1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0304-3940(91)90190-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0304-3940(91)90190-5</a>
Pages
50–52
Issue
1
Volume
122
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Adenosine depresses excitatory but not fast inhibitory synaptic transmission in area CA1 of the rat hippocampus.
Publisher
An entity responsible for making the resource available
Neuroscience letters
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-01
Subject
The topic of the resource
Animals; Rats; In Vitro Techniques; Quinoxalines/pharmacology; 2-Amino-5-phosphonovalerate/pharmacology; Membrane Potentials/drug effects; Hippocampus/drug effects/*physiology; Evoked Potentials/drug effects; Synaptic Transmission/*drug effects; Adenosine/*pharmacology; Synapses/*drug effects; Theophylline/analogs & derivatives/pharmacology
Creator
An entity primarily responsible for making the resource
Lambert N A; Teyler T J
Description
An account of the resource
The effects of adenosine on inhibitory synaptic transmission in area CA1 were examined using the rat hippocampal slice preparation and intracellular recording. Adenosine did not change fast inhibitory synaptic potentials (IPSPs) but depressed late IPSPs evoked by direct activation of interneurons in the presence of 6,7-dinitroquinoxaline-2,3-dione (DNQX) and D,L-2-amino-5-phosphonovalerate (APV). Directly activated IPSPs were unchanged by the selective adenosine A1 receptor antagonist 8-cyclopentyltheophylline (CPT), but CPT reversed hyperpolarization and depression of late IPSPs produced by adenosine. These results indicate that adenosine depresses disynaptic IPSPs in area CA1 by decreasing synaptic activation of inhibitory neurons.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0304-3940(91)90190-5" target="_blank" rel="noreferrer noopener">10.1016/0304-3940(91)90190-5</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
2-Amino-5-phosphonovalerate/pharmacology
Adenosine/*pharmacology
Animals
Evoked Potentials/drug effects
Hippocampus/drug effects/*physiology
In Vitro Techniques
Lambert N A
Membrane Potentials/drug effects
Neuroscience letters
Quinoxalines/pharmacology
Rats
Synapses/*drug effects
Synaptic Transmission/*drug effects
Teyler T J
Theophylline/analogs & derivatives/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0892-0362(88)90090-6" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0892-0362(88)90090-6</a>
Pages
539–548
Issue
6
Volume
10
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Triethyltin exposure suppresses synaptic transmission in area CA1 of the rat hippocampal slice.
Publisher
An entity responsible for making the resource available
Neurotoxicology and teratology
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988-12
Subject
The topic of the resource
Female; Animals; Rats; In Vitro Techniques; Synapses/drug effects/*physiology; Evoked Potentials/drug effects; Synaptic Transmission/*drug effects; Hippocampus/drug effects/*pathology/physiology; Pyramidal Tracts/drug effects/*pathology/physiology; Trialkyltin Compounds/*toxicity; Triethyltin Compounds/*toxicity
Creator
An entity primarily responsible for making the resource
Fountain S B; Ting Y L; Hennes S K; Teyler T J
Description
An account of the resource
To examine the effects of TET on the electrophysiology of area CA1 of hippocampus, hippocampal slices were obtained from adult hooded rats and were maintained in vitro using standard techniques. Stimulating and recording electrodes were placed in the Schaffer collaterals and CA1 pyramidal cell body layer, respectively. Following baseline measurements, slices were exposed to either 0, 1, 3, 6, or 10 microM TET in the incubating medium. Both pyramidal cell excitability and recurrent/feedforward inhibition were suppressed in a dose-dependent manner within 3 hr postexposure. The evoked population spike and population excitatory postsynaptic potential (EPSP) were suppressed significantly by 2 hr postexposure for 1 and 3 microM TET exposures, and by 45 min postexposure for 6 and 10 microM exposures. A similar dose-dependency was observed for the suppression of recurrent/feedforward inhibition in hippocampal CA1. A second procedure tested the specificity of TET effects to axonal conduction of Schaffer collaterals. Both the stimulating and recording electrode were placed in the Schaffer collaterals so that both the Schaffer collateral population fiber volley and the CA1 pyramidal cell population EPSP could be recorded. TET exposure suppressed pyramidal cell EPSPs without significantly affecting the amplitude of Schaffer collateral fiber volleys. The results support the view that acute TET exposure suppresses synaptic transmission in area CA1 of hippocampus.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0892-0362(88)90090-6" target="_blank" rel="noreferrer noopener">10.1016/0892-0362(88)90090-6</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1988
Animals
Evoked Potentials/drug effects
Female
Fountain S B
Hennes S K
Hippocampus/drug effects/*pathology/physiology
In Vitro Techniques
Neurotoxicology and teratology
Pyramidal Tracts/drug effects/*pathology/physiology
Rats
Synapses/drug effects/*physiology
Synaptic Transmission/*drug effects
Teyler T J
Ting Y L
Trialkyltin Compounds/*toxicity
Triethyltin Compounds/*toxicity
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(94)91335-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(94)91335-8</a>
Pages
353–356
Issue
2
Volume
647
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Spermine depresses NMDA, K/AMPA and GABAA-mediated synaptic transmission in the rat hippocampal slice preparation.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-06
Subject
The topic of the resource
AMPA/antagonists & inhibitors; Animals; Calcium Channels/drug effects; Evoked Potentials/drug effects; Excitatory Amino Acid Antagonists/*pharmacology; GABA-A Receptor Antagonists; Hippocampus/drug effects/*physiology; In Vitro Techniques; N-Methyl-D-Aspartate/antagonists & inhibitors; Rats; Receptors; Spermine/*pharmacology; Synapses/drug effects/*physiology; Synaptic Transmission/*drug effects
Creator
An entity primarily responsible for making the resource
DiScenna P G; Ferchmin P A; Eterovic V A; Teyler T J
Description
An account of the resource
The effects of spermine, an endogenous polyamine, were examined in area CA1 of the rat hippocampal slice preparation. Spermine, at low millimolar concentrations, rapidly and potently depressed NMDA and K/AMPA-mediated population EPSPs, and GABA-mediated monosynaptic population IPSPs. These effects contrast with its well-known potentiation of NMDA currents at lower concentrations. Our results raise the possibility that the large intracellular stores of spermine that are released after various neural insults could act as an endogenous neuroprotective mechanism by limiting excessive calcium entry.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(94)91335-8" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(94)91335-8</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1994
AMPA/antagonists & inhibitors
Animals
Brain research
Calcium Channels/drug effects
DiScenna P G
Eterovic V A
Evoked Potentials/drug effects
Excitatory Amino Acid Antagonists/*pharmacology
Ferchmin P A
GABA-A Receptor Antagonists
Hippocampus/drug effects/*physiology
In Vitro Techniques
N-Methyl-D-Aspartate/antagonists & inhibitors
Rats
Receptors
Spermine/*pharmacology
Synapses/drug effects/*physiology
Synaptic Transmission/*drug effects
Teyler T J