1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1177/1535370216675773" target="_blank" rel="noreferrer noopener">http://doi.org/10.1177/1535370216675773</a> Pages 384–396 Issue 4 Volume 242 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The contribution of interleukin-2 to effective wound healing. Publisher An entity responsible for making the resource available Experimental biology and medicine (Maywood, N.J.) Date A point or period of time associated with an event in the lifecycle of the resource 2017 2017-02 Subject The topic of the resource *cutaneous diseases; *cytokines; *immunotherapy; *Interleukin-2; *therapeutic targets; *wound healing; Animals; Cell Differentiation/physiology; Cell Proliferation/physiology; Diabetes Mellitus/metabolism/pathology; Humans; Interleukin-2/*metabolism; Interleukin-2/*metabolism/*therapeutic use; Lupus Erythematosus; Mice; Myocardial Infarction/metabolism/pathology; Receptors; Sarcoidosis/metabolism/pathology; Signal Transduction/physiology; Skin/*injuries; Systemic/metabolism/pathology; T-Lymphocytes/cytology/immunology; Wound Healing/*physiology Creator An entity primarily responsible for making the resource Doersch Karen M; DelloStritto Daniel J; Newell-Rogers M Karen Description An account of the resource Ineffective skin wound healing is a significant source of morbidity and mortality. Roughly 6.5 million Americans experience chronically open wounds and the cost of treating these wounds numbers in the billions of dollars annually. In contrast, robust wound healing can lead to the development of either hypertrophic scarring or keloidosis, both of which can cause discomfort and can be cosmetically undesirable. Appropriate wound healing requires the interplay of a variety of factors, including the skin, the local microenvironment, the immune system, and the external environment. When these interactions are perturbed, wounds can be a nidus for infection, which can cause them to remain open an extended period of time, or can scar excessively. Interleukin-2, a cytokine that directs T-cell expansion and phenotypic development, appears to play an important role in wound healing. The best-studied role for Interleukin-2 is in influencing Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1177/1535370216675773" target="_blank" rel="noreferrer noopener">10.1177/1535370216675773</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). *cutaneous diseases *CYTOKINES *immunotherapy *Interleukin-2 *therapeutic targets *Wound Healing 2017 Animals Cell Differentiation/physiology Cell Proliferation/physiology DelloStritto Daniel J Diabetes Mellitus/metabolism/pathology Doersch Karen M Experimental biology and medicine (Maywood, N.J.) Humans Interleukin-2/*metabolism Interleukin-2/*metabolism/*therapeutic use Lupus Erythematosus Mice Myocardial Infarction/metabolism/pathology Newell-Rogers M Karen Receptors Sarcoidosis/metabolism/pathology Signal Transduction/physiology Skin/*injuries Systemic/metabolism/pathology T-Lymphocytes/cytology/immunology Wound Healing/*physiology