analogs & derivatives/pharmacology; Chlorides/pharmacology; Dendrites/drug effects/*physiology; Evoked Potentials/drug effects; GABA-A Receptor Antagonists; GABA-A/drug effects/*physiology; Hippocampus/*physiology; In Vitro Techniques; Kinetics; Mathematics; Membrane Potentials/drug effects; Models; Neurological; Neurons/drug effects/*physiology; Organophosphorus Compounds/pharmacology; Pyramidal Tracts/drug effects/*physiology; Quinoxalines/pharmacology; Rats; Receptors; Synapses/drug effects/physiology
Creator
An entity primarily responsible for making the resource
Lambert N A; Borroni A M; Grover L M; Teyler T J
Description
An account of the resource
1. gamma-Aminobutyric acidA (GABAA) receptor-mediated inhibition of pyramidal neuron dendrites was studied in area CA1 of the rat hippocampal slice preparation with the use of intracellular and extracellular recording and one-dimensional current source-density (CSD) analysis. 2. Electrical stimulation of Schaffer collateral/commissural fibers evoked monosynaptic excitatory postsynaptic potentials (EPSPs) and population EPSPs, which were followed by biphasic inhibitory postsynaptic potentials (IPSPs). In the presence of the excitatory amino acid receptor antagonists 6,7-dinitroquinoxaline-2,3-dione (DNQX) and D,L-2-amino-5-phosphonovalerate (APV), stimulation in stratum radiatum evoked monosynaptic fast, GABAA and late, GABAB receptor-mediated IPSPs and fast and late positive field potentials recorded in s. radiatum. 3. Fast monosynaptic IPSPs and fast positive field potentials evoked in the presence of DNQX and APV were reversibly abolished by the GABAA receptor antagonist bicuculline methiodide (BMI; 30 microM) and were not changed by the GABAB receptor antagonist
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.1991.66.5.1538" target="_blank" rel="noreferrer noopener">10.1152/jn.1991.66.5.1538</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
2-Amino-5-phosphonovalerate/pharmacology
Animals
Bicuculline/analogs & derivatives/pharmacology
Borroni A M
Chlorides/pharmacology
Dendrites/drug effects/*physiology
Evoked Potentials/drug effects
GABA-A Receptor Antagonists
GABA-A/drug effects/*physiology
Grover L M
Hippocampus/*physiology
In Vitro Techniques
Journal of neurophysiology
Kinetics
Lambert N A
Mathematics
Membrane Potentials/drug effects
Models
Neurological
Neurons/drug effects/*physiology
Organophosphorus Compounds/pharmacology
Pyramidal Tracts/drug effects/*physiology
Quinoxalines/pharmacology
Rats
Receptors
Synapses/drug effects/physiology
Teyler T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/(SICI)1097-4547(19960201)43:3%3C282::AID-JNR3%3E3.0.CO;2-F" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/(SICI)1097-4547(19960201)43:3%3C282::AID-JNR3%3E3.0.CO;2-F</a>
Pages
282–288
Issue
3
Volume
43
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Inhibition of long-term potentiation development in rat hippocampal slice by alpha 2-macroglobulin, an acute-phase protein in the brain.
Publisher
An entity responsible for making the resource available
Journal of neuroscience research
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-02
Subject
The topic of the resource
alpha-Macroglobulins/*pharmacology; Animals; Electric Stimulation; Hippocampus/drug effects/*physiology; Humans; In Vitro Techniques; Long-Term Potentiation/*drug effects; Methylamines/pharmacology; Neurites/drug effects/*physiology; Pyramidal Cells/drug effects/physiology; Rats; Synapses/drug effects/physiology; Synaptic Transmission/drug effects; Time Factors
Creator
An entity primarily responsible for making the resource
Cavus I; Koo P H; Teyler T J
Description
An account of the resource
Alpha-2-macroglobulin (alpha 2M) in the rat and human brain is an acute-phase protein synthesized primarily by astrocytes, and it has been implicated in Alzheimer's disease and other neuropathological processes. The activated forms of alpha 2M, but not the native form, can suppress the neurite outgrowth of the central neurons, presumably through binding to neurotrophic factors and through direct inhibition of neurotrophic factor receptor signal transduction. Since neurotrophic factors are known to be involved in synaptic plasticity, we tested the effect of both the native and methylamine-activated (MA-alpha 2M) forms of alpha 2M on long-term potentiation (LTP) in area CA1 of adult rat hippocampal slice. Neither native alpha 2M nor MA-alpha 2M had an effect on baseline synaptic transmission. LTP induced by 200-Hz trains in the presence of 1.4 microM or 0.14 microM native alpha 2M was indistinguishable from control LTP. Although the presence of MA-alpha 2M at the same concentrations did not interfere with LTP induction, the development and maintenance of potentiation was blocked in a concentration-dependent time course. Results of this study indicate that the accumulation and activation of alpha 2M with inflammatory neuropathologies such as Alzheimer's disease can inhibit synaptic plasticity, which might partly account for the memory deficits seen in these patients.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/(SICI)1097-4547(19960201)43:3%3C282::AID-JNR3%3E3.0.CO;2-F" target="_blank" rel="noreferrer noopener">10.1002/(SICI)1097-4547(19960201)43:3%3C282::AID-JNR3%3E3.0.CO;2-F</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1996
alpha-Macroglobulins/*pharmacology
Animals
Cavus I
Electric Stimulation
Hippocampus/drug effects/*physiology
Humans
In Vitro Techniques
Journal of neuroscience research
Koo P H
Long-Term Potentiation/*drug effects
Methylamines/pharmacology
Neurites/drug effects/*physiology
Pyramidal Cells/drug effects/physiology
Rats
Synapses/drug effects/physiology
Synaptic Transmission/drug effects
Teyler T J
Time Factors