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Text
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<a href="http://doi.org/10.1007/s007020050114" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s007020050114</a>
Pages
1091–1101
Issue
10
Volume
105
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Title
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Alteration in L-DOPA evoked dopamine and DOPAC output under conditions of impaired vesicular dopamine storage.
Publisher
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Journal of neural transmission (Vienna, Austria : 1996)
Date
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1998
1905-06
Subject
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3; 4-Dihydroxyphenylacetic Acid/*metabolism; Animals; Dopamine Agents/*pharmacology; Dopamine/*metabolism; Levodopa/*pharmacology; Male; Pharmaceutical Vehicles; Rats; Reserpine/pharmacology; Sprague-Dawley; Synaptic Vesicles/*drug effects/metabolism; Tetrabenazine/pharmacology
Creator
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Xu K; Dluzen D E
Description
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We examined the effect of L-dihydroxyphenylalanine (L-DOPA) infusion in vitro upon dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) output from superfused corpus striatum of vehicle and reserpine or tetrabenazine (TBZ) treated male rats. Specifically, we tested the effects of two 20-min infusions of L-DOPA (5 uM) upon DA and DOPAC output (pg/mg/min) in reserpine (5 mg/kg, i.p., 24 hours before sacrifice; n=11), TBZ (30 mg/kg, i.p. 1 hour before sacrifice; n=8) or vehicle (n=21) treated rats. There was an overall significantly higher L-DOPA evoked DA output from the vehicle (12.22+/-1.74) versus reserpine (4.39+/-2.40) (p \textless 0.05), but not TBZ (9.16+/-2.81) treated rats. In addition, the DA response to the second L-DOPA infusion was significantly increased over that of the first response in the vehicle (9.40+/-2.11 vs. 15.04+/-2.78) (p \textless 0.05), but not reserpine or TBZ treated rats. The overall DOPAC outputs did not achieve a statistically significant difference among all treatment groups. However, the DOPAC outputs following the second L-DOPA infusion were significantly reduced in reserpine (41.15+/-6.10 vs. 20.27+/-4.54) and TBZ (21.38+/-4.41 vs. 10.87+/-2.36) (both p \textless 0.05), but not vehicle (28.99+/-4.00 vs. 24.91+/-4.78) treated rats. We conclude that: 1) the storage capacity of DA neurons is one of the important elements involved in affecting L-DOPA's effects upon DA and DOPAC output, 2) the shunting of storage to metabolism may represent a common characteristic in impaired nigrostriatal dopaminergic system, and 3) TBZ may operate differently from reserpine in the nigrostriatal dopaminergic system.
Identifier
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<a href="http://doi.org/10.1007/s007020050114" target="_blank" rel="noreferrer noopener">10.1007/s007020050114</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1998
3
4-Dihydroxyphenylacetic Acid/*metabolism
Animals
Dluzen D E
Dopamine Agents/*pharmacology
Dopamine/*metabolism
Journal of neural transmission (Vienna, Austria : 1996)
Levodopa/*pharmacology
Male
Pharmaceutical Vehicles
Rats
Reserpine/pharmacology
Sprague-Dawley
Synaptic Vesicles/*drug effects/metabolism
Tetrabenazine/pharmacology
Xu K